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Santa Isabel

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Santa Isabel Flights as Low as $188

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Frontier Airlines
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American Airlines
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Frontier Airlines
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Frontier Airlines
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American Airlines
JetBlue Airways

Cheap Flights to Santa Isabel

Fall in love at first flight with your vacation to Santa Isabel by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Santa Isabel on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Santa Isabel, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Santa Isabel

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Santa Isabel with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the SJU airport.

What is the cheapest month to fly to Santa Isabel?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Santa Isabel are in September, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Santa Isabel?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Santa Isabel.

What airport is best to fly into Santa Isabel?

When you’re planning your trip to Santa Isabel, convenience is the name of the game. Luckily, Santa Isabel Mercedita Airport is nearby so you can deplane and get going on checking off everything on your Santa Isabel must-do list.

How much are flights to Santa Isabel?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Santa Isabel on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $188, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Santa Isabel?

The trick to saving a stack of cash on your flight to Santa Isabel? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $188 right now, why wait?

Santa Isabel Flight Information
Destination airport
Mercedita
Destination airport IATA code
PSE
Roundtrip price
$189

Last Minute Hotel Deals in Santa Isabel

Hotel Las Vegas

Hotel Las Vegas

3 out of 5
PR 153, Km 2.9 Santa Isabel
Stay at this motel in Santa Isabel. Enjoy 24-hour room service, a 24-hour front desk, and daily housekeeping. Our guests praise the helpful staff and the clean ...
8/10 Very Good! (352 reviews)
"Todo"

Reviewed on Jun 26, 2026

Hotel Las Vegas
Hacienda del Sur

Hacienda del Sur

2 out of 5
Carr 545 KM 1.5, Sector Gabia Santa Isabel
Stay at this hotel in Santa Isabel. Enjoy free WiFi, free parking, and a garden. Popular attractions Carribbean Cinemas Santa Isabel and Coamo Springs are located ...
9.6/10 Exceptional! (51 reviews)
"Viaje en pareja ..... El lugar cuenta con canchas de tenis y pickerball los vagones quedan frente por lo que escucharas el sonido como a las 3 comienzan a llegar instructores y personal para uso de las mismas en mi caso me gustó el ambiente ya que cuenta con una barra donde puedes disfrutar de una ..."

Reviewed on Jun 23, 2026

Hacienda del Sur
Hotel Vista Alegre

Hotel Vista Alegre

2.5 out of 5
Carr. PR-152 KM 2.3 Int Sector El Hotel BO. Quebradillas Barranquitas
Stay at this hotel in Barranquitas. Enjoy free breakfast, free WiFi, and free parking.
7/10 Good! (12 reviews)
"Bueno, pero esperaba mucho más para ser un hotel recién abierto! Mejoras en proceso que bloquean el acceso a algunos lugares y las puestas de la habitación no aíslan el sonido del exterior! Restaurante caro y poca calidad."

Reviewed on Jun 24, 2026

Hotel Vista Alegre
Hilton Ponce Golf & Casino Resort

Hilton Ponce Golf & Casino Resort

4.5 out of 5
1150 Caribe Avenue Ponce
Book a stay at this luxury resort in Ponce. Enjoy free WiFi, 2 outdoor pools, and 3 restaurants. Our guests praise the helpful staff and the clean rooms in our ...
8.8/10 Excellent! (1,046 reviews)
"Not many people the beaches not that great it's not white sand it's dark sand kind of a rocky type of Beach big ways the pool is very clean as it hot tub tennis court basketball lifeguards don't mess with you and there's things to drink if you bother the weighted to come to you they don't bother ..."

Reviewed on Jun 26, 2026

Hilton Ponce Golf & Casino Resort
Aloft by Marriott Ponce Hotel & Casino

Aloft by Marriott Ponce Hotel & Casino

3.5 out of 5
Street No 2 KM 228.9 Ponce
Stay at this hotel in Ponce. Enjoy free parking, 2 outdoor pools, and 4 restaurants. Our guests praise the helpful staff in our reviews. Popular attractions ...
8.8/10 Excellent! (1,212 reviews)
"."

Reviewed on Jun 26, 2026

Aloft by Marriott Ponce Hotel & Casino
Spark by Hilton Ponce

Spark by Hilton Ponce

3.5 out of 5
103 Turpo Industrial Park Ponce
Book a stay at this business-friendly hotel in Ponce. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the pool and the helpful staff in ...
8.8/10 Excellent! (1,720 reviews)
"All Good Service And Food"

Reviewed on Jun 26, 2026

Spark by Hilton Ponce
Holiday Inn Ponce & Tropical Casino by IHG

Holiday Inn Ponce & Tropical Casino by IHG

3.5 out of 5
3315 Ponce By Pass Ponce
Stay at this hotel in Ponce. Enjoy free WiFi, free parking, and a casino. Our guests praise the helpful staff in our reviews. Popular attractions Carribbean ...
9/10 Wonderful! (1,002 reviews)
"The rooms, are not very cool. It gets hot at night."

Reviewed on Jun 25, 2026

Holiday Inn Ponce & Tropical Casino by IHG
Meliá Century Hotel Ponce

Meliá Century Hotel Ponce

3.5 out of 5
#75 Calle Cristina Ponce
Book a stay at this business-friendly hotel in Ponce. Enjoy room service, parking (surcharge), and a 24-hour front desk. Popular attractions La Guancha and Parque ...
6.6/10 (1,001 reviews)
"Such a beautiful hotel with very old rooms"

Reviewed on Jun 26, 2026

Meliá Century Hotel Ponce
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.