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Hotels in Santee

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Tonight Feb 2 - Feb 3Next weekend Feb 7 - Feb 9

Choose from 262 Santee Hotel Deals

Baymont by Wyndham Santee
Baymont by Wyndham Santee
2.5 out of 5
249 Britain Street, Santee, SC
  • 7 min drive from Santee State Park
The price is $83 per night from Feb 3 to Feb 4
$83
includes taxes & fees
Feb 3 - Feb 4
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (1,284 reviews)
Quick Stay
"Our stay was a quick, reasonably priced one night stay. After driving 16 hours, it was nice to find our room very clean, no odors and a heater with actual temperature controls versus hi-lo control. The continental breakfast was nice allowing us an early start the next day. The location was conveniently ..."

Reviewed on Jan 30, 2025

Baymont by Wyndham Santee
Tru By Hilton Santee
Tru By Hilton Santee
2.5 out of 5
263 Britain St. and 273 Britain St., Santee, SC
  • 7 min drive from Santee State Park
The price is $115 per night from Mar 3 to Mar 4
$115
includes taxes & fees
Mar 3 - Mar 4
Stay at this hotel in Santee. Enjoy free WiFi, free parking, and a 24-hour fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
9/10 Wonderful! (313 reviews)
Nice inexpensive hotel!
"My family did a quick stop here on the way to Florida. It is conveniently off I 95. There are some food options and restaurants nearby. The hotel seems very new. It is very clean. Staff was very friendly. They have a common area pool table and loungers. The soap/lotion was excellent with superb scents. ..."

Reviewed on Jan 26, 2025

Tru By Hilton Santee
Fairfield Inn & Suites by Marriott Santee
Fairfield Inn & Suites by Marriott Santee
2.5 out of 5
9074 Old Number Six Hwy, Santee, SC
  • 7 min drive from Santee State Park
The price is $144 per night from Feb 9 to Feb 10
$144
includes taxes & fees
Feb 9 - Feb 10
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
9.8/10 Exceptional! (1,007 reviews)
"Easy check-in/out. Friendly staff. Very clean. Minutes to I-95"

Reviewed on Jan 30, 2025

Fairfield Inn & Suites by Marriott Santee
Holiday Inn Santee, an IHG Hotel
Holiday Inn Santee, an IHG Hotel
3 out of 5
139 Bradford Blvd, Santee, SC
  • 6 min drive from Santee State Park
The price is $118 per night from Feb 9 to Feb 10
$118
includes taxes & fees
Feb 9 - Feb 10
Stay at this 3-star golf hotel in Santee. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the clean rooms in ...
8/10 Very Good! (834 reviews)
"The hotel is comfortable, and the staff is very nice. But for me the highlight was the restaurant that had a nice breakfast and a simple menu for dinner and a nice bar. There were two ladies working the restaurant and both were super nice. i am so sick of the free buffet mediocre breakfasts and did ..."

Reviewed on Jan 30, 2025

Holiday Inn Santee, an IHG Hotel
Comfort Inn & Suites Santee
Comfort Inn & Suites Santee
2.5 out of 5
221 Britain St, Santee, SC
  • 7 min drive from Santee State Park
The price is $117 per night from Feb 9 to Feb 10
$117
includes taxes & fees
Feb 9 - Feb 10
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Santee ...
7.8/10 Good! (939 reviews)
"Convenient to I95"

Reviewed on Feb 1, 2025

Comfort Inn & Suites Santee
Hampton Inn Santee-I-95
Hampton Inn Santee-I-95
2.5 out of 5
9060 Old Number Six Hwy, Santee, SC
  • 7 min drive from Santee State Park
The price is $146 per night from Feb 9 to Feb 10
$146
includes taxes & fees
Feb 9 - Feb 10
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
9.4/10 Exceptional! (1,003 reviews)
"Didn't view outdoors, rainy midnite check in"

Reviewed on Feb 1, 2025

Hampton Inn Santee-I-95
Best Western Plus Santee Inn
Best Western Plus Santee Inn
2.5 out of 5
I 95 Exit 98, Santee, SC
  • 7 min drive from Santee State Park
The price is $123 per night from Feb 9 to Feb 10
$123
includes taxes & fees
Feb 9 - Feb 10
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful ...
8.6/10 Excellent! (1,001 reviews)
"Great stop over when driving from NY to Florida. Clean rooms & comfortable beds also great for pets as grounds have poop bags."

Reviewed on Jan 28, 2025

Best Western Plus Santee Inn
Travelodge by Wyndham Santee
Travelodge by Wyndham Santee
2 out of 5
9117 Old Number Six Hwy, Santee, SC
  • 7 min drive from Santee State Park
The price is $67 per night from Feb 3 to Feb 4
$67
includes taxes & fees
Feb 3 - Feb 4
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
7/10 Good! (585 reviews)
"comfortable and convenient"

Reviewed on Jan 21, 2025

Travelodge by Wyndham Santee
Red Roof Inn Santee
Red Roof Inn Santee
2 out of 5
9091 Old Hwy 6, Santee, SC
  • 6 min drive from Santee State Park
The price is $74 per night from Feb 3 to Feb 4
$74
includes taxes & fees
Feb 3 - Feb 4
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Santee Cooper Country Club and ...
6.4/10 (593 reviews)
"The only thing I didn't like was the refrigerator wasn't working other than that everything was okay."

Reviewed on Jan 17, 2025

Red Roof Inn Santee
Ramada by Wyndham Santee I-95
Ramada by Wyndham Santee I-95
2 out of 5
123 Mall Street, Santee, SC
  • 7 min drive from Santee State Park
The price is $94 per night from Feb 10 to Feb 11
$94
includes taxes & fees
Feb 10 - Feb 11
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Santee Cooper Country Club and ...
6.2/10 (509 reviews)
"Nice room staf was excellent and i love the bars plaing pools and food was amazing try chicken wings"

Reviewed on Jan 4, 2025

Ramada by Wyndham Santee I-95
Wyndham Vacation Resorts Lake Marion
Wyndham Vacation Resorts Lake Marion
4 out of 5
401 Bass Drive, Santee, SC
  • 6 min drive from Santee State Park
Stay at this 4-star vacation home in Santee. Enjoy free WiFi, free parking, and cable TV channels. Popular attractions Santee Cooper Country Club and Santee ...
9.4/10 Exceptional! (17 reviews)
"Friendly staff. Excellent accomodations. Peaceful and beautiful vacation."

Reviewed on Nov 21, 2024

Wyndham Vacation Resorts Lake Marion
Super 8 by Wyndham Santee
Super 8 by Wyndham Santee
2 out of 5
9125 Old Highway 6, Santee, SC
  • 7 min drive from Santee State Park
The price is $83 per night from Feb 27 to Feb 28
$83
includes taxes & fees
Feb 27 - Feb 28
Book a stay at this golf motel in Santee. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Santee Cooper Country Club and Santee Outlets ...
6.6/10 (412 reviews)
"Close to exit. Easy checkin"

Reviewed on Nov 23, 2024

Super 8 by Wyndham Santee
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Santee

You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Santee hotel with Hotwire to complete your one-of-a-kind travel checklist.

For you, intrepid voyager, Hotwire has a large selection of the best hotels in Santee.

Choosing the right hotel in South Carolina has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Santee’s 262 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $67. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Santee hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Santee. No matter your reason for visiting Santee, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Santee hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Santee for as low as $67.

How many hotels are there in Santee?

With over 262 hotels in Santee, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $67.

How to find cheap car rentals in Santee?

Finding a cheap car rental deal in Santee is as easy as scoring cheap hotels in Santee. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.