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Hotels in Santee

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Tonight Apr 13 - Apr 14Next weekend Apr 18 - Apr 20

Choose from 268 Santee Hotel Deals

Baymont by Wyndham Santee
Baymont by Wyndham Santee
2.5 out of 5
249 Britain Street, Santee, SC
  • 7 min drive from Santee State Park
The price is $89 per night from Apr 14 to Apr 15
$89
includes taxes & fees
Apr 14 - Apr 15
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (1,299 reviews)
"Front desk was very helpful"

Reviewed on Apr 9, 2025

Baymont by Wyndham Santee
Tru By Hilton Santee
Tru By Hilton Santee
2.5 out of 5
263 Britain St. and 273 Britain St., Santee, SC
  • 7 min drive from Santee State Park
The price is $122 per night from May 11 to May 12
$122
includes taxes & fees
May 11 - May 12
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
9/10 Wonderful! (399 reviews)
"This property was clean & convenient; the staff was amazing! Breakfast was great and we had a wonderful experience overall."

Reviewed on Apr 6, 2025

Tru By Hilton Santee
Fairfield Inn & Suites by Marriott Santee
Fairfield Inn & Suites by Marriott Santee
2.5 out of 5
9074 Old Number Six Hwy, Santee, SC
  • 7 min drive from Santee State Park
The price is $159 per night from Apr 20 to Apr 21
$159
includes taxes & fees
Apr 20 - Apr 21
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
9.8/10 Exceptional! (1,001 reviews)
"The check in was very easy. There are plenty Parking"

Reviewed on Apr 9, 2025

Fairfield Inn & Suites by Marriott Santee
Holiday Inn Santee by IHG
Holiday Inn Santee by IHG
3 out of 5
139 Bradford Blvd, Santee, SC
  • 6 min drive from Santee State Park
The price is $129 per night from May 13 to May 14
$129
includes taxes & fees
May 13 - May 14
Stay at this 3-star golf hotel in Santee. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the clean rooms in ...
8/10 Very Good! (870 reviews)
"Our room was wonderful. The staff was so very nice, both at check in and in the restaurant"

Reviewed on Apr 8, 2025

Holiday Inn Santee by IHG
Hampton Inn Santee-I-95
Hampton Inn Santee-I-95
2.5 out of 5
9060 Old Number Six Hwy, Santee, SC
  • 7 min drive from Santee State Park
The price is $163 per night from Apr 20 to Apr 21
$163
includes taxes & fees
Apr 20 - Apr 21
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
9.4/10 Exceptional! (1,000 reviews)
"Only complaint is the entry tile floor and bathroom tile floors were dirty."

Reviewed on Apr 6, 2025

Hampton Inn Santee-I-95
Best Western Plus Santee Inn
Best Western Plus Santee Inn
2.5 out of 5
I 95 Exit 98, Santee, SC
  • 7 min drive from Santee State Park
The price is $127 per night from May 4 to May 5
$127
includes taxes & fees
May 4 - May 5
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful ...
8.6/10 Excellent! (1,002 reviews)
Nice hotel
"We stayed as we were driving through. Very nice hotel. I was concerned about the noisy groups of people hanging outside the hotel rooms but after a while they quieted down and the room is actually a bit sound proofed"

Reviewed on Apr 9, 2025

Best Western Plus Santee Inn
Comfort Inn & Suites Santee
Comfort Inn & Suites Santee
2.5 out of 5
221 Britain St, Santee, SC
  • 7 min drive from Santee State Park
The price is $122 per night from Apr 20 to Apr 21
$122
includes taxes & fees
Apr 20 - Apr 21
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Santee ...
7.8/10 Good! (972 reviews)
"Ok"

Reviewed on Apr 5, 2025

Comfort Inn & Suites Santee
Quality Inn & Suites
Quality Inn & Suites
2.5 out of 5
8929 Old Number Six Highway, Santee, SC
  • 6 min drive from Santee State Park
The price is $75 per night from May 11 to May 12
$75
includes taxes & fees
May 11 - May 12
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
6/10 (347 reviews)
"Needs a little work."

Reviewed on Apr 11, 2025

Quality Inn & Suites
Travelodge by Wyndham Santee
Travelodge by Wyndham Santee
2 out of 5
9117 Old Number Six Hwy, Santee, SC
  • 7 min drive from Santee State Park
The price is $68 per night from Apr 20 to Apr 21
$68
includes taxes & fees
Apr 20 - Apr 21
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
7/10 Good! (606 reviews)
"For the most part, everything was good.Except for the half used shampoo bottle in the shower left from whoever was there before."

Reviewed on Mar 9, 2025

Travelodge by Wyndham Santee
Red Roof Inn Santee
Red Roof Inn Santee
2 out of 5
9091 Old Hwy 6, Santee, SC
  • 6 min drive from Santee State Park
The price is $78 per night from Apr 14 to Apr 15
$78
includes taxes & fees
Apr 14 - Apr 15
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Santee Cooper Country Club and ...
6.4/10 (603 reviews)
"Comfortable , clean and friendly. Very convenient location."

Reviewed on Apr 4, 2025

Red Roof Inn Santee
Super 8 by Wyndham Santee
Super 8 by Wyndham Santee
2 out of 5
9125 Old Highway 6, Santee, SC
  • 7 min drive from Santee State Park
The price is $83 per night from Apr 14 to Apr 15
$83
includes taxes & fees
Apr 14 - Apr 15
Book a stay at this golf motel in Santee. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Santee Cooper Country Club and Santee Outlets ...
6.6/10 (419 reviews)
"Clean and tidy place bed a little lumpy but overall everything was good would I stay here again? Yes"

Reviewed on Mar 2, 2025

Super 8 by Wyndham Santee
Ramada by Wyndham Santee I-95
Ramada by Wyndham Santee I-95
2 out of 5
123 Mall Street, Santee, SC
  • 7 min drive from Santee State Park
The price is $97 per night from Apr 15 to Apr 16
$97
includes taxes & fees
Apr 15 - Apr 16
Book a stay at this golf hotel in Santee. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Santee Cooper Country Club and Santee ...
6.2/10 (519 reviews)
"Everyone that works here is very nice, including the owner. I feel safe and comfortable."

Reviewed on Mar 22, 2025

Ramada by Wyndham Santee I-95
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Santee

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For you, intrepid voyager, Hotwire has a large selection of the best hotels in Santee.

Choosing the right hotel in South Carolina has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Santee’s 268 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $68. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Santee hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Santee. No matter your reason for visiting Santee, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Santee hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Santee for as low as $68.

How many hotels are there in Santee?

With over 268 hotels in Santee, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $68.

How to find cheap car rentals in Santee?

Finding a cheap car rental deal in Santee is as easy as scoring cheap hotels in Santee. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.