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Hotels in Southwest Houston

Choose from 1313 Southwest Houston Hotel Deals

Blossom Hotel Houston
Blossom Hotel Houston
4 out of 5
7118 Bertner Ave, Houston, TX
  • 12 min walk from MD Anderson Cancer Center
The price is $171 per night from Dec 26 to Dec 27
$171
includes taxes & fees
Dec 26 - Dec 27
Stay at this 4-star spa hotel in Houston. Enjoy free WiFi, a full-service spa, and 2 bars/lounges. Our guests praise the pool and the helpful staff in our reviews. ...
9/10 Wonderful! (2,884 reviews)
"We were thrilled to get upgraded to a suite for our anniversary trip, but that isn’t swaying my rating. This is a beautiful hotel and has such sweet decorations and elegant details throughout. We will absolutely be back again :)"

Reviewed on Nov 25, 2024

Blossom Hotel Houston
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
4 out of 5
5353 Westheimer Rd, Houston, TX
  • 6 min drive from MD Anderson Cancer Center
The price is $119 per night from Dec 26 to Dec 27
$119
includes taxes & fees
Dec 26 - Dec 27
Stay at this hotel in Houston. Enjoy free WiFi, an outdoor pool, and breakfast (surcharge). Our guests praise the helpful staff and the clean rooms in our reviews. ...
8/10 Very Good! (1,586 reviews)
"Very awesome customer service! Clean comfortable rooms! And great views 😁"

Reviewed on Nov 24, 2024

DoubleTree by Hilton Hotel & Suites Houston by the Galleria
La Quinta Inn & Suites by Wyndham Houston Galleria Area
La Quinta Inn & Suites by Wyndham Houston Galleria Area
2.5 out of 5
1625 West Loop S, Houston, TX
  • 7 min drive from MD Anderson Cancer Center
The price is $86 per night from Nov 28 to Nov 29
$86
includes taxes & fees
Nov 28 - Nov 29
Book a stay at this business-friendly hotel in Houston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.6/10 Good! (1,225 reviews)
"I found the sign difficult to see from the street, causing me to miss the driveway."

Reviewed on Nov 23, 2024

La Quinta Inn & Suites by Wyndham Houston Galleria Area
Hyatt Place Houston Medical Center
Hyatt Place Houston Medical Center
3 out of 5
7329 FANNIN STREET Building 2, Houston, TX
  • 16 min walk from MD Anderson Cancer Center
The price is $137 per night from Dec 1 to Dec 2
$137
includes taxes & fees
Dec 1 - Dec 2
Stay at this 3-star business-friendly hotel in Houston. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
9/10 Wonderful! (1,185 reviews)
"Best Hotel I’ve ever stayed in. Give everyone a raise!"

Reviewed on Nov 25, 2024

Hyatt Place Houston Medical Center
Sonesta ES Suites Houston Galleria
Sonesta ES Suites Houston Galleria
3 out of 5
5190 Hidalgo St, Houston, TX
  • 5 min drive from MD Anderson Cancer Center
The price is $116 per night from Nov 28 to Nov 29
$116
includes taxes & fees
Nov 28 - Nov 29
Stay at this 3-star business-friendly hotel in Houston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.2/10 Very Good! (1,010 reviews)
"Overnight saty for buisness meeting only"

Reviewed on Nov 21, 2024

Sonesta ES Suites Houston Galleria
The Royal Sonesta Houston Galleria
The Royal Sonesta Houston Galleria
4 out of 5
2222 West Loop South, Houston, TX
  • 6 min drive from MD Anderson Cancer Center
The price is $235 per night from Nov 28 to Nov 29
$235
includes taxes & fees
Nov 28 - Nov 29
Stay at this 4-star business-friendly hotel in Houston. Enjoy breakfast (surcharge), room service, and a 24-hour health club. Our guests praise the helpful staff ...
8/10 Very Good! (1,011 reviews)
"Na"

Reviewed on Nov 24, 2024

The Royal Sonesta Houston Galleria
DoubleTree by Hilton Hotel Houston - Greenway Plaza
DoubleTree by Hilton Hotel Houston - Greenway Plaza
4 out of 5
Houston
  • 4 min drive from MD Anderson Cancer Center
The price is $108 per night from Dec 15 to Dec 16
$108
includes taxes & fees
Dec 15 - Dec 16
Book a stay at this business-friendly hotel in Houston. Enjoy free WiFi, breakfast (surcharge), and a free area shuttle. Our guests praise the helpful staff ...
7.4/10 Good! (1,010 reviews)
"Wonderful. I did wish I knew in advance that the hotel offers a shuttle to nearby locations."

