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Panama from $642

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Cheap round-trip flights to Panama

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Copa
Fri, Sep 4 - Tue, Sep 22
JFK
John F. Kennedy Intl.
DAV
Enrique Malek Intl.
$642 Roundtrip, found 2 days ago
$642
Roundtrip
found 2 days ago
Select Copa flight, departing Fri, Sep 4 from John F. Kennedy Intl. to Enrique Malek Intl., returning Tue, Sep 22, priced at $642 found 2 days ago
American Airlines
Sun, May 30 - Mon, Jun 28
SAT
San Antonio Intl.
PTY
Tocumen Intl.
$657 Roundtrip, found 4 days ago
$657
Roundtrip
found 4 days ago
Select American Airlines flight, departing Sun, May 30 from San Antonio Intl. to Tocumen Intl., returning Mon, Jun 28, priced at $657 found 4 days ago
United
Mon, Feb 1 - Sun, Feb 14
AUS
Austin-Bergstrom Intl.
PTY
Tocumen Intl.
$658 Roundtrip, found 6 days ago
$658
Roundtrip
found 6 days ago
Select United flight, departing Mon, Feb 1 from Austin-Bergstrom Intl. to Tocumen Intl., returning Sun, Feb 14, priced at $658 found 6 days ago
Delta
Tue, Apr 13 - Tue, Apr 27
SAT
San Antonio Intl.
PTY
Tocumen Intl.
$658 Roundtrip, found 16 hours ago
$658
Roundtrip
found 16 hours ago
Select Delta flight, departing Tue, Apr 13 from San Antonio Intl. to Tocumen Intl., returning Tue, Apr 27, priced at $658 found 16 hours ago
Copa
Sun, Nov 1 - Sun, Nov 15
AUS
Austin-Bergstrom Intl.
PTY
Tocumen Intl.
$663 Roundtrip, found 4 days ago
$663
Roundtrip
found 4 days ago
Select Copa flight, departing Sun, Nov 1 from Austin-Bergstrom Intl. to Tocumen Intl., returning Sun, Nov 15, priced at $663 found 4 days ago
United
Sun, May 30 - Fri, Jun 25
AUS
Austin-Bergstrom Intl.
PTY
Tocumen Intl.
$665 Roundtrip, found 6 days ago
$665
Roundtrip
found 6 days ago
Select United flight, departing Sun, May 30 from Austin-Bergstrom Intl. to Tocumen Intl., returning Fri, Jun 25, priced at $665 found 6 days ago
Delta
Tue, Apr 13 - Fri, Apr 30
SAT
San Antonio Intl.
PTY
Tocumen Intl.
$668 Roundtrip, found 16 hours ago
$668
Roundtrip
found 16 hours ago
Select Delta flight, departing Tue, Apr 13 from San Antonio Intl. to Tocumen Intl., returning Fri, Apr 30, priced at $668 found 16 hours ago
Delta
Tue, Apr 13 - Tue, Apr 27
SAT
San Antonio Intl.
PTY
Tocumen Intl.
$669 Roundtrip, found 16 hours ago
$669
Roundtrip
found 16 hours ago
Select Delta flight, departing Tue, Apr 13 from San Antonio Intl. to Tocumen Intl., returning Tue, Apr 27, priced at $669 found 16 hours ago
United
Mon, Feb 1 - Sun, Feb 14
AUS
Austin-Bergstrom Intl.
PTY
Tocumen Intl.
$671 Roundtrip, found 6 days ago
$671
Roundtrip
found 6 days ago
Select United flight, departing Mon, Feb 1 from Austin-Bergstrom Intl. to Tocumen Intl., returning Sun, Feb 14, priced at $671 found 6 days ago
Copa
Sat, Oct 31 - Sun, Nov 15
AUS
Austin-Bergstrom Intl.
PTY
Tocumen Intl.
$673 Roundtrip, found 4 days ago
$673
Roundtrip
found 4 days ago
Select Copa flight, departing Sat, Oct 31 from Austin-Bergstrom Intl. to Tocumen Intl., returning Sun, Nov 15, priced at $673 found 4 days ago
United
Tue, Apr 13 - Fri, Apr 30
SAT
San Antonio Intl.
PTY
Tocumen Intl.
$677 Roundtrip, found 16 hours ago
$677
Roundtrip
found 16 hours ago
Select United flight, departing Tue, Apr 13 from San Antonio Intl. to Tocumen Intl., returning Fri, Apr 30, priced at $677 found 16 hours ago
American Airlines
Sun, May 30 - Mon, Jun 28
AUS
Austin-Bergstrom Intl.
PTY
Tocumen Intl.
$678 Roundtrip, found 4 days ago
$678
Roundtrip
found 4 days ago
Select American Airlines flight, departing Sun, May 30 from Austin-Bergstrom Intl. to Tocumen Intl., returning Mon, Jun 28, priced at $678 found 4 days ago
Delta
Tue, Apr 13 - Fri, Apr 30
SAT
San Antonio Intl.
PTY
Tocumen Intl.
$679 Roundtrip, found 16 hours ago
$679
Roundtrip
found 16 hours ago
Select Delta flight, departing Tue, Apr 13 from San Antonio Intl. to Tocumen Intl., returning Fri, Apr 30, priced at $679 found 16 hours ago
American Airlines
Mon, Apr 12 - Mon, Apr 26
SAT
San Antonio Intl.
PTY
Tocumen Intl.
$681 Roundtrip, found 16 hours ago
$681
Roundtrip
found 16 hours ago
Select American Airlines flight, departing Mon, Apr 12 from San Antonio Intl. to Tocumen Intl., returning Mon, Apr 26, priced at $681 found 16 hours ago
avianca
Wed, Nov 25 - Wed, Dec 2
JFK
John F. Kennedy Intl.
PTY
Tocumen Intl.
$694 Roundtrip, found 2 days ago
$694
Roundtrip
found 2 days ago
Select avianca flight, departing Wed, Nov 25 from John F. Kennedy Intl. to Tocumen Intl., returning Wed, Dec 2, priced at $694 found 2 days ago
Aeromexico
Thu, Mar 18 - Thu, Apr 1
AUS
Austin-Bergstrom Intl.
PTY
Tocumen Intl.
$737 Roundtrip, found 6 days ago
$737
Roundtrip
found 6 days ago
Select Aeromexico flight, departing Thu, Mar 18 from Austin-Bergstrom Intl. to Tocumen Intl., returning Thu, Apr 1, priced at $737 found 6 days ago

