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O Brien

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O Brien Flights as Low as $147

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Breeze Airways
Fri, Apr 11 - Sun, Apr 13
MSY
Louis Armstrong New Orleans Intl.
JAX
Jacksonville Intl.
$147 Roundtrip, found 20 hours ago
$147
Roundtrip
found 20 hours ago
Select Breeze Airways flight, departing Fri, Apr 11 from Louis Armstrong New Orleans Intl. to Jacksonville Intl., returning Sun, Apr 13, priced at $147 found 20 hours ago
JetBlue Airways
Tue, Jan 28 - Thu, Jan 30
ORD
O'Hare Intl.
JAX
Jacksonville Intl.
$203 Roundtrip, found 4 days ago
$203
Roundtrip
found 4 days ago
Select JetBlue Airways flight, departing Tue, Jan 28 from O'Hare Intl. to Jacksonville Intl., returning Thu, Jan 30, priced at $203 found 4 days ago
JetBlue Airways
Thu, Jan 30 - Sun, Feb 2
ORD
O'Hare Intl.
JAX
Jacksonville Intl.
$234 Roundtrip, found 1 day ago
$234
Roundtrip
found 1 day ago
Select JetBlue Airways flight, departing Thu, Jan 30 from O'Hare Intl. to Jacksonville Intl., returning Sun, Feb 2, priced at $234 found 1 day ago
Delta
Tue, Jan 28 - Thu, Jan 30
ORD
O'Hare Intl.
JAX
Jacksonville Intl.
$234 Roundtrip, found 4 days ago
$234
Roundtrip
found 4 days ago
Select Delta flight, departing Tue, Jan 28 from O'Hare Intl. to Jacksonville Intl., returning Thu, Jan 30, priced at $234 found 4 days ago
American Airlines
Thu, Jan 30 - Sun, Feb 2
ORD
O'Hare Intl.
JAX
Jacksonville Intl.
$240 Roundtrip, found 1 day ago
$240
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Jan 30 from O'Hare Intl. to Jacksonville Intl., returning Sun, Feb 2, priced at $240 found 1 day ago
JetBlue Airways
Mon, Feb 10 - Tue, Feb 18
ORD
O'Hare Intl.
JAX
Jacksonville Intl.
$244 Roundtrip, found 6 days ago
$244
Roundtrip
found 6 days ago
Select JetBlue Airways flight, departing Mon, Feb 10 from O'Hare Intl. to Jacksonville Intl., returning Tue, Feb 18, priced at $244 found 6 days ago
Delta
Tue, Jan 28 - Thu, Jan 30
ORD
O'Hare Intl.
JAX
Jacksonville Intl.
$245 Roundtrip, found 4 days ago
$245
Roundtrip
found 4 days ago
Select Delta flight, departing Tue, Jan 28 from O'Hare Intl. to Jacksonville Intl., returning Thu, Jan 30, priced at $245 found 4 days ago
JetBlue Airways
Tue, Jan 28 - Wed, Jan 29
ORD
O'Hare Intl.
JAX
Jacksonville Intl.
$249 Roundtrip, found 5 days ago
$249
Roundtrip
found 5 days ago
Select JetBlue Airways flight, departing Tue, Jan 28 from O'Hare Intl. to Jacksonville Intl., returning Wed, Jan 29, priced at $249 found 5 days ago
Delta
Sat, Feb 1 - Thu, Feb 6
ORD
O'Hare Intl.
JAX
Jacksonville Intl.
$253 Roundtrip, found 1 day ago
$253
Roundtrip
found 1 day ago
Select Delta flight, departing Sat, Feb 1 from O'Hare Intl. to Jacksonville Intl., returning Thu, Feb 6, priced at $253 found 1 day ago
American Airlines
Sat, Jan 18 - Fri, Jan 31
ORD
O'Hare Intl.
JAX
Jacksonville Intl.
$254 Roundtrip, found 4 days ago
$254
Roundtrip
found 4 days ago
Select American Airlines flight, departing Sat, Jan 18 from O'Hare Intl. to Jacksonville Intl., returning Fri, Jan 31, priced at $254 found 4 days ago
JetBlue Airways
Tue, Feb 25 - Wed, Mar 5
CLE
Hopkins Intl.
JAX
Jacksonville Intl.
$278 Roundtrip, found 1 day ago
$278
Roundtrip
found 1 day ago
Select JetBlue Airways flight, departing Tue, Feb 25 from Hopkins Intl. to Jacksonville Intl., returning Wed, Mar 5, priced at $278 found 1 day ago
United
Wed, Feb 19 - Tue, Feb 25
CLE
Hopkins Intl.
JAX
Jacksonville Intl.
$297 Roundtrip, just found
$297
Roundtrip
just found
Select United flight, departing Wed, Feb 19 from Hopkins Intl. to Jacksonville Intl., returning Tue, Feb 25, priced at $297 just found
American Airlines
Wed, Feb 19 - Tue, Feb 25
CLE
Hopkins Intl.
JAX
Jacksonville Intl.
$297 Roundtrip, just found
$297
Roundtrip
just found
Select American Airlines flight, departing Wed, Feb 19 from Hopkins Intl. to Jacksonville Intl., returning Tue, Feb 25, priced at $297 just found
Frontier Airlines
Sat, Apr 12 - Tue, Apr 15
MSY
Louis Armstrong New Orleans Intl.
JAX
Jacksonville Intl.
$300 Roundtrip, found 1 day ago
$300
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Sat, Apr 12 from Louis Armstrong New Orleans Intl. to Jacksonville Intl., returning Tue, Apr 15, priced at $300 found 1 day ago
United
Thu, May 29 - Sun, Jun 1
ORD
O'Hare Intl.
JAX
Jacksonville Intl.
$397 Roundtrip, found 15 hours ago
$397
Roundtrip
found 15 hours ago
Select United flight, departing Thu, May 29 from O'Hare Intl. to Jacksonville Intl., returning Sun, Jun 1, priced at $397 found 15 hours ago
American Airlines
Thu, Jan 16 - Wed, Jan 22
ORD
O'Hare Intl.
TLH
Tallahassee Intl.
$639 Roundtrip, found 3 days ago
$639
Roundtrip
found 3 days ago
Select American Airlines flight, departing Thu, Jan 16 from O'Hare Intl. to Tallahassee Intl., returning Wed, Jan 22, priced at $639 found 3 days ago

