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Hotels in Southwest Houston

The St. Regis Houston
The St. Regis Houston
5 out of 5
Fully refundableReserve now, pay when you stay
  • 7 min drive from MD Anderson Cancer Center
The price is $482 per night from Apr 6 to Apr 7
$482
includes taxes & fees
Apr 6 - Apr 7
Stay at this 5-star luxury hotel in Houston. Enjoy a full-service spa, breakfast (surcharge), and 24-hour room service. Popular attractions NRG Stadium and Toyota ...
The St. Regis Houston
Hotel Ylem
Hotel Ylem
3.5 out of 5
Fully refundableReserve now, pay when you stay
  • 20 min walk from MD Anderson Cancer Center
The price is $94 per night from Mar 31 to Apr 1
$94
includes taxes & fees
Mar 31 - Apr 1
Stay at this 3.5-star business-friendly aparthotel in Houston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Hotel Ylem
Hotel Granduca Houston
Hotel Granduca Houston
4.5 out of 5
Fully refundableReserve now, pay when you stay
  • 8 min drive from MD Anderson Cancer Center
The price is $435 per night from Apr 3 to Apr 4
$435
includes taxes & fees
Apr 3 - Apr 4
Stay at this 4.5-star luxury aparthotel in Houston. Enjoy free WiFi, 2 bars/lounges, and breakfast (surcharge). Our guests praise the helpful staff and the property ...
Hotel Granduca Houston
Hotel Derek
Hotel Derek
4 out of 5
  • 6 min drive from MD Anderson Cancer Center
Stay at this aparthotel in Houston. Enjoy free WiFi, room service, and valet parking (surcharge). Our guests praise the clean rooms in our reviews. Popular attractions ...
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Hotel Derek
Hotel Vesper, Houston, a Tribute Portfolio Hotel
Hotel Vesper, Houston, a Tribute Portfolio Hotel
2.5 out of 5
Fully refundableReserve now, pay when you stay
  • 5 min drive from MD Anderson Cancer Center
The price is $188 per night from Apr 20 to Apr 21
$188
includes taxes & fees
Apr 20 - Apr 21
Book a stay at this business-friendly hotel in Houston. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff in our ...
Hotel Vesper, Houston, a Tribute Portfolio Hotel
Aloft Houston by the Galleria
Aloft Houston by the Galleria
3 out of 5
Fully refundableReserve now, pay when you stay
  • 6 min drive from MD Anderson Cancer Center
The price is $128 per night from Mar 30 to Mar 31
$128
includes taxes & fees
Mar 30 - Mar 31
Stay at this 3-star business-friendly hotel in Houston. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff in our ...
Aloft Houston by the Galleria
See all 1,285 properties in Southwest Houston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.