Search Cheap Flights to
Saltillo

Search 400 airlines and 321,000 hotels worldwide.

Stop Planning & Start Exploring

FREE 24 hour cancellation on most flights

Saltillo Flights as Low as $462

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

American Airlines
Tue, Jun 23 - Tue, Jun 30
DTW
Detroit Metropolitan Wayne County
TUP
Tupelo Regional
$462 Roundtrip, found 16 hours ago
$462
Roundtrip
found 16 hours ago
Select American Airlines flight, departing Tue, Jun 23 from Detroit Metropolitan Wayne County to Tupelo Regional, returning Tue, Jun 30, priced at $462 found 16 hours ago
United
Tue, Jun 23 - Tue, Jun 30
DTW
Detroit Metropolitan Wayne County
TUP
Tupelo Regional
$479 Roundtrip, found 16 hours ago
$479
Roundtrip
found 16 hours ago
Select United flight, departing Tue, Jun 23 from Detroit Metropolitan Wayne County to Tupelo Regional, returning Tue, Jun 30, priced at $479 found 16 hours ago
American Airlines
Tue, Jun 23 - Tue, Jun 30
DTW
Detroit Metropolitan Wayne County
TUP
Tupelo Regional
$485 Roundtrip, found 16 hours ago
$485
Roundtrip
found 16 hours ago
Select American Airlines flight, departing Tue, Jun 23 from Detroit Metropolitan Wayne County to Tupelo Regional, returning Tue, Jun 30, priced at $485 found 16 hours ago
United
Tue, Jun 23 - Tue, Jun 30
DTW
Detroit Metropolitan Wayne County
TUP
Tupelo Regional
$488 Roundtrip, found 16 hours ago
$488
Roundtrip
found 16 hours ago
Select United flight, departing Tue, Jun 23 from Detroit Metropolitan Wayne County to Tupelo Regional, returning Tue, Jun 30, priced at $488 found 16 hours ago
American Airlines
Tue, Jun 23 - Tue, Jun 30
DTW
Detroit Metropolitan Wayne County
TUP
Tupelo Regional
$502 Roundtrip, found 16 hours ago
$502
Roundtrip
found 16 hours ago
Select American Airlines flight, departing Tue, Jun 23 from Detroit Metropolitan Wayne County to Tupelo Regional, returning Tue, Jun 30, priced at $502 found 16 hours ago
United
Tue, Jun 23 - Tue, Jun 30
DTW
Detroit Metropolitan Wayne County
TUP
Tupelo Regional
$508 Roundtrip, found 16 hours ago
$508
Roundtrip
found 16 hours ago
Select United flight, departing Tue, Jun 23 from Detroit Metropolitan Wayne County to Tupelo Regional, returning Tue, Jun 30, priced at $508 found 16 hours ago
United
Tue, Jun 23 - Thu, Jul 2
DTW
Detroit Metropolitan Wayne County
TUP
Tupelo Regional
$517 Roundtrip, found 16 hours ago
$517
Roundtrip
found 16 hours ago
Select United flight, departing Tue, Jun 23 from Detroit Metropolitan Wayne County to Tupelo Regional, returning Thu, Jul 2, priced at $517 found 16 hours ago
American Airlines
Tue, Jun 23 - Tue, Jun 30
DTW
Detroit Metropolitan Wayne County
TUP
Tupelo Regional
$523 Roundtrip, found 16 hours ago
$523
Roundtrip
found 16 hours ago
