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5 Star Hotels in Southwest Houston

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Featured 5 Star Southwest Houston Hotels

The Post Oak Hotel at Uptown Houston
5 out of 5
Fully refundableReserve now, pay when you stay
  • 8 min drive from MD Anderson Cancer Center
The price is $653 per night from Dec 22 to Dec 23
$653
includes taxes & fees
Dec 22 - Dec 23
Stay at this 5-star luxury hotel in Houston. Enjoy free WiFi, a full-service spa, and 4 restaurants. Our guests praise the helpful staff and the room service ...
The Post Oak Hotel at Uptown Houston
The St. Regis Houston
5 out of 5
Fully refundableReserve now, pay when you stay
  • 7 min drive from MD Anderson Cancer Center
The price is $428 per night from Dec 15 to Dec 16
$428
includes taxes & fees
Dec 15 - Dec 16
Stay at this 5-star luxury hotel in Houston. Enjoy a full-service spa, breakfast (surcharge), and 24-hour room service. Popular attractions Houston Zoo and NRG ...
The St. Regis Houston
Hotel Granduca Houston
5 out of 5
Fully refundableReserve now, pay when you stay
  • 8 min drive from MD Anderson Cancer Center
The price is $455 per night from Dec 1 to Dec 2
$455
includes taxes & fees
Dec 1 - Dec 2
Stay at this 5-star luxury aparthotel in Houston. Enjoy free WiFi, breakfast (surcharge), and a free area shuttle. Our guests praise the helpful staff and the ...
Hotel Granduca Houston
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ACP Hotel Houston Westchase, MOD Collection by Sonesta
3 out of 5
Fully refundableReserve now, pay when you stay
  • 4 min drive from MD Anderson Cancer Center
The price is $89 per night from Dec 1 to Dec 2
$89
includes taxes & fees
Dec 1 - Dec 2
Stay at this 3-star family-friendly aparthotel in Houston. Enjoy free WiFi, free parking, and a free area shuttle. Our guests praise the helpful staff in our ...
ACP Hotel Houston Westchase, MOD Collection by Sonesta
7550 Kirby Dr
5 out of 5
  • 13 min walk from MD Anderson Cancer Center
The price is $195 per night from Dec 1 to Dec 2
$195
includes taxes & fees
Dec 1 - Dec 2
Stay at this 5-star luxury apartment in Houston. Enjoy free WiFi, free parking, and private pools. Popular attractions NRG Stadium and Houston Zoo are located ...
7550 Kirby Dr
TUSCAN VILLA
5 out of 5
  • 5 min drive from MD Anderson Cancer Center
The price is $2,876 per night from Dec 1 to Dec 2
$2,876
includes taxes & fees
Dec 1 - Dec 2
Stay at this 5-star luxury villa in Houston. Enjoy free WiFi, free parking, and in-room massages. Popular attractions Houston Zoo and NRG Stadium are located ...
TUSCAN VILLA
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

5-Star Hotel in Southwest Houston

It’s time. No more meh motels and so-so stays. This vacation it’s all about living it up, and that starts with a great hotel. You want first-class service and award-winning restaurants. Well, let us introduce you to a 5-star hotel in Southwest Houston.

So nice you’ll blink twice

What makes a hotel worthy of supreme star-age? For starters, the service has to be top-notch and personalized. These hotels often have 24-hour room service, a welcome gift upon your arrival, and help you with your bags—even if you travel light.

Are they nicer? Heck yeah, they are! Most 5-star hotels have jaw-dropping aesthetics that give an authentic feel of class. And we’re not talking about that faux-gold soap dish your Aunt Tilda puts out for the guests—it’s the real deal.

Stars in your eyes

Are 5-stars hotels worth it? If you like the finer things in life, then yes, they sure are. But we also know you’re the type that likes to get your caviar on a fish stick budget. We’re right there with you, and that is why we make it easy to find the best 5-star hotel in Southwest Houston for you. Sort by:

  • Price: Want to live large, but keep that budget balanced? We got you. We have 5-star hotels starting at $89.

  • Amenities: Southwest Houston skyline view? Maybe a heated indoor pool? Looking for a Michelin-star restaurant? Search for the hotels that have the amenities you desire.

  • Hotwire Hot Rate: We’ll tell you the name of the hotel after you book, and you might just save a ton.

When you’re looking for the top 5-star hotels in Southwest Houston—but don’t want to pay top dollar—let us help you out. You can get that posh palace of your dreams, and have money left to take on Southwest Houston your way.