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Hotels in Santee

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Baymont by Wyndham Santee

Baymont by Wyndham Santee

2.5 out of 5
249 Britain Street, Santee, SC
  • 7 min drive from Santee State Park
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (1,320 reviews)
Pleasant stay
"Second time staying. It's always a pleasure, I'm in the process of buying a home and i found the perfect place to help my stay through my process."

Reviewed on Jul 19, 2025

Baymont by Wyndham Santee
Fairfield Inn & Suites by Marriott Santee

Fairfield Inn & Suites by Marriott Santee

2.5 out of 5
9074 Old Number Six Hwy, Santee, SC
  • 7 min drive from Santee State Park
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
9.8/10 Exceptional! (1,005 reviews)
Our fav in Santee.
"We always stay here on our way up and down the east coast. It is our favorite. Great staff, clean rooms and great breakfast in the morning. Great restaurant across the street that we make sure we always go to. Great food, and drinks after a long drive. Would highly recommend!"

Reviewed on Jul 18, 2025

Fairfield Inn & Suites by Marriott Santee
Tru By Hilton Santee

Tru By Hilton Santee

2.5 out of 5
263 Britain St. and 273 Britain St., Santee, SC
  • 7 min drive from Santee State Park
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
9/10 Wonderful! (486 reviews)
"Love love love"

Reviewed on Jul 14, 2025

Tru By Hilton Santee
Comfort Inn & Suites Santee

Comfort Inn & Suites Santee

2.5 out of 5
221 Britain St, Santee, SC
  • 7 min drive from Santee State Park
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Santee ...
7.8/10 Good! (1,007 reviews)
"It was ok good enough for the night. Breakfast is good"

Reviewed on Jul 20, 2025

Comfort Inn & Suites Santee
Hampton Inn Santee-I-95

Hampton Inn Santee-I-95

2.5 out of 5
9060 Old Number Six Hwy, Santee, SC
  • 7 min drive from Santee State Park
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
9.4/10 Exceptional! (1,004 reviews)
"Awesome property. Great stay. Unfortunately the pool was closed for the grandkids. Breakfast was great staff was amazing."

Reviewed on Jul 21, 2025

Hampton Inn Santee-I-95
Holiday Inn Santee by IHG

Holiday Inn Santee by IHG

3 out of 5
139 Bradford Blvd, Santee, SC
  • 6 min drive from Santee State Park
Stay at this 3-star golf hotel in Santee. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the clean rooms in ...
8/10 Very Good! (913 reviews)
"Great"

Reviewed on Jul 14, 2025

Holiday Inn Santee by IHG
Quality Inn & Suites

Quality Inn & Suites

2.5 out of 5
8929 Old Number Six Highway, Santee, SC
  • 6 min drive from Santee State Park
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
5.8/10 (409 reviews)
"It was much better than the last time we tried to stay there. They are making progress renovating it."

Reviewed on Jun 23, 2025

Quality Inn & Suites
Best Western Plus Santee Inn

Best Western Plus Santee Inn

2.5 out of 5
I 95 Exit 98, Santee, SC
  • 7 min drive from Santee State Park
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful ...
8.6/10 Excellent! (1,002 reviews)
It is Deluxe!
"Perfect stop along 95! Allows pets for a reasonable cost of $30. Wonderful breakfast!"

Reviewed on Jul 20, 2025

Best Western Plus Santee Inn
Travelodge by Wyndham Santee

Travelodge by Wyndham Santee

2 out of 5
9117 Old Number Six Hwy, Santee, SC
  • 7 min drive from Santee State Park
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
7/10 Good! (642 reviews)
"Clean, comfortable, convenient stop on highway"

Reviewed on Jul 19, 2025

Travelodge by Wyndham Santee
Ramada by Wyndham Santee I-95

Ramada by Wyndham Santee I-95

2 out of 5
123 Mall Street, Santee, SC
  • 7 min drive from Santee State Park
Book a stay at this golf hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Santee Cooper Country Club and Santee National ...
6.2/10 (530 reviews)
"Nice clean friendly"

Reviewed on Jul 11, 2025

Ramada by Wyndham Santee I-95
Red Roof Inn Santee

Red Roof Inn Santee

2 out of 5
9091 Old Hwy 6, Santee, SC
  • 6 min drive from Santee State Park
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Santee Cooper Country Club and ...
6.4/10 (620 reviews)
"Great"

Reviewed on Jun 20, 2025

Red Roof Inn Santee
Super 8 by Wyndham Santee

Super 8 by Wyndham Santee

2 out of 5
9125 Old Highway 6, Santee, SC
  • 7 min drive from Santee State Park
Book a stay at this golf motel in Santee. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Santee Cooper Country Club and Santee National ...
6.6/10 (427 reviews)
"Resturants and stores close by"

Reviewed on May 15, 2025

Super 8 by Wyndham Santee
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Santee

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If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $69. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Santee hotel deals at the last minute.

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Frequently Asked Questions About Santee hotels

Where can I find the best last-minute travel deals?

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How many hotels are there in Santee?

With over 288 hotels in Santee, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $69.

How to find cheap car rentals in Santee?

Finding a cheap car rental deal in Santee is as easy as scoring cheap hotels in Santee. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.