Search for Cheap Deals on
Hotels in Hillsboro

Choose from 269 Hillsboro Hotel Deals

River City Casino & Hotel

River City Casino & Hotel

4 out of 5
777 River City Casino Blvd St. Louis MO
  • 50 min drive from Villa Antonio Winery
Book a stay at this business-friendly hotel in St. Louis. Enjoy free parking, 5 restaurants, and a casino. Our guests praise the helpful staff and the clean ...
9/10 Wonderful! (1,500 reviews)
Very nice room, good food at the sportsbook bar, cool atmosphere

Reviewed on Mar 10, 2026

River City Casino & Hotel
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

3 out of 5
1088 South Highway Drive Fenton MO
  • 44 min drive from Villa Antonio Winery
Book a stay at this business-friendly hotel in Fenton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8/10 Very Good! (1,126 reviews)
Room was not clean. Stains on the sheets stains on the shower curtains not to mention the sink or the tub would not drain! No toilet paper in the bathrooms just a half roll left on the holder. Two towels for a family of four the whole stay. They didn't even have towels in the pool area. And the pool ...

Reviewed on Mar 10, 2026

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Best Western St. Louis-Kirkwood Route 66

Best Western St. Louis-Kirkwood Route 66

3.5 out of 5
1200 S Kirkwood Road Kirkwood MO
  • 48 min drive from Villa Antonio Winery
Book a stay at this business-friendly hotel in Kirkwood. Enjoy free parking, an outdoor pool, and room service. Our guests praise the breakfast and the helpful ...
8.4/10 Very Good! (1,436 reviews)
Room was nice, clean, mostly quiet. As soon as we stepped off the elevator we could tell that someone had been smoking pot. That odor finally cleared after about 2 hours.

Reviewed on Mar 10, 2026

Best Western St. Louis-Kirkwood Route 66
The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
2801 Fountain Pl Wildwood MO
  • 54 min drive from Villa Antonio Winery
Book a stay at this business-friendly hotel in Wildwood. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the convenient ...
9.2/10 Wonderful! (1,620 reviews)
Great space for a couple

Reviewed on Mar 11, 2026

The Wildwood Hotel
Best Western St. Louis Inn

Best Western St. Louis Inn

2.5 out of 5
6224 Heimos Industrial Park Dr St. Louis MO
  • 34 min drive from Villa Antonio Winery
Book a stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful ...
8.2/10 Very Good! (1,016 reviews)
Very nice for the price. Inside pool is a big plus

Reviewed on Mar 10, 2026

Best Western St. Louis Inn
Drury Inn & Suites Southwest St. Louis

Drury Inn & Suites Southwest St. Louis

3 out of 5
5 Lambert Drury Place (I-44 & 141) Valley Park MO
  • 43 min drive from Villa Antonio Winery
Book a stay at this business-friendly hotel in Valley Park. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.6/10 Exceptional! (1,013 reviews)
We did not get to enjoy the pool but breakfast was good, room was clean and we enjoyed our stay.

Reviewed on Mar 9, 2026

Drury Inn & Suites Southwest St. Louis
Wingate by Wyndham St. Louis/Fenton Route 66

Wingate by Wyndham St. Louis/Fenton Route 66

3 out of 5
1100 S Highway Dr Fenton MO
  • 44 min drive from Villa Antonio Winery
Book a stay at this business-friendly hotel in Fenton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8/10 Very Good! (1,154 reviews)
Common areas like elevator and some hall areas were in dire need of deep cleaning as well as some trash pick up and general maintenance. Lobby great. Parking areas well lighted and clean.

Reviewed on Mar 9, 2026

Wingate by Wyndham St. Louis/Fenton Route 66
Best Western Plus Fenton

Best Western Plus Fenton

2.5 out of 5
1680 Fenton Business Park Ct Fenton MO
  • 44 min drive from Villa Antonio Winery
Book a stay at this business-friendly hotel in Fenton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
9.2/10 Wonderful! (222 reviews)
The staff was very helpful! The room was great! The breakfast, ice cream, coffee bar were excelent. The kids loved the indoor pool. Will be our go to stay from bow on when visiting Saint Louis.

Reviewed on Mar 7, 2026

Best Western Plus Fenton
Holiday Inn Express & Suites St. Louis South - I-55 by IHG

Holiday Inn Express & Suites St. Louis South - I-55 by IHG

2.5 out of 5
4250 Midamerica Lane St. Louis MO
  • 38 min drive from Villa Antonio Winery
Book a stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.6/10 Exceptional! (1,000 reviews)
The place was clean, the pool was functional, the food was decent, and my kids favorite part was the cookie hour! Will definitely pick this hotel when we come back to the St Louis area!

Reviewed on Mar 10, 2026

Holiday Inn Express & Suites St. Louis South - I-55 by IHG
Pear Tree Inn St. Louis Arnold

Pear Tree Inn St. Louis Arnold

2.5 out of 5
1201 Drury Ln Arnold MO
  • 30 min drive from Villa Antonio Winery
Book a stay at this business-friendly hotel in Arnold. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,011 reviews)
Parking was comfortable and safe to park. We always stay at this site because of the cleanliness and very comfortable beds! Breakfast is wonderful!

Reviewed on Mar 9, 2026

Pear Tree Inn St. Louis Arnold
La Quinta Inn & Suites by Wyndham St Louis Route 66

La Quinta Inn & Suites by Wyndham St Louis Route 66

3 out of 5
1580 S Kirkwood Rd St. Louis MO
  • 47 min drive from Villa Antonio Winery
Book a stay at this business-friendly hotel in St. Louis. Enjoy free WiFi, free parking, and a 24-hour fitness center. Our guests praise the helpful staff and ...
8.2/10 Very Good! (1,004 reviews)
Breakfast average

Reviewed on Mar 2, 2026

La Quinta Inn & Suites by Wyndham St Louis Route 66
Extended Stay America Suites - St Louis - Fenton

Extended Stay America Suites - St Louis - Fenton

2.5 out of 5
1662 Fenton Business Park Ct Fenton MO
  • 44 min drive from Villa Antonio Winery
Stay at this hotel in Fenton. Enjoy free breakfast, a 24-hour front desk, and laundry facilities. Our guests praise the helpful staff in our reviews. Popular ...
5.8/10 (248 reviews)
The room was so dirty. The floors were sticky and the walls were dirty. Bedding didn't look clean either.

Reviewed on Mar 10, 2026

Extended Stay America Suites - St Louis - Fenton
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Hillsboro

You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Hillsboro hotel with Hotwire to complete your one-of-a-kind travel checklist.

For you, intrepid voyager, Hotwire has a large selection of the best hotels in Hillsboro.

Choosing the right hotel in Missouri has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Hillsboro’s 269 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $78. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Hillsboro hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Hillsboro. No matter your reason for visiting Hillsboro, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Hillsboro hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Hillsboro for as low as $78.

How many hotels are there in Hillsboro?

With over 269 hotels in Hillsboro, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $78.

How to find cheap car rentals in Hillsboro?

Finding a cheap car rental deal in Hillsboro is as easy as scoring cheap hotels in Hillsboro. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.