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O Brien

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Cheap Flights to O Brien

Fall in love at first flight with your vacation to O Brien by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to O Brien on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in O Brien, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to O Brien

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to O Brien with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the null airport.

What is the cheapest month to fly to O Brien?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to O Brien are in , but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to O Brien?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find  to choose from for your flight to O Brien.

What airport is best to fly into O Brien?

When you’re planning your trip to O Brien, convenience is the name of the game. Luckily, O Brien Gainesville Regional Airport is nearby so you can deplane and get going on checking off everything on your O Brien must-do list.

How much are flights to O Brien?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to O Brien on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as , you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to O Brien?

The trick to saving a stack of cash on your flight to O Brien? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as  right now, why wait?

O Brien Flight Information
Destination airport
O Brien

Last Minute Hotel Deals in O Brien

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

3.5 out of 5
16367 NW 167TH BLVD Alachua FL
Book a stay at this business-friendly hotel in Alachua. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,004 reviews)
Great clean place to stay.

Reviewed on Nov 15, 2025

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
Best Western Plus Lake City

Best Western Plus Lake City

2.5 out of 5
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Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,007 reviews)
The young lady at the front deak was very sweet.

Reviewed on Nov 20, 2025

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La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City

2.5 out of 5
165NW CALI DRIVE Lake City FL
Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.6/10 Excellent! (1,014 reviews)
Very good

Reviewed on Nov 20, 2025

La Quinta Inn & Suite by Wyndham Lake City
Tru by Hilton Lake City

Tru by Hilton Lake City

2.5 out of 5
284 NW Centurion Court Lake City FL
Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9/10 Wonderful! (1,011 reviews)
clean room, pleasant staff

Reviewed on Nov 21, 2025

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Holiday Inn Express & Suites Live Oak by IHG

Holiday Inn Express & Suites Live Oak by IHG

2.5 out of 5
6694 Us Highway 129 Live Oak FL
Book a stay at this business-friendly hotel in Live Oak. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.2/10 Very Good! (764 reviews)
Na

Reviewed on Nov 16, 2025

Holiday Inn Express & Suites Live Oak by IHG
Postcard Cabins Gilchrest Spring, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Gilchrest Spring, Outdoor Collection by Marriott Bonvoy

2 out of 5
1699 NE Co Rd 337 High Springs FL
Stay at this cabin in High Springs. Enjoy free parking, patios, and climate control. Popular attractions Ruth B. Kirby Gilchrist Blue Springs State Park and ...
9.8/10 Exceptional! (139 reviews)
Cabin was very cozy. We were happily surprised by the S'mores kit and plenty of drink options (hot chocolate powder pouches, coffee, teas). Parking is really convenient in that you can back in your car right to the cabin providing more privacy while sitting at picnic bench and fireplace.

Reviewed on Nov 20, 2025

Postcard Cabins Gilchrest Spring, Outdoor Collection by Marriott Bonvoy
Motel 6 – Lake City, Fl – Medical Center

Motel 6 – Lake City, Fl – Medical Center

2 out of 5
3340 W US Highway 90 Lake City FL
Stay at this motel in Lake City. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Regal UA Cinema 90 and Lake City Mall are located ...
8.2/10 Very Good! (45 reviews)
It was all good, clean, AC worked fine. Junk car in the parking lot, fenders falling off trash around it it has been there awhile.

Reviewed on Nov 21, 2025

Motel 6 – Lake City, Fl – Medical Center
Hampton Inn & Suites Lake City

Hampton Inn & Suites Lake City

2.5 out of 5
450 SW Florida Gateway Drive Lake City FL
Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9.4/10 Exceptional! (1,001 reviews)
Very clean room and kind staff

Reviewed on Nov 18, 2025

Hampton Inn & Suites Lake City
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.