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Hotels in Santa Isabel

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Tonight Jun 26 - Jun 27This weekend Jun 26 - Jun 28

Choose from 321 Santa Isabel Hotel Deals

Hotel Las Vegas

Hotel Las Vegas

3 out of 5
PR 153, Km 2.9 Santa Isabel
  • 4 min drive from Carribbean Cinemas Santa Isabel
Stay at this motel in Santa Isabel. Enjoy 24-hour room service, a 24-hour front desk, and daily housekeeping. Our guests praise the helpful staff and the clean ...
Hotel Las Vegas
Hacienda del Sur

Hacienda del Sur

2 out of 5
Carr 545 KM 1.5, Sector Gabia Santa Isabel
  • 26 min walk from Carribbean Cinemas Santa Isabel
Stay at this hotel in Santa Isabel. Enjoy free WiFi, free parking, and a garden. Popular attractions Carribbean Cinemas Santa Isabel and Coamo Springs are located ...
9.6/10 Exceptional! (51 reviews)
"Viaje en pareja ..... El lugar cuenta con canchas de tenis y pickerball los vagones quedan frente por lo que escucharas el sonido como a las 3 comienzan a llegar instructores y personal para uso de las mismas en mi caso me gustó el ambiente ya que cuenta con una barra donde puedes disfrutar de una ..."

Reviewed on Jun 23, 2026

Hacienda del Sur
Hotel Vista Alegre

Hotel Vista Alegre

2.5 out of 5
Carr. PR-152 KM 2.3 Int Sector El Hotel BO. Quebradillas Barranquitas
  • 33 min drive from Carribbean Cinemas Santa Isabel
Stay at this hotel in Barranquitas. Enjoy free breakfast, free WiFi, and free parking.
7/10 Good! (12 reviews)
"Bueno, pero esperaba mucho más para ser un hotel recién abierto! Mejoras en proceso que bloquean el acceso a algunos lugares y las puestas de la habitación no aíslan el sonido del exterior! Restaurante caro y poca calidad."

Reviewed on Jun 24, 2026

Hotel Vista Alegre
Hilton Ponce Golf & Casino Resort

Hilton Ponce Golf & Casino Resort

4.5 out of 5
1150 Caribe Avenue Ponce
  • 25 min drive from Carribbean Cinemas Santa Isabel
Book a stay at this luxury resort in Ponce. Enjoy free WiFi, 2 outdoor pools, and 3 restaurants. Our guests praise the helpful staff and the clean rooms in our ...
8.8/10 Excellent! (1,043 reviews)
"Everything good"

Reviewed on Jun 25, 2026

Hilton Ponce Golf & Casino Resort
Aloft by Marriott Ponce Hotel & Casino

Aloft by Marriott Ponce Hotel & Casino

3.5 out of 5
Street No 2 KM 228.9 Ponce
  • 25 min drive from Carribbean Cinemas Santa Isabel
Stay at this hotel in Ponce. Enjoy free parking, 2 outdoor pools, and 4 restaurants. Our guests praise the helpful staff in our reviews. Popular attractions ...
8.8/10 Excellent! (1,212 reviews)
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Reviewed on Jun 26, 2026

Aloft by Marriott Ponce Hotel & Casino
Spark by Hilton Ponce

Spark by Hilton Ponce

3.5 out of 5
103 Turpo Industrial Park Ponce
  • 22 min drive from Carribbean Cinemas Santa Isabel
Book a stay at this business-friendly hotel in Ponce. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the pool and the helpful staff in ...
8.8/10 Excellent! (1,719 reviews)
"The room was large and clean. The parking was secure. The breakfast was excellent, but the air conditioning in the dining area was set to a very low temperature while we were having breakfast."

Reviewed on Jun 25, 2026

Spark by Hilton Ponce
Holiday Inn Ponce & Tropical Casino by IHG

Holiday Inn Ponce & Tropical Casino by IHG

3.5 out of 5
3315 Ponce By Pass Ponce
  • 32 min drive from Carribbean Cinemas Santa Isabel
Stay at this hotel in Ponce. Enjoy free WiFi, free parking, and a casino. Our guests praise the helpful staff in our reviews. Popular attractions Carribbean ...
9/10 Wonderful! (1,002 reviews)
"The rooms, are not very cool. It gets hot at night."

Reviewed on Jun 25, 2026

Holiday Inn Ponce & Tropical Casino by IHG
Meliá Century Hotel Ponce

Meliá Century Hotel Ponce

3.5 out of 5
#75 Calle Cristina Ponce
  • 26 min drive from Carribbean Cinemas Santa Isabel
Book a stay at this business-friendly hotel in Ponce. Enjoy room service, parking (surcharge), and a 24-hour front desk. Popular attractions La Guancha and Parque ...
6.6/10 (1,000 reviews)
"Todo muy bien excelente la ubicación"

Reviewed on Jun 21, 2026

Meliá Century Hotel Ponce
Ponce Plaza Hotel & Casino

Ponce Plaza Hotel & Casino

3.5 out of 5
Reina Street Ponce
  • 26 min drive from Carribbean Cinemas Santa Isabel
Book a stay at this historic hotel in Ponce. Enjoy free WiFi, a casino, and breakfast (surcharge). Our guests praise the helpful staff and the clean rooms in ...
9.2/10 Wonderful! (1,099 reviews)
"Excelente servicios me gusto mucho"

Reviewed on Jun 24, 2026

Ponce Plaza Hotel & Casino
Hotel Nuevo Mejico

Hotel Nuevo Mejico

3.5 out of 5
PR-501 Ponce Ponce
  • 31 min drive from Carribbean Cinemas Santa Isabel
Stay at this motel in Ponce. Enjoy free WiFi, free parking, and 24-hour room service. Our guests praise the helpful staff in our reviews. Popular attractions ...
8/10 Very Good! (849 reviews)
"Will stay again"

Reviewed on Jun 24, 2026

Hotel Nuevo Mejico
The Place at the Sea

The Place at the Sea

3 out of 5
3499 Av. Los Meros Ponce Ponce
  • 28 min drive from Carribbean Cinemas Santa Isabel
Stay at this apartment in Ponce. Enjoy free WiFi, free parking, and a garden. Popular attractions La Guancha and Carribbean Cinemas Ponce Towne are located ...
9.4/10 Exceptional! (366 reviews)
"Beautiful place. Will stay again"

Reviewed on Jun 25, 2026

The Place at the Sea
Solace by the Sea

Solace by the Sea

3 out of 5
Highway 2 at km 220.1 Ponce
  • 33 min drive from Carribbean Cinemas Santa Isabel
Book a stay at this family-friendly hotel in Ponce. Enjoy parking (surcharge), a 24-hour front desk, and daily housekeeping. Popular attractions La Guancha and ...
6/10 (1,003 reviews)
"La fotos que están en Google no son!! El lugar no está apto para quedarse"

Reviewed on Jun 25, 2026

Solace by the Sea
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Santa Isabel

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For you, intrepid voyager, Hotwire has a large selection of the best hotels in Santa Isabel.

Choosing the right hotel in has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Santa Isabel’s 321 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $78. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Santa Isabel hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Santa Isabel. No matter your reason for visiting Santa Isabel, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Santa Isabel hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Santa Isabel for as low as $78.

How many hotels are there in Santa Isabel?

With over 321 hotels in Santa Isabel, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $78.

How to find cheap car rentals in Santa Isabel?

Finding a cheap car rental deal in Santa Isabel is as easy as scoring cheap hotels in Santa Isabel. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.