Search Cheap Flights to
Santee

Search 400 airlines and 321,000 hotels worldwide.

Stop Planning & Start Exploring

FREE 24 hour cancellation on most flights

Santee Flights as Low as $163

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

American Airlines
Tue, Sep 16 - Wed, Sep 24
LGA
LaGuardia
CAE
Columbia Metropolitan
$163 Roundtrip, found 4 days ago
$163
Roundtrip
found 4 days ago
Select American Airlines flight, departing Tue, Sep 16 from LaGuardia to Columbia Metropolitan, returning Wed, Sep 24, priced at $163 found 4 days ago
American Airlines
Sat, Jun 28 - Wed, Jul 2
DCA
Ronald Reagan Washington National
CAE
Columbia Metropolitan
$189 Roundtrip, found 1 day ago
$189
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Jun 28 from Ronald Reagan Washington National to Columbia Metropolitan, returning Wed, Jul 2, priced at $189 found 1 day ago
Spirit Airlines
Sat, Jun 28 - Tue, Jul 8
IAH
George Bush Intercontinental
CAE
Columbia Metropolitan
$196 Roundtrip, just found
$196
Roundtrip
just found
Select Spirit Airlines flight, departing Sat, Jun 28 from George Bush Intercontinental to Columbia Metropolitan, returning Tue, Jul 8, priced at $196 just found
Bargain Flight
Tue, Sep 23 - Sat, Sep 27
BDL
Bradley Intl.
CAE
Columbia Metropolitan
$198 Roundtrip, found 11 hours ago
$198
Roundtrip
found 11 hours ago
Select Bargain Flight flight, departing Tue, Sep 23 from Bradley Intl. to Columbia Metropolitan, returning Sat, Sep 27, priced at $198 found 11 hours ago
Delta
Fri, Jul 4 - Tue, Jul 8
ORD
O'Hare Intl.
CAE
Columbia Metropolitan
$202 Roundtrip, found 1 day ago
$202
Roundtrip
found 1 day ago
Select Delta flight, departing Fri, Jul 4 from O'Hare Intl. to Columbia Metropolitan, returning Tue, Jul 8, priced at $202 found 1 day ago
Bargain Flight
Wed, Oct 1 - Sat, Oct 4
BOS
Logan Intl.
CAE
Columbia Metropolitan
$205 Roundtrip, found 1 day ago
$205
Roundtrip
found 1 day ago
Select Bargain Flight flight, departing Wed, Oct 1 from Logan Intl. to Columbia Metropolitan, returning Sat, Oct 4, priced at $205 found 1 day ago
Delta
Mon, Jul 28 - Sun, Aug 3
IAD
Washington Dulles Intl.
CAE
Columbia Metropolitan
$209 Roundtrip, found 18 hours ago
$209
Roundtrip
found 18 hours ago
Select Delta flight, departing Mon, Jul 28 from Washington Dulles Intl. to Columbia Metropolitan, returning Sun, Aug 3, priced at $209 found 18 hours ago
Spirit Airlines
Tue, Jul 8 - Sat, Jul 12
PHL
Philadelphia Intl.
CAE
Columbia Metropolitan
$212 Roundtrip, found 7 hours ago
$212
Roundtrip
found 7 hours ago
Select Spirit Airlines flight, departing Tue, Jul 8 from Philadelphia Intl. to Columbia Metropolitan, returning Sat, Jul 12, priced at $212 found 7 hours ago
Delta
Thu, Jun 12 - Tue, Jun 17
STL
Lambert-St. Louis Intl.
CAE
Columbia Metropolitan
$253 Roundtrip, found 4 days ago
$253
Roundtrip
found 4 days ago
Select Delta flight, departing Thu, Jun 12 from Lambert-St. Louis Intl. to Columbia Metropolitan, returning Tue, Jun 17, priced at $253 found 4 days ago
Delta
Tue, Sep 9 - Wed, Sep 10
BWI
Baltimore Washington Intl. Thurgood Marshall
CAE
Columbia Metropolitan
$259 Roundtrip, found 3 days ago
$259
Roundtrip
found 3 days ago
Select Delta flight, departing Tue, Sep 9 from Baltimore Washington Intl. Thurgood Marshall to Columbia Metropolitan, returning Wed, Sep 10, priced at $259 found 3 days ago
Delta
Thu, Jul 24 - Sun, Jul 27
OKC
Will Rogers World
CAE
Columbia Metropolitan
$259 Roundtrip, found 1 day ago
$259
Roundtrip
found 1 day ago
Select Delta flight, departing Thu, Jul 24 from Will Rogers World to Columbia Metropolitan, returning Sun, Jul 27, priced at $259 found 1 day ago
American Airlines
Sat, Aug 9 - Tue, Aug 12
MSP
Minneapolis - St. Paul Intl.
CAE
Columbia Metropolitan
$287 Roundtrip, found 22 hours ago
$287
Roundtrip
found 22 hours ago
Select American Airlines flight, departing Sat, Aug 9 from Minneapolis - St. Paul Intl. to Columbia Metropolitan, returning Tue, Aug 12, priced at $287 found 22 hours ago
Delta
Sun, Aug 31 - Tue, Sep 9
TUS
Tucson Intl.
CAE
Columbia Metropolitan
$289 Roundtrip, found 1 day ago
$289
Roundtrip
found 1 day ago
Select Delta flight, departing Sun, Aug 31 from Tucson Intl. to Columbia Metropolitan, returning Tue, Sep 9, priced at $289 found 1 day ago
Delta
Wed, Jul 30 - Tue, Aug 5
PDX
Portland Intl.
CAE
Columbia Metropolitan
$309 Roundtrip, found 11 hours ago
$309
Roundtrip
found 11 hours ago
Select Delta flight, departing Wed, Jul 30 from Portland Intl. to Columbia Metropolitan, returning Tue, Aug 5, priced at $309 found 11 hours ago
Delta
Tue, Jul 29 - Mon, Aug 4
ONT
Los Angeles - Ontario Intl.
CAE
Columbia Metropolitan
$309 Roundtrip, found 1 day ago
$309
Roundtrip
found 1 day ago
Select Delta flight, departing Tue, Jul 29 from Los Angeles - Ontario Intl. to Columbia Metropolitan, returning Mon, Aug 4, priced at $309 found 1 day ago
Spirit Airlines
Fri, Jul 25 - Fri, Jul 25
DFW
Dallas-Fort Worth Intl.
CAE
Columbia Metropolitan
$345 Roundtrip, found 2 days ago
$345
Roundtrip
found 2 days ago
Select Spirit Airlines flight, departing Fri, Jul 25 from Dallas-Fort Worth Intl. to Columbia Metropolitan, returning Fri, Jul 25, priced at $345 found 2 days ago

