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Hotels in South Houston

Choose from 5826 South Houston Hotel Deals

Club Quarters Hotel Downtown, Houston
Club Quarters Hotel Downtown, Houston
4 out of 5
1085 Rusk Street, Houston, TX
  • 9 min drive from MD Anderson Cancer Center
The price is $125 per night from Apr 6 to Apr 7
$125
includes taxes & fees
Apr 6 - Apr 7
Stay at this 4-star business-friendly hotel in Houston. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the restaurant and the helpful ...
8.2/10 Very Good! (3,156 reviews)
"Good hotel, we had a refurbed room. Good little bistro that did great breakfast. No self parking - we used a nearby public garage. Despite being one block from main street the area didn't exactly feel safe. The garages all had active security guards and there were many vagrants."

Reviewed on Mar 22, 2025

Club Quarters Hotel Downtown, Houston
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
4 out of 5
5353 Westheimer Rd, Houston, TX
  • 6 min drive from MD Anderson Cancer Center
The price is $169 per night from Apr 4 to Apr 5
$169
includes taxes & fees
Apr 4 - Apr 5
Stay at this hotel in Houston. Enjoy free WiFi, an outdoor pool, and breakfast (surcharge). Our guests praise the helpful staff and the clean rooms in our reviews. ...
8/10 Very Good! (1,864 reviews)
"Our room was spacious and clean. The hotel overall was great and we will be returning."

Reviewed on Mar 22, 2025

DoubleTree by Hilton Hotel & Suites Houston by the Galleria
The Whitehall Houston
The Whitehall Houston
4 out of 5
1700 Smith St, Houston, TX
  • 8 min drive from MD Anderson Cancer Center
The price is $167 per night from Apr 6 to Apr 7
$167
includes taxes & fees
Apr 6 - Apr 7
Stay at this 4-star business-friendly hotel in Houston. Enjoy free WiFi, breakfast (surcharge), and a free area shuttle. Our guests praise the helpful staff ...
8.2/10 Very Good! (1,295 reviews)
"Property is showing wear, John front desk was amazingly kind"

Reviewed on Mar 22, 2025

The Whitehall Houston
Holiday Inn Houston Downtown by IHG
Holiday Inn Houston Downtown by IHG
3 out of 5
1616 Main St, Houston, TX
  • 8 min drive from MD Anderson Cancer Center
The price is $139 per night from Apr 7 to Apr 8
$139
includes taxes & fees
Apr 7 - Apr 8
Stay at this 3-star business-friendly hotel in Houston. Enjoy free WiFi, breakfast (surcharge), and a free area shuttle. Our guests praise the breakfast and ...
8.6/10 Excellent! (1,091 reviews)
"We had a fantastic stay! This was a great pick for us for location, convenience and also amenities! The free shuttle and breakfast was sooo appreciated. Wonderful and helpful staff! Highly recommend"

Reviewed on Mar 22, 2025

Holiday Inn Houston Downtown by IHG
Blossom Hotel Houston
Blossom Hotel Houston
4 out of 5
7118 Bertner Ave, Houston, TX
  • 12 min walk from MD Anderson Cancer Center
The price is $158 per night from Mar 30 to Mar 31
$158
includes taxes & fees
Mar 30 - Mar 31
Stay at this 4-star spa hotel in Houston. Enjoy free WiFi, a full-service spa, and 2 bars/lounges. Our guests praise the pool and the helpful staff in our reviews. ...
9/10 Wonderful! (3,177 reviews)
"The rooms were spotless and very clean. The fitness center was perfect too, they gave everything you need at this hotel."

Reviewed on Mar 21, 2025

Blossom Hotel Houston
The Royal Sonesta Houston Galleria
The Royal Sonesta Houston Galleria
4 out of 5
2222 West Loop South, Houston, TX
  • 6 min drive from MD Anderson Cancer Center
The price is $221 per night from Apr 11 to Apr 12
$221
includes taxes & fees
Apr 11 - Apr 12
Stay at this 4-star business-friendly hotel in Houston. Enjoy breakfast (surcharge), room service, and a 24-hour health club. Our guests praise the helpful staff ...
8.2/10 Very Good! (1,021 reviews)
"10/10. The only place I’ll be staying from now on when I need a staycation away from home."

