Search Deals on
Otay Mesa Vacation Packages

Otay Mesa Flight + Hotel packages

Price found within the past 48 hours. Click for updated prices.
Hampton Inn & Suites San Diego Seaworld

Hampton Inn & Suites San Diego Seaworld

2.5 out of 5
Point Loma
Save 100% on your flight
per person
Oct 8 - Oct 13
found 1 day ago
Roundtrip non-stop flight included
Atlanta (ATL) to San Diego (SAN)
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and a fitness center. Popular attractions Mission Bay and Mission Beach are located nearby.
Sentral Gaslamp Quarter

Sentral Gaslamp Quarter

3 out of 5
Downtown San Diego
Save 100% on your flight
per person
Oct 8 - Oct 13
found 1 day ago
Roundtrip non-stop flight included
Atlanta (ATL) to San Diego (SAN)
Stay at this 3-star hotel in San Diego. Enjoy free WiFi, a rooftop terrace, and a 24-hour fitness center. Popular attractions Petco Park and Port of San Diego are located nearby.
Roam and Board

Roam and Board

2 out of 5
Save 100% on your flight
per person
Sep 25 - Sep 29
found 11 hours ago
Roundtrip flight included
Dallas (DFW) to San Diego (SAN)
Book a stay at this golf campground in San Diego. Enjoy free WiFi, free parking, and a beach locale. Popular attractions Mission Bay and Mission Beach are located nearby.
Margaritaville Hotel San Diego Gaslamp Quarter

Margaritaville Hotel San Diego Gaslamp Quarter

4 out of 5
Downtown San Diego
Save 100% on your flight
per person
Oct 8 - Oct 13
found 1 day ago
Roundtrip non-stop flight included
Atlanta (ATL) to San Diego (SAN)
Stay at this 4-star hotel in San Diego. Enjoy a rooftop terrace, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Petco Park and Port of San Diego are located nearby.
The Sofia Hotel

The Sofia Hotel

3.5 out of 5
Downtown San Diego
Save 100% on your flight
per person
Oct 8 - Oct 13
found 1 day ago
Roundtrip non-stop flight included
Atlanta (ATL) to San Diego (SAN)
Stay at this 3.5-star historic hotel in San Diego. Enjoy free WiFi, room service, and a 24-hour fitness center. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Port of San Diego and USS Midway Museum are located nearby.
Bahia Resort Hotel

Bahia Resort Hotel

3.5 out of 5
Central Mission Beach
Save 100% on your flight
per person
Oct 3 - Oct 10
found 1 day ago
Roundtrip non-stop flight included
Portland (PDX) to San Diego (SAN)
Stay at this 3.5-star beach resort in San Diego. Enjoy a beach locale, breakfast (surcharge), and 24-hour room service. Our guests praise the pool and the restaurant in our reviews. Popular attractions Mission Beach and Mission Bay are located nearby.
The Beau Downtown San Diego Gaslamp Quar

The Beau Downtown San Diego Gaslamp Quar

3 out of 5
Downtown San Diego
Save 100% on your flight
per person
Oct 8 - Oct 13
found 1 day ago
Roundtrip non-stop flight included
Atlanta (ATL) to San Diego (SAN)
Stay at this 3-star hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and parking (surcharge). Popular attractions Petco Park and Port of San Diego are located nearby.
The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
Save 100% on your flight
per person
Oct 8 - Oct 13
found 1 day ago
Roundtrip non-stop flight included
Atlanta (ATL) to San Diego (SAN)
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in our reviews. Popular attractions Mission Beach and Mission Bay are located nearby.

3-4 Night Vacations in Otay Mesa

Price found within the past 48 hours. Click for updated prices.
Hampton Inn & Suites San Diego Seaworld

Hampton Inn & Suites San Diego Seaworld

2.5 out of 5
Point Loma
per person
Sep 19 - Sep 22
found 15 hours ago
Roundtrip flight included
Atlanta (ATL) to San Diego (SAN)
Roam and Board

Roam and Board

2 out of 5
Save 100% on your flight
per person
Sep 25 - Sep 29
found 11 hours ago
Roundtrip flight included
Dallas (DFW) to San Diego (SAN)
Margaritaville Hotel San Diego Gaslamp Quarter

Margaritaville Hotel San Diego Gaslamp Quarter

4 out of 5
Downtown San Diego
Save 100% on your flight
per person
Oct 9 - Oct 13
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to San Diego (SAN)
Sentral Gaslamp Quarter

