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Otay Mesa Vacation Packages

Otay Mesa Flight + Hotel packages

Price found within the past 48 hours. Click for updated prices.
Sycuan Casino Resort

Sycuan Casino Resort

4 out of 5
Save 100% on your flight
per person
May 17 - May 24
found 1 day ago
Roundtrip non-stop flight included
New York (NYC) to San Diego (SAN)
Stay at this 4-star spa hotel in El Cajon. Enjoy free WiFi, free parking, and 3 outdoor pools. Our guests praise the pool and the helpful staff in our reviews. Popular attractions Sycuan Casino and Singing Hills Country Club - Willow Glen Course are located nearby.
Alma San Diego Downtown, a Tribute Portfolio Hotel

Alma San Diego Downtown, a Tribute Portfolio Hotel

4 out of 5
Downtown San Diego
Save 100% on your flight
per person
May 23 - May 27
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to San Diego (SAN)
Stay at this 4-star boutique hotel in San Diego. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the helpful staff in our reviews. Popular attractions Petco Park and Port of San Diego are located nearby.
Hyatt Vacation Club at The Welk, San Diego Area

Hyatt Vacation Club at The Welk, San Diego Area

3.5 out of 5
Lawrence Welk Resort Village
Save 100% on your flight
per person
May 17 - May 24
found 1 day ago
Roundtrip non-stop flight included
New York (NYC) to San Diego (SAN)
Book a stay at this spa hotel in Escondido. Enjoy free parking, 8 outdoor pools, and a full-service spa. Our guests praise the pool and the clean rooms in our reviews. Popular attractions The Oaks Course and Cal-a-vie are located nearby.
Kona Kai San Diego

Kona Kai San Diego

4 out of 5
Point Loma
per person
May 23 - May 27
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to San Diego (SAN)
Stay at this 4-star beach hotel in San Diego. Enjoy free WiFi, 2 outdoor pools, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular attractions Coronado Beach and USS Midway Museum are located nearby.
Margaritaville Hotel San Diego Gaslamp Quarter

Margaritaville Hotel San Diego Gaslamp Quarter

4 out of 5
Downtown San Diego
per person
May 23 - May 27
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to San Diego (SAN)
Stay at this 4-star hotel in San Diego. Enjoy a rooftop terrace, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Petco Park and Port of San Diego are located nearby.
The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
per person
May 23 - May 27
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to San Diego (SAN)
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in our reviews. Popular attractions Mission Beach and Mission Bay are located nearby.
Pala Casino Spa And Resort

Pala Casino Spa And Resort

4 out of 5
Save 100% on your flight
per person
May 17 - May 24
found 1 day ago
Roundtrip non-stop flight included
New York (NYC) to San Diego (SAN)
Stay at this 4-star hotel in Pala. Enjoy an outdoor pool, a casino, and a 24-hour front desk. Our guests praise the bar and the helpful staff in our reviews. Popular attractions Pala Casino Spa Resort and Pala Casino Spa & Resort are located nearby.
The Sofia Hotel

The Sofia Hotel

3.5 out of 5
Downtown San Diego
per person
May 23 - May 27
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to San Diego (SAN)
Stay at this 3.5-star spa hotel in San Diego. Enjoy free WiFi, a full-service spa, and room service. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Port of San Diego and USS Midway Museum are located nearby.

3-4 Night Vacations in Otay Mesa

Price found within the past 48 hours. Click for updated prices.
Alma San Diego Downtown, a Tribute Portfolio Hotel

Alma San Diego Downtown, a Tribute Portfolio Hotel

4 out of 5
Downtown San Diego
per person
May 8 - May 11
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to San Diego (SAN)
Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
Harbor Island
per person
May 8 - May 11
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to San Diego (SAN)
Kona Kai San Diego

Kona Kai San Diego

4 out of 5
Point Loma
per person
May 8 - May 11
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to San Diego (SAN)
City24 Hotel Little Italy Mission Hill

City24 Hotel Little Italy Mission Hill

4.5 out of 5
Middletown
per person
May 8 - May 11
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to San Diego (SAN)

5-7 Night Vacations in Otay Mesa

Price found within the past 48 hours. Click for updated prices.
Hyatt Vacation Club at The Welk, San Diego Area

