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Featured Santee Family Hotels

Comfort Inn & Suites Santee

221 Britain St Santee SC

Fully refundableReserve now, pay when you stay

Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Santee ...

Hampton Inn Santee-I-95

9060 Old Number Six Hwy Santee SC

Fully refundableReserve now, pay when you stay

Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...

Best Western Plus Santee Inn

I 95 Exit 98 Santee SC

Fully refundableReserve now, pay when you stay

Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful ...

Holiday Inn Santee by IHG

139 Bradford Blvd Santee SC

Fully refundable

Book a stay at this golf hotel in Santee. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the clean rooms in ...

Econo Lodge

9112 Old 6 Highway Santee SC

Fully refundableReserve now, pay when you stay

Stay at this hotel in Santee. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Santee Cooper Country Club and Santee National Golf ...

Travelodge by Wyndham Santee

9117 Old Number Six Hwy Santee SC

Fully refundableReserve now, pay when you stay

Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...

Super 8 by Wyndham Santee

9125 Old Highway 6 Santee SC

Fully refundableReserve now, pay when you stay

Book a stay at this golf motel in Santee. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Santee Cooper Country Club and Santee National ...

Baymont by Wyndham Santee

249 Britain Street Santee SC

Fully refundableReserve now, pay when you stay

Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...

Ramada by Wyndham Santee I-95

123 Mall Street Santee SC

Fully refundableReserve now, pay when you stay

Book a stay at this golf hotel in Santee. Enjoy free WiFi, free parking, and a 24-hour fitness center. Popular attractions Santee Cooper Country Club and Santee ...

See all 306 properties in Santee

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels with Pools in Santee

Best Western Plus Santee Inn

I 95 Exit 98 Santee SC

Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful ...

8.6/10 Excellent! (1,000 reviews)

Decorated for the holidays the public areas were warm and inviting. The staff was very efficient, but also pleasant and courteous. The room was comfortable. It was a pleasure to park and unload the car right by the room.

Reviewed on Nov 30, 2025