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Otay Mesa Vacation Packages

Otay Mesa Flight + Hotel packages

Price found within the past 48 hours. Click for updated prices.
Americas Best Value Inn Loma Lodge

Americas Best Value Inn Loma Lodge

2 out of 5
Point Loma
per person
Jun 6 - Jun 10
found 1 day ago
Roundtrip flight included
Chicago (ORD) to San Diego (SAN)
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Mission Bay and Port of San Diego are located nearby.
Big Motel Chula Vista

Big Motel Chula Vista

2.5 out of 5
per person
Jun 13 - Jun 21
found 1 day ago
Roundtrip flight included
Chicago (ORD) to San Diego (SAN)
Stay at this hotel in Chula Vista. Enjoy free WiFi, free parking, and room service. Our guests praise the helpful staff in our reviews. Popular attractions Petco Park and Hotel del Coronado are located nearby.
Alma San Diego Downtown, a Tribute Portfolio Hotel

Alma San Diego Downtown, a Tribute Portfolio Hotel

4 out of 5
Downtown San Diego
Save 100% on your flight
per person
Jun 6 - Jun 10
found 1 day ago
Roundtrip flight included
Chicago (ORD) to San Diego (SAN)
Stay at this 4-star boutique hotel in San Diego. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the helpful staff in our reviews. Popular attractions Petco Park and Port of San Diego are located nearby.
The Sofia Hotel

The Sofia Hotel

3.5 out of 5
Downtown San Diego
per person
May 30 - Jun 3
found 1 day ago
Roundtrip non-stop flight included
Chicago (ORD) to San Diego (SAN)
Stay at this 3.5-star spa hotel in San Diego. Enjoy free WiFi, a full-service spa, and room service. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Port of San Diego and USS Midway Museum are located nearby.
Estancia La Jolla Hotel & Spa

Estancia La Jolla Hotel & Spa

4 out of 5
La Jolla Farms
Save 100% on your flight
per person
Jun 7 - Jun 12
found 15 hours ago
Roundtrip non-stop flight included
New Orleans (MSY) to San Diego (SAN)
Stay at this 4-star spa hotel in La Jolla. Enjoy a full-service spa, 4 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Torrey Pines Golf Course and La Jolla Beach are located nearby.
Porto Vista Hotel Downtown

Porto Vista Hotel Downtown

3.5 out of 5
Downtown San Diego
per person
May 29 - Jun 2
found 11 hours ago
Roundtrip non-stop flight included
Chicago (ORD) to San Diego (SAN)
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Port of San Diego and USS Midway Museum are located nearby.
Sand Castle Inn

Sand Castle Inn

2.5 out of 5
per person
Jun 6 - Jun 10
found 1 day ago
Roundtrip flight included
Chicago (ORD) to San Diego (SAN)
Book a stay at this beach motel in Imperial Beach. Enjoy free WiFi, free parking, and laundry facilities. Our guests praise the helpful staff in our reviews. Popular attractions Las Americas Premium Outlets and Imperial Beach are located nearby.
Hotel Palmeras Chula Vista

Hotel Palmeras Chula Vista

2 out of 5
per person
Jun 6 - Jun 10
found 1 day ago
Roundtrip flight included
Chicago (ORD) to San Diego (SAN)
Stay at this hotel in Chula Vista. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Petco Park and Hotel del Coronado are located nearby.

3-4 Night Vacations in Otay Mesa

Price found within the past 48 hours. Click for updated prices.
Americas Best Value Inn Loma Lodge

Americas Best Value Inn Loma Lodge

2 out of 5
Point Loma
per person
Jun 6 - Jun 10
found 1 day ago
Roundtrip flight included
Chicago (ORD) to San Diego (SAN)
Porto Vista Hotel Downtown

Porto Vista Hotel Downtown

3.5 out of 5
Downtown San Diego
per person
May 29 - Jun 2
found 11 hours ago
Roundtrip non-stop flight included
Chicago (ORD) to San Diego (SAN)
Sand Castle Inn

Sand Castle Inn

2.5 out of 5
per person
Jun 6 - Jun 10
found 1 day ago
Roundtrip flight included
Chicago (ORD) to San Diego (SAN)
The Arthur

The Arthur

2 out of 5
Downtown San Diego
per person
Jun 25 - Jun 28
found 12 hours ago
Roundtrip flight included
Chicago (ORD) to San Diego (SAN)

