Search Deals onOtay Mesa Vacation Packages
Otay Mesa Flight + Hotel packages
Price found within the past 48 hours. Click for updated prices.

Americas Best Value Inn Loma Lodge
Point Loma
per person
Jun 6 - Jun 10
found 1 day ago
Roundtrip flight included
Chicago (ORD) to San Diego (SAN)
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Mission Bay and Port of San Diego are located nearby.

Big Motel Chula Vista
per person
Jun 13 - Jun 21
found 1 day ago
Roundtrip flight included
Chicago (ORD) to San Diego (SAN)
Stay at this hotel in Chula Vista. Enjoy free WiFi, free parking, and room service. Our guests praise the helpful staff in our reviews. Popular attractions Petco Park and Hotel del Coronado are located nearby.

Alma San Diego Downtown, a Tribute Portfolio Hotel
Downtown San Diego
Save 100% on your flight
per person
Jun 6 - Jun 10
found 1 day ago
Roundtrip flight included
Chicago (ORD) to San Diego (SAN)
Stay at this 4-star boutique hotel in San Diego. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the helpful staff in our reviews. Popular attractions Petco Park and Port of San Diego are located nearby.

The Sofia Hotel
Downtown San Diego
per person
May 30 - Jun 3
found 1 day ago
Roundtrip non-stop flight included
Chicago (ORD) to San Diego (SAN)
Stay at this 3.5-star spa hotel in San Diego. Enjoy free WiFi, a full-service spa, and room service. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Port of San Diego and USS Midway Museum are located nearby.

Estancia La Jolla Hotel & Spa
La Jolla Farms
Save 100% on your flight
per person
Jun 7 - Jun 12
found 15 hours ago
Roundtrip non-stop flight included
New Orleans (MSY) to San Diego (SAN)
Stay at this 4-star spa hotel in La Jolla. Enjoy a full-service spa, 4 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Torrey Pines Golf Course and La Jolla Beach are located nearby.

Porto Vista Hotel Downtown
Downtown San Diego
per person
May 29 - Jun 2
found 11 hours ago
Roundtrip non-stop flight included
Chicago (ORD) to San Diego (SAN)
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Port of San Diego and USS Midway Museum are located nearby.

Sand Castle Inn
per person
Jun 6 - Jun 10
found 1 day ago
Roundtrip flight included
Chicago (ORD) to San Diego (SAN)
Book a stay at this beach motel in Imperial Beach. Enjoy free WiFi, free parking, and laundry facilities. Our guests praise the helpful staff in our reviews. Popular attractions Las Americas Premium Outlets and Imperial Beach are located nearby.

Hotel Palmeras Chula Vista
per person
Jun 6 - Jun 10
found 1 day ago
Roundtrip flight included
Chicago (ORD) to San Diego (SAN)
Stay at this hotel in Chula Vista. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Petco Park and Hotel del Coronado are located nearby.
3-4 Night Vacations in Otay Mesa
Price found within the past 48 hours. Click for updated prices.



5-7 Night Vacations in Otay Mesa
Price found within the past 48 hours. Click for updated prices.



Cheap Hotel Deals in Otay Mesa

Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
2485 Hotel Circle Place, San Diego, CA
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...

San Diego Mission Bay Resort
1775 E Mission Bay Dr, San Diego, CA
Book a stay at this beach hotel in San Diego. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the pool and the helpful staff in our ...

Wyndham San Diego Bayside
1355 N Harbor Drive, San Diego, CA
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
Save an average of 15% on thousands of hotels when you're signed in

The Dana on Mission Bay
1710 W Mission Bay Dr, San Diego, CA
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in ...

Handlery Hotel
950 Hotel Cir N, San Diego, CA
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the bar in our reviews. ...

Hilton San Diego Mission Valley
901 Camino Del Rio S, San Diego, CA
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and 24-hour room service. Our guests praise the helpful staff ...

Paradise Point Resort & Spa
1404 Vacation Rd, San Diego, CA
Book a stay at this beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...

Lafayette Hotel & Club
2223 El Cajon Blvd, San Diego, CA
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 3 bars/lounges. Our guests praise the helpful staff in our reviews. ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Flight Deals
Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Tue, Jul 22 - Fri, Jul 25
SFO
San Francisco Intl.
SAN
San Diego Intl.
$57 Roundtrip, found 1 day ago
$57
Roundtrip
found 1 day ago

Wed, May 21 - Wed, May 28
PDX
Portland Intl.
SAN
San Diego Intl.
$94 Roundtrip, found 4 days ago
$94
Roundtrip
found 4 days ago

Wed, May 14 - Sat, May 17
DEN
Denver Intl.
SAN
San Diego Intl.
$98 Roundtrip, found 6 days ago
$98
Roundtrip
found 6 days ago

Tue, May 27 - Tue, Jun 3
SEA
Seattle - Tacoma Intl.
SAN
San Diego Intl.
$141 Roundtrip, found 1 hour ago
$141
Roundtrip
found 1 hour ago
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