Select American Airlines flight, departing Tue, Jun 23 from Detroit Metropolitan Wayne County to Tupelo Regional, returning Tue, Jun 30, priced at $523 found 16 hours ago
United
Tue, Jun 23 - Tue, Jun 30
DTW
Detroit Metropolitan Wayne County
TUP
Tupelo Regional
$529 Roundtrip, found 16 hours ago
$529
Roundtrip
found 16 hours ago
Select United flight, departing Tue, Jun 23 from Detroit Metropolitan Wayne County to Tupelo Regional, returning Tue, Jun 30, priced at $529 found 16 hours ago
United
Tue, Jun 23 - Tue, Jun 30
DTW
Detroit Metropolitan Wayne County
TUP
Tupelo Regional
$535 Roundtrip, found 16 hours ago
$535
Roundtrip
found 16 hours ago
Select United flight, departing Tue, Jun 23 from Detroit Metropolitan Wayne County to Tupelo Regional, returning Tue, Jun 30, priced at $535 found 16 hours ago
American Airlines
Tue, Jun 23 - Tue, Jun 30
DTW
Detroit Metropolitan Wayne County
TUP
Tupelo Regional
$540 Roundtrip, found 16 hours ago
$540
Roundtrip
found 16 hours ago
Select American Airlines flight, departing Tue, Jun 23 from Detroit Metropolitan Wayne County to Tupelo Regional, returning Tue, Jun 30, priced at $540 found 16 hours ago
United
Tue, Jun 23 - Sat, Jun 27
DTW
Detroit Metropolitan Wayne County
TUP
Tupelo Regional
$543 Roundtrip, found 16 hours ago
$543
Roundtrip
found 16 hours ago
Select United flight, departing Tue, Jun 23 from Detroit Metropolitan Wayne County to Tupelo Regional, returning Sat, Jun 27, priced at $543 found 16 hours ago
American Airlines
Tue, Jun 23 - Mon, Jun 29
DTW
Detroit Metropolitan Wayne County
TUP
Tupelo Regional
$553 Roundtrip, found 16 hours ago
$553
Roundtrip
found 16 hours ago
Select American Airlines flight, departing Tue, Jun 23 from Detroit Metropolitan Wayne County to Tupelo Regional, returning Mon, Jun 29, priced at $553 found 16 hours ago
American Airlines
Thu, Jun 25 - Thu, Jul 2
DTW
Detroit Metropolitan Wayne County
TUP
Tupelo Regional
$554 Roundtrip, found 16 hours ago
$554
Roundtrip
found 16 hours ago
Select American Airlines flight, departing Thu, Jun 25 from Detroit Metropolitan Wayne County to Tupelo Regional, returning Thu, Jul 2, priced at $554 found 16 hours ago
United
Tue, Jun 23 - Tue, Jun 30
DTW
Detroit Metropolitan Wayne County
TUP
Tupelo Regional
$558 Roundtrip, found 16 hours ago
$558
Roundtrip
found 16 hours ago
Select United flight, departing Tue, Jun 23 from Detroit Metropolitan Wayne County to Tupelo Regional, returning Tue, Jun 30, priced at $558 found 16 hours ago
United
Wed, May 20 - Sun, May 24
IND
Indianapolis Intl.
TUP
Tupelo Regional
$850 Roundtrip, found 1 day ago
$850
Roundtrip
found 1 day ago
Select United flight, departing Wed, May 20 from Indianapolis Intl. to Tupelo Regional, returning Sun, May 24, priced at $850 found 1 day ago

