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Hotels in Southwest Houston

Choose from 1330 Southwest Houston Hotel Deals

Blossom Hotel Houston
Blossom Hotel Houston
4 out of 5
7118 Bertner Ave, Houston, TX
  • 12 min walk from MD Anderson Cancer Center
The price is $175 per night from Feb 9 to Feb 10
$175
includes taxes & fees
Feb 9 - Feb 10
Stay at this 4-star spa hotel in Houston. Enjoy free WiFi, a full-service spa, and 2 bars/lounges. Our guests praise the pool and the helpful staff in our reviews. ...
9/10 Wonderful! (3,027 reviews)
"Just a quick getaway with my wife and had a fantastic time. The suite was spacious and I would come back just for the shower. My only issue was that the valet parking was friendly but extremely inefficient. Overall a great experience and I would stay here again."

Reviewed on Jan 6, 2025

Blossom Hotel Houston
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
4 out of 5
5353 Westheimer Rd, Houston, TX
  • 6 min drive from MD Anderson Cancer Center
The price is $159 per night from Jan 15 to Jan 16
$159
includes taxes & fees
Jan 15 - Jan 16
Stay at this hotel in Houston. Enjoy free WiFi, an outdoor pool, and breakfast (surcharge). Our guests praise the helpful staff and the clean rooms in our reviews. ...
8/10 Very Good! (1,684 reviews)
"The staff was very friendly and helpful, it’s an older hotel so the rooms weren’t spectacular."

Reviewed on Jan 6, 2025

DoubleTree by Hilton Hotel & Suites Houston by the Galleria
Hilton Houston Plaza/Medical Center
Hilton Houston Plaza/Medical Center
3.5 out of 5
6633 Travis St, Houston, TX
  • 4 min walk from MD Anderson Cancer Center
The price is $96 per night from Jan 25 to Jan 26
$96
includes taxes & fees
Jan 25 - Jan 26
Book a stay at this business-friendly hotel in Houston. Enjoy free WiFi, an outdoor pool, and a rooftop terrace. Our guests praise the helpful staff and the ...
8.2/10 Very Good! (1,123 reviews)
"My stay was amazing I enjoyed everything. Only down side was the room did not have a Microwave."

Reviewed on Jan 6, 2025

Hilton Houston Plaza/Medical Center
Hyatt Place Houston Medical Center
Hyatt Place Houston Medical Center
3 out of 5
7329 FANNIN STREET Building 2, Houston, TX
  • 16 min walk from MD Anderson Cancer Center
The price is $121 per night from Jan 17 to Jan 18
$121
includes taxes & fees
Jan 17 - Jan 18
Stay at this 3-star business-friendly hotel in Houston. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
9/10 Wonderful! (1,299 reviews)
"Modern amenities"

Reviewed on Jan 6, 2025

Hyatt Place Houston Medical Center
The Royal Sonesta Houston Galleria
The Royal Sonesta Houston Galleria
4 out of 5
2222 West Loop South, Houston, TX
  • 6 min drive from MD Anderson Cancer Center
The price is $212 per night from Feb 1 to Feb 2
$212
includes taxes & fees
Feb 1 - Feb 2
Stay at this 4-star business-friendly hotel in Houston. Enjoy breakfast (surcharge), room service, and a 24-hour health club. Our guests praise the helpful staff ...
8/10 Very Good! (1,009 reviews)
"The clerk was very nice they gave our children two stuffed bulls when we checked in. That made their day . The room was nice but needed some more cleaning also the conditioner was out but other than that we enjoyed our stay. The parking was right behind the hotel and an easy walk to the lobby entrance ..."

Reviewed on Jan 6, 2025

The Royal Sonesta Houston Galleria
Sonesta ES Suites Houston Galleria
Sonesta ES Suites Houston Galleria
3 out of 5
5190 Hidalgo St, Houston, TX
  • 5 min drive from MD Anderson Cancer Center
The price is $130 per night from Jan 10 to Jan 11
$130
includes taxes & fees
Jan 10 - Jan 11
Stay at this 3-star business-friendly hotel in Houston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.2/10 Very Good! (1,000 reviews)
"Great"

