Hotels Near
Texas Medical Center

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Featured Texas Medical Center Hotels

Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center

4.5 out of 5
6633 Travis St Houston TX
Fully refundableReserve now, pay when you stay
Book a stay at this luxury hotel in Houston. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean rooms in our ...
8.2/10 Very Good! (1,790 reviews)
The hotel was great and convenient. Easy check in an check out. Will definitely stay again.

Reviewed on Dec 22, 2025

Hilton Houston Plaza/Medical Center
Blossom Hotel Houston, Curio Collection by Hilton

Blossom Hotel Houston, Curio Collection by Hilton

4 out of 5
7118 Bertner Ave Houston TX
Fully refundableReserve now, pay when you stay
Book a stay at this spa hotel in Houston. Enjoy free WiFi, a full-service spa, and 2 bars/lounges. Our guests praise the pool and the helpful staff in our reviews. ...
9/10 Wonderful! (3,619 reviews)
We have tried different hotels near medical center, overall we like Blossom the best. The room is very spacious and clean, bed is comfortable and linen sheets are nice.

Reviewed on Dec 27, 2025

Blossom Hotel Houston, Curio Collection by Hilton
The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District

4 out of 5
1709 DRYDEN ROAD Houston TX
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Houston. Enjoy breakfast (surcharge), room service, and a 24-hour health club. Our guests praise the helpful staff ...
9/10 Wonderful! (1,029 reviews)
Room was as advertised. Clean and spacious. Enjoyed dinner at the restaurant. Food selection and quality was very good.

Reviewed on Dec 23, 2025

The Westin Houston Medical Center/Museum District
Hyatt Place Houston Medical Center

Hyatt Place Houston Medical Center

3 out of 5
7329 FANNIN STREET Building 2 Houston TX
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Houston. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
9/10 Wonderful! (2,201 reviews)
great size room with sofa, high tech TV with Chromecast option. Lobby area is nice with plenty of tables and seatings

Reviewed on Dec 24, 2025

Hyatt Place Houston Medical Center
InterContinental Houston by IHG

InterContinental Houston by IHG

4 out of 5
6750 Main St Houston TX
Fully refundable
Book a stay at this business-friendly hotel in Houston. Enjoy free WiFi, breakfast (surcharge), and a free area shuttle. Our guests praise the helpful staff ...
9.2/10 Wonderful! (1,001 reviews)
Clean quick check in

Reviewed on Dec 19, 2025

InterContinental Houston by IHG
Hilton Garden Inn Houston Medical Center, TX

Hilton Garden Inn Houston Medical Center, TX

3 out of 5
6840 Almeda Rd Houston TX
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Houston. Enjoy breakfast (surcharge), a free area shuttle, and room service. Our guests praise the helpful staff ...
9.2/10 Wonderful! (1,001 reviews)
LOVE STAYING AT THE HOTEL WHEN I TRAVEL TO HOUSTON.

Reviewed on Dec 22, 2025

Hilton Garden Inn Houston Medical Center, TX
Hyatt House Houston Medical Center

Hyatt House Houston Medical Center

3 out of 5
7329 FANNIN STREET Houston TX
Fully refundableReserve now, pay when you stay
Stay at this hotel in Houston. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the pool in our reviews. Popular ...
9/10 Wonderful! (1,203 reviews)
Everything was perfect per usual.. I’ve stayed at this hotel multiple times and each time is great. From the front desk staff to the beautiful hotel, clean rooms etc.

Reviewed on Dec 22, 2025

Hyatt House Houston Medical Center
Home2 Suites by Hilton Houston Medical Center, TX

Home2 Suites by Hilton Houston Medical Center, TX

3 out of 5
6840 Almeda Road Houston TX
Fully refundableReserve now, pay when you stay
Stay at this hotel in Houston. Enjoy free breakfast, a free area shuttle, and a 24-hour fitness center. Our guests praise the helpful staff and the clean rooms ...
9.2/10 Wonderful! (567 reviews)
Carlos, Elijah, and Anesha were very courteous and very professional during our stay.

Reviewed on Dec 20, 2025

Home2 Suites by Hilton Houston Medical Center, TX
DoubleTree by Hilton Hotel & Suites Houston by the Galleria

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

4 out of 5
5353 Westheimer Rd Houston TX
Fully refundableReserve now, pay when you stay
Stay at this hotel in Houston. Enjoy an outdoor pool, breakfast (surcharge), and a free area shuttle. Our guests praise the helpful staff and the clean rooms ...
8.2/10 Very Good! (3,163 reviews)
Everything exceeded our expectations

Reviewed on Dec 27, 2025

DoubleTree by Hilton Hotel & Suites Houston by the Galleria
Club Quarters Hotel Downtown, Houston

Club Quarters Hotel Downtown, Houston

4 out of 5
1085 Rusk Street Houston TX
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Houston. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the restaurant and the helpful ...
8.4/10 Very Good! (3,971 reviews)
Great hotel

Reviewed on Dec 27, 2025

Club Quarters Hotel Downtown, Houston
The Whitehall Houston

The Whitehall Houston

4 out of 5
1700 Smith St Houston TX
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Houston. Enjoy free WiFi, breakfast (surcharge), and a free area shuttle. Our guests praise the helpful staff ...
8.4/10 Very Good! (1,933 reviews)
The staff were very helpful and the place was beautiful.

Reviewed on Dec 23, 2025

The Whitehall Houston
The Royal Sonesta Houston Galleria

The Royal Sonesta Houston Galleria

4 out of 5
2222 West Loop South Houston TX
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Houston. Enjoy breakfast (surcharge), room service, and a 24-hour health club. Our guests praise the helpful staff ...
8.4/10 Very Good! (1,475 reviews)
Well located, clean and comfortable

Reviewed on Dec 22, 2025

The Royal Sonesta Houston Galleria
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Texas Medical Center

Houston is a city that has a lot going on, but you have your sights set on Texas Medical Center. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Texas Medical Center has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Texas Medical Center hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of Houston so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Texas Medical Center underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Texas Medical Center city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Texas Medical Center cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Texas Medical Center at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $103
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Texas Medical Center hotel you want, book it, and never look back. Because your great escape is ahead of you.