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Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach

2.5 out of 5
715 1st St N Jacksonville Beach FL
  • 6 min drive from Mayo Clinic Florida
Book a stay at this beach hotel in Jacksonville Beach. Enjoy free WiFi, a beach locale, and breakfast (surcharge). Our guests praise the pool and the helpful ...
9/10 Wonderful! (4,017 reviews)
"Stay here every time I come to JAX. Jason"

Reviewed on Jun 3, 2026

Margaritaville Jacksonville Beach
Hyatt Regency Jacksonville

Hyatt Regency Jacksonville

4 out of 5
225 E Coastline Dr Jacksonville FL
  • 19 min drive from Mayo Clinic Florida
Book a stay at this business-friendly hotel in Jacksonville. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the helpful staff and ...
9/10 Wonderful! (1,631 reviews)
"Hyatt Riverfront was a beautiful Hotel! Awesome bar and restaurant, Grerat view of the River. We Loved would definitely visit again. The only thing that needs to be changed are the toilets in the rooms. They are so low!"

Reviewed on Jun 2, 2026

Hyatt Regency Jacksonville
Embassy Suites by Hilton Jacksonville Baymeadows

Embassy Suites by Hilton Jacksonville Baymeadows

3.5 out of 5
9300 Baymeadows Road Jacksonville FL
  • 11 min drive from Mayo Clinic Florida
Book a stay at this business-friendly hotel in Jacksonville. Enjoy free breakfast, room service, and a 24-hour fitness center. Our guests praise the breakfast ...
8.4/10 Very Good! (1,419 reviews)
"The room itself is very outdated. Bedroom wall bubbled up due to the water damage from the bathroom."

Reviewed on Jun 3, 2026

Embassy Suites by Hilton Jacksonville Baymeadows
Amelia Hotel at the Beach

Amelia Hotel at the Beach

2.5 out of 5
1997 S Fletcher Ave Fernandina Beach FL
  • 1 hour drive from Mayo Clinic Florida
Book a stay at this business-friendly hotel in Fernandina Beach. Enjoy free breakfast, free WiFi, and parking (surcharge). Our guests praise the breakfast and ...
8.6/10 Excellent! (2,156 reviews)
"Excellent location, less than a block from the beach. Property and the room not well maintained and the room was somewhat musty. Charged me a pet deposit (Reasonable fee) but was very surprised when I was also charged for parking overnight. Would definitely not recommend this property."

Reviewed on Jun 1, 2026

Amelia Hotel at the Beach
Wyndham Garden Jacksonville

Wyndham Garden Jacksonville

3 out of 5
4660 Salisbury Road Jacksonville FL
  • 10 min drive from Mayo Clinic Florida
Book a stay at this business-friendly hotel in Jacksonville. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and ...
8/10 Very Good! (1,895 reviews)
"Wyndham Gardens has become my go to Jacksonville hotel for short trips and I have enjoyed the hotel. This location has been perfect for our 1-2 nights stays for concerts and shows. Only a 15 minute drive to the stadium and plenty of restaurants and attractions. The staff has always been friendly ..."

Reviewed on Jun 2, 2026

Wyndham Garden Jacksonville
Hampton Inn Jacksonville Beach/Oceanfront

Hampton Inn Jacksonville Beach/Oceanfront

3 out of 5
1515 1st St N Jacksonville Beach FL
  • 7 min drive from Mayo Clinic Florida
Book a stay at this beach hotel in Jacksonville Beach. Enjoy free breakfast, 2 outdoor pools, and a beach locale. Our guests praise the breakfast and the pool ...
9.2/10 Wonderful! (2,668 reviews)
"The hotel is under renovation. However, the room we were in needed to have the carpet cleaned. The overall cleanliness could have been better. The breakfast was fine."

Reviewed on Jun 2, 2026

Hampton Inn Jacksonville Beach/Oceanfront
The Villas of Amelia Island

The Villas of Amelia Island

4 out of 5
8 Amelia Village Circle, Amelia Island Fernandina Beach FL
  • 46 min drive from Mayo Clinic Florida
Book a stay at this beach vacation home in Fernandina Beach. Enjoy free WiFi, 2 outdoor pools, and a full-service spa. Our guests praise the helpful staff in ...
8.4/10 Very Good! (1,212 reviews)
"We loved the trails and easy access to restaurants and shopping. The room was a little dated, and the shuttle was unreliable, but overall, it was a great trip. The grounds were immaculate and the service was spot on."

