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O Brien

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O Brien Flights as Low as $140

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Frontier Airlines
Wed, May 6 - Wed, May 13
EWR
Newark Liberty Intl. Airport
JAX
Jacksonville Intl.
$140 Roundtrip, found 13 hours ago
$140
Roundtrip
found 13 hours ago
Select Frontier Airlines flight, departing Wed, May 6 from Newark Liberty Intl. Airport to Jacksonville Intl., returning Wed, May 13, priced at $140 found 13 hours ago
Frontier Airlines
Sat, Apr 25 - Thu, Apr 30
LGA
LaGuardia
JAX
Jacksonville Intl.
$142 Roundtrip, found 1 hour ago
$142
Roundtrip
found 1 hour ago
Select Frontier Airlines flight, departing Sat, Apr 25 from LaGuardia to Jacksonville Intl., returning Thu, Apr 30, priced at $142 found 1 hour ago
Frontier Airlines
Mon, May 11 - Wed, May 13
EWR
Newark Liberty Intl. Airport
JAX
Jacksonville Intl.
$153 Roundtrip, found 16 hours ago
$153
Roundtrip
found 16 hours ago
Select Frontier Airlines flight, departing Mon, May 11 from Newark Liberty Intl. Airport to Jacksonville Intl., returning Wed, May 13, priced at $153 found 16 hours ago
Frontier Airlines
Sat, Apr 18 - Tue, May 5
EWR
Newark Liberty Intl. Airport
JAX
Jacksonville Intl.
$160 Roundtrip, found 11 hours ago
$160
Roundtrip
found 11 hours ago
Select Frontier Airlines flight, departing Sat, Apr 18 from Newark Liberty Intl. Airport to Jacksonville Intl., returning Tue, May 5, priced at $160 found 11 hours ago
Frontier Airlines
Sat, May 9 - Tue, May 12
LGA
LaGuardia
JAX
Jacksonville Intl.
$162 Roundtrip, found 16 hours ago
$162
Roundtrip
found 16 hours ago
Select Frontier Airlines flight, departing Sat, May 9 from LaGuardia to Jacksonville Intl., returning Tue, May 12, priced at $162 found 16 hours ago
Frontier Airlines
Wed, May 6 - Tue, May 12
EWR
Newark Liberty Intl. Airport
JAX
Jacksonville Intl.
$170 Roundtrip, found 16 hours ago
$170
Roundtrip
found 16 hours ago
Select Frontier Airlines flight, departing Wed, May 6 from Newark Liberty Intl. Airport to Jacksonville Intl., returning Tue, May 12, priced at $170 found 16 hours ago
Frontier Airlines
Mon, May 11 - Tue, May 12
EWR
Newark Liberty Intl. Airport
JAX
Jacksonville Intl.
$173 Roundtrip, found 16 hours ago
$173
Roundtrip
found 16 hours ago
Select Frontier Airlines flight, departing Mon, May 11 from Newark Liberty Intl. Airport to Jacksonville Intl., returning Tue, May 12, priced at $173 found 16 hours ago
United
Wed, May 6 - Sat, May 16
EWR
Newark Liberty Intl. Airport
JAX
Jacksonville Intl.
$217 Roundtrip, found 7 hours ago
$217
Roundtrip
found 7 hours ago
Select United flight, departing Wed, May 6 from Newark Liberty Intl. Airport to Jacksonville Intl., returning Sat, May 16, priced at $217 found 7 hours ago
Delta
Sat, Jun 13 - Mon, Jun 29
EWR
Newark Liberty Intl. Airport
JAX
Jacksonville Intl.
$237 Roundtrip, found 4 hours ago
$237
Roundtrip
found 4 hours ago
Select Delta flight, departing Sat, Jun 13 from Newark Liberty Intl. Airport to Jacksonville Intl., returning Mon, Jun 29, priced at $237 found 4 hours ago
JetBlue Airways
Tue, Jul 21 - Tue, Jul 28
EWR
Newark Liberty Intl. Airport
JAX
Jacksonville Intl.
$245 Roundtrip, found 4 hours ago
$245
Roundtrip
found 4 hours ago
Select JetBlue Airways flight, departing Tue, Jul 21 from Newark Liberty Intl. Airport to Jacksonville Intl., returning Tue, Jul 28, priced at $245 found 4 hours ago
American Airlines
Fri, May 8 - Mon, May 11
LGA
LaGuardia
JAX
Jacksonville Intl.
$257 Roundtrip, found 16 hours ago
$257
Roundtrip
found 16 hours ago
Select American Airlines flight, departing Fri, May 8 from LaGuardia to Jacksonville Intl., returning Mon, May 11, priced at $257 found 16 hours ago
American Airlines
Tue, Jun 16 - Tue, Jun 23
LGA
LaGuardia
GNV
Gainesville Regional
$315 Roundtrip, found 3 hours ago
$315
Roundtrip
found 3 hours ago
Select American Airlines flight, departing Tue, Jun 16 from LaGuardia to Gainesville Regional, returning Tue, Jun 23, priced at $315 found 3 hours ago
Delta
Tue, Apr 28 - Tue, May 12
EWR
Newark Liberty Intl. Airport
TLH
Tallahassee Intl.
$317 Roundtrip, found 5 hours ago
$317
Roundtrip
found 5 hours ago
Select Delta flight, departing Tue, Apr 28 from Newark Liberty Intl. Airport to Tallahassee Intl., returning Tue, May 12, priced at $317 found 5 hours ago
JetBlue Airways
Fri, Jun 19 - Sat, Jul 4
SXM
Princess Juliana Intl.
JAX
Jacksonville Intl.
$359 Roundtrip, found 18 hours ago
$359
Roundtrip
found 18 hours ago
Select JetBlue Airways flight, departing Fri, Jun 19 from Princess Juliana Intl. to Jacksonville Intl., returning Sat, Jul 4, priced at $359 found 18 hours ago
Delta
Thu, Jun 18 - Tue, Jun 30
EWR
Newark Liberty Intl. Airport
GNV
Gainesville Regional
$367 Roundtrip, found 7 hours ago
$367
Roundtrip
found 7 hours ago
Select Delta flight, departing Thu, Jun 18 from Newark Liberty Intl. Airport to Gainesville Regional, returning Tue, Jun 30, priced at $367 found 7 hours ago
American Airlines
Sat, May 23 - Wed, Jun 10
LGA
LaGuardia
TLH
Tallahassee Intl.
$429 Roundtrip, found 2 days ago
$429
Roundtrip
found 2 days ago
Select American Airlines flight, departing Sat, May 23 from LaGuardia to Tallahassee Intl., returning Wed, Jun 10, priced at $429 found 2 days ago

