Search Cheap Flights to
O Brien

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O Brien Flights as Low as $102

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Breeze Airways
Sat, Apr 26 - Wed, Apr 30
CMH
John Glenn Columbus Intl.
JAX
Jacksonville Intl.
$102 Roundtrip, found 4 hours ago
$102
Roundtrip
found 4 hours ago
Select Breeze Airways flight, departing Sat, Apr 26 from John Glenn Columbus Intl. to Jacksonville Intl., returning Wed, Apr 30, priced at $102 found 4 hours ago
Breeze Airways
Sat, Apr 26 - Wed, Apr 30
CMH
John Glenn Columbus Intl.
JAX
Jacksonville Intl.
$107 Roundtrip, found 4 hours ago
$107
Roundtrip
found 4 hours ago
Select Breeze Airways flight, departing Sat, Apr 26 from John Glenn Columbus Intl. to Jacksonville Intl., returning Wed, Apr 30, priced at $107 found 4 hours ago
Breeze Airways
Sat, Apr 26 - Wed, Apr 30
CMH
John Glenn Columbus Intl.
JAX
Jacksonville Intl.
$112 Roundtrip, found 4 hours ago
$112
Roundtrip
found 4 hours ago
Select Breeze Airways flight, departing Sat, Apr 26 from John Glenn Columbus Intl. to Jacksonville Intl., returning Wed, Apr 30, priced at $112 found 4 hours ago
Delta
Sat, Apr 26 - Wed, Apr 30
CMH
John Glenn Columbus Intl.
JAX
Jacksonville Intl.
$159 Roundtrip, found 4 hours ago
$159
Roundtrip
found 4 hours ago
Select Delta flight, departing Sat, Apr 26 from John Glenn Columbus Intl. to Jacksonville Intl., returning Wed, Apr 30, priced at $159 found 4 hours ago
American Airlines
Sat, Apr 26 - Wed, Apr 30
CMH
John Glenn Columbus Intl.
JAX
Jacksonville Intl.
$191 Roundtrip, found 4 hours ago
$191
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Sat, Apr 26 from John Glenn Columbus Intl. to Jacksonville Intl., returning Wed, Apr 30, priced at $191 found 4 hours ago
Delta
Sat, Apr 26 - Wed, Apr 30
CMH
John Glenn Columbus Intl.
JAX
Jacksonville Intl.
$192 Roundtrip, found 4 hours ago
$192
Roundtrip
found 4 hours ago
Select Delta flight, departing Sat, Apr 26 from John Glenn Columbus Intl. to Jacksonville Intl., returning Wed, Apr 30, priced at $192 found 4 hours ago
United
Sat, Apr 26 - Wed, Apr 30
CMH
John Glenn Columbus Intl.
JAX
Jacksonville Intl.
$196 Roundtrip, found 4 hours ago
$196
Roundtrip
found 4 hours ago
Select United flight, departing Sat, Apr 26 from John Glenn Columbus Intl. to Jacksonville Intl., returning Wed, Apr 30, priced at $196 found 4 hours ago
Breeze Airways
Sat, Apr 26 - Thu, May 1
CMH
John Glenn Columbus Intl.
JAX
Jacksonville Intl.
$201 Roundtrip, found 1 day ago
$201
Roundtrip
found 1 day ago
