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Hotels in Santee

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Tru By Hilton Santee

Tru By Hilton Santee

2.5 out of 5
263 Britain St. and 273 Britain St. Santee SC
  • 7 min drive from Santee State Park
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
9.2/10 Wonderful! (742 reviews)
Clean modern room nice breakfast

Reviewed on Mar 1, 2026

Tru By Hilton Santee
Baymont by Wyndham Santee

Baymont by Wyndham Santee

2.5 out of 5
249 Britain Street Santee SC
  • 7 min drive from Santee State Park
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8/10 Very Good! (1,431 reviews)
Yes

Reviewed on Mar 1, 2026

Baymont by Wyndham Santee
Fairfield Inn & Suites by Marriott Santee

Fairfield Inn & Suites by Marriott Santee

2.5 out of 5
9074 Old Number Six Hwy Santee SC
  • 7 min drive from Santee State Park
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
9.8/10 Exceptional! (1,006 reviews)
Clean comfortable stay. Breakfast was a nice plus.

Reviewed on Feb 28, 2026

Fairfield Inn & Suites by Marriott Santee
Hampton Inn Santee-I-95

Hampton Inn Santee-I-95

2.5 out of 5
9060 Old Number Six Hwy Santee SC
  • 7 min drive from Santee State Park
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
9.6/10 Exceptional! (1,003 reviews)
Clean, great staff

Reviewed on Feb 27, 2026

Hampton Inn Santee-I-95
Best Western Plus Santee Inn

Best Western Plus Santee Inn

2.5 out of 5
I 95 Exit 98 Santee SC
  • 7 min drive from Santee State Park
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful ...
8.8/10 Excellent! (1,005 reviews)
Staff was nice. Room was average but it was one night

Reviewed on Mar 1, 2026

Best Western Plus Santee Inn
Holiday Inn Santee by IHG

Holiday Inn Santee by IHG

3 out of 5
139 Bradford Blvd Santee SC
  • 6 min drive from Santee State Park
Book a stay at this golf hotel in Santee. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the clean rooms in ...
8.2/10 Very Good! (1,000 reviews)
Ashley at the front desk was amazing. Personable and professional…she’s a keeper !!!

Reviewed on Feb 20, 2026

Holiday Inn Santee by IHG
Comfort Inn & Suites Santee

Comfort Inn & Suites Santee

2.5 out of 5
221 Britain St Santee SC
  • 7 min drive from Santee State Park
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Santee ...
8/10 Very Good! (1,002 reviews)
The bed linens were disgusting.

Reviewed on Mar 1, 2026

Comfort Inn & Suites Santee
Travelodge by Wyndham Santee

Travelodge by Wyndham Santee

2 out of 5
9117 Old Number Six Hwy Santee SC
  • 7 min drive from Santee State Park
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
7/10 Good! (703 reviews)
Good location for amenities and walking and driving distance

Reviewed on Feb 28, 2026

Travelodge by Wyndham Santee
Quality Inn & Suites

Quality Inn & Suites

2.5 out of 5
8929 Old Number Six Highway Santee SC
  • 6 min drive from Santee State Park
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
6/10 (478 reviews)
Is ok to pass a night but little expensive

Reviewed on Mar 1, 2026

Quality Inn & Suites
Ramada by Wyndham Santee I-95

Ramada by Wyndham Santee I-95

2 out of 5
123 Mall Street Santee SC
  • 7 min drive from Santee State Park
Book a stay at this golf hotel in Santee. Enjoy free WiFi, free parking, and a 24-hour fitness center. Popular attractions Santee Cooper Country Club and Santee ...
6.4/10 (552 reviews)
Clean room and good staff

Reviewed on Mar 1, 2026

Ramada by Wyndham Santee I-95
Super 8 by Wyndham Santee

Super 8 by Wyndham Santee

2 out of 5
9125 Old Highway 6 Santee SC
  • 7 min drive from Santee State Park
Book a stay at this golf motel in Santee. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Santee Cooper Country Club and Santee National ...
6.8/10 (444 reviews)
First room had leaking tub faucet and water dripping from ceiling above toilet. 2nd room was better, cleaner, but the fridge was making a loud noise. Positive was good water pressure and bed was clean.

Reviewed on Mar 1, 2026

Super 8 by Wyndham Santee
Elloree Vacation Rental ~ 7 Mi to Lake Marion!

Elloree Vacation Rental ~ 7 Mi to Lake Marion!

3 out of 5
7022 Old Number Six Hwy Santee SC
  • 4 min drive from Santee State Park
Stay at this cottage in Santee. Enjoy free parking and air conditioning. Popular attractions Santee National Golf Club and Santee State Park are located ...
Elloree Vacation Rental ~ 7 Mi to Lake Marion!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Santee

You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Santee hotel with Hotwire to complete your one-of-a-kind travel checklist.

For you, intrepid voyager, Hotwire has a large selection of the best hotels in Santee.

Choosing the right hotel in South Carolina has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Santee’s 306 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $66. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Santee hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Santee. No matter your reason for visiting Santee, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Santee hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Santee for as low as $66.

How many hotels are there in Santee?

With over 306 hotels in Santee, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $66.

How to find cheap car rentals in Santee?

Finding a cheap car rental deal in Santee is as easy as scoring cheap hotels in Santee. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.