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Hotels in Santee

Choose from 264 Santee Hotel Deals

Baymont by Wyndham Santee
Baymont by Wyndham Santee
2.5 out of 5
249 Britain Street, Santee, SC
  • 7 min drive from Santee State Park
The price is $89 per night from Mar 23 to Mar 24
$89
includes taxes & fees
Mar 23 - Mar 24
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (1,294 reviews)
My Stay at the Wyndham in Santee SC
"The overall stay at the Wyndham was good. The room was comfortable and clean. The only problem I had was the water pressure in the sink. The water comes out real slow and it didn't get hot enough. Everything else was good. The clerk at the desk for check in was awesome. Real friendly and explained ..."

Reviewed on Mar 17, 2025

Baymont by Wyndham Santee
Tru By Hilton Santee
Tru By Hilton Santee
2.5 out of 5
263 Britain St. and 273 Britain St., Santee, SC
  • 7 min drive from Santee State Park
The price is $122 per night from Mar 31 to Apr 1
$122
includes taxes & fees
Mar 31 - Apr 1
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
9/10 Wonderful! (373 reviews)
"We liked the modern vibe and clean appearance. Our bathroom was spotless. The main area could have used a mop - floors were a little sticky. My wife described the red LED on the floor lamp as "the eye of Locutus" and she found a way to cover it so she could sleep. The bright white numbers on the ..."

Reviewed on Mar 17, 2025

Tru By Hilton Santee
Fairfield Inn & Suites by Marriott Santee
Fairfield Inn & Suites by Marriott Santee
2.5 out of 5
9074 Old Number Six Hwy, Santee, SC
  • 7 min drive from Santee State Park
The price is $154 per night from Mar 26 to Mar 27
$154
includes taxes & fees
Mar 26 - Mar 27
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
9.8/10 Exceptional! (1,000 reviews)
No complaints
"We only stayed once night as a stop over on our trip from FL to NY, and we had no complaints! We would stay again if passing through!"

Reviewed on Mar 14, 2025

Fairfield Inn & Suites by Marriott Santee
Holiday Inn Santee by IHG
Holiday Inn Santee by IHG
3 out of 5
139 Bradford Blvd, Santee, SC
  • 6 min drive from Santee State Park
The price is $124 per night from Apr 13 to Apr 14
$124
includes taxes & fees
Apr 13 - Apr 14
Stay at this 3-star golf hotel in Santee. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the clean rooms in ...
8/10 Very Good! (860 reviews)
"No"

Reviewed on Mar 17, 2025

Holiday Inn Santee by IHG
Hampton Inn Santee-I-95
Hampton Inn Santee-I-95
2.5 out of 5
9060 Old Number Six Hwy, Santee, SC
  • 7 min drive from Santee State Park
The price is $159 per night from Apr 7 to Apr 8
$159
includes taxes & fees
Apr 7 - Apr 8
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
9.4/10 Exceptional! (1,000 reviews)
"Very clean and comfortable!"

Reviewed on Mar 18, 2025

Hampton Inn Santee-I-95
Best Western Plus Santee Inn
Best Western Plus Santee Inn
2.5 out of 5
I 95 Exit 98, Santee, SC
  • 7 min drive from Santee State Park
The price is $123 per night from Mar 26 to Mar 27
$123
includes taxes & fees
Mar 26 - Mar 27
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful ...
8.6/10 Excellent! (1,002 reviews)
"Excellent hotel for everyone, but especially if you are traveling with fur-babies, very pet friendly facility with plenty of walk areas and all ground levels rooms, fees for pets are modest and very fair, would stay again for sure."

Reviewed on Mar 11, 2025

Best Western Plus Santee Inn
Comfort Inn & Suites Santee
Comfort Inn & Suites Santee
2.5 out of 5
221 Britain St, Santee, SC
  • 7 min drive from Santee State Park
The price is $117 per night from Mar 30 to Mar 31
$117
includes taxes & fees
Mar 30 - Mar 31
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Santee ...
7.8/10 Good! (959 reviews)
usb
"The usb ports did not work on nightstand."

Reviewed on Mar 18, 2025

Comfort Inn & Suites Santee
Travelodge by Wyndham Santee
Travelodge by Wyndham Santee
2 out of 5
9117 Old Number Six Hwy, Santee, SC
  • 7 min drive from Santee State Park
The price is $67 per night from Mar 23 to Mar 24
$67
includes taxes & fees
Mar 23 - Mar 24
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
7/10 Good! (598 reviews)
"For the most part, everything was good.Except for the half used shampoo bottle in the shower left from whoever was there before."

Reviewed on Mar 9, 2025

Travelodge by Wyndham Santee
Quality Inn & Suites
Quality Inn & Suites
2.5 out of 5
8929 Old Number Six Highway, Santee, SC
  • 6 min drive from Santee State Park
The price is $75 per night from Mar 27 to Mar 28
$75
includes taxes & fees
Mar 27 - Mar 28
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
6/10 (330 reviews)
"Bed was very comfy."

Reviewed on Feb 11, 2025

Quality Inn & Suites
Ramada by Wyndham Santee I-95
Ramada by Wyndham Santee I-95
2 out of 5
123 Mall Street, Santee, SC
  • 7 min drive from Santee State Park
The price is $82 per night from Mar 27 to Mar 28
$82
includes taxes & fees
Mar 27 - Mar 28
Book a stay at this golf hotel in Santee. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Santee Cooper Country Club and Santee ...
6.2/10 (515 reviews)
"The property needs some work but it was quiet and close to a few restaurants we could walk to."

Reviewed on Mar 11, 2025

Ramada by Wyndham Santee I-95
Red Roof Inn Santee
Red Roof Inn Santee
2 out of 5
9091 Old Hwy 6, Santee, SC
  • 6 min drive from Santee State Park
The price is $78 per night from Mar 23 to Mar 24
$78
includes taxes & fees
Mar 23 - Mar 24
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Santee Cooper Country Club and ...
6.4/10 (596 reviews)
"The only thing I didn't like was the refrigerator wasn't working other than that everything was okay."

Reviewed on Jan 17, 2025

Red Roof Inn Santee
Super 8 by Wyndham Santee
Super 8 by Wyndham Santee
2 out of 5
9125 Old Highway 6, Santee, SC
  • 7 min drive from Santee State Park
The price is $83 per night from Mar 23 to Mar 24
$83
includes taxes & fees
Mar 23 - Mar 24
Book a stay at this golf motel in Santee. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Santee Cooper Country Club and Santee Outlets ...
6.6/10 (418 reviews)
"Clean and tidy place bed a little lumpy but overall everything was good would I stay here again? Yes"

Reviewed on Mar 2, 2025

Super 8 by Wyndham Santee
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Santee

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For you, intrepid voyager, Hotwire has a large selection of the best hotels in Santee.

Choosing the right hotel in South Carolina has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Santee’s 264 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $67. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Santee hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Santee. No matter your reason for visiting Santee, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Santee hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Santee for as low as $67.

How many hotels are there in Santee?

With over 264 hotels in Santee, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $67.

How to find cheap car rentals in Santee?

Finding a cheap car rental deal in Santee is as easy as scoring cheap hotels in Santee. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.