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Hotels in Santee

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Tonight Mar 14 - Mar 15This weekend Mar 14 - Mar 16

Choose from 261 Santee Hotel Deals

Baymont by Wyndham Santee
Baymont by Wyndham Santee
2.5 out of 5
249 Britain Street, Santee, SC
  • 7 min drive from Santee State Park
The price is $89 per night from Mar 16 to Mar 17
$89
includes taxes & fees
Mar 16 - Mar 17
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (1,284 reviews)
"Plush towels, spacious room, clean utilitarian surfaces, fresh paint, very friendly staff, good breakfast with make your own waffles."

Reviewed on Mar 11, 2025

Baymont by Wyndham Santee
Tru By Hilton Santee
Tru By Hilton Santee
2.5 out of 5
263 Britain St. and 273 Britain St., Santee, SC
  • 7 min drive from Santee State Park
The price is $119 per night from Mar 23 to Mar 24
$119
includes taxes & fees
Mar 23 - Mar 24
Stay at this hotel in Santee. Enjoy free WiFi, free parking, and a 24-hour fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
9/10 Wonderful! (366 reviews)
"TRU sits directly on I-95. Not a pleasant surrounding area."

Reviewed on Mar 12, 2025

Tru By Hilton Santee
Fairfield Inn & Suites by Marriott Santee
Fairfield Inn & Suites by Marriott Santee
2.5 out of 5
9074 Old Number Six Hwy, Santee, SC
  • 7 min drive from Santee State Park
The price is $154 per night from Mar 20 to Mar 21
$154
includes taxes & fees
Mar 20 - Mar 21
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
9.8/10 Exceptional! (1,000 reviews)
"Staff was very friendly. We travel a lot and the breakfast was well above average."

Reviewed on Mar 11, 2025

Fairfield Inn & Suites by Marriott Santee
Holiday Inn Santee by IHG
Holiday Inn Santee by IHG
3 out of 5
139 Bradford Blvd, Santee, SC
  • 6 min drive from Santee State Park
The price is $117 per night from Mar 23 to Mar 24
$117
includes taxes & fees
Mar 23 - Mar 24
Stay at this 3-star golf hotel in Santee. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the clean rooms in ...
8/10 Very Good! (855 reviews)
"Please renovate! Plumbing noisy and walls uninsulated between our room (203) and the elevator shaft. Dreary decor. We stay here often but this facility has seen better days. Clarkes Inn restaurant across the street is highly recommended and there are lots of open spaces to walk dogs around the ..."

Reviewed on Mar 13, 2025

Holiday Inn Santee by IHG
Hampton Inn Santee-I-95
Hampton Inn Santee-I-95
2.5 out of 5
9060 Old Number Six Hwy, Santee, SC
  • 7 min drive from Santee State Park
The price is $153 per night from Mar 25 to Mar 26
$153
includes taxes & fees
Mar 25 - Mar 26
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
9.4/10 Exceptional! (1,004 reviews)
Great olace!
"The staff was friendly, rooms were clean, and the bed super comfy! It's a great place to stay, and it's right off of 95!"

Reviewed on Mar 13, 2025

Hampton Inn Santee-I-95
Best Western Plus Santee Inn
Best Western Plus Santee Inn
2.5 out of 5
I 95 Exit 98, Santee, SC
  • 7 min drive from Santee State Park
The price is $123 per night from Mar 25 to Mar 26
$123
includes taxes & fees
Mar 25 - Mar 26
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful ...
8.6/10 Excellent! (1,002 reviews)
"Excellent hotel for everyone, but especially if you are traveling with fur-babies, very pet friendly facility with plenty of walk areas and all ground levels rooms, fees for pets are modest and very fair, would stay again for sure."

Reviewed on Mar 11, 2025

Best Western Plus Santee Inn
Comfort Inn & Suites Santee
Comfort Inn & Suites Santee
2.5 out of 5
221 Britain St, Santee, SC
  • 7 min drive from Santee State Park
The price is $112 per night from Mar 23 to Mar 24
$112
includes taxes & fees
Mar 23 - Mar 24
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Santee ...
7.8/10 Good! (958 reviews)
"Great place , not so easy food ."

Reviewed on Mar 10, 2025

Comfort Inn & Suites Santee
Travelodge by Wyndham Santee
Travelodge by Wyndham Santee
2 out of 5
9117 Old Number Six Hwy, Santee, SC
  • 7 min drive from Santee State Park
The price is $67 per night from Mar 16 to Mar 17
$67
includes taxes & fees
Mar 16 - Mar 17
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
7/10 Good! (595 reviews)
"For the most part, everything was good.Except for the half used shampoo bottle in the shower left from whoever was there before."

Reviewed on Mar 9, 2025

Travelodge by Wyndham Santee
Ramada by Wyndham Santee I-95
Ramada by Wyndham Santee I-95
2 out of 5
123 Mall Street, Santee, SC
  • 7 min drive from Santee State Park
The price is $67 per night from Mar 19 to Mar 20
$67
includes taxes & fees
Mar 19 - Mar 20
Book a stay at this golf hotel in Santee. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Santee Cooper Country Club and Santee ...
6.2/10 (514 reviews)
Would stay here again!
"Great cheesesteak and friendly management."

Reviewed on Feb 14, 2025

Ramada by Wyndham Santee I-95
Quality Inn & Suites
Quality Inn & Suites
2.5 out of 5
8929 Old Number Six Highway, Santee, SC
  • 6 min drive from Santee State Park
The price is $75 per night from Mar 20 to Mar 21
$75
includes taxes & fees
Mar 20 - Mar 21
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
6/10 (329 reviews)
"Bed was very comfy."

Reviewed on Feb 11, 2025

Quality Inn & Suites
Red Roof Inn Santee
Red Roof Inn Santee
2 out of 5
9091 Old Hwy 6, Santee, SC
  • 6 min drive from Santee State Park
The price is $74 per night from Mar 16 to Mar 17
$74
includes taxes & fees
Mar 16 - Mar 17
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Santee Cooper Country Club and ...
6.4/10 (595 reviews)
"The only thing I didn't like was the refrigerator wasn't working other than that everything was okay."

Reviewed on Jan 17, 2025

Red Roof Inn Santee
Super 8 by Wyndham Santee
Super 8 by Wyndham Santee
2 out of 5
9125 Old Highway 6, Santee, SC
  • 7 min drive from Santee State Park
The price is $83 per night from Mar 16 to Mar 17
$83
includes taxes & fees
Mar 16 - Mar 17
Book a stay at this golf motel in Santee. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Santee Cooper Country Club and Santee Outlets ...
6.6/10 (417 reviews)
"Clean and tidy place bed a little lumpy but overall everything was good would I stay here again? Yes"

Reviewed on Mar 2, 2025

Super 8 by Wyndham Santee
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Santee

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For you, intrepid voyager, Hotwire has a large selection of the best hotels in Santee.

Choosing the right hotel in South Carolina has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Santee’s 261 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $67. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Santee hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Santee. No matter your reason for visiting Santee, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Santee hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Santee for as low as $67.

How many hotels are there in Santee?

With over 261 hotels in Santee, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $67.

How to find cheap car rentals in Santee?

Finding a cheap car rental deal in Santee is as easy as scoring cheap hotels in Santee. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.