Search Cheap Flights to
Santa Isabel

Search 400 airlines and 321,000 hotels worldwide.

Stop Planning & Start Exploring

FREE 24 hour cancellation on most flights

Santa Isabel Flights as Low as $133

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Frontier Airlines
Tue, Nov 10 - Tue, Nov 10
PHL
Philadelphia Intl.
SJU
Luis Munoz Marin Intl.
$133 Roundtrip, found 3 hours ago
$133
Roundtrip
found 3 hours ago
Select Frontier Airlines flight, departing Tue, Nov 10 from Philadelphia Intl. to Luis Munoz Marin Intl., returning Tue, Nov 10, priced at $133 found 3 hours ago
Frontier Airlines
Mon, Jan 11 - Thu, Jan 14
IAH
George Bush Intercontinental
SJU
Luis Munoz Marin Intl.
$155 Roundtrip, found 1 hour ago
$155
Roundtrip
found 1 hour ago
Select Frontier Airlines flight, departing Mon, Jan 11 from George Bush Intercontinental to Luis Munoz Marin Intl., returning Thu, Jan 14, priced at $155 found 1 hour ago
Frontier Airlines
Mon, Feb 1 - Thu, Feb 4
PHL
Philadelphia Intl.
SJU
Luis Munoz Marin Intl.
$158 Roundtrip, found 3 hours ago
$158
Roundtrip
found 3 hours ago
Select Frontier Airlines flight, departing Mon, Feb 1 from Philadelphia Intl. to Luis Munoz Marin Intl., returning Thu, Feb 4, priced at $158 found 3 hours ago
Frontier Airlines
Mon, Nov 23 - Wed, Dec 2
MCO
Orlando Intl.
BQN
Rafael Hernandez
$168 Roundtrip, found 8 hours ago
$168
Roundtrip
found 8 hours ago
Select Frontier Airlines flight, departing Mon, Nov 23 from Orlando Intl. to Rafael Hernandez, returning Wed, Dec 2, priced at $168 found 8 hours ago
Delta
Tue, Nov 10 - Tue, Nov 10
PHL
Philadelphia Intl.
SJU
Luis Munoz Marin Intl.
$171 Roundtrip, found 3 hours ago
$171
Roundtrip
found 3 hours ago
Select Delta flight, departing Tue, Nov 10 from Philadelphia Intl. to Luis Munoz Marin Intl., returning Tue, Nov 10, priced at $171 found 3 hours ago
Southwest Airlines
Tue, Dec 8 - Tue, Dec 15
PHL
Philadelphia Intl.
SJU
Luis Munoz Marin Intl.
$176 Roundtrip, just found
$176
Roundtrip
just found
Select Southwest Airlines flight, departing Tue, Dec 8 from Philadelphia Intl. to Luis Munoz Marin Intl., returning Tue, Dec 15, priced at $176 just found
Frontier Airlines
Tue, Nov 24 - Sat, Dec 5
MCO
Orlando Intl.
PSE
Mercedita
$188 Roundtrip, found 5 hours ago
$188
Roundtrip
found 5 hours ago
Select Frontier Airlines flight, departing Tue, Nov 24 from Orlando Intl. to Mercedita, returning Sat, Dec 5, priced at $188 found 5 hours ago
Frontier Airlines
Tue, Dec 8 - Tue, Dec 15
PHL
Philadelphia Intl.
BQN
Rafael Hernandez
$198 Roundtrip, found 1 hour ago
$198
Roundtrip
found 1 hour ago
