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Choose from 4743 Jacksonville Hotel Deals

Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach

2.5 out of 5
715 1st St N Jacksonville Beach FL
  • 6 min drive from Mayo Clinic Florida
Book a stay at this beach hotel in Jacksonville Beach. Enjoy free WiFi, a beach locale, and breakfast (surcharge). Our guests praise the pool and the helpful ...
8.8/10 Excellent! (3,520 reviews)
Great views

Reviewed on Jan 20, 2026

Margaritaville Jacksonville Beach
Hyatt Regency Jacksonville

Hyatt Regency Jacksonville

4 out of 5
225 E Coastline Dr Jacksonville FL
  • 19 min drive from Mayo Clinic Florida
Book a stay at this business-friendly hotel in Jacksonville. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the helpful staff and ...
8.8/10 Excellent! (1,426 reviews)
Very clean and comfortable room.

Reviewed on Jan 18, 2026

Hyatt Regency Jacksonville
Comfort Suites Baymeadows Near Butler Blvd

Comfort Suites Baymeadows Near Butler Blvd

3 out of 5
8277 Western Way Cir Jacksonville FL
  • 11 min drive from Mayo Clinic Florida
Book a stay at this business-friendly hotel in Jacksonville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8.2/10 Very Good! (1,014 reviews)
Breakfast should be served until 9.30am!

Reviewed on Jan 18, 2026

Comfort Suites Baymeadows Near Butler Blvd
Southbank Hotel by Marriott Jacksonville Riverwalk

Southbank Hotel by Marriott Jacksonville Riverwalk

3.5 out of 5
1515 Prudential Dr Jacksonville FL
  • 18 min drive from Mayo Clinic Florida
Book a stay at this business-friendly hotel in Jacksonville. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and ...
8.2/10 Very Good! (1,640 reviews)
The bar 😂 and the restaurant had a good variety of food. Overall it was close to the marina although it was a little cold for us but we still enjoy a small stroll. It’s close to a few other restaurants to walk. It just needs a little store or working vending machines but nothing the near by gas ...

Reviewed on Jan 19, 2026

Southbank Hotel by Marriott Jacksonville Riverwalk
Hyatt Place Jacksonville Airport

Hyatt Place Jacksonville Airport

3 out of 5
14565 Duval Rd Jacksonville FL
  • 40 min drive from Mayo Clinic Florida
Book a stay at this business-friendly hotel in Jacksonville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.8/10 Excellent! (2,359 reviews)
Yes

Reviewed on Jan 22, 2026

Hyatt Place Jacksonville Airport
The Villas of Amelia Island

The Villas of Amelia Island

4 out of 5
8 Amelia Village Circle, Amelia Island Fernandina Beach FL
  • 46 min drive from Mayo Clinic Florida
Book a stay at this beach vacation home in Fernandina Beach. Enjoy free WiFi, 2 outdoor pools, and a full-service spa. Our guests praise the helpful staff in ...
8.4/10 Very Good! (1,148 reviews)
Beautiful grounds, very helpful staff, great amenities. Cedric the tram driver was the highlight of our trip! Great stories, helpful suggestions about where to eat and such a pleasant perspective! The shops are wonderful with unique clothing and accessories.

Reviewed on Jan 14, 2026

The Villas of Amelia Island
Wyndham Garden Jacksonville

Wyndham Garden Jacksonville

3 out of 5
4660 Salisbury Road Jacksonville FL
  • 10 min drive from Mayo Clinic Florida
Book a stay at this business-friendly hotel in Jacksonville. Enjoy free WiFi, free parking, and a fitness center. Our guests praise the helpful staff and the ...
7.8/10 Good! (1,803 reviews)
Room was very clean, staff was helpful.

Reviewed on Jan 18, 2026

Wyndham Garden Jacksonville
San Marco Inn East

San Marco Inn East

3 out of 5
3558 Phillips Hwy Jacksonville FL
  • 14 min drive from Mayo Clinic Florida
Stay at this motel in Jacksonville. Enjoy free WiFi, free parking, and 24-hour room service. Our guests praise the helpful staff and the clean rooms in our reviews. ...
8.4/10 Very Good! (1,360 reviews)
Clean and polite

Reviewed on Jan 21, 2026

San Marco Inn East
Extended Stay America Premier Suites - Jacksonville - Airport

Extended Stay America Premier Suites - Jacksonville - Airport

2.5 out of 5
15678 Max Leggett Parkway Jacksonville FL
  • 41 min drive from Mayo Clinic Florida
Book a stay at this business-friendly hotel in Jacksonville. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Jacksonville Zoo and Gardens ...
8.6/10 Excellent! (190 reviews)
Best service we have had in a long time. Clean rooms and great location! Pleasantly surprised for such a great price!!