Select Breeze Airways flight, departing Sat, Apr 26 from John Glenn Columbus Intl. to Jacksonville Intl., returning Thu, May 1, priced at $201 found 1 day ago
Delta
Tue, Apr 29 - Tue, Apr 29
CMH
John Glenn Columbus Intl.
JAX
Jacksonville Intl.
$211 Roundtrip, found 1 day ago
$211
Roundtrip
found 1 day ago
Select Delta flight, departing Tue, Apr 29 from John Glenn Columbus Intl. to Jacksonville Intl., returning Tue, Apr 29, priced at $211 found 1 day ago
American Airlines
Sat, Apr 26 - Wed, Apr 30
CMH
John Glenn Columbus Intl.
JAX
Jacksonville Intl.
$218 Roundtrip, found 4 hours ago
$218
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Sat, Apr 26 from John Glenn Columbus Intl. to Jacksonville Intl., returning Wed, Apr 30, priced at $218 found 4 hours ago
JetBlue Airways
Mon, Jun 2 - Tue, Jun 10
SAN
San Diego Intl.
JAX
Jacksonville Intl.
$268 Roundtrip, found 4 days ago
$268
Roundtrip
found 4 days ago
Select JetBlue Airways flight, departing Mon, Jun 2 from San Diego Intl. to Jacksonville Intl., returning Tue, Jun 10, priced at $268 found 4 days ago
United
Sat, Apr 26 - Wed, Apr 30
CMH
John Glenn Columbus Intl.
JAX
Jacksonville Intl.
$289 Roundtrip, found 4 hours ago
$289
Roundtrip
found 4 hours ago
Select United flight, departing Sat, Apr 26 from John Glenn Columbus Intl. to Jacksonville Intl., returning Wed, Apr 30, priced at $289 found 4 hours ago
Delta
Wed, Jul 2 - Fri, Jul 4
LIT
Clinton National Airport
GNV
Gainesville Regional
$337 Roundtrip, found 3 days ago
$337
Roundtrip
found 3 days ago
Select Delta flight, departing Wed, Jul 2 from Clinton National Airport to Gainesville Regional, returning Fri, Jul 4, priced at $337 found 3 days ago
Delta
Tue, Apr 1 - Sat, Apr 5
LIT
Clinton National Airport
JAX
Jacksonville Intl.
$384 Roundtrip, found 1 day ago
$384
Roundtrip
found 1 day ago
Select Delta flight, departing Tue, Apr 1 from Clinton National Airport to Jacksonville Intl., returning Sat, Apr 5, priced at $384 found 1 day ago
American Airlines
Thu, Jun 5 - Mon, Jun 9
CLD
McClellan-Palomar
JAX
Jacksonville Intl.
$529 Roundtrip, found 4 days ago
$529
Roundtrip
found 4 days ago
Select American Airlines flight, departing Thu, Jun 5 from McClellan-Palomar to Jacksonville Intl., returning Mon, Jun 9, priced at $529 found 4 days ago
Alaska Airlines
Mon, Jun 30 - Wed, Jul 9
SAN
San Diego Intl.
JAX
Jacksonville Intl.
$582 Roundtrip, found 1 day ago
$582
Roundtrip
found 1 day ago
Select Alaska Airlines flight, departing Mon, Jun 30 from San Diego Intl. to Jacksonville Intl., returning Wed, Jul 9, priced at $582 found 1 day ago