Select Frontier Airlines flight, departing Tue, Dec 8 from Philadelphia Intl. to Rafael Hernandez, returning Tue, Dec 15, priced at $198 found 1 hour ago
Frontier Airlines
Mon, Feb 8 - Tue, Feb 9
MCO
Orlando Intl.
SJU
Luis Munoz Marin Intl.
$223 Roundtrip, found 2 hours ago
$223
Roundtrip
found 2 hours ago
Select Frontier Airlines flight, departing Mon, Feb 8 from Orlando Intl. to Luis Munoz Marin Intl., returning Tue, Feb 9, priced at $223 found 2 hours ago
Frontier Airlines
Sun, Jan 24 - Wed, Feb 3
TTN
Mercer
SJU
Luis Munoz Marin Intl.
$252 Roundtrip, found 2 hours ago
$252
Roundtrip
found 2 hours ago
Select Frontier Airlines flight, departing Sun, Jan 24 from Mercer to Luis Munoz Marin Intl., returning Wed, Feb 3, priced at $252 found 2 hours ago
Frontier Airlines
Tue, Dec 8 - Thu, Dec 17
TTN
Mercer
BQN
Rafael Hernandez
$315 Roundtrip, found 3 days ago
$315
Roundtrip
found 3 days ago
Select Frontier Airlines flight, departing Tue, Dec 8 from Mercer to Rafael Hernandez, returning Thu, Dec 17, priced at $315 found 3 days ago
JetBlue Airways
Tue, Nov 17 - Wed, Dec 2
IAH
George Bush Intercontinental
BQN
Rafael Hernandez
$318 Roundtrip, found 5 hours ago
$318
Roundtrip
found 5 hours ago
Select JetBlue Airways flight, departing Tue, Nov 17 from George Bush Intercontinental to Rafael Hernandez, returning Wed, Dec 2, priced at $318 found 5 hours ago
Frontier Airlines
Wed, Dec 2 - Thu, Dec 17
IAH
George Bush Intercontinental
PSE
Mercedita
$323 Roundtrip, just found
$323
Roundtrip
just found
Select Frontier Airlines flight, departing Wed, Dec 2 from George Bush Intercontinental to Mercedita, returning Thu, Dec 17, priced at $323 just found
Frontier Airlines
Sat, Dec 5 - Tue, Dec 8
PHL
Philadelphia Intl.
PSE
Mercedita
$366 Roundtrip, found 5 hours ago
$366
Roundtrip
found 5 hours ago
Select Frontier Airlines flight, departing Sat, Dec 5 from Philadelphia Intl. to Mercedita, returning Tue, Dec 8, priced at $366 found 5 hours ago
JetBlue Airways
Mon, Nov 9 - Tue, Dec 1
MCO
Orlando Intl.
MAZ
Eugenio María de Hostos
$522 Roundtrip, found 6 days ago
$522
Roundtrip
found 6 days ago
Select JetBlue Airways flight, departing Mon, Nov 9 from Orlando Intl. to Eugenio María de Hostos, returning Tue, Dec 1, priced at $522 found 6 days ago
JetBlue Airways
Thu, Dec 24 - Fri, Dec 25
IAH
George Bush Intercontinental
MAZ
Eugenio María de Hostos
$750 Roundtrip, found 5 hours ago
$750
Roundtrip
found 5 hours ago
Select JetBlue Airways flight, departing Thu, Dec 24 from George Bush Intercontinental to Eugenio María de Hostos, returning Fri, Dec 25, priced at $750 found 5 hours ago