Reviewed on Jun 2, 2026

The Villas of Amelia Island
Weekly Inn

Weekly Inn

2 out of 5
8016 Arlington Expressway Service Rd Jacksonville FL
  • 14 min drive from Mayo Clinic Florida
Stay at this motel in Jacksonville. Enjoy free WiFi, free parking, and a 24-hour fitness center. Our guests praise the helpful staff and the clean rooms in our ...
7.6/10 Good! (1,304 reviews)
"All good"

Reviewed on Jun 1, 2026

Weekly Inn
Home2 Suites by Hilton Jacksonville Airport

Home2 Suites by Hilton Jacksonville Airport

3 out of 5
13475 Ranch Road Jacksonville FL
  • 40 min drive from Mayo Clinic Florida
Book a stay at this business-friendly hotel in Jacksonville. Enjoy free breakfast, free WiFi, and a free airport shuttle. Our guests praise the breakfast and ...
8.8/10 Excellent! (1,006 reviews)
"Room was nice size and clean. Water temperature and pressure was great. Didn’t like having to pay to park wasn’t aware til check in would’ve been nice to know ahead. Would stay there again when in the area."

Reviewed on Jun 2, 2026

Home2 Suites by Hilton Jacksonville Airport
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

2.5 out of 5
1220 Marsh Landing Pkwy Jacksonville Beach FL
  • 26 min walk from Mayo Clinic Florida
Book a stay at this business-friendly hotel in Jacksonville Beach. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the ...
9/10 Wonderful! (1,130 reviews)
"Excellent location not far from family. Very enjoyable stay."

Reviewed on Jun 1, 2026

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
Omni Amelia Island Resort & Spa

Omni Amelia Island Resort & Spa

4 out of 5
39 Beach Lagoon Road Fernandina Beach FL
  • 49 min drive from Mayo Clinic Florida
Book a stay at this beach resort in Fernandina Beach. Enjoy free WiFi, 2 outdoor pools, and a full-service spa. Our guests praise the helpful staff in our reviews. ...
8.8/10 Excellent! (1,000 reviews)
"The staff were very friendly and welcoming. We ate at Surfcaster and Florabelle on site restaurants as well as Marche Burette-all excellent dining options. Oceanfront room and balcony were a highlight for us to enjoy the ocean breezes and sunrise views. We were content to enjoy the pool, shops, and ..."

Reviewed on May 25, 2026

Omni Amelia Island Resort & Spa
Courtyard by Marriott Amelia Island

Courtyard by Marriott Amelia Island

3 out of 5
2700 Atlantic Avenue Fernandina Beach FL
  • 1 hour drive from Mayo Clinic Florida
Book a stay at this business-friendly hotel in Fernandina Beach. Enjoy free WiFi, an outdoor pool, and 2 restaurants. Our guests praise the helpful staff in ...
9/10 Wonderful! (716 reviews)
"Be prepared to pay an additional fee for parking each day,"

Reviewed on Jun 2, 2026

Courtyard by Marriott Amelia Island
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Book Last-Minute Hotel Deals in Jacksonville

If there’s a state in America with the corner market on bold experiences, it would be Florida. From snapping gators to strong flavors, this state doesn’t know how to do anything in half measure. Unsurprisingly, Jacksonville embodies this to a tee.

Why go out for a beer when you can hit 19 breweries in a row? Why visit a zoo when you can work as a zookeeper? And why look at the stars when you can watch the planets? Come see what we’re talking about when you book last-minute hotel deals in Jacksonville, FL. This is a place that pushes all expectations.

  • Beer Trail: Some cities are all about walking trails. Jacksonville does things differently. Pick up a Jax Ale Trail Brewery Passport, which will lead you to over a dozen of the best breweries in the city. Fun fact: Jacksonville is considered a mecca in the state for beer, so prepare to treat your taste buds. You may also want to book your hotel in downtown Jacksonville so you’re not far from a bed for a mid-trail nap.

  • Stargazing the Heavens: Regular ole telescopes aren’t good enough for this dynamic city. The Bryan-Gooding Planetarium is one of the largest single-lens planetariums in the country. With that much attention to the stars and planets, you can bet the exhibits are top-notch. Bring the kids with you as you enjoy the shows and live presentations given by experts. You might just go home from your trip with a budding astronaut on your hands.

  • Lions, Tigers, and Bears, Oh My: When you visit the Jacksonville Zoo, you can certainly spend your afternoon viewing the various wildlife. But we know you’re more adventurous than that. Sign up to be a zookeeper for a day. You’ll be welcomed into the animal enclosures and get up close and personal with zebras, elephants, and storks, to name just a few.

  • Really, Really Old Art: Most art museums can claim some antique pieces, but Jacksonville goes back a little further than most. Make a stop at Cummer Museum of Art & Gardens, which features pieces from 2100 BC all the way up to modernist styles. After gazing at the indoor beauty, be sure to take a spin outside in the gardens, which are lined with sculptures and fountains.

Jacksonville knows how to impress—and this applies just as much to its hotels. From hotels near the Museum of Science and History to hotels in Jacksonville with free parking, you’ll always feel right at home. And with Hotwire Hot Rates, you can scoop up 4-star hotels for 2-star prices.