Cheap Flights to O Brien

Fall in love at first flight with your vacation to O Brien by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to O Brien on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in O Brien, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to O Brien

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to O Brien with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the null airport.

What is the cheapest month to fly to O Brien?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to O Brien are in April, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to O Brien?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to O Brien.

What airport is best to fly into O Brien?

When you’re planning your trip to O Brien, convenience is the name of the game. Luckily, O Brien Gainesville Regional Airport is nearby so you can deplane and get going on checking off everything on your O Brien must-do list.

How much are flights to O Brien?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to O Brien on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $102, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to O Brien?

The trick to saving a stack of cash on your flight to O Brien? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $102 right now, why wait?

O Brien Flight Information
Destination airport
Jacksonville Intl.
Destination airport IATA code
JAX
Roundtrip price
$190

Last Minute Hotel Deals in O Brien

La Quinta Inn & Suite by Wyndham Lake City
La Quinta Inn & Suite by Wyndham Lake City
2.5 out of 5
165NW CALI DRIVE, Lake City, FL
The price is $125 per night from Mar 30 to Mar 31
$125
includes taxes & fees
Mar 30 - Mar 31
Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.8/10 Excellent! (1,001 reviews)
We loved it
"Very nice clean motel"

Reviewed on Mar 18, 2025

La Quinta Inn & Suite by Wyndham Lake City
Courtyard By Marriott Lake City
Courtyard By Marriott Lake City
3 out of 5
3004 West US HWY 90, Lake City, FL
The price is $120 per night from Apr 6 to Apr 7
$120
includes taxes & fees
Apr 6 - Apr 7
Stay at this 3-star business-friendly hotel in Lake City. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Lake City Mall and Southside ...
9.6/10 Exceptional! (36 reviews)
"One of the nicest hotels I've stayed in in a long time"

Reviewed on Mar 15, 2025

Courtyard By Marriott Lake City
Americas Best Value Inn Lake City
Americas Best Value Inn Lake City
2 out of 5
3835 West US Highway 90, Lake City, FL
The price is $95 per night from Mar 23 to Mar 24
$95
includes taxes & fees
Mar 23 - Mar 24
Stay at this motel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
8.6/10 Excellent! (1,009 reviews)
"Super friendly staff"

Reviewed on Mar 21, 2025

Americas Best Value Inn Lake City
Days Inn by Wyndham Lake City I-75
Days Inn by Wyndham Lake City I-75
2 out of 5
3144 West US Highway 90, Lake City, FL
The price is $77 per night from Mar 30 to Mar 31
$77
includes taxes & fees
Mar 30 - Mar 31
Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free parking, and WiFi (surcharge). Our guests praise the helpful staff and the ...
7.2/10 Good! (1,003 reviews)
"It was clean and staff was nice."

Reviewed on Mar 22, 2025

Days Inn by Wyndham Lake City I-75
Holiday Inn & Suites Lake City by IHG
Holiday Inn & Suites Lake City by IHG
3 out of 5
213 Sw Commerce Dr, Lake City, FL
The price is $114 per night from Mar 30 to Mar 31
$114
includes taxes & fees
Mar 30 - Mar 31
Stay at this 3-star business-friendly hotel in Lake City. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in our ...
8.4/10 Very Good! (1,000 reviews)
Easy access from I 75, clean & comfortable
"The hotel was so fresh and clean. The beds were amazing. Right across the street from Cracker barrell and I 75 super close. Love it"

Reviewed on Mar 10, 2025

Holiday Inn & Suites Lake City by IHG
TownePlace Suites by Marriott Lake City
TownePlace Suites by Marriott Lake City
3 out of 5
178 NW COMMERCE DR, Lake City, FL
The price is $134 per night from Mar 23 to Mar 24
$134
includes taxes & fees
Mar 23 - Mar 24
Stay at this 3-star business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Lake City Mall and Southside ...
9.8/10 Exceptional! (33 reviews)
"Awesome place."

Reviewed on Mar 21, 2025

TownePlace Suites by Marriott Lake City
Fairfield Inn & Suites Lake City
Fairfield Inn & Suites Lake City
2.5 out of 5
538 Sw Corporate Dr, Lake City, FL
The price is $134 per night from Mar 23 to Mar 24
$134
includes taxes & fees
Mar 23 - Mar 24
Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9.2/10 Wonderful! (58 reviews)
"Clean and conveniently located. Staff welcoming and kind."

Reviewed on Mar 18, 2025

Fairfield Inn & Suites Lake City
Americas Best Value Inn Alachua
Americas Best Value Inn Alachua
2 out of 5
16100 NW US Highway 441, Alachua, FL
The price is $77 per night from Mar 25 to Mar 26
$77
includes taxes & fees
Mar 25 - Mar 26
Stay at this motel in Alachua. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions City of Alachua Recreation and Community Center ...
4.6/10 (533 reviews)
"Property needs full renovation"

Reviewed on Mar 11, 2025

Americas Best Value Inn Alachua
See all 312 properties in O Brien
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.