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Featured Orangeburg Family Hotels

Comfort Inn & Suites Santee
221 Britain St, Santee, SC
Fully refundableReserve now, pay when you stay
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Santee ...

Baymont by Wyndham Orangeburg North
3583 Saint Matthews Rd, Orangeburg, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Orangeburg. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Smith-Hammond-Middleton Memorial ...

Spark by Hilton Orangeburg
731 Citadel Road, Orangeburg, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Orangeburg. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...

Hampton Inn Santee-I-95
9060 Old Number Six Hwy, Santee, SC
Fully refundableReserve now, pay when you stay
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...

Best Western Plus Santee Inn
I 95 Exit 98, Santee, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful ...

Holiday Inn Express & Suites Orangeburg by IHG
118 Sleep Inn Road, Orangeburg, SC
Fully refundable
Book a stay at this business-friendly hotel in Orangeburg. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...

Holiday Inn Santee by IHG
139 Bradford Blvd, Santee, SC
Fully refundable
Stay at this 3-star golf hotel in Santee. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the clean rooms in ...

Comfort Inn & Suites
746 Citadel Rd, Orangeburg, SC
Book a stay at this business-friendly hotel in Orangeburg. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...

Super 8 by Wyndham, Orangeburg
3608 Saint Matthews Rd, Orangeburg, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly motel in Orangeburg. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...

American INN of Orangeburg
610 John C Calhoun Dr, Orangeburg, SC
Stay at this hotel in Orangeburg. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions South Carolina State College Historic District ...

Econo Lodge
9112 Old 6 Highway, Santee, SC
Fully refundableReserve now, pay when you stay
Stay at this hotel in Santee. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Santee Cooper Country Club and Santee National Golf ...

Days Inn by Wyndham Orangeburg
3691 Saint Matthews Rd, Orangeburg, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Orangeburg. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Smith-Hammond-Middleton Memorial ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels with Pools in Orangeburg

Best Western Plus Santee Inn
I 95 Exit 98, Santee, SC
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful ...
8.6/10 Excellent! (1,006 reviews)
"Cockroach in our bathroom discovered soon upon our entry. The room was located next to the pool area. Furniture is dated, but showed signs of former elegance. Breakfast was excellent. Much broader selection than at most other places. We have seen the woman who oversees the breakfast area on another ..."
Reviewed on Oct 13, 2025

Baymont by Wyndham Orangeburg North
3583 Saint Matthews Rd, Orangeburg, SC
Book a stay at this business-friendly hotel in Orangeburg. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Smith-Hammond-Middleton Memorial ...
6/10 (1,010 reviews)
"Bed was clean and comfortable. The bathroom had some damage like broken door and cracked tile but otherwise was clean and everything worked."
Reviewed on Sep 30, 2025

Spark by Hilton Orangeburg
731 Citadel Road, Orangeburg, SC
Book a stay at this business-friendly hotel in Orangeburg. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
7.6/10 Good! (1,006 reviews)
"The front desk clerk/manager who was on shift during my check-in was extremely sarcastic and unfriendly. She asked a question with a question each time whether about the property or the surrounding area. Otherwise the hotel was excellent for the price and the room was comfortable."
Reviewed on Oct 12, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels With Connecting Rooms in Orangeburg

Baymont by Wyndham Orangeburg North
3583 Saint Matthews Rd, Orangeburg, SC
Book a stay at this business-friendly hotel in Orangeburg. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Smith-Hammond-Middleton Memorial ...

Best Western Plus Santee Inn
I 95 Exit 98, Santee, SC
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful ...

Comfort Inn & Suites
746 Citadel Rd, Orangeburg, SC
Book a stay at this business-friendly hotel in Orangeburg. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels by Star Rating
More Hotel Options
- Hotels with Free Parking in Orangeburg
- Hotels with a Pool in Orangeburg
- Pet-friendly Hotels in Orangeburg
- Historic Hotels in Orangeburg
- Luxury Hotels in Orangeburg
- Hotels with Hot Tubs in Orangeburg
- Hotels with an Indoor Pool in Orangeburg
- Resorts & Hotels with Spas in Orangeburg
- Hotels with smoking rooms in Orangeburg
- Adults Only Resorts & Hotels in Orangeburg
Top Points of Interests in Orangeburg
- Hotels near Edisto Memorial Gardens
- Hotels near Congaree National Park
- Hotels near Lake Marion
- Hotels near Santee State Park
- Hotels near South Carolina State University
- Hotels near God's Acre Healing Springs
- Hotels near Santee Cooper Country Club
- Hotels near Santee National Golf Club
- Hotels near Barnwell State Park
- Hotels near Santee National Wildlife Refuge
- Hotels near Harry Hampton Visitor Center
- Hotels near St. George United Methodist Church
- Hotels near I.P. Stanback Museum & Planetarium
- Hotels near Santee Indian Mound and Fort Watson Site
- Hotels near Jennie J McMahan Library
Cities near Orangeburg
- Columbia Hotels (36.93 mi)
- Lexington Hotels (40.26 mi)
- Santee Hotels (21.85 mi)
- West Columbia Hotels (36.84 mi)
- Coastal South Carolina Hotels (54.63 mi)
- St. George Hotels (26.68 mi)
- Summerton Hotels (30.12 mi)
- Leesville Hotels (47.81 mi)
- Southeastern United States Hotels (191.02 mi)
- The Carolinas Hotels (116.83 mi)
- Eutawville Hotels (30.13 mi)
- Gaston Hotels (26.52 mi)
- Barnwell Hotels (34.36 mi)
- Hopkins Hotels (28.51 mi)
- Saint Matthews Hotels (12.76 mi)
- Holly Hill Hotels (28.25 mi)
- Bamberg Hotels (16.96 mi)
- Elloree Hotels (16.52 mi)
- Vance Hotels (25.25 mi)
- Harleyville Hotels (30.34 mi)