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Santee

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Santee Flights as Low as $224

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Bargain Flight
Sat, May 2 - Wed, May 6
LGA
LaGuardia
CAE
Columbia Metropolitan
$224 Roundtrip, found 1 hour ago
$224
Roundtrip
found 1 hour ago
Select Bargain Flight flight, departing Sat, May 2 from LaGuardia to Columbia Metropolitan, returning Wed, May 6, priced at $224 found 1 hour ago
Bargain Flight
Sat, May 2 - Tue, May 19
CLE
Hopkins Intl.
CAE
Columbia Metropolitan
$229 Roundtrip, found 1 day ago
$229
Roundtrip
found 1 day ago
Select Bargain Flight flight, departing Sat, May 2 from Hopkins Intl. to Columbia Metropolitan, returning Tue, May 19, priced at $229 found 1 day ago
American Airlines
Tue, May 5 - Sat, May 16
DCA
Ronald Reagan Washington National
CAE
Columbia Metropolitan
$260 Roundtrip, found 1 day ago
$260
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, May 5 from Ronald Reagan Washington National to Columbia Metropolitan, returning Sat, May 16, priced at $260 found 1 day ago
United
Wed, Apr 22 - Mon, Apr 27
EWR
Newark Liberty Intl. Airport
CAE
Columbia Metropolitan
$269 Roundtrip, found 4 hours ago
$269
Roundtrip
found 4 hours ago
Select United flight, departing Wed, Apr 22 from Newark Liberty Intl. Airport to Columbia Metropolitan, returning Mon, Apr 27, priced at $269 found 4 hours ago
United
Thu, Apr 23 - Sat, Apr 25
ORD
O'Hare Intl.
CAE
Columbia Metropolitan
$281 Roundtrip, found 16 hours ago
$281
Roundtrip
found 16 hours ago
Select United flight, departing Thu, Apr 23 from O'Hare Intl. to Columbia Metropolitan, returning Sat, Apr 25, priced at $281 found 16 hours ago
Bargain Flight
Tue, Jun 9 - Tue, Jun 16
PHX
Sky Harbor Intl.
CAE
Columbia Metropolitan
$291 Roundtrip, found 1 day ago
$291
Roundtrip
found 1 day ago
Select Bargain Flight flight, departing Tue, Jun 9 from Sky Harbor Intl. to Columbia Metropolitan, returning Tue, Jun 16, priced at $291 found 1 day ago
Delta
Sun, May 3 - Mon, May 11
JFK
John F. Kennedy Intl.
CAE
Columbia Metropolitan
$296 Roundtrip, found 5 days ago
$296
Roundtrip
found 5 days ago
Select Delta flight, departing Sun, May 3 from John F. Kennedy Intl. to Columbia Metropolitan, returning Mon, May 11, priced at $296 found 5 days ago
Delta
Sat, Jul 4 - Tue, Jul 14
MLI
Quad City Intl.
CAE
Columbia Metropolitan
$311 Roundtrip, found 13 hours ago
$311
Roundtrip
found 13 hours ago
Select Delta flight, departing Sat, Jul 4 from Quad City Intl. to Columbia Metropolitan, returning Tue, Jul 14, priced at $311 found 13 hours ago
Bargain Flight
Sat, Apr 25 - Wed, May 13
MKE
General Mitchell Intl.
CAE
Columbia Metropolitan
$319 Roundtrip, found 17 hours ago
$319
Roundtrip
found 17 hours ago
Select Bargain Flight flight, departing Sat, Apr 25 from General Mitchell Intl. to Columbia Metropolitan, returning Wed, May 13, priced at $319 found 17 hours ago
American Airlines
Sat, Apr 18 - Tue, Apr 21
FLL
Fort Lauderdale - Hollywood Intl.
CAE
Columbia Metropolitan
$329 Roundtrip, found 5 hours ago
$329
Roundtrip
found 5 hours ago
Select American Airlines flight, departing Sat, Apr 18 from Fort Lauderdale - Hollywood Intl. to Columbia Metropolitan, returning Tue, Apr 21, priced at $329 found 5 hours ago
Delta
Tue, Jul 21 - Sat, Aug 8
CID
Eastern Iowa
CAE
Columbia Metropolitan
$334 Roundtrip, found 6 days ago
$334
Roundtrip
found 6 days ago
Select Delta flight, departing Tue, Jul 21 from Eastern Iowa to Columbia Metropolitan, returning Sat, Aug 8, priced at $334 found 6 days ago
Delta
Sat, Jun 13 - Wed, Jun 17
GRR
Gerald R. Ford Intl.
CAE
Columbia Metropolitan
$334 Roundtrip, found 15 hours ago
$334
Roundtrip
found 15 hours ago
Select Delta flight, departing Sat, Jun 13 from Gerald R. Ford Intl. to Columbia Metropolitan, returning Wed, Jun 17, priced at $334 found 15 hours ago
Delta
Sat, May 9 - Tue, May 12
MSY
Louis Armstrong New Orleans Intl.
CAE
Columbia Metropolitan
$343 Roundtrip, found 1 day ago
$343
Roundtrip
found 1 day ago
Select Delta flight, departing Sat, May 9 from Louis Armstrong New Orleans Intl. to Columbia Metropolitan, returning Tue, May 12, priced at $343 found 1 day ago
Delta
Wed, May 13 - Tue, May 19
LIT
Clinton National Airport
CAE
Columbia Metropolitan
$343 Roundtrip, found 20 hours ago
$343
Roundtrip
found 20 hours ago
Select Delta flight, departing Wed, May 13 from Clinton National Airport to Columbia Metropolitan, returning Tue, May 19, priced at $343 found 20 hours ago
Delta
Wed, Apr 22 - Fri, May 1
SAT
San Antonio Intl.
CAE
Columbia Metropolitan
$353 Roundtrip, found 21 hours ago
$353
Roundtrip
found 21 hours ago
Select Delta flight, departing Wed, Apr 22 from San Antonio Intl. to Columbia Metropolitan, returning Fri, May 1, priced at $353 found 21 hours ago
American Airlines
Fri, May 1 - Sat, May 2
PDX
Portland Intl.
CAE
Columbia Metropolitan
$389 Roundtrip, found 13 hours ago
$389
Roundtrip
found 13 hours ago
Select American Airlines flight, departing Fri, May 1 from Portland Intl. to Columbia Metropolitan, returning Sat, May 2, priced at $389 found 13 hours ago

