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Santee

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Santee Flights as Low as $326

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Bargain Flight
Sat, Oct 31 - Tue, Nov 10
MSY
Louis Armstrong New Orleans Intl.
CAE
Columbia Metropolitan
$326 Roundtrip, found 8 hours ago
$326
Roundtrip
found 8 hours ago
Select Bargain Flight flight, departing Sat, Oct 31 from Louis Armstrong New Orleans Intl. to Columbia Metropolitan, returning Tue, Nov 10, priced at $326 found 8 hours ago
Bargain Flight
Thu, Oct 15 - Tue, Oct 27
LGA
LaGuardia
CAE
Columbia Metropolitan
$328 Roundtrip, found 3 days ago
$328
Roundtrip
found 3 days ago
Select Bargain Flight flight, departing Thu, Oct 15 from LaGuardia to Columbia Metropolitan, returning Tue, Oct 27, priced at $328 found 3 days ago
Bargain Flight
Sat, Oct 17 - Sat, Oct 31
LGA
LaGuardia
CAE
Columbia Metropolitan
$333 Roundtrip, found 6 days ago
$333
Roundtrip
found 6 days ago
Select Bargain Flight flight, departing Sat, Oct 17 from LaGuardia to Columbia Metropolitan, returning Sat, Oct 31, priced at $333 found 6 days ago
United
Sat, Oct 31 - Tue, Nov 10
MSY
Louis Armstrong New Orleans Intl.
CAE
Columbia Metropolitan
$339 Roundtrip, found 8 hours ago
$339
Roundtrip
found 8 hours ago
Select United flight, departing Sat, Oct 31 from Louis Armstrong New Orleans Intl. to Columbia Metropolitan, returning Tue, Nov 10, priced at $339 found 8 hours ago
Delta
Mon, Mar 1 - Tue, Mar 16
MSY
Louis Armstrong New Orleans Intl.
CAE
Columbia Metropolitan
$343 Roundtrip, found 5 days ago
$343
Roundtrip
found 5 days ago
Select Delta flight, departing Mon, Mar 1 from Louis Armstrong New Orleans Intl. to Columbia Metropolitan, returning Tue, Mar 16, priced at $343 found 5 days ago
Delta
Thu, Nov 19 - Tue, Dec 8
GRB
Austin Straubel Intl.
CAE
Columbia Metropolitan
$344 Roundtrip, found 5 days ago
$344
Roundtrip
found 5 days ago
Select Delta flight, departing Thu, Nov 19 from Austin Straubel Intl. to Columbia Metropolitan, returning Tue, Dec 8, priced at $344 found 5 days ago
Delta
Tue, Nov 17 - Tue, Nov 24
MSY
Louis Armstrong New Orleans Intl.
CAE
Columbia Metropolitan
$346 Roundtrip, found 1 day ago
$346
Roundtrip
found 1 day ago
Select Delta flight, departing Tue, Nov 17 from Louis Armstrong New Orleans Intl. to Columbia Metropolitan, returning Tue, Nov 24, priced at $346 found 1 day ago
Delta
Tue, Nov 3 - Tue, Nov 10
MSY
Louis Armstrong New Orleans Intl.
CAE
Columbia Metropolitan
$348 Roundtrip, found 4 days ago
$348
Roundtrip
found 4 days ago
Select Delta flight, departing Tue, Nov 3 from Louis Armstrong New Orleans Intl. to Columbia Metropolitan, returning Tue, Nov 10, priced at $348 found 4 days ago
United
Sat, Oct 31 - Tue, Nov 10
MSY
Louis Armstrong New Orleans Intl.
CAE
Columbia Metropolitan
$349 Roundtrip, found 8 hours ago
$349
Roundtrip
found 8 hours ago
Select United flight, departing Sat, Oct 31 from Louis Armstrong New Orleans Intl. to Columbia Metropolitan, returning Tue, Nov 10, priced at $349 found 8 hours ago
Delta
Tue, Nov 3 - Mon, Nov 9
MSY
Louis Armstrong New Orleans Intl.
CAE
Columbia Metropolitan
$350 Roundtrip, found 4 days ago
$350
Roundtrip
found 4 days ago
Select Delta flight, departing Tue, Nov 3 from Louis Armstrong New Orleans Intl. to Columbia Metropolitan, returning Mon, Nov 9, priced at $350 found 4 days ago
United
Thu, Nov 19 - Tue, Dec 8
GRB
Austin Straubel Intl.
CAE
Columbia Metropolitan
$354 Roundtrip, found 5 days ago
$354
Roundtrip
found 5 days ago
Select United flight, departing Thu, Nov 19 from Austin Straubel Intl. to Columbia Metropolitan, returning Tue, Dec 8, priced at $354 found 5 days ago
Delta
Fri, Feb 26 - Tue, Mar 9
MSY
Louis Armstrong New Orleans Intl.
CAE
Columbia Metropolitan
$360 Roundtrip, found 5 days ago
$360
Roundtrip
found 5 days ago
Select Delta flight, departing Fri, Feb 26 from Louis Armstrong New Orleans Intl. to Columbia Metropolitan, returning Tue, Mar 9, priced at $360 found 5 days ago
American Airlines
Tue, Nov 3 - Mon, Dec 14
LGA
LaGuardia
CAE
Columbia Metropolitan
$364 Roundtrip, found 12 hours ago
$364
Roundtrip
found 12 hours ago
Select American Airlines flight, departing Tue, Nov 3 from LaGuardia to Columbia Metropolitan, returning Mon, Dec 14, priced at $364 found 12 hours ago
Delta
Wed, Nov 25 - Tue, Dec 1
RSW
Southwest Florida Intl.
CAE
Columbia Metropolitan
$413 Roundtrip, found 16 hours ago
$413
Roundtrip
found 16 hours ago
Select Delta flight, departing Wed, Nov 25 from Southwest Florida Intl. to Columbia Metropolitan, returning Tue, Dec 1, priced at $413 found 16 hours ago
American Airlines
Tue, Oct 6 - Wed, Oct 14
ROC
Greater Rochester Intl.
CAE
Columbia Metropolitan
$483 Roundtrip, found 1 day ago
$483
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Oct 6 from Greater Rochester Intl. to Columbia Metropolitan, returning Wed, Oct 14, priced at $483 found 1 day ago
Delta
Wed, Nov 4 - Mon, Nov 9
HNL
Daniel K. Inouye Intl.
CAE
Columbia Metropolitan
$779 Roundtrip, found 12 hours ago
$779
Roundtrip
found 12 hours ago
Select Delta flight, departing Wed, Nov 4 from Daniel K. Inouye Intl. to Columbia Metropolitan, returning Mon, Nov 9, priced at $779 found 12 hours ago