Cheap Flights to Saltillo

Fall in love at first flight with your vacation to Saltillo by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Saltillo on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Saltillo, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Saltillo

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Saltillo with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the TUP airport.

What is the cheapest month to fly to Saltillo?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Saltillo are in June, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Saltillo?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Saltillo.

What airport is best to fly into Saltillo?

When you’re planning your trip to Saltillo, convenience is the name of the game. Luckily, Saltillo Tupelo Regional Airport is nearby so you can deplane and get going on checking off everything on your Saltillo must-do list.

How much are flights to Saltillo?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Saltillo on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $462, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Saltillo?

The trick to saving a stack of cash on your flight to Saltillo? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $462 right now, why wait?

Saltillo Flight Information
Destination airport
Tupelo Regional
Destination airport IATA code
TUP
Roundtrip price
$461

Last Minute Hotel Deals in Saltillo

Best Western Plus Tupelo Inn & Suites

Best Western Plus Tupelo Inn & Suites

2.5 out of 5
3158 N Gloster Street Tupelo MS
Book a stay at this business-friendly hotel in Tupelo. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.8/10 Excellent! (1,003 reviews)
Dirty linen on sofa and had to wait a couple times for towels

Reviewed on May 16, 2026

Get rates
Best Western Plus Tupelo Inn & Suites
Red Roof Inn Tupelo

Red Roof Inn Tupelo

2 out of 5
1516 Mccullough Blvd Tupelo MS
Book a stay at this business-friendly hotel in Tupelo. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.2/10 Very Good! (1,003 reviews)
Perfect

Reviewed on May 16, 2026

Get rates
Red Roof Inn Tupelo
La Quinta Inn & Suites by Wyndham Tupelo

La Quinta Inn & Suites by Wyndham Tupelo

3 out of 5
1013 N Gloster St Tupelo MS
Book a stay at this business-friendly hotel in Tupelo. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.6/10 Excellent! (1,002 reviews)
Great staff, great area

Reviewed on May 15, 2026

Get rates
La Quinta Inn & Suites by Wyndham Tupelo
Spark by Hilton Tupelo

Spark by Hilton Tupelo

2.5 out of 5
186 Stone Creek Blvd Tupelo MS
Book a stay at this business-friendly hotel in Tupelo. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.4/10 Very Good! (1,002 reviews)
It seemed as though the shower pan was leaking, the tile bathroom floor was crackly. The room had an odor to it. The Lobby was cute and the staff was helpful.

Reviewed on May 16, 2026

Get rates
Spark by Hilton Tupelo
Americas Best Value Inn Tupelo

Americas Best Value Inn Tupelo

2 out of 5
4701 Leeb Drive Tupelo MS
Stay at this hotel in Tupelo. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
8.4/10 Very Good! (1,003 reviews)
Room was clean, but smelled.

Reviewed on May 14, 2026

Get rates
Americas Best Value Inn Tupelo
Baymont by Wyndham Tupelo

Baymont by Wyndham Tupelo

2.5 out of 5
625 Spicer Drive Tupelo MS
Book a stay at this business-friendly motel in Tupelo. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
7.6/10 Good! (1,002 reviews)
We chose this hotel because it was on route to driving to our son's graduation in Missouri. The lady who checked us in was super nice. When we got to the room, it was not clean. My daughter pulled her sheets back and there were dog paw prints all over her bedding and the bed smelled like pee. We ...

Reviewed on May 15, 2026

Get rates
Baymont by Wyndham Tupelo
Holiday Inn Hotel & Suites Tupelo North by IHG

Holiday Inn Hotel & Suites Tupelo North by IHG

3 out of 5
923 North Gloster Tupelo MS
Book a stay at this business-friendly hotel in Tupelo. Enjoy free WiFi, an outdoor pool, and breakfast (surcharge). Our guests praise the helpful staff and the ...
9.2/10 Wonderful! (1,001 reviews)
Good breakfast with a great variety of foods, fruits, etc. Staff waa friendly and would definitely stay again..

Reviewed on May 9, 2026

Get rates
Holiday Inn Hotel & Suites Tupelo North by IHG
Holiday Inn Express Hotel & Suites Fulton by IHG

Holiday Inn Express Hotel & Suites Fulton by IHG

2.5 out of 5
1505 S. Adams St Fulton MS
Book a stay at this business-friendly hotel in Fulton. Enjoy free breakfast, free parking, and a 24-hour fitness center. Our guests praise the breakfast and ...
8.8/10 Excellent! (1,000 reviews)
It was a short, pleasurable stay. The room was clean overall. There was mold along the side of the tub and in the shower head. Enjoyed breakfast each morning but disappointed there was no fresh fruit either morning.

Reviewed on May 9, 2026

Get rates
Holiday Inn Express Hotel & Suites Fulton by IHG
See all 123 properties in Saltillo
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.