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Santa Isabel

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Santa Isabel Flights as Low as $110

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Frontier Airlines
Sat, Mar 28 - Wed, Apr 15
MCO
Orlando Intl.
BQN
Rafael Hernandez
$110 Roundtrip, found 6 hours ago
$110
Roundtrip
found 6 hours ago
Select Frontier Airlines flight, departing Sat, Mar 28 from Orlando Intl. to Rafael Hernandez, returning Wed, Apr 15, priced at $110 found 6 hours ago
Frontier Airlines
Thu, Mar 26 - Wed, Apr 15
MCO
Orlando Intl.
BQN
Rafael Hernandez
$119 Roundtrip, found 3 days ago
$119
Roundtrip
found 3 days ago
Select Frontier Airlines flight, departing Thu, Mar 26 from Orlando Intl. to Rafael Hernandez, returning Wed, Apr 15, priced at $119 found 3 days ago
Frontier Airlines
Mon, Mar 30 - Wed, Apr 15
MCO
Orlando Intl.
BQN
Rafael Hernandez
$134 Roundtrip, found 7 hours ago
$134
Roundtrip
found 7 hours ago
Select Frontier Airlines flight, departing Mon, Mar 30 from Orlando Intl. to Rafael Hernandez, returning Wed, Apr 15, priced at $134 found 7 hours ago
Frontier Airlines
Sat, Mar 28 - Fri, Apr 10
MCO
Orlando Intl.
BQN
Rafael Hernandez
$138 Roundtrip, found 10 hours ago
$138
Roundtrip
found 10 hours ago
Select Frontier Airlines flight, departing Sat, Mar 28 from Orlando Intl. to Rafael Hernandez, returning Fri, Apr 10, priced at $138 found 10 hours ago
Frontier Airlines
Thu, Apr 9 - Sun, Apr 19
MCO
Orlando Intl.
PSE
Mercedita
$154 Roundtrip, found 12 hours ago
$154
Roundtrip
found 12 hours ago
Select Frontier Airlines flight, departing Thu, Apr 9 from Orlando Intl. to Mercedita, returning Sun, Apr 19, priced at $154 found 12 hours ago
Spirit Airlines
Wed, Mar 4 - Wed, Mar 11
MCO
Orlando Intl.
SJU
Luis Munoz Marin Intl.
$159 Roundtrip, found 3 days ago
$159
Roundtrip
found 3 days ago
Select Spirit Airlines flight, departing Wed, Mar 4 from Orlando Intl. to Luis Munoz Marin Intl., returning Wed, Mar 11, priced at $159 found 3 days ago
Frontier Airlines
Tue, Mar 3 - Thu, Mar 5
EWR
Newark Liberty Intl. Airport
SJU
Luis Munoz Marin Intl.
$166 Roundtrip, found 6 hours ago
$166
Roundtrip
found 6 hours ago
Select Frontier Airlines flight, departing Tue, Mar 3 from Newark Liberty Intl. Airport to Luis Munoz Marin Intl., returning Thu, Mar 5, priced at $166 found 6 hours ago
Frontier Airlines
Tue, Mar 3 - Wed, Mar 4
JFK
John F. Kennedy Intl.
SJU
Luis Munoz Marin Intl.
$166 Roundtrip, found 6 hours ago
$166
Roundtrip
found 6 hours ago
Select Frontier Airlines flight, departing Tue, Mar 3 from John F. Kennedy Intl. to Luis Munoz Marin Intl., returning Wed, Mar 4, priced at $166 found 6 hours ago
Frontier Airlines
Mon, Apr 20 - Sun, May 10
EWR
Newark Liberty Intl. Airport
BQN
Rafael Hernandez
$192 Roundtrip, found 8 hours ago
$192
Roundtrip
found 8 hours ago
Select Frontier Airlines flight, departing Mon, Apr 20 from Newark Liberty Intl. Airport to Rafael Hernandez, returning Sun, May 10, priced at $192 found 8 hours ago
JetBlue Airways
Thu, Apr 9 - Fri, Apr 10
JFK
John F. Kennedy Intl.
SJU
Luis Munoz Marin Intl.
$222 Roundtrip, found 2 hours ago
$222
Roundtrip
found 2 hours ago
Select JetBlue Airways flight, departing Thu, Apr 9 from John F. Kennedy Intl. to Luis Munoz Marin Intl., returning Fri, Apr 10, priced at $222 found 2 hours ago
JetBlue Airways
Tue, Mar 10 - Wed, Apr 1
JFK
John F. Kennedy Intl.
BQN
Rafael Hernandez
$229 Roundtrip, found 14 hours ago
$229
Roundtrip
found 14 hours ago
Select JetBlue Airways flight, departing Tue, Mar 10 from John F. Kennedy Intl. to Rafael Hernandez, returning Wed, Apr 1, priced at $229 found 14 hours ago
Delta
Wed, Apr 8 - Thu, Apr 23
JFK
John F. Kennedy Intl.
SJU
Luis Munoz Marin Intl.
$247 Roundtrip, found 1 day ago
$247
Roundtrip
found 1 day ago
Select Delta flight, departing Wed, Apr 8 from John F. Kennedy Intl. to Luis Munoz Marin Intl., returning Thu, Apr 23, priced at $247 found 1 day ago
United
Fri, Apr 10 - Wed, Apr 29
EWR
Newark Liberty Intl. Airport
SJU
Luis Munoz Marin Intl.
$257 Roundtrip, found 6 hours ago
$257
Roundtrip
found 6 hours ago
Select United flight, departing Fri, Apr 10 from Newark Liberty Intl. Airport to Luis Munoz Marin Intl., returning Wed, Apr 29, priced at $257 found 6 hours ago
American Airlines
Tue, Mar 3 - Wed, Mar 4
JFK
John F. Kennedy Intl.
SJU
Luis Munoz Marin Intl.
$271 Roundtrip, found 6 hours ago
$271
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Tue, Mar 3 from John F. Kennedy Intl. to Luis Munoz Marin Intl., returning Wed, Mar 4, priced at $271 found 6 hours ago
Frontier Airlines
Fri, Feb 27 - Sun, Mar 8
EWR
Newark Liberty Intl. Airport
PSE
Mercedita
$402 Roundtrip, found 3 hours ago
$402
Roundtrip
found 3 hours ago
Select Frontier Airlines flight, departing Fri, Feb 27 from Newark Liberty Intl. Airport to Mercedita, returning Sun, Mar 8, priced at $402 found 3 hours ago
Frontier Airlines
Fri, Feb 27 - Mon, Mar 2
JFK
John F. Kennedy Intl.
PSE
Mercedita
$506 Roundtrip, found 3 hours ago
$506
Roundtrip
found 3 hours ago
Select Frontier Airlines flight, departing Fri, Feb 27 from John F. Kennedy Intl. to Mercedita, returning Mon, Mar 2, priced at $506 found 3 hours ago