Cheap Flights to O Brien

Fall in love at first flight with your vacation to O Brien by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to O Brien on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in O Brien, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to O Brien

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to O Brien with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the null airport.

What is the cheapest month to fly to O Brien?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to O Brien are in April, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to O Brien?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to O Brien.

What airport is best to fly into O Brien?

When you’re planning your trip to O Brien, convenience is the name of the game. Luckily, O Brien Gainesville Regional Airport is nearby so you can deplane and get going on checking off everything on your O Brien must-do list.

How much are flights to O Brien?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to O Brien on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $147, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to O Brien?

The trick to saving a stack of cash on your flight to O Brien? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $147 right now, why wait?

O Brien Flight Information
Destination airport
Jacksonville Intl.
Destination airport IATA code
JAX
Roundtrip price
$218

Last Minute Hotel Deals in O Brien

La Quinta Inn & Suite by Wyndham Lake City
La Quinta Inn & Suite by Wyndham Lake City
2.5 out of 5
165NW CALI DRIVE, Lake City, FL
The price is $114 per night from Jan 14 to Jan 15
$114
includes taxes & fees
Jan 14 - Jan 15
Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.8/10 Excellent! (1,002 reviews)
"Awesome stay. Liked the eCheckout"

Reviewed on Jan 8, 2025

La Quinta Inn & Suite by Wyndham Lake City
Americas Best Value Inn Lake City
Americas Best Value Inn Lake City
2 out of 5
3835 West US Highway 90, Lake City, FL
The price is $80 per night from Jan 13 to Jan 14
$80
includes taxes & fees
Jan 13 - Jan 14
Stay at this motel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
8.6/10 Excellent! (1,005 reviews)
Clean, quiet and economic!
"Great place to stay on our way through Florida. Clean and quiet and economic!"

Reviewed on Jan 10, 2025

Americas Best Value Inn Lake City
Best Western Plus Lake City
Best Western Plus Lake City
2.5 out of 5
350 SW Florida Gateway Dr, Lake City, FL
The price is $103 per night from Jan 19 to Jan 20
$103
includes taxes & fees
Jan 19 - Jan 20
Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,003 reviews)
"Perfect"

Reviewed on Jan 4, 2025

Best Western Plus Lake City
Holiday Inn Express & Suites Alachua - Gainesville Area, an IHG Hotel
Holiday Inn Express & Suites Alachua - Gainesville Area, an IHG Hotel
3.5 out of 5
16367 NW 167TH BLVD, Alachua, FL
The price is $144 per night from Jan 19 to Jan 20
$144
includes taxes & fees
Jan 19 - Jan 20
Stay at this 3.5-star business-friendly hotel in Alachua. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,001 reviews)
"great property! great Breakfast!"

Reviewed on Jan 5, 2025

Holiday Inn Express & Suites Alachua - Gainesville Area, an IHG Hotel
Comfort Suites Lake City
Comfort Suites Lake City
2.5 out of 5
3690 W Us Highway 90, Lake City, FL
The price is $128 per night from Jan 14 to Jan 15
$128
includes taxes & fees
Jan 14 - Jan 15
Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (1,003 reviews)
"Staff was friendly and helpful."

Reviewed on Jan 5, 2025

Comfort Suites Lake City
Hampton Inn & Suites Lake City
Hampton Inn & Suites Lake City
2.5 out of 5
450 SW Florida Gateway Drive, Lake City, FL
The price is $126 per night from Feb 9 to Feb 10
$126
includes taxes & fees
Feb 9 - Feb 10
Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9.4/10 Exceptional! (912 reviews)
"Had a very comfortable stay! Will be back."

Reviewed on Jan 8, 2025

Hampton Inn & Suites Lake City
Days Inn by Wyndham Lake City I-75
Days Inn by Wyndham Lake City I-75
2 out of 5
3144 West US Highway 90, Lake City, FL
The price is $87 per night from Jan 14 to Jan 15
$87
includes taxes & fees
Jan 14 - Jan 15
Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,000 reviews)
Ok for the price
"Ok for the price. Neighbors were kind of noisy. Handicap shower head was nice. Towels fine. Sheets rough. Breakfast simple continental. Park right outside your door. No interior halls or elevator."

Reviewed on Jan 4, 2025

Days Inn by Wyndham Lake City I-75
Tru by Hilton Lake City
Tru by Hilton Lake City
2.5 out of 5
284 NW Centurion Court, Lake City, FL
The price is $145 per night from Jan 19 to Jan 20
$145
includes taxes & fees
Jan 19 - Jan 20
Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9/10 Wonderful! (1,001 reviews)
Overnight stay
"Modern design and furnishings. No carpet which I liked. They allow dogs which is a plus. Breakfast was subpar."

Reviewed on Jan 10, 2025

Tru by Hilton Lake City
See all 297 properties in O Brien
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.