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Hotels in Santee

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Choose from 306 Santee Hotel Deals

Baymont by Wyndham Santee

Baymont by Wyndham Santee

2.5 out of 5
249 Britain Street Santee SC
  • 7 min drive from Santee State Park
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8/10 Very Good! (1,453 reviews)
Room was clean and comfy, staff was nice and professional. It is an older building so it smelled a little musty, But overall it was a good place to stay for the night during travel.

Reviewed on May 1, 2026

Baymont by Wyndham Santee
Tru By Hilton Santee

Tru By Hilton Santee

2.5 out of 5
263 Britain St. and 273 Britain St. Santee SC
  • 7 min drive from Santee State Park
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
9.2/10 Wonderful! (810 reviews)
Liked everything about this property

Reviewed on Apr 30, 2026

Tru By Hilton Santee
Hampton Inn Santee-I-95

Hampton Inn Santee-I-95

2.5 out of 5
9060 Old Number Six Hwy Santee SC
  • 7 min drive from Santee State Park
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
9.6/10 Exceptional! (1,000 reviews)
The breakfast staff ladies were wonderful. They made the last moments of our stay so much nicer.

Reviewed on Apr 28, 2026

Hampton Inn Santee-I-95
Comfort Inn & Suites Santee

Comfort Inn & Suites Santee

2.5 out of 5
221 Britain St Santee SC
  • 7 min drive from Santee State Park
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Santee ...
8/10 Very Good! (1,002 reviews)
Trop dispendieux pour ce type d'hôtel je classerais ca plus comme Motel et non Hotel.

Reviewed on May 2, 2026

Comfort Inn & Suites Santee
Best Western Plus Santee Inn

Best Western Plus Santee Inn

2.5 out of 5
I 95 Exit 98 Santee SC
  • 7 min drive from Santee State Park
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful ...
8.8/10 Excellent! (1,001 reviews)
Easy parking, clean, quiet room. Friendly staff. Easy on/off interstate. Good overnight stay.

Reviewed on Apr 30, 2026

Best Western Plus Santee Inn
Quality Inn & Suites Santee I-95

Quality Inn & Suites Santee I-95

2.5 out of 5
8929 Old Number Six Highway Santee SC
  • 6 min drive from Santee State Park
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
6/10 (520 reviews)
I want my money back. Hotel clerk cancelled reservation due to ceiling falling down and he could not give me a comparable room.

Reviewed on May 2, 2026

Quality Inn & Suites Santee I-95
Fairfield Inn & Suites by Marriott Santee

Fairfield Inn & Suites by Marriott Santee

3 out of 5
9074 Old Number Six Hwy Santee SC
  • 7 min drive from Santee State Park
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
9.8/10 Exceptional! (1,000 reviews)
Breakfast was good, a staff member present refreshing the food throughout and she brought me some gluten free bread which was appreciated. Parking plentiful and staff very friendly. They also put my ice packs in their freezer which was very helpful. Our room was clean, well supplied and beds and ...

Reviewed on Apr 24, 2026

Fairfield Inn & Suites by Marriott Santee
Holiday Inn Santee by IHG

Holiday Inn Santee by IHG

3 out of 5
139 Bradford Blvd Santee SC
  • 6 min drive from Santee State Park
Book a stay at this golf hotel in Santee. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the clean rooms in ...
8.2/10 Very Good! (1,001 reviews)
Have to pay

Reviewed on Apr 30, 2026

Holiday Inn Santee by IHG
Travelodge by Wyndham Santee

Travelodge by Wyndham Santee

2 out of 5
9117 Old Number Six Hwy Santee SC
  • 7 min drive from Santee State Park
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
7.2/10 Good! (724 reviews)
We pulled in late just to sleep and were surprised by how nice the room was, it was renovated and smelled clean. AC got nice and cold, 5 stars.

Reviewed on Apr 24, 2026

Travelodge by Wyndham Santee
Super 8 by Wyndham Santee

Super 8 by Wyndham Santee

2 out of 5
9125 Old Highway 6 Santee SC
  • 7 min drive from Santee State Park
Book a stay at this golf motel in Santee. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Santee Cooper Country Club and Santee National ...
6.8/10 (457 reviews)
It was nice and clean but an older building

Reviewed on May 1, 2026

Super 8 by Wyndham Santee
Ramada by Wyndham Santee I-95

Ramada by Wyndham Santee I-95

2 out of 5
123 Mall Street Santee SC
  • 7 min drive from Santee State Park
Book a stay at this golf hotel in Santee. Enjoy free WiFi, free parking, and a nightclub. Popular attractions Santee Cooper Country Club and Santee National ...
6.4/10 (557 reviews)
Nice clean rooms for a peaceful good nights sleep. Very helpful staff. Coffee service and snacks in the morning.

Reviewed on Apr 25, 2026

Ramada by Wyndham Santee I-95
Red Roof Inn Santee

Red Roof Inn Santee

2 out of 5
9091 Old Hwy 6 Santee SC
  • 6 min drive from Santee State Park
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Santee Cooper Country Club and ...
6.6/10 (653 reviews)
Staff was rude and the motel had roaches.

Reviewed on Apr 22, 2026

Red Roof Inn Santee
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Santee

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Frequently Asked Questions About Santee hotels

Where can I find the best last-minute travel deals?

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How many hotels are there in Santee?

With over 306 hotels in Santee, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $66.

How to find cheap car rentals in Santee?

Finding a cheap car rental deal in Santee is as easy as scoring cheap hotels in Santee. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.