Last Minute Hotel Deals in Panama

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella Panama City Panama
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. ...
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Opens in a new windowHotel Riu Plaza Panama
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

4 out of 5
Ave. Domingo Diaz Tocumen Panama
Book a stay at this family-friendly hotel in Tocumen. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the breakfast and ...
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Opens in a new windowCrowne Plaza Panama Airport by IHG
Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Plaza de la Independencia Casco Viejo Panama City Panama
Book a stay at this spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff and the clean rooms ...
9.2/10 Wonderful! (1,014 reviews)
"The bathrooms and plumbing is poor. Leaking sink, water in the bath doesn’t drain The thermostat can’t be adjusted easily No bedroom slippers Breakfast was packed but ok. Not 5 star at all. Good location."

Reviewed on Aug 7, 2026

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Opens in a new windowCentral Hotel Panama Casco Viejo
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Gran Evenia Bijao - All Inclusive

Gran Evenia Bijao - All Inclusive

3.5 out of 5
Carretera Interamericana km 108, guias de Anton Rio Hato Coclé
Book a stay at this beach hotel in Rio Hato. Enjoy free WiFi, free parking, and 3 outdoor pools. Our guests praise the helpful staff in our reviews. Popular ...
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Opens in a new windowGran Evenia Bijao - All Inclusive
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.