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Santee

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Santee Flights as Low as $223

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Bargain Flight
Wed, Sep 2 - Tue, Sep 15
IND
Indianapolis Intl.
CAE
Columbia Metropolitan
$223 Roundtrip, found 2 days ago
$223
Roundtrip
found 2 days ago
Select Bargain Flight flight, departing Wed, Sep 2 from Indianapolis Intl. to Columbia Metropolitan, returning Tue, Sep 15, priced at $223 found 2 days ago
Bargain Flight
Wed, May 13 - Mon, May 18
BDL
Bradley Intl.
CAE
Columbia Metropolitan
$258 Roundtrip, found 1 day ago
$258
Roundtrip
found 1 day ago
Select Bargain Flight flight, departing Wed, May 13 from Bradley Intl. to Columbia Metropolitan, returning Mon, May 18, priced at $258 found 1 day ago
American Airlines
Thu, Jul 23 - Sun, Jul 26
LGA
LaGuardia
CAE
Columbia Metropolitan
$259 Roundtrip, found 3 days ago
$259
Roundtrip
found 3 days ago
Select American Airlines flight, departing Thu, Jul 23 from LaGuardia to Columbia Metropolitan, returning Sun, Jul 26, priced at $259 found 3 days ago
United
Wed, Jun 24 - Tue, Jun 30
CMH
John Glenn Columbus Intl.
CAE
Columbia Metropolitan
$261 Roundtrip, found 2 days ago
$261
Roundtrip
found 2 days ago
Select United flight, departing Wed, Jun 24 from John Glenn Columbus Intl. to Columbia Metropolitan, returning Tue, Jun 30, priced at $261 found 2 days ago
Bargain Flight
Fri, May 15 - Thu, May 21
BNA
Nashville Intl.
CAE
Columbia Metropolitan
$267 Roundtrip, found 2 days ago
$267
Roundtrip
found 2 days ago
Select Bargain Flight flight, departing Fri, May 15 from Nashville Intl. to Columbia Metropolitan, returning Thu, May 21, priced at $267 found 2 days ago
American Airlines
Wed, Jun 17 - Fri, Jun 26
ORD
O'Hare Intl.
CAE
Columbia Metropolitan
$275 Roundtrip, found 2 hours ago
$275
Roundtrip
found 2 hours ago
Select American Airlines flight, departing Wed, Jun 17 from O'Hare Intl. to Columbia Metropolitan, returning Fri, Jun 26, priced at $275 found 2 hours ago
American Airlines
Sat, May 30 - Tue, Jun 9
EWR
Newark Liberty Intl. Airport
CAE
Columbia Metropolitan
$285 Roundtrip, found 4 days ago
$285
Roundtrip
found 4 days ago
Select American Airlines flight, departing Sat, May 30 from Newark Liberty Intl. Airport to Columbia Metropolitan, returning Tue, Jun 9, priced at $285 found 4 days ago
Delta
Wed, May 27 - Tue, Jun 16
IAH
George Bush Intercontinental
CAE
Columbia Metropolitan
$310 Roundtrip, found 3 days ago
$310
Roundtrip
found 3 days ago
Select Delta flight, departing Wed, May 27 from George Bush Intercontinental to Columbia Metropolitan, returning Tue, Jun 16, priced at $310 found 3 days ago
Delta
Mon, Jun 8 - Tue, Jun 16
BWI
Baltimore Washington Intl. Thurgood Marshall
CAE
Columbia Metropolitan
$312 Roundtrip, found 4 days ago
$312
Roundtrip
found 4 days ago
Select Delta flight, departing Mon, Jun 8 from Baltimore Washington Intl. Thurgood Marshall to Columbia Metropolitan, returning Tue, Jun 16, priced at $312 found 4 days ago
Delta
Wed, Jul 8 - Wed, Jul 15
STL
Lambert-St. Louis Intl.
CAE
Columbia Metropolitan
$317 Roundtrip, found 1 day ago
$317
Roundtrip
found 1 day ago
Select Delta flight, departing Wed, Jul 8 from Lambert-St. Louis Intl. to Columbia Metropolitan, returning Wed, Jul 15, priced at $317 found 1 day ago
American Airlines
Sat, Jul 4 - Tue, Jul 14
MSP
Minneapolis - St. Paul Intl.
CAE
Columbia Metropolitan
$320 Roundtrip, found 6 hours ago
$320
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Sat, Jul 4 from Minneapolis - St. Paul Intl. to Columbia Metropolitan, returning Tue, Jul 14, priced at $320 found 6 hours ago
Delta
Thu, Jun 18 - Fri, Jul 3
RSW
Southwest Florida Intl.
CAE
Columbia Metropolitan
$326 Roundtrip, found 1 day ago
$326
Roundtrip
found 1 day ago
Select Delta flight, departing Thu, Jun 18 from Southwest Florida Intl. to Columbia Metropolitan, returning Fri, Jul 3, priced at $326 found 1 day ago
Delta
Wed, May 27 - Tue, Jun 9
FLL
Fort Lauderdale - Hollywood Intl.
CAE
Columbia Metropolitan
$343 Roundtrip, found 16 hours ago
$343
Roundtrip
found 16 hours ago
Select Delta flight, departing Wed, May 27 from Fort Lauderdale - Hollywood Intl. to Columbia Metropolitan, returning Tue, Jun 9, priced at $343 found 16 hours ago
Delta
Wed, Jul 8 - Wed, Jul 29
ONT
Ontario Intl. Airport
CAE
Columbia Metropolitan
$361 Roundtrip, found 1 day ago
$361
Roundtrip
found 1 day ago
Select Delta flight, departing Wed, Jul 8 from Ontario Intl. Airport to Columbia Metropolitan, returning Wed, Jul 29, priced at $361 found 1 day ago
Delta
Tue, Jul 21 - Sat, Aug 8
AUS
Austin-Bergstrom Intl.
CAE
Columbia Metropolitan
$363 Roundtrip, found 1 day ago
$363
Roundtrip
found 1 day ago
Select Delta flight, departing Tue, Jul 21 from Austin-Bergstrom Intl. to Columbia Metropolitan, returning Sat, Aug 8, priced at $363 found 1 day ago
Delta
Wed, May 20 - Fri, May 29
OMA
Eppley Field
CAE
Columbia Metropolitan
$379 Roundtrip, found 1 day ago
$379
Roundtrip
found 1 day ago
Select Delta flight, departing Wed, May 20 from Eppley Field to Columbia Metropolitan, returning Fri, May 29, priced at $379 found 1 day ago

