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Santee

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Santee Flights as Low as $225

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Bargain Flight
Wed, Sep 16 - Tue, Sep 29
LGA
LaGuardia
CAE
Columbia Metropolitan
$225 Roundtrip, found 4 days ago
$225
Roundtrip
found 4 days ago
Select Bargain Flight flight, departing Wed, Sep 16 from LaGuardia to Columbia Metropolitan, returning Tue, Sep 29, priced at $225 found 4 days ago
Delta
Sat, Aug 29 - Tue, Sep 1
IND
Indianapolis Intl.
CAE
Columbia Metropolitan
$269 Roundtrip, found 22 hours ago
$269
Roundtrip
found 22 hours ago
Select Delta flight, departing Sat, Aug 29 from Indianapolis Intl. to Columbia Metropolitan, returning Tue, Sep 1, priced at $269 found 22 hours ago
Delta
Fri, Sep 4 - Sat, Sep 5
IND
Indianapolis Intl.
CAE
Columbia Metropolitan
$282 Roundtrip, found 22 hours ago
$282
Roundtrip
found 22 hours ago
Select Delta flight, departing Fri, Sep 4 from Indianapolis Intl. to Columbia Metropolitan, returning Sat, Sep 5, priced at $282 found 22 hours ago
Bargain Flight
Sat, Aug 15 - Sat, Aug 22
OKC
Will Rogers World
CAE
Columbia Metropolitan
$282 Roundtrip, found 1 day ago
$282
Roundtrip
found 1 day ago
Select Bargain Flight flight, departing Sat, Aug 15 from Will Rogers World to Columbia Metropolitan, returning Sat, Aug 22, priced at $282 found 1 day ago
Delta
Fri, Aug 14 - Tue, Aug 18
EWR
Newark Liberty Intl. Airport
CAE
Columbia Metropolitan
$289 Roundtrip, found 22 hours ago
$289
Roundtrip
found 22 hours ago
Select Delta flight, departing Fri, Aug 14 from Newark Liberty Intl. Airport to Columbia Metropolitan, returning Tue, Aug 18, priced at $289 found 22 hours ago
American Airlines
Fri, Aug 14 - Tue, Aug 18
EWR
Newark Liberty Intl. Airport
CAE
Columbia Metropolitan
$289 Roundtrip, found 22 hours ago
$289
Roundtrip
found 22 hours ago
Select American Airlines flight, departing Fri, Aug 14 from Newark Liberty Intl. Airport to Columbia Metropolitan, returning Tue, Aug 18, priced at $289 found 22 hours ago
Delta
Sat, Aug 29 - Mon, Sep 7
IND
Indianapolis Intl.
CAE
Columbia Metropolitan
$291 Roundtrip, found 22 hours ago
$291
Roundtrip
found 22 hours ago
Select Delta flight, departing Sat, Aug 29 from Indianapolis Intl. to Columbia Metropolitan, returning Mon, Sep 7, priced at $291 found 22 hours ago
American Airlines
Fri, Jul 31 - Sun, Aug 2
IND
Indianapolis Intl.
CAE
Columbia Metropolitan
$296 Roundtrip, found 2 days ago
$296
Roundtrip
found 2 days ago
Select American Airlines flight, departing Fri, Jul 31 from Indianapolis Intl. to Columbia Metropolitan, returning Sun, Aug 2, priced at $296 found 2 days ago
Delta
Tue, Aug 25 - Tue, Sep 1
BDL
Bradley Intl.
CAE
Columbia Metropolitan
$300 Roundtrip, found 4 days ago
$300
Roundtrip
found 4 days ago
Select Delta flight, departing Tue, Aug 25 from Bradley Intl. to Columbia Metropolitan, returning Tue, Sep 1, priced at $300 found 4 days ago
Delta
Thu, Nov 26 - Wed, Dec 2
IAH
George Bush Intercontinental
CAE
Columbia Metropolitan
$305 Roundtrip, found 3 days ago
$305
Roundtrip
found 3 days ago
Select Delta flight, departing Thu, Nov 26 from George Bush Intercontinental to Columbia Metropolitan, returning Wed, Dec 2, priced at $305 found 3 days ago
Bargain Flight
Sat, Sep 5 - Sat, Sep 12
PHL
Philadelphia Intl.
CAE
Columbia Metropolitan
$317 Roundtrip, found 1 day ago
$317
Roundtrip
found 1 day ago
Select Bargain Flight flight, departing Sat, Sep 5 from Philadelphia Intl. to Columbia Metropolitan, returning Sat, Sep 12, priced at $317 found 1 day ago
Delta
Mon, Sep 21 - Mon, Sep 28
LGA
LaGuardia
CAE
Columbia Metropolitan
$357 Roundtrip, found 21 hours ago
$357
Roundtrip
found 21 hours ago
Select Delta flight, departing Mon, Sep 21 from LaGuardia to Columbia Metropolitan, returning Mon, Sep 28, priced at $357 found 21 hours ago
American Airlines
Sat, Sep 5 - Sat, Sep 12
TTN
Mercer
CAE
Columbia Metropolitan
$388 Roundtrip, found 4 days ago
$388
Roundtrip
found 4 days ago
Select American Airlines flight, departing Sat, Sep 5 from Mercer to Columbia Metropolitan, returning Sat, Sep 12, priced at $388 found 4 days ago
Delta
Fri, Jul 31 - Fri, Aug 7
JFK
John F. Kennedy Intl.
CAE
Columbia Metropolitan
$506 Roundtrip, found 6 days ago
$506
Roundtrip
found 6 days ago
Select Delta flight, departing Fri, Jul 31 from John F. Kennedy Intl. to Columbia Metropolitan, returning Fri, Aug 7, priced at $506 found 6 days ago
American Airlines
Thu, Jul 16 - Tue, Aug 4
LIM
Jorge Chávez Intl.
CAE
Columbia Metropolitan
$757 Roundtrip, found 1 day ago
$757
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Jul 16 from Jorge Chávez Intl. to Columbia Metropolitan, returning Tue, Aug 4, priced at $757 found 1 day ago
LATAM Airlines Group
Thu, Jul 16 - Tue, Aug 4
LIM
Jorge Chávez Intl.
CAE
Columbia Metropolitan
$2,529 Roundtrip, found 1 day ago
$2,529
Roundtrip
found 1 day ago
Select LATAM Airlines Group flight, departing Thu, Jul 16 from Jorge Chávez Intl. to Columbia Metropolitan, returning Tue, Aug 4, priced at $2,529 found 1 day ago