Cheap Flights to Santee

Fall in love at first flight with your vacation to Santee by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Santee on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Santee, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Santee

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Santee with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the CAE airport.

What is the cheapest month to fly to Santee?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Santee are in October, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Santee?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 13 to choose from for your flight to Santee.

What airport is best to fly into Santee?

When you’re planning your trip to Santee, convenience is the name of the game. Luckily, Santee Charleston Intl. Airport is nearby so you can deplane and get going on checking off everything on your Santee must-do list.

How much are flights to Santee?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Santee on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $326, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Santee?

The trick to saving a stack of cash on your flight to Santee? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $326 right now, why wait?

Santee Flight Information
Destination airport
Columbia Metropolitan
Destination airport IATA code
CAE
Roundtrip price
$326

Last Minute Hotel Deals in Santee

Tru By Hilton Santee

Tru By Hilton Santee

2.5 out of 5
263 Britain St. and 273 Britain St. Santee SC
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
9.2/10 Wonderful! (979 reviews)
"Everything is excellent!!"

Reviewed on Oct 3, 2026

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Tru By Hilton Santee
Baymont by Wyndham Santee

Baymont by Wyndham Santee

2.5 out of 5
249 Britain Street Santee SC
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8/10 Very Good! (1,495 reviews)
"Property was great for quick overnight stay off of 95 withy my dog. Walking distance to Cracker Barrel. I would definitely stay here again"

Reviewed on Oct 1, 2026

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Baymont by Wyndham Santee
Fairfield Inn & Suites by Marriott Santee

Fairfield Inn & Suites by Marriott Santee

3 out of 5
9074 Old Number Six Hwy Santee SC
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
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Fairfield Inn & Suites by Marriott Santee
Comfort Inn & Suites Santee

Comfort Inn & Suites Santee

2.5 out of 5
221 Britain St Santee SC
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Santee ...
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Comfort Inn & Suites Santee
Best Western Plus Santee Inn

Best Western Plus Santee Inn

2.5 out of 5
I 95 Exit 98 Santee SC
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful ...
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Best Western Plus Santee Inn
Hampton Inn Santee-I-95

Hampton Inn Santee-I-95

2.5 out of 5
9060 Old Number Six Hwy Santee SC
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
9.6/10 Exceptional! (1,001 reviews)
"Pros: the staff was friendly, especially the breakfast staff. The hotel was located near several nice restaurants. Cons: I realize this was a pet friendly hotel, but the pet odor was very strong in our room, especially from the bed. It was obvious that some guests allowed their pet to sleep on the ..."

Reviewed on Oct 3, 2026

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Hampton Inn Santee-I-95
Holiday Inn Santee by IHG

Holiday Inn Santee by IHG

3 out of 5
139 Bradford Blvd Santee SC
Book a stay at this golf hotel in Santee. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the clean rooms in ...
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Holiday Inn Santee by IHG
Quality Inn & Suites Santee I-95

Quality Inn & Suites Santee I-95

2.5 out of 5
8929 Old Number Six Highway Santee SC
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
6/10 (597 reviews)
"After check in we did not see any staff. Upon check out we simply put our keys in a bowl. The room was dirty. The floors were never mopped and if they were it was with dirty water. Had to wear shoes at ALL times. Went down to lobby for breakfast at 8:30 and there was only sausage left in the hot ..."

Reviewed on Oct 4, 2026

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Quality Inn & Suites Santee I-95
See all 347 properties in Santee
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.