Cheap Flights to Santa Isabel

Fall in love at first flight with your vacation to Santa Isabel by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Santa Isabel on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Santa Isabel, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Santa Isabel

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Santa Isabel with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the SJU airport.

What is the cheapest month to fly to Santa Isabel?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Santa Isabel are in March, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Santa Isabel?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Santa Isabel.

What airport is best to fly into Santa Isabel?

When you’re planning your trip to Santa Isabel, convenience is the name of the game. Luckily, Santa Isabel Mercedita Airport is nearby so you can deplane and get going on checking off everything on your Santa Isabel must-do list.

How much are flights to Santa Isabel?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Santa Isabel on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $110, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Santa Isabel?

The trick to saving a stack of cash on your flight to Santa Isabel? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $110 right now, why wait?

Santa Isabel Flight Information
Destination airport
Rafael Hernandez
Destination airport IATA code
BQN
Roundtrip price
$110

Last Minute Hotel Deals in Santa Isabel

Hotel Las Vegas

Hotel Las Vegas

3 out of 5
PR 153, Km 2.9 Santa Isabel
Stay at this motel in Santa Isabel. Enjoy 24-hour room service, a 24-hour front desk, and daily housekeeping. Our guests praise the helpful staff and the clean ...
8/10 Very Good! (330 reviews)
We had not been informed that there was no office for check in. A man spoke to us thru a gate and told us what room we had. The room had no written info about anything, except a small piece of paper about housekeeping. To try to get the wifi password, I called the number on the paper, but no one ...