Cheap Flights to Santee

Fall in love at first flight with your vacation to Santee by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Santee on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Santee, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Santee

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Santee with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the CAE airport.

What is the cheapest month to fly to Santee?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Santee are in September, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Santee?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 14 to choose from for your flight to Santee.

What airport is best to fly into Santee?

When you’re planning your trip to Santee, convenience is the name of the game. Luckily, Santee Charleston Intl. Airport is nearby so you can deplane and get going on checking off everything on your Santee must-do list.

How much are flights to Santee?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Santee on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $163, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Santee?

The trick to saving a stack of cash on your flight to Santee? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $163 right now, why wait?

Santee Flight Information
Destination airport
Columbia Metropolitan
Destination airport IATA code
CAE
Roundtrip price
$163

Last Minute Hotel Deals in Santee

Baymont by Wyndham Santee
Baymont by Wyndham Santee
2.5 out of 5
249 Britain Street, Santee, SC
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (1,302 reviews)
A great port after a bad storm
"Very friendly front desk, he made sure we had first floor room as I use a walker."

Reviewed on May 27, 2025

Get rates
Baymont by Wyndham Santee
Holiday Inn Santee by IHG
Holiday Inn Santee by IHG
3 out of 5
139 Bradford Blvd, Santee, SC
Stay at this 3-star golf hotel in Santee. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the clean rooms in ...
8/10 Very Good! (884 reviews)
"It was a good stay with friendly and helpful staff! My only complaint was the hallways smelled like per urine."

Reviewed on May 20, 2025

Get rates
Holiday Inn Santee by IHG
Tru By Hilton Santee
Tru By Hilton Santee
2.5 out of 5
263 Britain St. and 273 Britain St., Santee, SC
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
9/10 Wonderful! (425 reviews)
"this is one of my favorite hotels along the East Coast I-95 corridor. Clean, modern, friendly staff, very very convenient to I 95. I always enjoy staying here. The rooms are large and very clean. A+++++"

Reviewed on May 22, 2025

Get rates
Tru By Hilton Santee
Fairfield Inn & Suites by Marriott Santee
Fairfield Inn & Suites by Marriott Santee
2.5 out of 5
9074 Old Number Six Hwy, Santee, SC
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
9.8/10 Exceptional! (1,002 reviews)
"Good"

Reviewed on May 22, 2025

Get rates
Fairfield Inn & Suites by Marriott Santee
Comfort Inn & Suites Santee
Comfort Inn & Suites Santee
2.5 out of 5
221 Britain St, Santee, SC
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Santee ...
8/10 Very Good! (992 reviews)
"We had an enjoyable stay."

Reviewed on May 7, 2025

Get rates
Comfort Inn & Suites Santee
Quality Inn & Suites
Quality Inn & Suites
2.5 out of 5
8929 Old Number Six Highway, Santee, SC
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
6/10 (374 reviews)
"Great property"

Reviewed on May 22, 2025

Get rates
Quality Inn & Suites
Hampton Inn Santee-I-95
Hampton Inn Santee-I-95
2.5 out of 5
9060 Old Number Six Hwy, Santee, SC
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
9.4/10 Exceptional! (1,001 reviews)
"Clean room. Easy check in even late at night. We were staying here as a quick overnight to split up a long drive. Breakfast was good. They had the crib ready to go for us in the room when we arrived and there were highchairs in the dining area."

Reviewed on May 24, 2025

Get rates
Hampton Inn Santee-I-95
Travelodge by Wyndham Santee
Travelodge by Wyndham Santee
2 out of 5
9117 Old Number Six Hwy, Santee, SC
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
7/10 Good! (627 reviews)
"The desk clerk was amazingly helpful t me during a tough time"

Reviewed on May 21, 2025

Get rates
Travelodge by Wyndham Santee
See all 276 properties in Santee
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.