Search for Cheap Deals on
Hotels in Hillsboro

Choose from 273 Hillsboro Hotel Deals

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

3 out of 5
1088 South Highway Drive Fenton MO
  • 44 min drive from Villa Antonio Winery
Book a stay at this business-friendly hotel in Fenton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8/10 Very Good! (1,289 reviews)
"All was good except the variety of food available for breakfast. Very limited, and the motel staples of biscuits and gravy, reconstituted eggs and a few cereals is not healthy for people with diabetes."

Reviewed on May 19, 2026

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
River City Casino & Hotel

River City Casino & Hotel

4 out of 5
777 River City Casino Blvd St. Louis MO
  • 50 min drive from Villa Antonio Winery
Book a stay at this business-friendly hotel in St. Louis. Enjoy free parking, 5 restaurants, and a casino. Our guests praise the helpful staff and the clean ...
9/10 Wonderful! (1,563 reviews)
"Beautiful place to stay. Helpful staff. Good food.. Clean. Very nice. Would definitely stay again."

Reviewed on May 18, 2026

River City Casino & Hotel
The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
2801 Fountain Pl Wildwood MO
  • 54 min drive from Villa Antonio Winery
Book a stay at this business-friendly hotel in Wildwood. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the convenient ...
9.2/10 Wonderful! (1,649 reviews)
"Nice property in the St. Louis area! Very clean and luxurious feel to it. Very safe area as it is up in the mountains and away from the city, police department is even next door. Everything is in walking distance. Our room had a very comfortable king size bed, a couch, nice chair with foot stool, ..."

Reviewed on May 17, 2026

The Wildwood Hotel
Best Western St. Louis Inn

Best Western St. Louis Inn

2.5 out of 5
6224 Heimos Industrial Park Dr St. Louis MO
  • 34 min drive from Villa Antonio Winery
Book a stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful ...
8.2/10 Very Good! (1,011 reviews)
"Everything was good"

Reviewed on May 18, 2026

Best Western St. Louis Inn
Best Western St. Louis-Kirkwood Route 66

Best Western St. Louis-Kirkwood Route 66

3.5 out of 5
1200 S Kirkwood Road Kirkwood MO
  • 48 min drive from Villa Antonio Winery
Book a stay at this business-friendly hotel in Kirkwood. Enjoy free parking, an outdoor pool, and room service. Our guests praise the breakfast and the helpful ...
8.4/10 Very Good! (1,458 reviews)
"The Pro & Cons of staying here. The place and room were pretty clean for a hotel that could use some updating. We had a room with 2 queen beds(?Full) for 3 Adults. But only 1 wash cloth and 2 Large Towels? Now with a room with 2 (Double) beds in it, you surely would think that more than 2 people ..."

Reviewed on May 18, 2026

Best Western St. Louis-Kirkwood Route 66
Drury Inn & Suites Southwest St. Louis

Drury Inn & Suites Southwest St. Louis

3 out of 5
5 Lambert Drury Place (I-44 & 141) Valley Park MO
  • 43 min drive from Villa Antonio Winery
Book a stay at this business-friendly hotel in Valley Park. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.6/10 Exceptional! (1,023 reviews)
"I felt like I was “home.” The staff were so nice! Having breakfast and supper was insane. Best hotel stay in many years."

Reviewed on May 19, 2026

Drury Inn & Suites Southwest St. Louis
Wingate by Wyndham St. Louis/Fenton Route 66

Wingate by Wyndham St. Louis/Fenton Route 66

3 out of 5
1100 S Highway Dr Fenton MO
  • 44 min drive from Villa Antonio Winery
Book a stay at this business-friendly hotel in Fenton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
7.8/10 Good! (1,225 reviews)
"The staff need training on coustom service, rooms was not clean front desk personnel ask if she was upset with everyone."

Reviewed on May 19, 2026

Wingate by Wyndham St. Louis/Fenton Route 66
Extended Stay America Suites - St Louis - Fenton

Extended Stay America Suites - St Louis - Fenton

2.5 out of 5
1662 Fenton Business Park Ct Fenton MO
  • 44 min drive from Villa Antonio Winery
Stay at this hotel in Fenton. Enjoy free breakfast, a 24-hour front desk, and laundry facilities. Our guests praise the helpful staff in our reviews. Popular ...
5.8/10 (279 reviews)
"Extremely thin walls..up all night with the couple next to us smoking and talking loud all night"

Reviewed on May 18, 2026

Extended Stay America Suites - St Louis - Fenton
Best Western Plus Fenton

Best Western Plus Fenton

2.5 out of 5
1680 Fenton Business Park Ct Fenton MO
  • 44 min drive from Villa Antonio Winery
Book a stay at this business-friendly hotel in Fenton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
9.2/10 Wonderful! (292 reviews)
"I called at least a week in advance to reserve a specific executive room. I was told it will be on hold. I even called back a few days later to confirm the room and was told yes.. only to arrive to a completely different room than I asked for. Which was annoying and loud from highway noise. I don’t ..."

Reviewed on May 18, 2026

Best Western Plus Fenton
La Quinta Inn & Suites by Wyndham St Louis Route 66

La Quinta Inn & Suites by Wyndham St Louis Route 66

3 out of 5
1580 S Kirkwood Rd St. Louis MO
  • 47 min drive from Villa Antonio Winery
Book a stay at this business-friendly hotel in St. Louis. Enjoy free WiFi, free parking, and a 24-hour fitness center. Our guests praise the helpful staff and ...
8.2/10 Very Good! (1,008 reviews)
"Excellent hotel facilities;enjoyed the hot tub, pool There is a very positive welcoming hospitality culture that permeates every encounter with staff members be it front desk staff or breakfast ladies etc We truly enjoyed our stay as a family"

Reviewed on May 16, 2026

La Quinta Inn & Suites by Wyndham St Louis Route 66
The Principal Hotel

The Principal Hotel

3.5 out of 5
310 S Main St Columbia IL
  • 46 min drive from Villa Antonio Winery
Stay at this hotel in Columbia. Enjoy free WiFi, free parking, and a fitness center. Popular attractions Triple Lakes Golf Course and Eckert’s Millstadt Farm ...
9.8/10 Exceptional! (267 reviews)
"I loved staying at this place!!! It's was extra clean and had luxury amenities. The staff was very nice and accommodating. This is a 5-Star hotel. It's a newly renovated old school-house turned into a hotel and it's in the cutest town about 20 miles away from the Gateway Arch in St Louis. I especially ..."

Reviewed on May 18, 2026

The Principal Hotel
Pear Tree Inn St. Louis Arnold

Pear Tree Inn St. Louis Arnold

2.5 out of 5
1201 Drury Ln Arnold MO
  • 30 min drive from Villa Antonio Winery
Book a stay at this business-friendly hotel in Arnold. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,000 reviews)
"Very clean rooms an area. Breakfast was very well prepared. They even have a soda machine for guest"

Reviewed on May 11, 2026

Pear Tree Inn St. Louis Arnold
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Hillsboro

You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Hillsboro hotel with Hotwire to complete your one-of-a-kind travel checklist.

For you, intrepid voyager, Hotwire has a large selection of the best hotels in Hillsboro.

Choosing the right hotel in Missouri has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Hillsboro’s 273 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $80. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Hillsboro hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Hillsboro. No matter your reason for visiting Hillsboro, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Hillsboro hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Hillsboro for as low as $80.

How many hotels are there in Hillsboro?

With over 273 hotels in Hillsboro, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $80.

How to find cheap car rentals in Hillsboro?

Finding a cheap car rental deal in Hillsboro is as easy as scoring cheap hotels in Hillsboro. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.