Search for Cheap Deals onHotels in Santee
Check Last Minute Santee Hotel Deals
Choose from 303 Santee Hotel Deals

Baymont by Wyndham Santee
The room was clean, the breakfast was good, and it was dog-friendly! The room was a great price and staff was helpful and friendly.
Reviewed on Jan 27, 2026

Tru By Hilton Santee
Staff was excellent
Reviewed on Jan 28, 2026

Hampton Inn Santee-I-95
Facility and service were excellent
Reviewed on Jan 29, 2026

Fairfield Inn & Suites by Marriott Santee
Our room was super clean, breakfast was good. And the hotel was nice and quiet.
Reviewed on Jan 24, 2026

Best Western Plus Santee Inn
yes
Reviewed on Jan 21, 2026

Holiday Inn Santee by IHG
Staff in the restaurant Dinner shift were excellent.
Reviewed on Jan 2, 2026

Comfort Inn & Suites Santee
Check-in staff courteous and efficient. Clean, basic, comfortable room for a one night travel stay at good price. Good breakfast.
Reviewed on Jan 24, 2026

Ramada by Wyndham Santee I-95
The room was the cleanest of many hotels on a long road trip; cleaner than fancier hotels. Don't freak out when you drive up....it looks like an abandoned building...but the rooms are nice
Reviewed on Jan 4, 2026

Travelodge by Wyndham Santee
Clean and basic. Huge fridge. Friendly staff. Value aligned with price. Parking in front of your door. Solo female traveler - felt very safe.
Reviewed on Jan 31, 2026

Quality Inn & Suites
Clean room but needs an exhaust fan in the bathroom
Reviewed on Jan 28, 2026

Super 8 by Wyndham Santee
The staff was very friendly and helpful. Room was clean and beds were so comfortable.
Reviewed on Dec 8, 2025

Wyndham Vacation Resorts Lake Marion
The room was spacious and very clean. The front desk person was friendly and they did try to sell my fiance some things, but he wasn't interested. Once we kindly said no they understood and wasn't being pushy which we greatly appreciated. My family and I will stay here each time. My fiance and I ...
Reviewed on Jan 9, 2026
Find cheap hotels in Santee
You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Santee hotel with Hotwire to complete your one-of-a-kind travel checklist.
For you, intrepid voyager, Hotwire has a large selection of the best hotels in Santee.
Choosing the right hotel in South Carolina has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Santee’s 303 hotels. Choose the one that best catches your trip’s tourist drift.
If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $66. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Santee hotel deals at the last minute.
While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Santee. No matter your reason for visiting Santee, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.
Frequently Asked Questions About Santee hotels
Where can I find the best last-minute travel deals?
If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Santee for as low as $66.
How many hotels are there in Santee?
With over 303 hotels in Santee, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $66.
How to find cheap car rentals in Santee?
Finding a cheap car rental deal in Santee is as easy as scoring cheap hotels in Santee. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.
- Hotels near Santee State Park
- Hotels near Santee Cooper Country Club
- Hotels near Santee National Golf Club
- Hotels near Congaree National Park
- Hotels near Lake Marion
- Hotels near South Carolina State University
- Hotels near Santee National Wildlife Refuge
- Hotels near Wyboo Golf Club
- Hotels near St. George Country Club
- Hotels near Edisto Memorial Gardens
- Hotels near Santee Indian Mound and Fort Watson Site
- Hotels near St. George United Methodist Church
- Hotels near I.P. Stanback Museum & Planetarium
- Hotels with Free Parking in Santee
- Hotels with a Pool in Santee
- Pet-friendly Hotels in Santee
- Family Hotels in Santee
- Luxury Hotels in Santee
- Hotels with Hot Tubs in Santee
- Resorts & Hotels with Spas in Santee
- Hotels with smoking rooms in Santee
- Hotels with an Indoor Pool in Santee
- Beach Hotels in Santee
- Sumter Hotels
- Orangeburg Hotels
- Coastal South Carolina Hotels
- The Carolinas Hotels
- Manning Hotels
- St. George Hotels
- Southeastern United States Hotels
- Summerton Hotels
- Eutawville Hotels
- Ridgeville Hotels
- Holly Hill Hotels
- Saint Matthews Hotels
- Elloree Hotels
- Cross Hotels
- Pineville Hotels
- Vance Hotels
- Harleyville Hotels
- Gadsden Hotels
- Bamberg Hotels
- Walterboro - St. George Hotels