Reviewed on Jan 17, 2026

Extended Stay America Premier Suites - Jacksonville - Airport
Omni Amelia Island Resort & Spa

Omni Amelia Island Resort & Spa

4 out of 5
39 Beach Lagoon Road Fernandina Beach FL
  • 49 min drive from Mayo Clinic Florida
Book a stay at this beach resort in Fernandina Beach. Enjoy free WiFi, 2 outdoor pools, and a full-service spa. Our guests praise the helpful staff in our reviews. ...
8.6/10 Excellent! (1,003 reviews)
Clean, remodeled, friendly staff!

Reviewed on Jan 22, 2026

Omni Amelia Island Resort & Spa
Amelia Hotel at the Beach

Amelia Hotel at the Beach

2.5 out of 5
1997 S Fletcher Ave Fernandina Beach FL
  • 1 hour drive from Mayo Clinic Florida
Book a stay at this business-friendly hotel in Fernandina Beach. Enjoy free breakfast, free WiFi, and parking (surcharge). Our guests praise the breakfast and ...
8.4/10 Very Good! (2,136 reviews)
Staff were very friendly! Room was very clean and nice.

Reviewed on Jan 19, 2026

Amelia Hotel at the Beach
Hampton Inn Jacksonville Beach/Oceanfront

Hampton Inn Jacksonville Beach/Oceanfront

3 out of 5
1515 1st St N Jacksonville Beach FL
  • 7 min drive from Mayo Clinic Florida
Book a stay at this beach hotel in Jacksonville Beach. Enjoy free breakfast, 2 outdoor pools, and a beach locale. Our guests praise the breakfast and the pool ...
9/10 Wonderful! (2,639 reviews)
The hotel room was bigger than expected and the breakfast was delicious. I loved being able to walk right out onto the beach even though there was a cold front coming through. We were still able to walk the beach and soak up the sun. The pool looked really cool, and was heated but I couldn’t get ...

Reviewed on Jan 18, 2026

Hampton Inn Jacksonville Beach/Oceanfront
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Book Last-Minute Hotel Deals in Jacksonville

If there’s a state in America with the corner market on bold experiences, it would be Florida. From snapping gators to strong flavors, this state doesn’t know how to do anything in half measure. Unsurprisingly, Jacksonville embodies this to a tee.

Why go out for a beer when you can hit 19 breweries in a row? Why visit a zoo when you can work as a zookeeper? And why look at the stars when you can watch the planets? Come see what we’re talking about when you book last-minute hotel deals in Jacksonville, FL. This is a place that pushes all expectations.

  • Beer Trail: Some cities are all about walking trails. Jacksonville does things differently. Pick up a Jax Ale Trail Brewery Passport, which will lead you to over a dozen of the best breweries in the city. Fun fact: Jacksonville is considered a mecca in the state for beer, so prepare to treat your taste buds. You may also want to book your hotel in downtown Jacksonville so you’re not far from a bed for a mid-trail nap.

  • Stargazing the Heavens: Regular ole telescopes aren’t good enough for this dynamic city. The Bryan-Gooding Planetarium is one of the largest single-lens planetariums in the country. With that much attention to the stars and planets, you can bet the exhibits are top-notch. Bring the kids with you as you enjoy the shows and live presentations given by experts. You might just go home from your trip with a budding astronaut on your hands.

  • Lions, Tigers, and Bears, Oh My: When you visit the Jacksonville Zoo, you can certainly spend your afternoon viewing the various wildlife. But we know you’re more adventurous than that. Sign up to be a zookeeper for a day. You’ll be welcomed into the animal enclosures and get up close and personal with zebras, elephants, and storks, to name just a few.

  • Really, Really Old Art: Most art museums can claim some antique pieces, but Jacksonville goes back a little further than most. Make a stop at Cummer Museum of Art & Gardens, which features pieces from 2100 BC all the way up to modernist styles. After gazing at the indoor beauty, be sure to take a spin outside in the gardens, which are lined with sculptures and fountains.

Jacksonville knows how to impress—and this applies just as much to its hotels. From hotels near the Museum of Science and History to hotels in Jacksonville with free parking, you’ll always feel right at home. And with Hotwire Hot Rates, you can scoop up 4-star hotels for 2-star prices.