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Santa Clara

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Santa Clara Flights as Low as $282

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Copa
Tue, Oct 20 - Sun, Oct 25
SJO
Juan Santamaría Intl.
PTY
Tocumen Intl.
$282 Roundtrip, found 1 hour ago
$282
Roundtrip
found 1 hour ago
Select Copa flight, departing Tue, Oct 20 from Juan Santamaría Intl. to Tocumen Intl., returning Sun, Oct 25, priced at $282 found 1 hour ago
avianca
Tue, Oct 20 - Sun, Oct 25
SJO
Juan Santamaría Intl.
PTY
Tocumen Intl.
$290 Roundtrip, found 1 hour ago
$290
Roundtrip
found 1 hour ago
Select avianca flight, departing Tue, Oct 20 from Juan Santamaría Intl. to Tocumen Intl., returning Sun, Oct 25, priced at $290 found 1 hour ago
avianca
Fri, Aug 28 - Sun, Sep 6
SJO
Juan Santamaría Intl.
PTY
Tocumen Intl.
$293 Roundtrip, found 4 hours ago
$293
Roundtrip
found 4 hours ago
Select avianca flight, departing Fri, Aug 28 from Juan Santamaría Intl. to Tocumen Intl., returning Sun, Sep 6, priced at $293 found 4 hours ago
avianca
Tue, Oct 20 - Sun, Oct 25
SJO
Juan Santamaría Intl.
PTY
Tocumen Intl.
$302 Roundtrip, found 1 hour ago
$302
Roundtrip
found 1 hour ago
Select avianca flight, departing Tue, Oct 20 from Juan Santamaría Intl. to Tocumen Intl., returning Sun, Oct 25, priced at $302 found 1 hour ago
avianca
Tue, Oct 20 - Sun, Oct 25
SJO
Juan Santamaría Intl.
PTY
Tocumen Intl.
$304 Roundtrip, found 1 hour ago
$304
Roundtrip
found 1 hour ago
Select avianca flight, departing Tue, Oct 20 from Juan Santamaría Intl. to Tocumen Intl., returning Sun, Oct 25, priced at $304 found 1 hour ago
avianca
Fri, Aug 28 - Sun, Sep 6
SJO
Juan Santamaría Intl.
PTY
Tocumen Intl.
$307 Roundtrip, found 4 hours ago
$307
Roundtrip
found 4 hours ago
Select avianca flight, departing Fri, Aug 28 from Juan Santamaría Intl. to Tocumen Intl., returning Sun, Sep 6, priced at $307 found 4 hours ago
avianca
Tue, Oct 20 - Sun, Oct 25
SJO
Juan Santamaría Intl.
PTY
Tocumen Intl.
$309 Roundtrip, found 1 hour ago
$309
Roundtrip
found 1 hour ago
Select avianca flight, departing Tue, Oct 20 from Juan Santamaría Intl. to Tocumen Intl., returning Sun, Oct 25, priced at $309 found 1 hour ago
avianca
Sat, Oct 31 - Mon, Nov 9
MIA
Miami Intl.
PTY
Tocumen Intl.
$368 Roundtrip, found 2 hours ago
$368
Roundtrip
found 2 hours ago
Select avianca flight, departing Sat, Oct 31 from Miami Intl. to Tocumen Intl., returning Mon, Nov 9, priced at $368 found 2 hours ago
avianca
Tue, Oct 27 - Sun, Nov 1
FLL
Fort Lauderdale - Hollywood Intl.
PTY
Tocumen Intl.
$398 Roundtrip, found 2 hours ago
$398
Roundtrip
found 2 hours ago
Select avianca flight, departing Tue, Oct 27 from Fort Lauderdale - Hollywood Intl. to Tocumen Intl., returning Sun, Nov 1, priced at $398 found 2 hours ago
American Airlines
Sat, Oct 31 - Mon, Nov 9
MIA
Miami Intl.
PTY
Tocumen Intl.
$416 Roundtrip, found 2 hours ago
$416
Roundtrip
found 2 hours ago
Select American Airlines flight, departing Sat, Oct 31 from Miami Intl. to Tocumen Intl., returning Mon, Nov 9, priced at $416 found 2 hours ago
United
Sat, Oct 31 - Mon, Nov 9
FLL
Fort Lauderdale - Hollywood Intl.
PTY
Tocumen Intl.
$517 Roundtrip, found 2 hours ago
$517
Roundtrip
found 2 hours ago
Select United flight, departing Sat, Oct 31 from Fort Lauderdale - Hollywood Intl. to Tocumen Intl., returning Mon, Nov 9, priced at $517 found 2 hours ago
Delta
Sun, Jan 17 - Thu, Feb 4
SEA
Seattle - Tacoma Intl.
PTY
Tocumen Intl.
$539 Roundtrip, found 4 hours ago
$539
Roundtrip
found 4 hours ago
Select Delta flight, departing Sun, Jan 17 from Seattle - Tacoma Intl. to Tocumen Intl., returning Thu, Feb 4, priced at $539 found 4 hours ago
Aeromexico
Sat, Oct 31 - Mon, Nov 9
MIA
Miami Intl.
PTY
Tocumen Intl.
$558 Roundtrip, found 2 hours ago
$558
Roundtrip
found 2 hours ago
Select Aeromexico flight, departing Sat, Oct 31 from Miami Intl. to Tocumen Intl., returning Mon, Nov 9, priced at $558 found 2 hours ago
Copa
Mon, Sep 14 - Wed, Sep 30
AUS
Austin-Bergstrom Intl.
PTY
Tocumen Intl.
$692 Roundtrip, found 3 days ago
$692
Roundtrip
found 3 days ago
Select Copa flight, departing Mon, Sep 14 from Austin-Bergstrom Intl. to Tocumen Intl., returning Wed, Sep 30, priced at $692 found 3 days ago
American Airlines
Mon, Apr 12 - Sun, Apr 18
ERI
Erie Intl.
PTY
Tocumen Intl.
$772 Roundtrip, found 1 day ago
$772
Roundtrip
found 1 day ago
Select American Airlines flight, departing Mon, Apr 12 from Erie Intl. to Tocumen Intl., returning Sun, Apr 18, priced at $772 found 1 day ago
Alaska Airlines
Mon, Jan 18 - Thu, Jan 28
PAE
Seattle Paine Field Intl. Airport
PTY
Tocumen Intl.
$810 Roundtrip, found 4 hours ago
$810
Roundtrip
found 4 hours ago
Select Alaska Airlines flight, departing Mon, Jan 18 from Seattle Paine Field Intl. Airport to Tocumen Intl., returning Thu, Jan 28, priced at $810 found 4 hours ago