Cheap Flights to Santa Isabel

Fall in love at first flight with your vacation to Santa Isabel by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Santa Isabel on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Santa Isabel, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Santa Isabel

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Santa Isabel with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the SJU airport.

What is the cheapest month to fly to Santa Isabel?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Santa Isabel are in November, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Santa Isabel?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Santa Isabel.

What airport is best to fly into Santa Isabel?

When you’re planning your trip to Santa Isabel, convenience is the name of the game. Luckily, Santa Isabel Mercedita Airport is nearby so you can deplane and get going on checking off everything on your Santa Isabel must-do list.

How much are flights to Santa Isabel?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Santa Isabel on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $133, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Santa Isabel?

The trick to saving a stack of cash on your flight to Santa Isabel? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $133 right now, why wait?

Santa Isabel Flight Information
Destination airport
Luis Munoz Marin Intl.
Destination airport IATA code
SJU
Roundtrip price
$133

Last Minute Hotel Deals in Santa Isabel

Hotel Las Vegas

Hotel Las Vegas

3 out of 5
PR 153, Km 2.9 Santa Isabel
Stay at this motel in Santa Isabel. Enjoy 24-hour room service, a 24-hour front desk, and daily housekeeping. Our guests praise the helpful staff and the clean ...
8.2/10 Very Good! (397 reviews)
"Love it"

Reviewed on Nov 5, 2026

Get rates
Hotel Las Vegas
Hacienda del Sur

Hacienda del Sur

2 out of 5
Carr 545 KM 1.5, Sector Gabia Santa Isabel
Stay at this hotel in Santa Isabel. Enjoy free WiFi, free parking, and a garden. Popular attractions Carribbean Cinemas Santa Isabel and Coamo Springs are located ...
Get rates
Hacienda del Sur
Hilton Ponce Golf & Casino Resort

Hilton Ponce Golf & Casino Resort

4.5 out of 5
1150 Caribe Avenue Ponce
Book a stay at this luxury resort in Ponce. Enjoy free WiFi, 2 outdoor pools, and 3 restaurants. Our guests praise the helpful staff and the clean rooms in our ...
8.8/10 Excellent! (1,171 reviews)
"Hilton Ponce continues to be a great location to relax and enjoy your day with family. The place is currently doing some renovations in the breakfast area of ‘La Terraza ‘ and in the west side thus the unexpected drilling noise early in the morning and through the day can be a bit annoying. Nevertheless ..."

Reviewed on Nov 4, 2026

Get rates
Hilton Ponce Golf & Casino Resort
Aloft by Marriott Ponce Hotel & Casino

Aloft by Marriott Ponce Hotel & Casino

3.5 out of 5
Street No 2 KM 228.9 Ponce
Stay at this hotel in Ponce. Enjoy free parking, 2 outdoor pools, and 4 restaurants. Our guests praise the helpful staff in our reviews. Popular attractions ...
Get rates
Aloft by Marriott Ponce Hotel & Casino
Ponce Plaza Hotel & Casino

Ponce Plaza Hotel & Casino

3.5 out of 5
Reina Street Ponce
Book a stay at this historic hotel in Ponce. Enjoy free WiFi, a casino, and breakfast (surcharge). Our guests praise the helpful staff and the clean rooms in ...
9.2/10 Wonderful! (1,179 reviews)
"Excellent location in the centre of old Ponce with loads of secure parking. Our room was clean and well-equipped including a fridge. The swimming pool is small, but clean and perfect for a cooling dip at the end of a hot day. Breakfast was exceptional, we also had lunch one day which was also excellent; ..."

Reviewed on Nov 7, 2026

Get rates
Ponce Plaza Hotel & Casino
Hotel Vista Bahia & Marina

Hotel Vista Bahia & Marina

3 out of 5
296 Cll A Salinas Salinas
Stay at this hotel in Salinas. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Marina de Salinas and Playa La Ochenta are located ...
Get rates
Hotel Vista Bahia & Marina
Spark by Hilton Ponce

Spark by Hilton Ponce

3.5 out of 5
103 Turpo Industrial Park Ponce
Book a stay at this business-friendly hotel in Ponce. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the pool and the helpful staff in ...
8.8/10 Excellent! (1,891 reviews)
"Un personal muy atento, la habitación muy limpia y los desayunos deliciosos."

Reviewed on Nov 6, 2026

Get rates
Spark by Hilton Ponce
Hotel Vista Alegre

Hotel Vista Alegre

3 out of 5
Carr. PR-152 KM 2.3 Int Sector El Hotel BO. Quebradillas Barranquitas
Stay at this hotel in Barranquitas. Enjoy free breakfast, free WiFi, and free parking. Popular attraction Plaza Las Flores is located nearby.
8.6/10 Excellent! (72 reviews)
"Personal de Front Desk muy amables y serviciales Igualmente el personal de la piscina y de los barres."

Reviewed on Nov 5, 2026

Get rates
Hotel Vista Alegre
See all 324 properties in Santa Isabel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.