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4 Star Hotels in South Houston

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Featured 4 Star South Houston Hotels

Club Quarters Hotel Downtown, Houston
4 out of 5
Fully refundableReserve now, pay when you stay
  • 9 min drive from MD Anderson Cancer Center
The price is $112 per night from Dec 16 to Dec 17
$112
includes taxes & fees
Dec 16 - Dec 17
Stay at this 4-star aparthotel in Houston. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the restaurant and the helpful staff in ...
Club Quarters Hotel Downtown, Houston
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
4 out of 5
Fully refundableReserve now, pay when you stay
  • 6 min drive from MD Anderson Cancer Center
The price is $135 per night from Dec 15 to Dec 16
$135
includes taxes & fees
Dec 15 - Dec 16
Stay at this hotel in Houston. Enjoy free WiFi, an outdoor pool, and breakfast (surcharge). Our guests praise the helpful staff and the clean rooms in our reviews. ...
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
Blossom Hotel Houston
4 out of 5
Fully refundableReserve now, pay when you stay
  • 12 min walk from MD Anderson Cancer Center
The price is $172 per night from Nov 17 to Nov 18
$172
includes taxes & fees
Nov 17 - Nov 18
Stay at this 4-star spa hotel in Houston. Enjoy free WiFi, a full-service spa, and 2 bars/lounges. Our guests praise the pool and the helpful staff in our reviews. ...
Blossom Hotel Houston
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The Whitehall Houston
4 out of 5
Fully refundableReserve now, pay when you stay
  • 8 min drive from MD Anderson Cancer Center
The price is $149 per night from Nov 24 to Nov 25
$149
includes taxes & fees
Nov 24 - Nov 25
Stay at this 4-star business-friendly hotel in Houston. Enjoy free WiFi, breakfast (surcharge), and a free area shuttle. Our guests praise the helpful staff ...
The Whitehall Houston
The Westin Oaks Houston at the Galleria
4 out of 5
Fully refundableReserve now, pay when you stay
  • 6 min drive from MD Anderson Cancer Center
The price is $284 per night from Dec 6 to Dec 7
$284
includes taxes & fees
Dec 6 - Dec 7
Book a stay at this business-friendly hotel in Houston. Enjoy free parking, breakfast (surcharge), and a 24-hour health club. Our guests praise the helpful staff ...
The Westin Oaks Houston at the Galleria
Hotel Zaza Houston Museum District
4.5 out of 5
Fully refundableReserve now, pay when you stay
  • 23 min walk from MD Anderson Cancer Center
The price is $350 per night from Nov 22 to Nov 23
$350
includes taxes & fees
Nov 22 - Nov 23
Book a stay at this luxury aparthotel in Houston. Enjoy free WiFi, a full-service spa, and a rooftop terrace. Our guests praise the helpful staff and the property ...
Hotel Zaza Houston Museum District
C. Baldwin, Curio Collection by Hilton
4 out of 5
Fully refundableReserve now, pay when you stay
  • 9 min drive from MD Anderson Cancer Center
The price is $214 per night from Dec 1 to Dec 2
$214
includes taxes & fees
Dec 1 - Dec 2
Stay at this hotel in Houston. Enjoy breakfast (surcharge), a free area shuttle, and a 24-hour fitness center. Our guests praise the helpful staff and the clean ...
C. Baldwin, Curio Collection by Hilton
Hilton Americas-Houston
4 out of 5
Fully refundableReserve now, pay when you stay
  • 7 min drive from MD Anderson Cancer Center
The price is $180 per night from Nov 26 to Nov 27
$180
includes taxes & fees
Nov 26 - Nov 27
Stay at this 4-star spa hotel in Houston. Enjoy a full-service spa, 2 restaurants, and 3 bars/lounges. Our guests praise the helpful staff and the clean rooms ...
Hilton Americas-Houston
The Westin Galleria Houston
4.5 out of 5
Fully refundableReserve now, pay when you stay
  • 5 min drive from MD Anderson Cancer Center
The price is $295 per night from Dec 6 to Dec 7
$295
includes taxes & fees
Dec 6 - Dec 7
Book a stay at this golf hotel in Houston. Enjoy free parking, breakfast (surcharge), and room service. Our guests praise the helpful staff and the clean rooms ...
The Westin Galleria Houston
The Laura Hotel, Houston Downtown, Autograph Collection
4.5 out of 5
Fully refundableReserve now, pay when you stay
  • 8 min drive from MD Anderson Cancer Center
The price is $224 per night from Nov 25 to Nov 26
$224
includes taxes & fees
Nov 25 - Nov 26
Stay at this 4.5-star luxury hotel in Houston. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the helpful staff and the clean ...
The Laura Hotel, Houston Downtown, Autograph Collection
Omni Houston Hotel
4 out of 5
Fully refundableReserve now, pay when you stay
  • 9 min drive from MD Anderson Cancer Center
The price is $175 per night from Dec 15 to Dec 16
$175
includes taxes & fees
Dec 15 - Dec 16
Book a stay at this spa aparthotel in Houston. Enjoy 2 outdoor pools, a full-service spa, and 3 bars/lounges. Our guests praise the helpful staff and the property ...
Omni Houston Hotel
Hyatt Regency Houston/Galleria
4 out of 5
Fully refundableReserve now, pay when you stay
  • 5 min drive from MD Anderson Cancer Center
The price is $187 per night from Nov 30 to Dec 1
$187
includes taxes & fees
Nov 30 - Dec 1
Stay at this 4-star business-friendly aparthotel in Houston. Enjoy free WiFi, 2 bars/lounges, and breakfast (surcharge). Our guests praise the helpful staff ...
Hyatt Regency Houston/Galleria
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

4-star hotels in South Houston

When you want to live it up, but not bust your bank account, then there’s nothing better than a 4-star hotel in South Houston for your next trip. You’ll get all the amenities you can think of (and then some) at a rate within your means.

No fault in our stars

So what’s with the star rating anyway? Good question. The star rating has little to do with the price, and more to do with the amenities. 4-Star hotels in South Houston as well as everywhere else, usually have all those thoughtful touches that make you go “Ooh,” “Ahh,” and ”YES!” Think amenities like luxury bedding, high-end electronics, concierge service, and restaurants that make eating in a gourmet experience.

Stars that shine

You know there are as many underground spots, inviting lounges, memory-making music venues as there are stars in the sky. But you’ll need the funds to check them all off. That’s why we give you the chance to take us up on the Hotwire Hot Rate. You can snag South Houston 4-star hotels and still have plenty of leftover cash to paint the town whatever color you want. Filter hotels by:

  • Hotwire Hot Rate: We’ll snag you a crazy deal on a room by finding your hotel name after you book.
  • Price: You know that paying full price is for suckers? You can get a cheap 4-star hotel in South Houston starting at $112 per night.
  • Amenities: What makes you flip for your trip? Full-service spa? Heated pool? 24-hour room service? Get a hotel that’ll send you over the moon.

Do you deserve a swanky hotel with a ton of amenities? Yes, yes you do. And you also deserve a sweet deal on it. Book with Hotwire today and get that star-studded South Houston 4-star hotel and have plenty of cash left over to spend at that secret super star joint in the city.