Cheap Flights to Santee

Fall in love at first flight with your vacation to Santee by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Santee on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Santee, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Santee

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Santee with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the CAE airport.

What is the cheapest month to fly to Santee?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Santee are in September, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Santee?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 13 to choose from for your flight to Santee.

What airport is best to fly into Santee?

When you’re planning your trip to Santee, convenience is the name of the game. Luckily, Santee Charleston Intl. Airport is nearby so you can deplane and get going on checking off everything on your Santee must-do list.

How much are flights to Santee?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Santee on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $225, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Santee?

The trick to saving a stack of cash on your flight to Santee? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $225 right now, why wait?

Santee Flight Information
Destination airport
Columbia Metropolitan
Destination airport IATA code
CAE
Roundtrip price
$224

Last Minute Hotel Deals in Santee

Tru By Hilton Santee

Tru By Hilton Santee

2.5 out of 5
263 Britain St. and 273 Britain St. Santee SC
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
9.2/10 Wonderful! (877 reviews)
"The staff and breakfast and atmosphere was excellent and welcoming. The only down side is there weren’t any closets or dressers in the hotel room to fully settle in. Also the pool wasn’t completely clean and had some floating brown bubbles. Other than that the hotel and staff were amazing."

Reviewed on Jul 9, 2026

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Tru By Hilton Santee
Best Western Plus Santee Inn

Best Western Plus Santee Inn

2.5 out of 5
I 95 Exit 98 Santee SC
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful ...
8.8/10 Excellent! (1,010 reviews)
"Friendly staff, which always makes traveling better. Normal basic rooms but with many amenities and within a half mile of many quick eat places."

Reviewed on Jul 13, 2026

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Best Western Plus Santee Inn
Baymont by Wyndham Santee

Baymont by Wyndham Santee

2.5 out of 5
249 Britain Street Santee SC
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8/10 Very Good! (1,484 reviews)
"Clean room and pet friendly"

Reviewed on Jul 13, 2026

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Baymont by Wyndham Santee
Hampton Inn Santee-I-95

Hampton Inn Santee-I-95

2.5 out of 5
9060 Old Number Six Hwy Santee SC
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
9.6/10 Exceptional! (1,004 reviews)
"Wonderful staff!"

Reviewed on Jul 8, 2026

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Hampton Inn Santee-I-95
Comfort Inn & Suites Santee

Comfort Inn & Suites Santee

2.5 out of 5
221 Britain St Santee SC
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Santee ...
8/10 Very Good! (1,006 reviews)
"Checking in process was excellent. Staff was great and always available. Breakfast was great one exception the time. Breakfast time should be extended ends at 9:30am. Parking availability was great. This will be my stay when I'm visiting family. Thank you for great service."

Reviewed on Jul 10, 2026

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Comfort Inn & Suites Santee
Quality Inn & Suites Santee I-95

Quality Inn & Suites Santee I-95

2.5 out of 5
8929 Old Number Six Highway Santee SC
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
6/10 (556 reviews)
"The 1st fact was that I was asked to pay a fee of 100. At check-in that would be refunded after checkout. I was not told about that beforehand. I was refunded that after the room was checked when I complained. (See pics inserted) I never stayed here. I left this property and booked a room at another ..."

Reviewed on Jul 12, 2026

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Quality Inn & Suites Santee I-95
Ramada by Wyndham Santee I-95

Ramada by Wyndham Santee I-95

2 out of 5
123 Mall Street Santee SC
Book a stay at this golf hotel in Santee. Enjoy free WiFi, free parking, and a nightclub. Popular attractions Santee Cooper Country Club and Santee National ...
6.4/10 (571 reviews)
"Canceled my reservation without even calling or emailing me about why they canceled it!!! Smh"

Reviewed on Jul 11, 2026

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Ramada by Wyndham Santee I-95
Travelodge by Wyndham Santee

Travelodge by Wyndham Santee

2 out of 5
9117 Old Number Six Hwy Santee SC
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
7.2/10 Good! (756 reviews)
"Very clean. Perfect for price"

Reviewed on Jul 11, 2026

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Travelodge by Wyndham Santee
See all 313 properties in Santee
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.