Cheap Flights to Santa Clara

Fall in love at first flight with your vacation to Santa Clara by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Santa Clara on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Santa Clara, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Santa Clara

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Santa Clara with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the PAC airport.

What is the cheapest month to fly to Santa Clara?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Santa Clara are in October, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Santa Clara?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Santa Clara.

What airport is best to fly into Santa Clara?

When you’re planning your trip to Santa Clara, convenience is the name of the game. Luckily, Santa Clara Panama Pacifico Intl. Airport is nearby so you can deplane and get going on checking off everything on your Santa Clara must-do list.

How much are flights to Santa Clara?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Santa Clara on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $282, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Santa Clara?

The trick to saving a stack of cash on your flight to Santa Clara? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $282 right now, why wait?

Santa Clara Flight Information
Destination airport
Tocumen Intl.
Destination airport IATA code
PTY
Roundtrip price
$282

Last Minute Hotel Deals in Santa Clara

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella Panama City Panama
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. ...
9/10 Wonderful! (5,891 reviews)
"The hotel is beautiful. The staff was attentive and always professional. My room was very clean and comfortable and my view of the city from my room was top tier. Breakfast was great with a lot of options. I will be staying at the Riu each time I visit Panamá."

Reviewed on Aug 26, 2026

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Hotel Riu Plaza Panama
Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Plaza de la Independencia Casco Viejo Panama City Panama
Book a stay at this spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff and the clean rooms ...
9.2/10 Wonderful! (1,001 reviews)
"Don’t expect to be able to rest. A beautiful historic hotel in an unbeatable location BUT the hotel’s atrium is very noisy, so don’t expect to be able to rest if in an interior facing room. No late sleep ins, no napping after morning excursions and no “getting an early night”. Daily live entertainment ..."

Reviewed on Aug 26, 2026

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Central Hotel Panama Casco Viejo
Dreams Playa Bonita Panama - All Inclusive

Dreams Playa Bonita Panama - All Inclusive

4 out of 5
KM 7, Road to Veracruz Veracruz Panama
Book a stay at this beach property in Veracruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the pool and the helpful staff in our reviews. ...
7.6/10 Good! (1,060 reviews)
"I did not have to ask for towels, my room stayed clean water in refrigerator. I had an issue with my toilet day one and same day when I entered my room I had a whole new toilet"

Reviewed on Aug 25, 2026

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Dreams Playa Bonita Panama - All Inclusive
Waymore Hotel Spa & Casino

Waymore Hotel Spa & Casino

4 out of 5
Calle Augusto Samuel Boyd y Calle Eusebi Panama City
Book a stay at this spa B&B in Panama City. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Albrook Shopping Mall and Via Espana are located ...
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Waymore Hotel Spa & Casino
Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
Avenida Balboa Panama City
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
8.4/10 Very Good! (1,694 reviews)
"The room service was good. We got no discount voucher as promised for anything. The refrigerator was never stocked. We booked for 3 and only got 2 bottles of water at any given time. They were short on towels and rags. No valet service was available to assist with our bags in the morning of our departure ..."

Reviewed on Aug 25, 2026

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Megapolis Hotel Panamá
Principe Hotel and Suites

Principe Hotel and Suites

3 out of 5
Via Argentina Panama City Panama
Book a stay at this business-friendly hotel in Panama City. Enjoy free WiFi, free parking, and room service. Our guests praise the helpful staff and the clean ...
9/10 Wonderful! (2,039 reviews)
"I do not like the fact I was NOT offered the possibility of DELAYIng my arrival due to the last minute change in my transfer. Multiple times I tried to unsuccessfully."

Reviewed on Aug 26, 2026

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Principe Hotel and Suites
Waldorf Astoria Panama

Waldorf Astoria Panama

5 out of 5
47th St. & Uruguay Street Panama City Panama
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff in our reviews. ...
9/10 Wonderful! (1,007 reviews)
"Desafortunadamente es mi peor experiencia con la marca Waldorf Astoria. Las instalaciones estan a medio reformarse. El trato en el check in muy indiferente, pero pero al check out. Nuestro vuelo se retraso y cancelaron nuestra habitacion porque no avisamos! (Veniamos volando con retrasos). Pero lo ..."

Reviewed on Aug 25, 2026

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Waldorf Astoria Panama
Courtyard by Marriott Panama Metromall

Courtyard by Marriott Panama Metromall

4 out of 5
Avenida Domingo Diaz via Tocumen San Miguelito Panama
Book a stay at this business-friendly hotel in San Miguelito. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in ...
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Courtyard by Marriott Panama Metromall
See all 1,786 properties in Santa Clara
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.