Search for Cheap Deals on
Hotels in Santa Isabel

Check Last Minute Santa Isabel Hotel Deals

Tonight Mar 7 - Mar 8Next weekend Mar 13 - Mar 15

Choose from 315 Santa Isabel Hotel Deals

Hotel Las Vegas

Hotel Las Vegas

3 out of 5
PR 153, Km 2.9 Santa Isabel
  • 4 min drive from Carribbean Cinemas Santa Isabel
Stay at this motel in Santa Isabel. Enjoy 24-hour room service, a 24-hour front desk, and daily housekeeping. Our guests praise the helpful staff and the clean ...
8/10 Very Good! (331 reviews)
Good staff

Reviewed on Feb 25, 2026

Hotel Las Vegas
Hacienda del Sur

Hacienda del Sur

2 out of 5
Carr 545 KM 1.5, Sector Gabia Santa Isabel
  • 26 min walk from Carribbean Cinemas Santa Isabel
Stay at this hotel in Santa Isabel. Enjoy free WiFi, free parking, and a garden. Popular attractions Carribbean Cinemas Santa Isabel and Coamo Springs are located ...
9.6/10 Exceptional! (32 reviews)
This place was so impressive. The grounds are immaculate. The rooms are super clean and Modern. The Pool area is very calming. The food from the bar area was really tasty. Everyone was very nice and accommodating. I will definitely stay there again.

Reviewed on Feb 20, 2026

Hacienda del Sur
Hilton Ponce Golf & Casino Resort

Hilton Ponce Golf & Casino Resort

4.5 out of 5
1150 Caribe Avenue Ponce
  • 25 min drive from Carribbean Cinemas Santa Isabel
Book a stay at this luxury resort in Ponce. Enjoy free WiFi, 2 outdoor pools, and 3 restaurants. Our guests praise the helpful staff and the clean rooms in our ...
8.8/10 Excellent! (1,010 reviews)
Rooms are outdated. Jacuzzis were cold. Beach is not for swimming.

Reviewed on Mar 6, 2026

Hilton Ponce Golf & Casino Resort
Aloft Ponce Hotel & Casino

Aloft Ponce Hotel & Casino

3.5 out of 5
Street No 2 KM 228.9 Ponce
  • 25 min drive from Carribbean Cinemas Santa Isabel
Stay at this hotel in Ponce. Enjoy free parking, 2 outdoor pools, and 4 restaurants. Our guests praise the helpful staff in our reviews. Popular attractions ...
8.8/10 Excellent! (1,141 reviews)
Everything was great

Reviewed on Mar 7, 2026

Aloft Ponce Hotel & Casino
Spark by Hilton Ponce

Spark by Hilton Ponce

3.5 out of 5
103 Turpo Industrial Park Ponce
  • 22 min drive from Carribbean Cinemas Santa Isabel
Book a stay at this business-friendly hotel in Ponce. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the pool and the helpful staff in ...
8.6/10 Excellent! (1,616 reviews)
It was good.

Reviewed on Mar 6, 2026

Spark by Hilton Ponce
Ponce Plaza Hotel & Casino

Ponce Plaza Hotel & Casino

3.5 out of 5
Reina Street Ponce
  • 26 min drive from Carribbean Cinemas Santa Isabel
Book a stay at this historic hotel in Ponce. Enjoy free WiFi, a casino, and breakfast (surcharge). Our guests praise the helpful staff and the clean rooms in ...
9.2/10 Wonderful! (1,014 reviews)
Room was nice, wifi was iffy, great location

Reviewed on Mar 6, 2026

Ponce Plaza Hotel & Casino
Hotel Nuevo Mejico

Hotel Nuevo Mejico

3.5 out of 5
PR-501 Ponce Ponce
  • 31 min drive from Carribbean Cinemas Santa Isabel
Stay at this motel in Ponce. Enjoy free WiFi, free parking, and 24-hour room service. Our guests praise the helpful staff in our reviews. Popular attractions ...
8/10 Very Good! (755 reviews)
Clean, large space, comfy couch, fun lights

Reviewed on Feb 24, 2026

Hotel Nuevo Mejico
1912 Boutique Hotel

1912 Boutique Hotel

2 out of 5
112 C. Barbosa Cayey Cayey
  • 31 min drive from Carribbean Cinemas Santa Isabel
Stay at this hotel in Cayey. Enjoy free WiFi, cable TV channels, and an in-room espresso maker. Popular attractions Carribbean Cinemas Cayey and Monumento al ...
9.4/10 Exceptional! (55 reviews)
Clean room and hotel.size of room was very spacious and staff was very nice

Reviewed on Feb 27, 2026

1912 Boutique Hotel
Hotel Vista Bahia & Marina

Hotel Vista Bahia & Marina

3 out of 5
296 Cll A Salinas Salinas
  • 13 min drive from Carribbean Cinemas Santa Isabel
Stay at this property in Salinas. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Marina de Salinas and Playa La Ochenta are located ...
8.8/10 Excellent! (78 reviews)
Great experience, clean room, great customer service.

Reviewed on Mar 6, 2026

Hotel Vista Bahia & Marina
Meliá Century Hotel Ponce

Meliá Century Hotel Ponce

3.5 out of 5
#75 Calle Cristina Ponce
  • 26 min drive from Carribbean Cinemas Santa Isabel
Book a stay at this business-friendly hotel in Ponce. Enjoy room service, parking (surcharge), and a 24-hour front desk. Popular attractions Parque de Bombas ...
6.6/10 (1,006 reviews)
Nice place to stay. I'll stay in my next trip.

Reviewed on Mar 6, 2026

Meliá Century Hotel Ponce
Holiday Inn Ponce & Tropical Casino by IHG

Holiday Inn Ponce & Tropical Casino by IHG

3.5 out of 5
3315 Ponce By Pass Ponce
  • 32 min drive from Carribbean Cinemas Santa Isabel
Stay at this hotel in Ponce. Enjoy free WiFi, free parking, and a casino. Our guests praise the helpful staff in our reviews. Popular attractions Carribbean ...
Holiday Inn Ponce & Tropical Casino by IHG
The Place at the Sea

The Place at the Sea

2 out of 5
3499 Av. Los Meros Ponce Ponce
  • 28 min drive from Carribbean Cinemas Santa Isabel
Stay at this aparthotel in Ponce. Enjoy free WiFi, free parking, and a garden. Popular attractions Carribbean Cinemas Ponce Towne and Vicens Coliseum are located ...
9.4/10 Exceptional! (273 reviews)
Beautiful room! It was very clean and

Reviewed on Mar 2, 2026

The Place at the Sea
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Santa Isabel

You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Santa Isabel hotel with Hotwire to complete your one-of-a-kind travel checklist.

For you, intrepid voyager, Hotwire has a large selection of the best hotels in Santa Isabel.

Choosing the right hotel in has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Santa Isabel’s 315 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $78. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Santa Isabel hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Santa Isabel. No matter your reason for visiting Santa Isabel, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Santa Isabel hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Santa Isabel for as low as $78.

How many hotels are there in Santa Isabel?

With over 315 hotels in Santa Isabel, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $78.

How to find cheap car rentals in Santa Isabel?

Finding a cheap car rental deal in Santa Isabel is as easy as scoring cheap hotels in Santa Isabel. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.