Search for Cheap Deals onLuxury Hotels in Santee
You choose what matters — star rating, location, amenities.
We pick the perfect hotel, packed with all your must-haves.
Your hotel is revealed right after booking!
Featured Luxury Santee

Red Roof Inn Santee
9091 Old Hwy 6, Santee, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Santee Cooper Country Club and ...

Comfort Inn & Suites Santee
221 Britain St, Santee, SC
Fully refundableReserve now, pay when you stay
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Santee ...

Baymont by Wyndham Santee
249 Britain Street, Santee, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...

Ramada by Wyndham Santee I-95
123 Mall Street, Santee, SC
Book a stay at this golf hotel in Santee. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Santee Cooper Country Club and Santee ...

Econo Lodge
9112 Old 6 Highway, Santee, SC
Stay at this hotel in Santee. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Santee Cooper Country Club and Santee Outlets are ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels by Star Rating
More Hotel Options in Santee
Top Points of Interests in Santee
- Hotels near Santee State Park
- Hotels near Santee Outlets
- Hotels near Santee Cooper Country Club
- Hotels near Santee National Golf Club
- Hotels near Congaree National Park
- Hotels near South Carolina State University
- Hotels near Santee National Wildlife Refuge
- Hotels near Edisto Memorial Gardens
- Hotels near Wyboo Golf Club
- Hotels near St. George Country Club
- Hotels near Foxboro Golf Club
- Hotels near St. George United Methodist Church
- Hotels near I.P. Stanback Museum & Planetarium
- Hotels near Jennie J McMahan Library
Cities near Santee
- Coastal South Carolina Hotels (39.54 mi)
- Orangeburg Hotels (21.85 mi)
- Sumter Hotels (30.87 mi)
- Manning Hotels (20.95 mi)
- St. George Hotels (21.56 mi)
- Summerton Hotels (11.01 mi)
- Lake Marion Hotels (7.89 mi)
- Cross Hotels (21.9 mi)
- The Carolinas Hotels (107.21 mi)
- Southeastern United States Hotels (212.28 mi)
- Eutawville Hotels (9.84 mi)
- Ridgeville Hotels (28.75 mi)
- Holly Hill Hotels (12.11 mi)
- Pineville Hotels (26.07 mi)
- Saint Matthews Hotels (21.24 mi)
- Vance Hotels (4.82 mi)
- Elloree Hotels (6.29 mi)
- Harleyville Hotels (18.94 mi)
- Gadsden Hotels (29.81 mi)
- The South Hotels (543.71 mi)
Car Rentals Near Santee
- Car rentals in Coastal South Carolina
- Car rentals in Orangeburg
- Car rentals in Sumter
- Car rentals in Manning
- Car rentals in St. George
- Car rentals in Summerton
- Car rentals in Lake Marion
- Car rentals in Cross
- Car rentals in The Carolinas
- Car rentals in Southeastern United States
- Car rentals in Eutawville
- Car rentals in Ridgeville
- Car rentals in Holly Hill
- Car rentals in Pineville
- Car rentals in Saint Matthews
- Car rentals in Vance
Top Luxury Hotel Destinations
- Amarillo Luxury Hotels
- Sioux Falls Luxury Hotels
- Fort Wayne Luxury Hotels
- South Padre Island Luxury Hotels
- Cheyenne Luxury Hotels
- Corpus Christi Luxury Hotels
- Gettysburg Luxury Hotels
- Fresno Luxury Hotels
- Fayetteville Luxury Hotels
- Springfield Luxury Hotels
- Flagstaff Luxury Hotels
- Tuscaloosa Luxury Hotels
- Toledo Luxury Hotels
- Traverse City Luxury Hotels
- Twin Falls Luxury Hotels
- Scranton Luxury Hotels
- Columbia Luxury Hotels
- Catalina Island Luxury Hotels
- Shreveport Luxury Hotels
- Tallahassee Luxury Hotels