5-7 Night Vacations in Otay Mesa

Price found within the past 48 hours. Click for updated prices.
Pala Casino Spa And Resort

Pala Casino Spa And Resort

4 out of 5
Save 100% on your flight
per person
Jun 4 - Jun 10
found 1 day ago
Roundtrip non-stop flight included
Chicago (ORD) to San Diego (SAN)
Estancia La Jolla Hotel & Spa

Estancia La Jolla Hotel & Spa

4 out of 5
La Jolla Farms
Save 100% on your flight
per person
Jun 7 - Jun 12
found 15 hours ago
Roundtrip non-stop flight included
New Orleans (MSY) to San Diego (SAN)
The Sofia Hotel

The Sofia Hotel

3.5 out of 5
Downtown San Diego
Save 100% on your flight
per person
Jun 2 - Jun 7
found 1 day ago
Roundtrip non-stop flight included
Chicago (ORD) to San Diego (SAN)
Staypineapple, Hotel Z, Gaslamp San Diego

Staypineapple, Hotel Z, Gaslamp San Diego

3 out of 5
Downtown San Diego
per person
Jun 2 - Jun 7
found 1 day ago
Roundtrip non-stop flight included
Chicago (ORD) to San Diego (SAN)

Cheap Hotel Deals in Otay Mesa

Best Western Inn & Suites San Diego – Zoo/SeaWorld Area

Best Western Inn & Suites San Diego – Zoo/SeaWorld Area

2.5 out of 5
2485 Hotel Circle Place, San Diego, CA
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
San Diego Mission Bay Resort

San Diego Mission Bay Resort

4 out of 5
1775 E Mission Bay Dr, San Diego, CA
Book a stay at this beach hotel in San Diego. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the pool and the helpful staff in our ...
San Diego Mission Bay Resort
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive, San Diego, CA
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
Wyndham San Diego Bayside
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The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr, San Diego, CA
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in ...
The Dana on Mission Bay
Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N, San Diego, CA
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the bar in our reviews. ...
Handlery Hotel
Hilton San Diego Mission Valley

Hilton San Diego Mission Valley

4 out of 5
901 Camino Del Rio S, San Diego, CA
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and 24-hour room service. Our guests praise the helpful staff ...
Hilton San Diego Mission Valley
Paradise Point Resort & Spa

Paradise Point Resort & Spa

4 out of 5
1404 Vacation Rd, San Diego, CA
Book a stay at this beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
Paradise Point Resort & Spa
Lafayette Hotel & Club

Lafayette Hotel & Club

4 out of 5
2223 El Cajon Blvd, San Diego, CA
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 3 bars/lounges. Our guests praise the helpful staff in our reviews. ...
Lafayette Hotel & Club
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Flight Deals

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Hawaiian Airlines
Tue, Jul 22 - Fri, Jul 25
SFO
San Francisco Intl.
SAN
San Diego Intl.
$57 Roundtrip, found 1 day ago
$57
Roundtrip
found 1 day ago
Select Hawaiian Airlines flight, departing Tue, Jul 22 from San Francisco Intl. to San Diego Intl., returning Fri, Jul 25, priced at $57 found 1 day ago
Spirit Airlines
Wed, May 21 - Wed, May 28
PDX
Portland Intl.
SAN
San Diego Intl.
$94 Roundtrip, found 4 days ago
$94
Roundtrip
found 4 days ago
Select Spirit Airlines flight, departing Wed, May 21 from Portland Intl. to San Diego Intl., returning Wed, May 28, priced at $94 found 4 days ago
Frontier Airlines
Wed, May 14 - Sat, May 17
DEN
Denver Intl.
SAN
San Diego Intl.
$98 Roundtrip, found 6 days ago
$98
Roundtrip
found 6 days ago
Select Frontier Airlines flight, departing Wed, May 14 from Denver Intl. to San Diego Intl., returning Sat, May 17, priced at $98 found 6 days ago
Spirit Airlines
Tue, May 27 - Tue, Jun 3
SEA
Seattle - Tacoma Intl.
SAN
San Diego Intl.
$141 Roundtrip, found 1 hour ago
$141
Roundtrip
found 1 hour ago
Select Spirit Airlines flight, departing Tue, May 27 from Seattle - Tacoma Intl. to San Diego Intl., returning Tue, Jun 3, priced at $141 found 1 hour ago