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Choose from 549 Southeast Jacksonville Hotel Deals

Wyndham Garden Jacksonville

Wyndham Garden Jacksonville

3 out of 5
4660 Salisbury Road Jacksonville FL
  • 10 min drive from Mayo Clinic Florida
Book a stay at this business-friendly hotel in Jacksonville. Enjoy free WiFi, free parking, and a fitness center. Our guests praise the helpful staff and the ...
7.8/10 Good! (1,798 reviews)
Was clean room. Staff was friendly

Reviewed on Jan 26, 2026

Wyndham Garden Jacksonville
San Marco Inn East

San Marco Inn East

3 out of 5
3558 Phillips Hwy Jacksonville FL
  • 14 min drive from Mayo Clinic Florida
Stay at this motel in Jacksonville. Enjoy free WiFi, free parking, and 24-hour room service. Our guests praise the helpful staff and the clean rooms in our reviews. ...
8.4/10 Very Good! (1,360 reviews)
Clean and polite

Reviewed on Jan 21, 2026

San Marco Inn East
Midtown Lodge

Midtown Lodge

2.5 out of 5
4141 Philips Hwy Jacksonville FL
  • 14 min drive from Mayo Clinic Florida
Stay at this motel in Jacksonville. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff in our reviews. Popular attractions ...
8/10 Very Good! (578 reviews)
Staff is nice

Reviewed on Jan 14, 2026

Midtown Lodge
Comfort Suites Baymeadows Near Butler Blvd

Comfort Suites Baymeadows Near Butler Blvd

3 out of 5
8277 Western Way Cir Jacksonville FL
  • 11 min drive from Mayo Clinic Florida
Book a stay at this business-friendly hotel in Jacksonville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8.2/10 Very Good! (1,011 reviews)
The room was super clean and the breakfast was a great bonus. Good amount of choices.

Reviewed on Jan 25, 2026

Comfort Suites Baymeadows Near Butler Blvd
Holiday Inn Express Jacksonville South Bartram Prk by IHG

Holiday Inn Express Jacksonville South Bartram Prk by IHG

2.5 out of 5
13934 VILLAGE LAKE CIRCLE Jacksonville FL
  • 22 min drive from Mayo Clinic Florida
Book a stay at this business-friendly hotel in Jacksonville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,205 reviews)
Very nice. Comfy beds and great selection at breakfast.

Reviewed on Jan 21, 2026

Holiday Inn Express Jacksonville South Bartram Prk by IHG
Sheraton Jacksonville Hotel

Sheraton Jacksonville Hotel

4 out of 5
10605 Deerwood Park Blvd Jacksonville FL
  • 7 min drive from Mayo Clinic Florida
Book a stay at this business-friendly hotel in Jacksonville. Enjoy free WiFi, breakfast (surcharge), and a free area shuttle. Our guests praise the helpful staff ...
9/10 Wonderful! (1,007 reviews)
Ok

Reviewed on Jan 23, 2026

Sheraton Jacksonville Hotel
Embassy Suites by Hilton Jacksonville Baymeadows

Embassy Suites by Hilton Jacksonville Baymeadows

3.5 out of 5
9300 Baymeadows Road Jacksonville FL
  • 11 min drive from Mayo Clinic Florida
Book a stay at this business-friendly hotel in Jacksonville. Enjoy free breakfast, room service, and a 24-hour fitness center. Our guests praise the breakfast ...
8.4/10 Very Good! (1,332 reviews)
Good

Reviewed on Jan 22, 2026

Embassy Suites by Hilton Jacksonville Baymeadows
Baymont by Wyndham Jacksonville/Butler Blvd

Baymont by Wyndham Jacksonville/Butler Blvd

2.5 out of 5
7030 Bonneval Road Jacksonville FL
  • 11 min drive from Mayo Clinic Florida
Book a stay at this business-friendly hotel in Jacksonville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8/10 Very Good! (1,320 reviews)
Good location, dining in area, safe

Reviewed on Jan 19, 2026

Baymont by Wyndham Jacksonville/Butler Blvd
Hyatt Place Jacksonville / St. Johns Town Center

Hyatt Place Jacksonville / St. Johns Town Center

3 out of 5
4742 Town Center Parkway Jacksonville FL
  • 6 min drive from Mayo Clinic Florida
Book a stay at this business-friendly hotel in Jacksonville. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the breakfast ...
9.2/10 Wonderful! (1,003 reviews)
Clean room and friendly staff!

Reviewed on Jan 23, 2026

Hyatt Place Jacksonville / St. Johns Town Center
Homewood Suites by Hilton Jacksonville-South/St. Johns Ctr.

Homewood Suites by Hilton Jacksonville-South/St. Johns Ctr.

3 out of 5
10434 Midtown Pkwy Jacksonville FL
  • 6 min drive from Mayo Clinic Florida
Book a stay at this business-friendly hotel in Jacksonville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.2/10 Very Good! (1,001 reviews)
Great clean hotel

Reviewed on Jan 18, 2026

Homewood Suites by Hilton Jacksonville-South/St. Johns Ctr.
Candlewood Suites Jacksonville Southpoint by IHG

Candlewood Suites Jacksonville Southpoint by IHG

2.5 out of 5
4699 Lenoir Avenue South Jacksonville FL
  • 11 min drive from Mayo Clinic Florida
Book a stay at this business-friendly hotel in Jacksonville. Enjoy free WiFi, free parking, and a 24-hour fitness center. Popular attractions St. Johns Town ...
9/10 Wonderful! (332 reviews)
Room was great, dtaff was good

Reviewed on Jan 22, 2026

Candlewood Suites Jacksonville Southpoint by IHG
Delta Hotels by Marriott™ Jacksonville Deerwood

Delta Hotels by Marriott™ Jacksonville Deerwood

4 out of 5
4700 Salisbury Rd Jacksonville FL
  • 10 min drive from Mayo Clinic Florida
Book a stay at this business-friendly hotel in Jacksonville. Enjoy free parking, breakfast (surcharge), and a free area shuttle. Our guests praise the helpful ...
8.4/10 Very Good! (515 reviews)
The room was clean, comfortable bed. Though I did not use the amenities there is an outdoor pool, a gym, and an eatery. The staff was an approachable, professional, and helpful. I will stay there again.

Reviewed on Jan 19, 2026

Delta Hotels by Marriott™ Jacksonville Deerwood
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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