Reviewed on Mar 21, 2025

The Royal Sonesta Houston Galleria
Hilton Americas-Houston
Hilton Americas-Houston
4 out of 5
1600 Lamar Street, Houston, TX
  • 7 min drive from MD Anderson Cancer Center
The price is $210 per night from Apr 5 to Apr 6
$210
includes taxes & fees
Apr 5 - Apr 6
Stay at this 4-star spa hotel in Houston. Enjoy a full-service spa, 2 restaurants, and 3 bars/lounges. Our guests praise the helpful staff and the clean rooms ...
9.2/10 Wonderful! (1,208 reviews)
"Convenient to Discovery Green"

Reviewed on Mar 21, 2025

Hilton Americas-Houston
Magnolia Hotel Houston, A Tribute Portfolio Hotel
Magnolia Hotel Houston, A Tribute Portfolio Hotel
4 out of 5
1100 Texas St, Houston, TX
  • 9 min drive from MD Anderson Cancer Center
The price is $145 per night from Mar 30 to Mar 31
$145
includes taxes & fees
Mar 30 - Mar 31
Stay at this 4-star business-friendly hotel in Houston. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the pool and the helpful ...
9/10 Wonderful! (1,006 reviews)
"Great stay. Room service was awesome!"

Reviewed on Mar 21, 2025

Magnolia Hotel Houston, A Tribute Portfolio Hotel
Hotel Zaza Houston Museum District
Hotel Zaza Houston Museum District
4.5 out of 5
5701 Main Street, Houston, TX
  • 23 min walk from MD Anderson Cancer Center
The price is $381 per night from Mar 27 to Mar 28
$381
includes taxes & fees
Mar 27 - Mar 28
Stay at this 4.5-star luxury aparthotel in Houston. Enjoy free WiFi, a full-service spa, and a rooftop terrace. Our guests praise the helpful staff and the property ...
8.8/10 Excellent! (1,617 reviews)
"Zaza customer service is top notch! There attention to detail is on point! Love staying here. Highly recommend this hotel!"

Reviewed on Mar 14, 2025

Hotel Zaza Houston Museum District
Houston Marriott Westchase
Houston Marriott Westchase
4 out of 5
2900 Briarpark Dr, Houston, TX
  • 6 min drive from MD Anderson Cancer Center
The price is $121 per night from Apr 5 to Apr 6
$121
includes taxes & fees
Apr 5 - Apr 6
Book a stay at this business-friendly hotel in Houston. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the ...
8/10 Very Good! (1,011 reviews)
"Staff were wonderful and quick to check in and help in any way asked. My only issue with this property in my 3 separate visits has been the air conditioning! Rooms feel humid and hot, day and night no matter how much you lower the AC. For this reason I will not be returning."

Reviewed on Mar 23, 2025

Houston Marriott Westchase
Wyndham Houston near NRG Park/Medical Center
Wyndham Houston near NRG Park/Medical Center
3.5 out of 5
8686 Kirby Drive, Houston, TX
  • 5 min drive from MD Anderson Cancer Center
Stay at this 3.5-star business-friendly hotel in Houston. Enjoy free WiFi, a 24-hour fitness center, and a 24-hour front desk. Our guests praise the helpful ...
7.2/10 Good! (1,025 reviews)
"Much more than I expected"

Reviewed on Mar 20, 2025

Wyndham Houston near NRG Park/Medical Center
C. Baldwin, Curio Collection by Hilton
C. Baldwin, Curio Collection by Hilton
4 out of 5
400 Dallas St, Houston, TX
  • 9 min drive from MD Anderson Cancer Center
The price is $223 per night from Apr 4 to Apr 5
$223
includes taxes & fees
Apr 4 - Apr 5
Stay at this 4-star hotel in Houston. Enjoy breakfast (surcharge), a free area shuttle, and a 24-hour fitness center. Our guests praise the helpful staff and ...
8.4/10 Very Good! (1,004 reviews)
"I had a fantastic stay! The staff were warm and welcoming from the moment I arrived. My room was spotless, comfortable, and had all the amenities I needed. The location was perfect—close to everything I wanted to explore. What really stood out was the attention to detail and excellent customer service ..."

Reviewed on Mar 21, 2025

C. Baldwin, Curio Collection by Hilton
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in South Houston

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