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Hotels in Santee

Choose from 262 Santee Hotel Deals

Baymont by Wyndham Santee
Baymont by Wyndham Santee
2.5 out of 5
249 Britain Street, Santee, SC
  • 7 min drive from Santee State Park
The price is $89 per night from Feb 18 to Feb 19
$89
includes taxes & fees
Feb 18 - Feb 19
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (1,272 reviews)
"The check in was quick and the room was comfortable"

Reviewed on Feb 15, 2025

Baymont by Wyndham Santee
Fairfield Inn & Suites by Marriott Santee
Fairfield Inn & Suites by Marriott Santee
2.5 out of 5
9074 Old Number Six Hwy, Santee, SC
  • 7 min drive from Santee State Park
The price is $144 per night from Feb 23 to Feb 24
$144
includes taxes & fees
Feb 23 - Feb 24
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
9.8/10 Exceptional! (1,006 reviews)
"Convenient for easy access to highway for our trip"

Reviewed on Feb 15, 2025

Fairfield Inn & Suites by Marriott Santee
Tru By Hilton Santee
Tru By Hilton Santee
2.5 out of 5
263 Britain St. and 273 Britain St., Santee, SC
  • 7 min drive from Santee State Park
The price is $110 per night from Mar 9 to Mar 10
$110
includes taxes & fees
Mar 9 - Mar 10
Stay at this hotel in Santee. Enjoy free WiFi, free parking, and a 24-hour fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
9/10 Wonderful! (329 reviews)
"Very new, clean, comfortable, staff was excellent"

Reviewed on Feb 14, 2025

Tru By Hilton Santee
Hampton Inn Santee-I-95
Hampton Inn Santee-I-95
2.5 out of 5
9060 Old Number Six Hwy, Santee, SC
  • 7 min drive from Santee State Park
The price is $142 per night from Mar 10 to Mar 11
$142
includes taxes & fees
Mar 10 - Mar 11
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
9.4/10 Exceptional! (1,001 reviews)
"Our stay was very nice and the staff was so friendly."

Reviewed on Feb 14, 2025

Hampton Inn Santee-I-95
Holiday Inn Santee, an IHG Hotel
Holiday Inn Santee, an IHG Hotel
3 out of 5
139 Bradford Blvd, Santee, SC
  • 6 min drive from Santee State Park
The price is $116 per night from Feb 23 to Feb 24
$116
includes taxes & fees
Feb 23 - Feb 24
Stay at this 3-star golf hotel in Santee. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the clean rooms in ...
8/10 Very Good! (838 reviews)
"Easy to check in"

Reviewed on Feb 3, 2025

Holiday Inn Santee, an IHG Hotel
Best Western Plus Santee Inn
Best Western Plus Santee Inn
2.5 out of 5
I 95 Exit 98, Santee, SC
  • 7 min drive from Santee State Park
The price is $123 per night from Feb 25 to Feb 26
$123
includes taxes & fees
Feb 25 - Feb 26
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful ...
8.6/10 Excellent! (1,003 reviews)
"Great hotel!"

Reviewed on Feb 13, 2025

Best Western Plus Santee Inn
Travelodge by Wyndham Santee
Travelodge by Wyndham Santee
2 out of 5
9117 Old Number Six Hwy, Santee, SC
  • 7 min drive from Santee State Park
The price is $67 per night from Feb 18 to Feb 19
$67
includes taxes & fees
Feb 18 - Feb 19
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
7/10 Good! (589 reviews)
Good Deal!
"It's clean, quiet, and very reasonably priced. What more do you need?"

Reviewed on Feb 5, 2025

Travelodge by Wyndham Santee
Comfort Inn & Suites Santee
Comfort Inn & Suites Santee
2.5 out of 5
221 Britain St, Santee, SC
  • 7 min drive from Santee State Park
The price is $117 per night from Feb 23 to Feb 24
$117
includes taxes & fees
Feb 23 - Feb 24
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Santee ...
7.8/10 Good! (943 reviews)
"The Front Desk workers are friendly and effecient!"

Reviewed on Feb 14, 2025

Comfort Inn & Suites Santee
Quality Inn & Suites
Quality Inn & Suites
2.5 out of 5
8929 Old Number Six Highway, Santee, SC
  • 6 min drive from Santee State Park
The price is $90 per night from Mar 2 to Mar 3
$90
includes taxes & fees
Mar 2 - Mar 3
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
6/10 (321 reviews)
"Bed was very comfy."

Reviewed on Feb 11, 2025

Quality Inn & Suites
Ramada by Wyndham Santee I-95
Ramada by Wyndham Santee I-95
2 out of 5
123 Mall Street, Santee, SC
  • 7 min drive from Santee State Park
The price is $90 per night from Feb 23 to Feb 24
$90
includes taxes & fees
Feb 23 - Feb 24
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Santee Cooper Country Club and ...
6.2/10 (510 reviews)
Would stay here again!
"Great cheesesteak and friendly management."

Reviewed on Feb 14, 2025

Ramada by Wyndham Santee I-95
Red Roof Inn Santee
Red Roof Inn Santee
2 out of 5
9091 Old Hwy 6, Santee, SC
  • 6 min drive from Santee State Park
The price is $74 per night from Feb 18 to Feb 19
$74
includes taxes & fees
Feb 18 - Feb 19
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Santee Cooper Country Club and ...
6.4/10 (594 reviews)
"The only thing I didn't like was the refrigerator wasn't working other than that everything was okay."

Reviewed on Jan 17, 2025

Red Roof Inn Santee
Wyndham Vacation Resorts Lake Marion
Wyndham Vacation Resorts Lake Marion
4 out of 5
401 Bass Drive, Santee, SC
  • 6 min drive from Santee State Park
Stay at this 4-star vacation home in Santee. Enjoy free WiFi, free parking, and cable TV channels. Popular attractions Santee Cooper Country Club and Santee ...
9.4/10 Exceptional! (17 reviews)
"Friendly staff. Excellent accomodations. Peaceful and beautiful vacation."

Reviewed on Nov 21, 2024

Wyndham Vacation Resorts Lake Marion
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Santee

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For you, intrepid voyager, Hotwire has a large selection of the best hotels in Santee.

Choosing the right hotel in South Carolina has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Santee’s 262 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $67. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Santee hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Santee. No matter your reason for visiting Santee, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Santee hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Santee for as low as $67.

How many hotels are there in Santee?

With over 262 hotels in Santee, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $67.

How to find cheap car rentals in Santee?

Finding a cheap car rental deal in Santee is as easy as scoring cheap hotels in Santee. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.