Sentral Gaslamp Quarter

3 out of 5
Downtown San Diego
Save 100% on your flight
per person
Oct 9 - Oct 13
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to San Diego (SAN)

5-7 Night Vacations in Otay Mesa

Price found within the past 48 hours. Click for updated prices.
Hampton Inn & Suites San Diego Seaworld

Hampton Inn & Suites San Diego Seaworld

2.5 out of 5
Point Loma
Save 100% on your flight
per person
Oct 8 - Oct 13
found 1 day ago
Roundtrip non-stop flight included
Atlanta (ATL) to San Diego (SAN)
Sentral Gaslamp Quarter

Sentral Gaslamp Quarter

3 out of 5
Downtown San Diego
Save 100% on your flight
per person
Oct 8 - Oct 13
found 1 day ago
Roundtrip non-stop flight included
Atlanta (ATL) to San Diego (SAN)
Margaritaville Hotel San Diego Gaslamp Quarter

Margaritaville Hotel San Diego Gaslamp Quarter

4 out of 5
Downtown San Diego
Save 100% on your flight
per person
Oct 8 - Oct 13
found 1 day ago
Roundtrip non-stop flight included
Atlanta (ATL) to San Diego (SAN)
The Sofia Hotel

The Sofia Hotel

3.5 out of 5
Downtown San Diego
Save 100% on your flight
per person
Oct 8 - Oct 13
found 1 day ago
Roundtrip non-stop flight included
Atlanta (ATL) to San Diego (SAN)

Cheap Hotel Deals in Otay Mesa

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

2.5 out of 5
2296 Niels Bohr Ct, San Diego, CA
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl, San Diego, CA
Stay at this 4-star eco-certified hotel in San Diego. Enjoy free WiFi, 6 restaurants, and 3 bars/lounges. Our guests praise the pool and the bar in our reviews. ...
Manchester Grand Hyatt San Diego
The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr, San Diego, CA
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in ...
The Dana on Mission Bay
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive, San Diego, CA
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
Wyndham San Diego Bayside
Hyatt Regency Mission Bay Spa and Marina

Hyatt Regency Mission Bay Spa and Marina

4 out of 5
1441 Quivira Rd, San Diego, CA
Stay at this 4-star spa hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...
Hyatt Regency Mission Bay Spa and Marina
Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N, San Diego, CA
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the bar in our ...
Handlery Hotel
Embassy Suites by Hilton San Diego Bay Downtown

Embassy Suites by Hilton San Diego Bay Downtown

4 out of 5
601 Pacific Hwy, San Diego, CA
Book a stay at this family-friendly hotel in San Diego. Enjoy free breakfast, room service, and a fitness center. Our guests praise the breakfast and the helpful ...
Embassy Suites by Hilton San Diego Bay Downtown
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

3 out of 5
1617 1st Avenue, San Diego, CA
Stay at this 3-star business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
The DEXTRO Little Italy, BW Premier Collection
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Flight Deals

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Alaska Airlines
Tue, Sep 2 - Tue, Sep 9
SFO
San Francisco Intl.
SAN
San Diego Intl.
$77 Roundtrip, found 2 days ago
$77
Roundtrip
found 2 days ago
Select Alaska Airlines flight, departing Tue, Sep 2 from San Francisco Intl. to San Diego Intl., returning Tue, Sep 9, priced at $77 found 2 days ago
Frontier Airlines
Tue, Oct 14 - Wed, Oct 15
DEN
Denver Intl.
SAN
San Diego Intl.
$108 Roundtrip, found 4 days ago
$108
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Tue, Oct 14 from Denver Intl. to San Diego Intl., returning Wed, Oct 15, priced at $108 found 4 days ago
Spirit Airlines
Sat, Sep 6 - Wed, Sep 10
ORD
O'Hare Intl.
SAN
San Diego Intl.
$109 Roundtrip, found 1 day ago
$109
Roundtrip
found 1 day ago
Select Spirit Airlines flight, departing Sat, Sep 6 from O'Hare Intl. to San Diego Intl., returning Wed, Sep 10, priced at $109 found 1 day ago
Spirit Airlines
Wed, Sep 17 - Sat, Sep 20
DFW
Dallas-Fort Worth Intl.
SAN
San Diego Intl.
$112 Roundtrip, found 5 days ago
$112
Roundtrip
found 5 days ago
Select Spirit Airlines flight, departing Wed, Sep 17 from Dallas-Fort Worth Intl. to San Diego Intl., returning Sat, Sep 20, priced at $112 found 5 days ago