Cheap Flights to Santee

Fall in love at first flight with your vacation to Santee by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Santee on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Santee, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Santee

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Santee with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the CAE airport.

What is the cheapest month to fly to Santee?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Santee are in September, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Santee?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 13 to choose from for your flight to Santee.

What airport is best to fly into Santee?

When you’re planning your trip to Santee, convenience is the name of the game. Luckily, Santee Charleston Intl. Airport is nearby so you can deplane and get going on checking off everything on your Santee must-do list.

How much are flights to Santee?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Santee on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $223, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Santee?

The trick to saving a stack of cash on your flight to Santee? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $223 right now, why wait?

Santee Flight Information
Destination airport
Columbia Metropolitan
Destination airport IATA code
CAE
Roundtrip price
$222

Last Minute Hotel Deals in Santee

Baymont by Wyndham Santee

Baymont by Wyndham Santee

2.5 out of 5
249 Britain Street Santee SC
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8/10 Very Good! (1,466 reviews)
The woman at the front desk was amazing and personable, wonderful personality.

Reviewed on May 9, 2026

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Baymont by Wyndham Santee
Tru By Hilton Santee

Tru By Hilton Santee

2.5 out of 5
263 Britain St. and 273 Britain St. Santee SC
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
9.2/10 Wonderful! (819 reviews)
The room was immaculate; the property staff was friendly and very helpful. I'm not a breakfast eater, but the coffee was excellent. Both the check-in and check-out experiences were exceptional. I would highly recommend this hotel to anyone traveling in the Santee area.

Reviewed on May 8, 2026

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Tru By Hilton Santee
Comfort Inn & Suites Santee

Comfort Inn & Suites Santee

2.5 out of 5
221 Britain St Santee SC
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Santee ...
8/10 Very Good! (1,010 reviews)
Excellent value for the money! Clean rooms, clean public spaces. The Breakfast man Chris was so helpful and friendly! Very hard working! Front desk friendly. Coffee very good. Beds comfy. No complaints.

Reviewed on May 9, 2026

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Comfort Inn & Suites Santee
Hampton Inn Santee-I-95

Hampton Inn Santee-I-95

2.5 out of 5
9060 Old Number Six Hwy Santee SC
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
9.6/10 Exceptional! (1,006 reviews)
Check-in was a breeze. The staff was really friendly. The room was clean, quiet and well a portion breakfast was very tasty. I would stay at this hotel again and again.

Reviewed on May 5, 2026

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Hampton Inn Santee-I-95
Best Western Plus Santee Inn

Best Western Plus Santee Inn

2.5 out of 5
I 95 Exit 98 Santee SC
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful ...
8.8/10 Excellent! (1,004 reviews)
This Best Western, while nothin fancy, is definitely a cut above other highway motels. It has everything a weary traveler could want. Really comfortable bed, a clean, decent sized bathroom with plenty of hot water and a decent breakfast with fresh fruit. It also has a good sized heated outdoor pool. ...

Reviewed on May 6, 2026

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Best Western Plus Santee Inn
Fairfield Inn & Suites by Marriott Santee

Fairfield Inn & Suites by Marriott Santee

3 out of 5
9074 Old Number Six Hwy Santee SC
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
9.8/10 Exceptional! (1,005 reviews)
Great

Reviewed on May 7, 2026

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Fairfield Inn & Suites by Marriott Santee
Quality Inn & Suites Santee I-95

Quality Inn & Suites Santee I-95

2.5 out of 5
8929 Old Number Six Highway Santee SC
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
6/10 (528 reviews)
It looks like it is in the course of renovation. I guess everything was OK, but it was a little spooky with hundreds of rooms and so few people.

Reviewed on May 9, 2026

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Quality Inn & Suites Santee I-95
Travelodge by Wyndham Santee

Travelodge by Wyndham Santee

2 out of 5
9117 Old Number Six Hwy Santee SC
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
7.2/10 Good! (728 reviews)
Parking lot as nice, you park right in front of your room. No bells and whistles but clean, nice shower and bed was very comfortable. Great stop and the price was right.

Reviewed on May 7, 2026

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Travelodge by Wyndham Santee
See all 306 properties in Santee
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.