Cheap Flights to O Brien

Fall in love at first flight with your vacation to O Brien by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to O Brien on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in O Brien, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to O Brien

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to O Brien with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the null airport.

What is the cheapest month to fly to O Brien?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to O Brien are in May, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to O Brien?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to O Brien.

What airport is best to fly into O Brien?

When you’re planning your trip to O Brien, convenience is the name of the game. Luckily, O Brien Gainesville Regional Airport is nearby so you can deplane and get going on checking off everything on your O Brien must-do list.

How much are flights to O Brien?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to O Brien on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $140, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to O Brien?

The trick to saving a stack of cash on your flight to O Brien? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $140 right now, why wait?

O Brien Flight Information
Destination airport
Jacksonville Intl.
Destination airport IATA code
JAX
Roundtrip price
$142

Last Minute Hotel Deals in O Brien

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

3.5 out of 5
16367 NW 167TH BLVD Alachua FL
Book a stay at this business-friendly hotel in Alachua. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,002 reviews)
Good

Reviewed on Apr 1, 2026

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Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City

2.5 out of 5
165NW CALI DRIVE Lake City FL
Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.8/10 Excellent! (1,083 reviews)
The night time check in young lady was amazing. She was very kind and friendly on my late night arrival. Room was clean, bed was comfortable and the breakfast was the good. All around a great stay.

Reviewed on Apr 4, 2026

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La Quinta Inn & Suite by Wyndham Lake City
Best Western Plus Lake City

Best Western Plus Lake City

2.5 out of 5
350 SW Florida Gateway Dr Lake City FL
Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,033 reviews)
The bathroom was a little dirty z possible mold on ceiling and dirty underneath the mat in the bathroom.

Reviewed on Apr 3, 2026

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Best Western Plus Lake City
Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

2 out of 5
1699 NE Co Rd 337 High Springs FL
Stay at this cabin in High Springs. Enjoy free parking, patios, and climate control. Popular attractions Ruth B. Kirby Gilchrist Blue Springs State Park and ...
10/10 Exceptional! (196 reviews)
The cabin was perfect, though we wish ours was more off the beaten path. The amenities were sufficient for our needs, though it would have been nice to not need to ask for specific items. We were not allowed to use outdoor cookware, only foil over the fire. The stove inside takes FOREVER to heat, ...

Reviewed on Apr 2, 2026

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Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy
Americas Best Value Inn Lake City

Americas Best Value Inn Lake City

2 out of 5
3835 West US Highway 90 Lake City FL
Stay at this motel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
8.6/10 Excellent! (1,005 reviews)
Great breakfast and clean room. Dog friendly.

Reviewed on Apr 3, 2026

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Americas Best Value Inn Lake City
Tru by Hilton Lake City

Tru by Hilton Lake City

2.5 out of 5
284 NW Centurion Court Lake City FL
Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9.2/10 Wonderful! (1,001 reviews)
Mattresses could be firmer.

Reviewed on Mar 31, 2026

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Tru by Hilton Lake City
Holiday Inn Express & Suites Live Oak by IHG

Holiday Inn Express & Suites Live Oak by IHG

2.5 out of 5
6694 Us Highway 129 Live Oak FL
Book a stay at this business-friendly hotel in Live Oak. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (818 reviews)
Breakfast and pool were fine. Shower in room 108 nedswork.

Reviewed on Mar 28, 2026

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Holiday Inn Express & Suites Live Oak by IHG
Courtyard By Marriott Lake City

Courtyard By Marriott Lake City

3 out of 5
3004 West US HWY 90 Lake City FL
Book a stay at this business-friendly hotel in Lake City. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Regal UA Cinema 90 and ...
9.4/10 Exceptional! (229 reviews)
The room was clean, staff was friendly, and it was in walking distance to many different places to eat (restaurants and fast food). There was a grocery store and a Walmart nearby, and state parks and springs were a short drive away.

Reviewed on Mar 19, 2026

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Courtyard By Marriott Lake City
See all 370 properties in O Brien
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.