Reviewed on Feb 18, 2026

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Hotel Las Vegas
Hacienda del Sur

Hacienda del Sur

2 out of 5
Carr 545 KM 1.5, Sector Gabia Santa Isabel
Stay at this hotel in Santa Isabel. Enjoy free WiFi, free parking, and cable TV channels. Popular attractions Carribbean Cinemas Santa Isabel and Coamo Springs ...
9.6/10 Exceptional! (31 reviews)
This place was so impressive. The grounds are immaculate. The rooms are super clean and Modern. The Pool area is very calming. The food from the bar area was really tasty. Everyone was very nice and accommodating. I will definitely stay there again.

Reviewed on Feb 20, 2026

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Hacienda del Sur
Hilton Ponce Golf & Casino Resort

Hilton Ponce Golf & Casino Resort

4.5 out of 5
1150 Caribe Avenue Ponce
Book a stay at this luxury resort in Ponce. Enjoy free WiFi, 2 outdoor pools, and 4 restaurants. Our guests praise the helpful staff and the clean rooms in our ...
8.8/10 Excellent! (1,009 reviews)
Amazing stay during the week nice and quiet with plenty to do!

Reviewed on Feb 21, 2026

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Hilton Ponce Golf & Casino Resort
Aloft Ponce Hotel & Casino

Aloft Ponce Hotel & Casino

3.5 out of 5
Street No 2 KM 228.9 Ponce
Stay at this hotel in Ponce. Enjoy free parking, 2 outdoor pools, and 4 restaurants. Our guests praise the helpful staff in our reviews. Popular attractions ...
8.8/10 Excellent! (1,131 reviews)
Yes

Reviewed on Feb 21, 2026

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Aloft Ponce Hotel & Casino
Ponce Plaza Hotel & Casino

Ponce Plaza Hotel & Casino

3.5 out of 5
Reina Street Ponce
Book a stay at this historic hotel in Ponce. Enjoy free WiFi, a casino, and breakfast (surcharge). Our guests praise the helpful staff and the clean rooms in ...
9.2/10 Wonderful! (1,009 reviews)
The room was very clean. If you need quiet sleep be aware that the rooms overlook a road and the cars passing by can be loud. The surrounding area is a bit dead but there are a few places to hang out.

Reviewed on Feb 22, 2026

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Ponce Plaza Hotel & Casino
Caribe Hotel Ponce

Caribe Hotel Ponce

3.5 out of 5
103 Turpo Industrial Park Ponce
Book a stay at this business-friendly hotel in Ponce. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the pool and the helpful staff ...
8.6/10 Excellent! (1,622 reviews)
Room was very nice. It was a little different in that the dresser etc. had no drawers… it was all shelves which was not my favorite. Also had a little problem with temperature control but all in all it was good. Cannot say enough good things about the staff. Every aspect of interacting with them ...

Reviewed on Feb 20, 2026

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Caribe Hotel Ponce
1912 Boutique Hotel

1912 Boutique Hotel

2 out of 5
112 C. Barbosa Cayey Cayey
Stay at this hotel in Cayey. Enjoy free WiFi, cable TV channels, and an in-room espresso maker. Popular attractions Carribbean Cinemas Cayey and Monumento al ...
9.4/10 Exceptional! (48 reviews)
The hotel has no elevator which was a big problem. But even before that, we arrived and couldn’t get into the building. We rang the doorbell no one answered. Finally I found a phone number on my confirmation. The person who answered said she sent me information about arrival but I had given them ...

Reviewed on Feb 19, 2026

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1912 Boutique Hotel
Hotel Vista Bahia & Marina

Hotel Vista Bahia & Marina

3 out of 5
296 Cll A Salinas Salinas
Stay at this property in Salinas. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Marina de Salinas and Playa La Ochenta are located ...
8.6/10 Excellent! (65 reviews)
Staff were fantastic. All were friendly and patient and helpful. Room was clean and quiet. Ac worked well.

Reviewed on Feb 18, 2026

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Hotel Vista Bahia & Marina
See all 314 properties in Santa Isabel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.