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4 Star Hotels in South Houston

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Featured 4 Star South Houston Hotels

DoubleTree by Hilton Hotel & Suites Houston by the Galleria
4 out of 5
Fully refundableReserve now, pay when you stay
  • 6 min drive from MD Anderson Cancer Center
The price is $151 per night from Mar 3 to Mar 4
$151
includes taxes & fees
Mar 3 - Mar 4
Stay at this hotel in Houston. Enjoy free WiFi, an outdoor pool, and breakfast (surcharge). Our guests praise the helpful staff and the clean rooms in our reviews. ...
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
Blossom Hotel Houston
4 out of 5
Fully refundableReserve now, pay when you stay
  • 12 min walk from MD Anderson Cancer Center
The price is $161 per night from Mar 5 to Mar 6
$161
includes taxes & fees
Mar 5 - Mar 6
Stay at this 4-star spa hotel in Houston. Enjoy free WiFi, a full-service spa, and 2 bars/lounges. Our guests praise the pool and the helpful staff in our reviews. ...
Blossom Hotel Houston
Club Quarters Hotel Downtown, Houston
4 out of 5
Fully refundableReserve now, pay when you stay
  • 9 min drive from MD Anderson Cancer Center
The price is $137 per night from Feb 4 to Feb 5
$137
includes taxes & fees
Feb 4 - Feb 5
Stay at this 4-star business-friendly hotel in Houston. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the restaurant and the helpful ...
Club Quarters Hotel Downtown, Houston
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C. Baldwin, Curio Collection by Hilton
4 out of 5
Fully refundableReserve now, pay when you stay
  • 9 min drive from MD Anderson Cancer Center
The price is $223 per night from Feb 8 to Feb 9
$223
includes taxes & fees
Feb 8 - Feb 9
Stay at this 4-star hotel in Houston. Enjoy breakfast (surcharge), a free area shuttle, and a 24-hour fitness center. Our guests praise the helpful staff and ...
C. Baldwin, Curio Collection by Hilton
The Westin Galleria Houston
4.5 out of 5
Fully refundableReserve now, pay when you stay
  • 5 min drive from MD Anderson Cancer Center
The price is $332 per night from Feb 21 to Feb 22
$332
includes taxes & fees
Feb 21 - Feb 22
Book a stay at this eco-certified hotel in Houston. Enjoy free parking, breakfast (surcharge), and room service. Our guests praise the helpful staff and the ...
The Westin Galleria Houston
The Whitehall Houston
4 out of 5
  • 8 min drive from MD Anderson Cancer Center
The price is $167 per night from Feb 8 to Feb 9
$167
includes taxes & fees
Feb 8 - Feb 9
Stay at this 4-star business-friendly hotel in Houston. Enjoy free WiFi, breakfast (surcharge), and a free area shuttle. Our guests praise the helpful staff ...
The Whitehall Houston
Omni Houston Hotel
4 out of 5
Fully refundableReserve now, pay when you stay
  • 9 min drive from MD Anderson Cancer Center
The price is $194 per night from Feb 28 to Mar 1
$194
includes taxes & fees
Feb 28 - Mar 1
Book a stay at this spa hotel in Houston. Enjoy 2 outdoor pools, a full-service spa, and 3 bars/lounges. Our guests praise the helpful staff and the property ...
Omni Houston Hotel
Hilton Houston Westchase
4 out of 5
Fully refundableReserve now, pay when you stay
  • 6 min drive from MD Anderson Cancer Center
The price is $116 per night from Feb 7 to Feb 8
$116
includes taxes & fees
Feb 7 - Feb 8
Stay at this 4-star business-friendly hotel in Houston. Enjoy free parking, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
Hilton Houston Westchase
Hyatt Regency Houston/Galleria
4 out of 5
Fully refundableReserve now, pay when you stay
  • 5 min drive from MD Anderson Cancer Center
The price is $187 per night from Feb 16 to Feb 17
$187
includes taxes & fees
Feb 16 - Feb 17
Stay at this 4-star business-friendly hotel in Houston. Enjoy free WiFi, 2 bars/lounges, and breakfast (surcharge). Our guests praise the helpful staff and the ...
Hyatt Regency Houston/Galleria
Hilton Americas-Houston
4 out of 5
Fully refundableReserve now, pay when you stay
  • 7 min drive from MD Anderson Cancer Center
The price is $227 per night from Feb 21 to Feb 22
$227
includes taxes & fees
Feb 21 - Feb 22
Stay at this 4-star spa hotel in Houston. Enjoy a full-service spa, 2 restaurants, and 3 bars/lounges. Our guests praise the helpful staff and the clean rooms ...
Hilton Americas-Houston
Marriott Marquis Houston
4 out of 5
Fully refundableReserve now, pay when you stay
  • 8 min drive from MD Anderson Cancer Center
The price is $394 per night from Feb 27 to Feb 28
$394
includes taxes & fees
Feb 27 - Feb 28
Stay at this 4-star spa hotel in Houston. Enjoy 2 outdoor pools, a full-service spa, and 4 restaurants. Our guests praise the pool and the helpful staff in our ...
Marriott Marquis Houston
DoubleTree by Hilton Houston Medical Center Hotel & Suites
4 out of 5
Fully refundableReserve now, pay when you stay
  • 2 min walk from MD Anderson Cancer Center
The price is $148 per night from Feb 9 to Feb 10
$148
includes taxes & fees
Feb 9 - Feb 10
Book a stay at this business-friendly hotel in Houston. Enjoy free WiFi, breakfast (surcharge), and a free area shuttle. Our guests praise the helpful staff ...
DoubleTree by Hilton Houston Medical Center Hotel & Suites
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

4-star hotels in South Houston

When you want to live it up, but not bust your bank account, then there’s nothing better than a 4-star hotel in South Houston for your next trip. You’ll get all the amenities you can think of (and then some) at a rate within your means.

No fault in our stars

So what’s with the star rating anyway? Good question. The star rating has little to do with the price, and more to do with the amenities. 4-Star hotels in South Houston as well as everywhere else, usually have all those thoughtful touches that make you go “Ooh,” “Ahh,” and ”YES!” Think amenities like luxury bedding, high-end electronics, concierge service, and restaurants that make eating in a gourmet experience.

Stars that shine

You know there are as many underground spots, inviting lounges, memory-making music venues as there are stars in the sky. But you’ll need the funds to check them all off. That’s why we give you the chance to take us up on the Hotwire Hot Rate. You can snag South Houston 4-star hotels and still have plenty of leftover cash to paint the town whatever color you want. Filter hotels by:

  • Hotwire Hot Rate: We’ll snag you a crazy deal on a room by finding your hotel name after you book.
  • Price: You know that paying full price is for suckers? You can get a cheap 4-star hotel in South Houston starting at $116 per night.
  • Amenities: What makes you flip for your trip? Full-service spa? Heated pool? 24-hour room service? Get a hotel that’ll send you over the moon.

Do you deserve a swanky hotel with a ton of amenities? Yes, yes you do. And you also deserve a sweet deal on it. Book with Hotwire today and get that star-studded South Houston 4-star hotel and have plenty of cash left over to spend at that secret super star joint in the city.