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5 Star Hotels in South Houston

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Featured 5 Star South Houston Hotels

The Post Oak Hotel at Uptown Houston
5 out of 5
Fully refundableReserve now, pay when you stay
  • 8 min drive from MD Anderson Cancer Center
The price is $653 per night from Dec 1 to Dec 2
$653
includes taxes & fees
Dec 1 - Dec 2
Stay at this 5-star luxury hotel in Houston. Enjoy free WiFi, a full-service spa, and 4 restaurants. Our guests praise the helpful staff and the room service ...
The Post Oak Hotel at Uptown Houston
Four Seasons Hotel Houston
5 out of 5
Fully refundableReserve now, pay when you stay
  • 8 min drive from MD Anderson Cancer Center
The price is $514 per night from Dec 1 to Dec 2
$514
includes taxes & fees
Dec 1 - Dec 2
Book a stay at this spa hotel in Houston. Enjoy free WiFi, a full-service spa, and 2 restaurants. Popular attractions Toyota Center and Minute Maid Park are ...
Four Seasons Hotel Houston
JW Marriott Houston Downtown
5 out of 5
Fully refundableReserve now, pay when you stay
  • 9 min drive from MD Anderson Cancer Center
The price is $247 per night from Nov 28 to Nov 29
$247
includes taxes & fees
Nov 28 - Nov 29
Stay at this 5-star luxury hotel in Houston. Enjoy a full-service spa, 24-hour room service, and a health club. Our guests praise the helpful staff and the clean ...
JW Marriott Houston Downtown
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The St. Regis Houston
5 out of 5
Fully refundableReserve now, pay when you stay
  • 7 min drive from MD Anderson Cancer Center
The price is $428 per night from Nov 25 to Nov 26
$428
includes taxes & fees
Nov 25 - Nov 26
Stay at this 5-star luxury hotel in Houston. Enjoy a full-service spa, breakfast (surcharge), and 24-hour room service. Popular attractions Houston Zoo and NRG ...
The St. Regis Houston
Hotel Granduca Houston
5 out of 5
Fully refundableReserve now, pay when you stay
  • 8 min drive from MD Anderson Cancer Center
The price is $455 per night from Dec 1 to Dec 2
$455
includes taxes & fees
Dec 1 - Dec 2
Stay at this 5-star luxury aparthotel in Houston. Enjoy free WiFi, breakfast (surcharge), and a free area shuttle. Our guests praise the helpful staff and the ...
Hotel Granduca Houston
La Colombe d'Or Hotel
5 out of 5
Fully refundableReserve now, pay when you stay
  • 6 min drive from MD Anderson Cancer Center
The price is $506 per night from Nov 29 to Nov 30
$506
includes taxes & fees
Nov 29 - Nov 30
Stay at this 5-star luxury hotel in Houston. Enjoy free WiFi, breakfast (surcharge), and 24-hour room service. Popular attractions Toyota Center and Houston ...
La Colombe d'Or Hotel
7550 Kirby Dr
5 out of 5
  • 13 min walk from MD Anderson Cancer Center
The price is $180 per night from Nov 17 to Nov 18
$180
includes taxes & fees
Nov 17 - Nov 18
Stay at this 5-star luxury apartment in Houston. Enjoy free WiFi, free parking, and private pools. Popular attractions NRG Stadium and Houston Zoo are located ...
7550 Kirby Dr
TUSCAN VILLA
5 out of 5
  • 5 min drive from MD Anderson Cancer Center
The price is $2,876 per night from Nov 16 to Nov 17
$2,876
includes taxes & fees
Nov 16 - Nov 17
Stay at this 5-star luxury villa in Houston. Enjoy free WiFi, free parking, and in-room massages. Popular attractions Houston Zoo and NRG Stadium are located ...
TUSCAN VILLA
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

5-Star Hotel in South Houston

It’s time. No more meh motels and so-so stays. This vacation it’s all about living it up, and that starts with a great hotel. You want first-class service and award-winning restaurants. Well, let us introduce you to a 5-star hotel in South Houston.

So nice you’ll blink twice

What makes a hotel worthy of supreme star-age? For starters, the service has to be top-notch and personalized. These hotels often have 24-hour room service, a welcome gift upon your arrival, and help you with your bags—even if you travel light.

Are they nicer? Heck yeah, they are! Most 5-star hotels have jaw-dropping aesthetics that give an authentic feel of class. And we’re not talking about that faux-gold soap dish your Aunt Tilda puts out for the guests—it’s the real deal.

Stars in your eyes

Are 5-stars hotels worth it? If you like the finer things in life, then yes, they sure are. But we also know you’re the type that likes to get your caviar on a fish stick budget. We’re right there with you, and that is why we make it easy to find the best 5-star hotel in South Houston for you. Sort by:

  • Price: Want to live large, but keep that budget balanced? We got you. We have 5-star hotels starting at $180.

  • Amenities: South Houston skyline view? Maybe a heated indoor pool? Looking for a Michelin-star restaurant? Search for the hotels that have the amenities you desire.

  • Hotwire Hot Rate: We’ll tell you the name of the hotel after you book, and you might just save a ton.

When you’re looking for the top 5-star hotels in South Houston—but don’t want to pay top dollar—let us help you out. You can get that posh palace of your dreams, and have money left to take on South Houston your way.