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Featured Santee Family Hotels
Comfort Inn & Suites Santee
221 Britain St, Santee, SC
Fully refundableReserve now, pay when you stay
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Santee ...
Hampton Inn Santee-I-95
9060 Old Number Six Hwy, Santee, SC
Fully refundableReserve now, pay when you stay
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
Best Western Plus Santee Inn
I 95 Exit 98, Santee, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful ...
Holiday Inn Santee by IHG
139 Bradford Blvd, Santee, SC
Fully refundable
Stay at this 3-star golf hotel in Santee. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the clean rooms in ...
Econo Lodge
9112 Old 6 Highway, Santee, SC
Stay at this hotel in Santee. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Santee Cooper Country Club and Santee Outlets are ...
Travelodge by Wyndham Santee
9117 Old Number Six Hwy, Santee, SC
Fully refundableReserve now, pay when you stay
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
Super 8 by Wyndham Santee
9125 Old Highway 6, Santee, SC
Fully refundableReserve now, pay when you stay
Book a stay at this golf motel in Santee. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Santee Cooper Country Club and Santee Outlets ...
Baymont by Wyndham Santee
249 Britain Street, Santee, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Ramada by Wyndham Santee I-95
123 Mall Street, Santee, SC
Fully refundableReserve now, pay when you stay
Book a stay at this golf hotel in Santee. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Santee Cooper Country Club and Santee ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels with Pools in Santee
Best Western Plus Santee Inn
I 95 Exit 98, Santee, SC
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful ...
8.6/10 Excellent! (1,003 reviews)
"Customer services. Barbara whowas in charge of the buffet breakfast was working very hard, cleaning the area and made sure all breakfast was available for everyone.She is very nice and"
Reviewed on Mar 21, 2025
Comfort Inn & Suites Santee
221 Britain St, Santee, SC
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Santee ...
7.8/10 Good! (959 reviews)
usb
"The usb ports did not work on nightstand."
Reviewed on Mar 18, 2025
Baymont by Wyndham Santee
249 Britain Street, Santee, SC
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (1,292 reviews)
"Excellent stay."
Reviewed on Mar 20, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels With Connecting Rooms in Santee
Best Western Plus Santee Inn
I 95 Exit 98, Santee, SC
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful ...
Comfort Inn & Suites Santee
221 Britain St, Santee, SC
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Santee ...
Super 8 by Wyndham Santee
9125 Old Highway 6, Santee, SC
Book a stay at this golf motel in Santee. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Santee Cooper Country Club and Santee Outlets ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels by Star Rating
Top Points of Interests in Santee
- Hotels near Santee State Park
- Hotels near Santee Outlets
- Hotels near Santee Cooper Country Club
- Hotels near Santee National Golf Club
- Hotels near Congaree National Park
- Hotels near South Carolina State University
- Hotels near Santee National Wildlife Refuge
- Hotels near Edisto Memorial Gardens
- Hotels near Wyboo Golf Club
- Hotels near St. George Country Club
- Hotels near Foxboro Golf Club
- Hotels near St. George United Methodist Church
- Hotels near I.P. Stanback Museum & Planetarium
- Hotels near Jennie J McMahan Library
Cities near Santee
- Coastal South Carolina Hotels (39.54 mi)
- Orangeburg Hotels (21.85 mi)
- Sumter Hotels (30.87 mi)
- Manning Hotels (20.95 mi)
- St. George Hotels (21.56 mi)
- Summerton Hotels (11.01 mi)
- Lake Marion Hotels (7.89 mi)
- Cross Hotels (21.9 mi)
- The Carolinas Hotels (107.21 mi)
- Southeastern United States Hotels (212.28 mi)
- Eutawville Hotels (9.84 mi)
- Ridgeville Hotels (28.75 mi)
- Holly Hill Hotels (12.11 mi)
- Pineville Hotels (26.07 mi)
- Saint Matthews Hotels (21.24 mi)
- Vance Hotels (4.82 mi)
- Elloree Hotels (6.29 mi)
- Harleyville Hotels (18.94 mi)
- Gadsden Hotels (29.81 mi)
- The South Hotels (543.71 mi)
Car Rentals Near Santee
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Top Family Hotel Destinations
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Top Booked Hotels in Santee
- Fairfield Inn & Suites by Marriott Santee
- Holiday Inn Santee by IHG
- Hampton Inn Santee-I-95
- Comfort Inn & Suites Santee
- Best Western Plus Santee Inn
- Travelodge by Wyndham Santee
- Ramada by Wyndham Santee I-95
- Red Roof Inn Santee
- Super 8 by Wyndham Santee
- Days Inn by Wyndham St George
- Tru by Hilton Orangeburg
- Inn at Orangeburg
- Hampton Inn & Suites Orangeburg