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Choose from 262 Santee Hotel Deals
![Baymont by Wyndham Santee](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/320acff9_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Reviewed on Feb 15, 2025
![Fairfield Inn & Suites by Marriott Santee](https://images.trvl-media.com/lodging/1000000/30000/26200/26116/fee9cbfc_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Reviewed on Feb 15, 2025
![Tru By Hilton Santee](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/c1dfa766_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Reviewed on Feb 14, 2025
![Hampton Inn Santee-I-95](https://images.trvl-media.com/lodging/1000000/210000/203700/203667/w5235h3100x5y0-d80a3a05_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Reviewed on Feb 14, 2025
![Holiday Inn Santee, an IHG Hotel](https://images.trvl-media.com/lodging/2000000/1220000/1220000/1219924/c3a52f3e_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Reviewed on Feb 3, 2025
![Best Western Plus Santee Inn](https://images.trvl-media.com/lodging/1000000/30000/21900/21863/93ba5eb3_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Reviewed on Feb 13, 2025
![Travelodge by Wyndham Santee](https://images.trvl-media.com/lodging/6000000/5640000/5630800/5630775/4ab49efd_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Reviewed on Feb 5, 2025
![Comfort Inn & Suites Santee](https://images.trvl-media.com/lodging/1000000/520000/518500/518401/8e89959e_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Reviewed on Feb 14, 2025
![Quality Inn & Suites](https://images.trvl-media.com/lodging/92000000/91280000/91274500/91274426/659c7183_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Reviewed on Feb 11, 2025
![Ramada by Wyndham Santee I-95](https://images.trvl-media.com/lodging/1000000/20000/11700/11623/1ffacc8d_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Reviewed on Feb 14, 2025
![Red Roof Inn Santee](https://images.trvl-media.com/lodging/1000000/860000/856700/856695/9e846421_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Reviewed on Jan 17, 2025
![Wyndham Vacation Resorts Lake Marion](https://images.trvl-media.com/lodging/44000000/44000000/43992600/43992569/bfd80ad8_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Reviewed on Nov 21, 2024
Find cheap hotels in Santee
You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Santee hotel with Hotwire to complete your one-of-a-kind travel checklist.
For you, intrepid voyager, Hotwire has a large selection of the best hotels in Santee.
Choosing the right hotel in South Carolina has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Santee’s 262 hotels. Choose the one that best catches your trip’s tourist drift.
If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $67. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Santee hotel deals at the last minute.
While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Santee. No matter your reason for visiting Santee, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.
Frequently Asked Questions About Santee hotels
Where can I find the best last-minute travel deals?
If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Santee for as low as $67.
How many hotels are there in Santee?
With over 262 hotels in Santee, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $67.
How to find cheap car rentals in Santee?
Finding a cheap car rental deal in Santee is as easy as scoring cheap hotels in Santee. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.
Top Booked Hotels in Santee
- Fairfield Inn & Suites by Marriott Santee
- Hampton Inn Santee-I-95
- Holiday Inn Santee, an IHG Hotel
- Best Western Plus Santee Inn
- Travelodge by Wyndham Santee
- Comfort Inn & Suites Santee
- Ramada by Wyndham Santee I-95
- Red Roof Inn Santee
- Super 8 by Wyndham Santee
- Inn at Orangeburg
- Days Inn by Wyndham St George
- Tru by Hilton Orangeburg
- Hotels near Santee State Park
- Hotels near Santee Cooper Country Club
- Hotels near Santee Outlets
- Hotels near Santee National Golf Club
- Hotels near Lake Marion
- Hotels near Congaree National Park
- Hotels near South Carolina State University
- Hotels near Santee National Wildlife Refuge
- Hotels near Wyboo Golf Club
- Hotels near Edisto Memorial Gardens
- Hotels near Foxboro Golf Club
- Hotels near St. George Country Club
- Hotels with Free Parking in Santee
- Hotels with a Pool in Santee
- Pet-friendly Hotels in Santee
- Family Hotels in Santee
- Luxury Hotels in Santee
- Hotels with Hot Tubs in Santee
- Resorts & Hotels with Spas in Santee
- Hotels with smoking rooms in Santee
- Hotels with an Indoor Pool in Santee
- Beach Hotels in Santee
- Coastal South Carolina Hotels
- Orangeburg Hotels
- Sumter Hotels
- Southeastern United States Hotels
- Manning Hotels
- St. George Hotels
- Summerton Hotels
- The Carolinas Hotels
- Cross Hotels
- Eutawville Hotels
- Ridgeville Hotels
- The South Hotels
- Saint Matthews Hotels
- Harleyville Hotels
- Pineville Hotels
- Holly Hill Hotels
- Elloree Hotels
- Vance Hotels
- Walterboro - St. George Hotels
- Bamberg Hotels