Cheap Flights to Santee

Fall in love at first flight with your vacation to Santee by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Santee on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Santee, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Santee

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Santee with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the CAE airport.

What is the cheapest month to fly to Santee?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Santee are in May, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Santee?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 12 to choose from for your flight to Santee.

What airport is best to fly into Santee?

When you’re planning your trip to Santee, convenience is the name of the game. Luckily, Santee Charleston Intl. Airport is nearby so you can deplane and get going on checking off everything on your Santee must-do list.

How much are flights to Santee?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Santee on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $224, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Santee?

The trick to saving a stack of cash on your flight to Santee? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $224 right now, why wait?

Santee Flight Information
Destination airport
Columbia Metropolitan
Destination airport IATA code
CAE
Roundtrip price
$223

Last Minute Hotel Deals in Santee

Baymont by Wyndham Santee

Baymont by Wyndham Santee

2.5 out of 5
249 Britain Street Santee SC
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (1,437 reviews)
The room was dirty, smelly and bugs. Left room within a hour. Asked for a refund which we haven’t received. Booked this room because it said it had a rating of 8. Can’t imagine how it got this rating.Very disappointing!!!

Reviewed on Mar 23, 2026

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Baymont by Wyndham Santee
Tru By Hilton Santee

Tru By Hilton Santee

2.5 out of 5
263 Britain St. and 273 Britain St. Santee SC
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
9.2/10 Wonderful! (768 reviews)
The only thing I can say about this place was that it was adequate. My opinion is that it was not up to Hilton standards. The room was spacious and that’s all. There was only one clothes hanger in the room. The blinds wouldn’t come go up, There was no coffee or water cups in the room. I will not ...

Reviewed on Mar 21, 2026

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Tru By Hilton Santee
Best Western Plus Santee Inn

Best Western Plus Santee Inn

2.5 out of 5
I 95 Exit 98 Santee SC
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful ...
8.8/10 Excellent! (1,006 reviews)
N/a

Reviewed on Mar 22, 2026

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Best Western Plus Santee Inn
Hampton Inn Santee-I-95

Hampton Inn Santee-I-95

2.5 out of 5
9060 Old Number Six Hwy Santee SC
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
9.6/10 Exceptional! (1,002 reviews)
This property is AMAZING!! The rooms are beautiful and well maintained. The breakfast (included) was exceptional as were the ladies preparing it and maintaining the area for cleanliness. The entire staff were helpful, polite and professional. We recommend it highly!!

Reviewed on Mar 22, 2026

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Hampton Inn Santee-I-95
Fairfield Inn & Suites by Marriott Santee

Fairfield Inn & Suites by Marriott Santee

3 out of 5
9074 Old Number Six Hwy Santee SC
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
9.8/10 Exceptional! (1,001 reviews)
.

Reviewed on Mar 18, 2026

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Fairfield Inn & Suites by Marriott Santee
Holiday Inn Santee by IHG

Holiday Inn Santee by IHG

3 out of 5
139 Bradford Blvd Santee SC
Book a stay at this golf hotel in Santee. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the clean rooms in ...
8.2/10 Very Good! (1,003 reviews)
The property is very nice and convenient for the family to visit with. My only issue was that there wasn’t enough soap in the shower for two people but overall we enjoyed our stay.

Reviewed on Mar 22, 2026

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Holiday Inn Santee by IHG
Comfort Inn & Suites Santee

Comfort Inn & Suites Santee

2.5 out of 5
221 Britain St Santee SC
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Santee ...
8/10 Very Good! (1,002 reviews)
This hotel worked fine as a quick overnight stop right off I-95, which is exactly what we needed. We arrived around midnight with two toddlers, and while the front desk staff was on the phone when we got there, we did have to wait about 10 minutes to check in. Thankfully, our kids handled it well. ...

Reviewed on Mar 21, 2026

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Comfort Inn & Suites Santee
Quality Inn & Suites Santee I-95

Quality Inn & Suites Santee I-95

2.5 out of 5
8929 Old Number Six Highway Santee SC
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
6/10 (488 reviews)
There was no one there, we got there about midnight to check in, asked for bottom floor room, told there was non but looked like there were plenty. Was put on the back side of the 2nd floor near so called pool. Beds were NIT comfortable at all, room were nasty. Glad we only slept couple hours and ...

Reviewed on Mar 22, 2026

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Quality Inn & Suites Santee I-95
See all 301 properties in Santee
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.