Reviewed on Jan 5, 2025

Sonesta ES Suites Houston Galleria
Hyatt Regency Houston/Galleria
Hyatt Regency Houston/Galleria
4 out of 5
2626 Sage Road, Houston, TX
  • 5 min drive from MD Anderson Cancer Center
The price is $234 per night from Jan 23 to Jan 24
$234
includes taxes & fees
Jan 23 - Jan 24
Stay at this 4-star business-friendly hotel in Houston. Enjoy free WiFi, 2 bars/lounges, and breakfast (surcharge). Our guests praise the helpful staff and the ...
8.8/10 Excellent! (1,002 reviews)
"I’ll definitely recommend this property to friends and family! I’ll definitely come back! The staff was amazing the room was clean and the water in the lobby is infused with fruits and things of greatness 🤗 I only have a problem with paying for parking everyday after what u pay a night! 🙈 but it ..."

Reviewed on Jan 7, 2025

Hyatt Regency Houston/Galleria
The Westin Oaks Houston at the Galleria
The Westin Oaks Houston at the Galleria
4 out of 5
5011 Westheimer Road, Houston, TX
  • 6 min drive from MD Anderson Cancer Center
The price is $298 per night from Jan 24 to Jan 25
$298
includes taxes & fees
Jan 24 - Jan 25
Stay at this 4-star eco-certified hotel in Houston. Enjoy free parking, breakfast (surcharge), and a 24-hour health club. Our guests praise the helpful staff ...
8.8/10 Excellent! (1,000 reviews)
"Great place to stay"

Reviewed on Jan 7, 2025

The Westin Oaks Houston at the Galleria
Omni Houston Hotel
Omni Houston Hotel
4 out of 5
4 Riverway, Houston, TX
  • 9 min drive from MD Anderson Cancer Center
The price is $199 per night from Feb 1 to Feb 2
$199
includes taxes & fees
Feb 1 - Feb 2
Book a stay at this spa hotel in Houston. Enjoy 2 outdoor pools, a full-service spa, and 3 bars/lounges. Our guests praise the helpful staff and the property ...
8.6/10 Excellent! (1,002 reviews)
"Overall, it was a great stay! The pool and workout facility are nice. The free shuttle within 3 miles is excellent. Good product in the room and three waters. The property is pretty and were kind and helpful. It wasn’t very busy and so it was quiet which was nice. The negatives would be the paint ..."

Reviewed on Jan 7, 2025

Omni Houston Hotel
The Chifley Houston, Tapestry Collection by Hilton
The Chifley Houston, Tapestry Collection by Hilton
4 out of 5
2400 West Loop S, Houston, TX
  • 6 min drive from MD Anderson Cancer Center
The price is $188 per night from Jan 12 to Jan 13
$188
includes taxes & fees
Jan 12 - Jan 13
Stay at this 4-star business-friendly hotel in Houston. Enjoy breakfast (surcharge), a 24-hour fitness center, and valet parking (surcharge). Our guests praise ...
8.8/10 Excellent! (1,002 reviews)
"This property is beautiful and well maintained. The room is nice and spacious as well. The parking is expensive so be mindful of that. I parked somewhere else and just walked."

Reviewed on Jan 7, 2025

The Chifley Houston, Tapestry Collection by Hilton
Hotel Ylem
Hotel Ylem
3.5 out of 5
8080 S Main St, Houston, TX
  • 20 min walk from MD Anderson Cancer Center
The price is $84 per night from Jan 15 to Jan 16
$84
includes taxes & fees
Jan 15 - Jan 16
Stay at this 3.5-star business-friendly aparthotel in Houston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.4/10 Very Good! (1,841 reviews)
"All good"

Reviewed on Jan 6, 2025

Hotel Ylem
The Post Oak Hotel at Uptown Houston
The Post Oak Hotel at Uptown Houston
5 out of 5
1600 West Loop South, Houston, TX
  • 8 min drive from MD Anderson Cancer Center
The price is $674 per night from Jan 23 to Jan 24
$674
includes taxes & fees
Jan 23 - Jan 24
Stay at this 5-star luxury hotel in Houston. Enjoy free WiFi, a full-service spa, and 4 restaurants. Our guests praise the helpful staff and the room service ...
9.4/10 Exceptional! (687 reviews)
"The best hotel in Houston by far!!!"

Reviewed on Jan 5, 2025

The Post Oak Hotel at Uptown Houston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Southwest Houston

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