Hyatt Vacation Club at The Welk, San Diego Area

3.5 out of 5
Lawrence Welk Resort Village
Save 100% on your flight
per person
May 17 - May 24
found 1 day ago
Roundtrip non-stop flight included
New York (NYC) to San Diego (SAN)
Bahia Resort Hotel

Bahia Resort Hotel

3.5 out of 5
Central Mission Beach
Save 100% on your flight
per person
May 17 - May 24
found 1 day ago
Roundtrip non-stop flight included
New York (NYC) to San Diego (SAN)
Paradise Point Resort & Spa

Paradise Point Resort & Spa

4 out of 5
Save 100% on your flight
per person
May 17 - May 24
found 1 day ago
Roundtrip non-stop flight included
New York (NYC) to San Diego (SAN)
Humphreys Half Moon Inn

Humphreys Half Moon Inn

3.5 out of 5
Point Loma
Save 100% on your flight
per person
May 17 - May 24
found 1 day ago
Roundtrip non-stop flight included
New York (NYC) to San Diego (SAN)

Cheap Hotel Deals in Otay Mesa

Best Western Inn & Suites San Diego – Zoo/SeaWorld Area

Best Western Inn & Suites San Diego – Zoo/SeaWorld Area

2.5 out of 5
2485 Hotel Circle Place, San Diego, CA
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N, San Diego, CA
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the bar in our reviews. ...
Handlery Hotel
The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr, San Diego, CA
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in ...
The Dana on Mission Bay
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Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive, San Diego, CA
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
Wyndham San Diego Bayside
San Diego Mission Bay Resort

San Diego Mission Bay Resort

4 out of 5
1775 E Mission Bay Dr, San Diego, CA
Book a stay at this beach hotel in San Diego. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the pool and the helpful staff in our ...
San Diego Mission Bay Resort
Best Western Seven Seas

Best Western Seven Seas

3 out of 5
411 Hotel Circle South, San Diego, CA
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, free parking, and 2 hot tubs. Our guests praise the pool and the restaurant in our ...
Best Western Seven Seas
Hyatt Regency Mission Bay Spa and Marina

Hyatt Regency Mission Bay Spa and Marina

4 out of 5
1441 Quivira Rd, San Diego, CA
Stay at this 4-star spa hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...
Hyatt Regency Mission Bay Spa and Marina
Loews Coronado Bay Resort

Loews Coronado Bay Resort

4 out of 5
4000 Coronado Bay Rd, Coronado, CA
Stay at this 4-star beach hotel in Coronado. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...
Loews Coronado Bay Resort
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Flight Deals

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Spirit Airlines
Tue, Apr 22 - Wed, Apr 30
PDX
Portland Intl.
SAN
San Diego Intl.
$66 Roundtrip, found 2 days ago
$66
Roundtrip
found 2 days ago
Select Spirit Airlines flight, departing Tue, Apr 22 from Portland Intl. to San Diego Intl., returning Wed, Apr 30, priced at $66 found 2 days ago
Hawaiian Airlines
Wed, Apr 2 - Tue, Apr 8
SFO
San Francisco Intl.
SAN
San Diego Intl.
$67 Roundtrip, found 5 days ago
$67
Roundtrip
found 5 days ago
Select Hawaiian Airlines flight, departing Wed, Apr 2 from San Francisco Intl. to San Diego Intl., returning Tue, Apr 8, priced at $67 found 5 days ago
Spirit Airlines
Sat, Apr 26 - Tue, Apr 29
DFW
Dallas-Fort Worth Intl.
SAN
San Diego Intl.
$93 Roundtrip, found 2 days ago
$93
Roundtrip
found 2 days ago
Select Spirit Airlines flight, departing Sat, Apr 26 from Dallas-Fort Worth Intl. to San Diego Intl., returning Tue, Apr 29, priced at $93 found 2 days ago
Spirit Airlines
Wed, May 28 - Wed, Jun 4
SEA
Seattle - Tacoma Intl.
SAN
San Diego Intl.
$102 Roundtrip, found 1 day ago
$102
Roundtrip
found 1 day ago
Select Spirit Airlines flight, departing Wed, May 28 from Seattle - Tacoma Intl. to San Diego Intl., returning Wed, Jun 4, priced at $102 found 1 day ago