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Featured 4 Star Main South Hotels

Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in Westborough. Enjoy free WiFi, free parking, and room service. Our guests praise the helpful staff and the clean ...

Fully refundableReserve now, pay when you stay
Stay at this 4-star luxury hotel in Worcester. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the clean rooms ...

Fully refundableReserve now, pay when you stay
Stay at this 4-star hotel in Milford. Enjoy free WiFi, free parking, and 3 restaurants. Our guests praise the helpful staff in our reviews. Popular attractions ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Popular Main South Hotels
- Motel 6 Framingham, MA - Boston West
- DoubleTree by Hilton Hotel Boston - Westborough
- Wellsworth Hotel
- Best Western Royal Plaza Hotel & Trade Center
- Courtyard by Marriott Boston Marlborough
- Publick House Historic Inn and Country Motor Lodge
- Red Roof Inn Boston - Southborough/ Worcester
- Extended Stay America Suites Boston Westborough Computer Dr
- Hilton Garden Inn Boston/Marlborough
- Hyatt Place Marlborough/Apex Center
- Comfort Inn Auburn - Worcester
Top Attractions in Main South
- Hotels near Clark University (0.11 mi)
- Hotels near Burnside Fountain (0.13 mi)
- Hotels near DCU Center (1.39 mi)
- Hotels near Union Station (1.47 mi)
- Hotels near Old Sturbridge Village (17.28 mi)
- Hotels near College of the Holy Cross (1.22 mi)
- Hotels near Worcester Polytechnic Institute (1.71 mi)
- Hotels near New England Sports Center (13.72 mi)
- Hotels near Apex Entertainment Center (13.39 mi)
- Hotels near Wachusett Mountain Ski Area (17.33 mi)
- Hotels near Southwick's Zoo (17.65 mi)
- Hotels near UMass Memorial Medical Center (2.08 mi)
- Hotels near Indian Ranch (13.68 mi)
- Hotels near Tower Hill Botanic Garden (8.99 mi)
- Hotels near Worcester Art Museum (1.83 mi)
- Hotels near The Hanover Theatre for the Performing Arts (1.11 mi)
- Hotels near Thompson International Speedway (18.55 mi)
- Hotels near New England Baseball Complex (8.16 mi)
- Hotels near Hopkinton State Park (14.76 mi)
- Hotels near Cummings School of Veterinary Medicine at Tufts University (7.39 mi)
Nearby Cities
- Worcester Hotels (1.21 mi)
- Sturbridge Hotels (16.5 mi)
- Marlborough Hotels (15.16 mi)
- Framingham Hotels (20.7 mi)
- Westborough Hotels (10.65 mi)
- Milford Hotels (17.33 mi)
- Auburn Hotels (3.99 mi)
- Leominster Hotels (19.17 mi)
- Southbridge Hotels (16.34 mi)
- Sudbury Hotels (22.56 mi)
- Shrewsbury Hotels (6.29 mi)
- Brimfield Hotels (21.39 mi)
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Car Rentals Near Main South
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