Reviewed on Nov 15, 2024

DoubleTree by Hilton Hotel Houston - Greenway Plaza
The Chifley Houston, Tapestry Collection by Hilton
The Chifley Houston, Tapestry Collection by Hilton
4 out of 5
2400 West Loop S, Houston, TX
  • 6 min drive from MD Anderson Cancer Center
The price is $174 per night from Nov 30 to Dec 1
$174
includes taxes & fees
Nov 30 - Dec 1
Stay at this 4-star business-friendly hotel in Houston. Enjoy breakfast (surcharge), a 24-hour fitness center, and valet parking (surcharge). Our guests praise ...
8.6/10 Excellent! (1,001 reviews)
"Close to shopping mall and nearby stores"

Reviewed on Nov 21, 2024

The Chifley Houston, Tapestry Collection by Hilton
Hyatt Regency Houston/Galleria
Hyatt Regency Houston/Galleria
4 out of 5
2626 Sage Road, Houston, TX
  • 5 min drive from MD Anderson Cancer Center
The price is $159 per night from Nov 29 to Nov 30
$159
includes taxes & fees
Nov 29 - Nov 30
Stay at this 4-star business-friendly aparthotel in Houston. Enjoy free WiFi, 2 bars/lounges, and breakfast (surcharge). Our guests praise the helpful staff ...
8.6/10 Excellent! (1,005 reviews)
"The valet guys were great! I appreciate their promptness and courtesy. We stayed in room 608 and the light bulb in the bathroom needs to be changed out. The hotel was fantastic in all ways 😊"

Reviewed on Nov 26, 2024

Hyatt Regency Houston/Galleria
Omni Houston Hotel
Omni Houston Hotel
4 out of 5
4 Riverway, Houston, TX
  • 9 min drive from MD Anderson Cancer Center
The price is $180 per night from Dec 21 to Dec 22
$180
includes taxes & fees
Dec 21 - Dec 22
Book a stay at this spa hotel in Houston. Enjoy 2 outdoor pools, a full-service spa, and 3 bars/lounges. Our guests praise the helpful staff and the property ...
8.6/10 Excellent! (1,007 reviews)
"We had a nice stay! Pretty rooms and enjoyed our dinner at Birdies."

Reviewed on Nov 24, 2024

Omni Houston Hotel
Hilton Houston Plaza/Medical Center
Hilton Houston Plaza/Medical Center
3.5 out of 5
6633 Travis St, Houston, TX
  • 4 min walk from MD Anderson Cancer Center
The price is $94 per night from Nov 28 to Nov 29
$94
includes taxes & fees
Nov 28 - Nov 29
Book a stay at this business-friendly hotel in Houston. Enjoy free WiFi, an outdoor pool, and a rooftop terrace. Our guests praise the helpful staff and the ...
8.2/10 Very Good! (1,063 reviews)
"Hotel staff was very professional and eager to accommodate any requests."

Reviewed on Nov 22, 2024

Hilton Houston Plaza/Medical Center
InterContinental Houston, an IHG Hotel
InterContinental Houston, an IHG Hotel
4 out of 5
6750 Main St, Houston, TX
  • 2 min walk from MD Anderson Cancer Center
The price is $169 per night from Nov 29 to Nov 30
$169
includes taxes & fees
Nov 29 - Nov 30
Stay at this 4-star business-friendly hotel in Houston. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the ...
9.2/10 Wonderful! (1,007 reviews)
"The property itself was fantastic! Valet had a few issues, but all-in-all, InterContinental was good. The area around it however felt rough and unkempt"

Reviewed on Nov 25, 2024

InterContinental Houston, an IHG Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Southwest Houston

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For you, intrepid voyager, Hotwire has a large selection of the best hotels in Southwest Houston.

Choosing the right hotel in Texas has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Southwest Houston’s 1,313 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $86. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get up to 60% Southwest Houston hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Southwest Houston. No matter your reason for visiting Southwest Houston, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Southwest Houston hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can save up to 60% off your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Southwest Houston for as low as $86.

How many hotels are there in Southwest Houston?

With over 1,313 hotels in Southwest Houston, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $86.

How to find cheap car rentals in Southwest Houston?

Finding a cheap car rental deal in Southwest Houston is as easy as scoring cheap hotels in Southwest Houston. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can even save up to 60% off a car rental deal if you book a Hotwire Hot Rate at the last minute.

Is it safe to travel to Southwest Houston now?

With recent COVID-19 closures and reopenings, many people are wondering, “Is it safe to travel to Southwest Houston right now?” When it’s time to book your getaway, be sure to check out the most up-to-date information on all safety measures, any restrictions, and guidance on traveling during the coronavirus pandemic.