Hotels Near
Texas Medical Center

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Featured Texas Medical Center Hotels

Blossom Hotel Houston, Curio Collection by Hilton

Blossom Hotel Houston, Curio Collection by Hilton

4 out of 5
7118 Bertner Ave, Houston, TX
Fully refundableReserve now, pay when you stay
Stay at this 4-star spa hotel in Houston. Enjoy free WiFi, a full-service spa, and 2 bars/lounges. Our guests praise the pool and the helpful staff in our reviews. ...
9/10 Wonderful! (3,579 reviews)
There wasn’t a way to reach the front desk over the phone. I reached a voicemail which was full and unable to accept calls. Generally a nice property but a colleague on the area told me that it was not a safe area for a single person.

Reviewed on Oct 23, 2025

Blossom Hotel Houston, Curio Collection by Hilton
Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center

4.5 out of 5
6633 Travis St, Houston, TX
Fully refundableReserve now, pay when you stay
Stay at this 4.5-star luxury hotel in Houston. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean rooms in ...
8.2/10 Very Good! (1,637 reviews)
I didn’t have any breakfast

Reviewed on Oct 24, 2025

Hilton Houston Plaza/Medical Center
Hyatt Place Houston Medical Center

Hyatt Place Houston Medical Center

3 out of 5
7329 FANNIN STREET Building 2, Houston, TX
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in Houston. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
9/10 Wonderful! (2,059 reviews)
The staff was exceptional, offer me there shuttle service after noticing I was going to the event near by

Reviewed on Oct 24, 2025

Hyatt Place Houston Medical Center
InterContinental Houston by IHG

InterContinental Houston by IHG

4 out of 5
6750 Main St, Houston, TX
Fully refundable
Stay at this 4-star business-friendly hotel in Houston. Enjoy free WiFi, breakfast (surcharge), and a free area shuttle. Our guests praise the helpful staff ...
9.2/10 Wonderful! (1,016 reviews)
Our room was very clean and the bed was super comfortable. The front desk was very friendly

Reviewed on Oct 14, 2025

InterContinental Houston by IHG
The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District

4 out of 5
1709 DRYDEN ROAD, Houston, TX
Stay at this 4-star business-friendly hotel in Houston. Enjoy breakfast (surcharge), room service, and a 24-hour health club. Our guests praise the helpful staff ...
9/10 Wonderful! (1,001 reviews)
The staff and rooms were more than i expected

Reviewed on Oct 24, 2025

The Westin Houston Medical Center/Museum District
Hilton Garden Inn Houston Medical Center, TX

Hilton Garden Inn Houston Medical Center, TX

3 out of 5
6840 Almeda Rd, Houston, TX
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in Houston. Enjoy breakfast (surcharge), a free area shuttle, and room service. Our guests praise the helpful staff ...
9.2/10 Wonderful! (987 reviews)
Room was excellent, power went out a couple times but wasn’t too long. Overall satisfied with Hotel

Reviewed on Oct 20, 2025

Hilton Garden Inn Houston Medical Center, TX
Hyatt House Houston Medical Center

Hyatt House Houston Medical Center

3 out of 5
7329 FANNIN STREET, Houston, TX
Fully refundableReserve now, pay when you stay
Stay at this 3-star hotel in Houston. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the pool in our reviews. ...
9/10 Wonderful! (1,140 reviews)
Weekend staycation
Didn’t use bar but do use the hot tub and it was clean and hot

Reviewed on Oct 23, 2025

Hyatt House Houston Medical Center
DoubleTree by Hilton Hotel & Suites Houston by the Galleria

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

4 out of 5
5353 Westheimer Rd, Houston, TX
Fully refundableReserve now, pay when you stay
Stay at this hotel in Houston. Enjoy an outdoor pool, breakfast (surcharge), and a free area shuttle. Our guests praise the helpful staff and the clean rooms ...
8.2/10 Very Good! (2,741 reviews)
Awesome service plus the room super nice and clean

Reviewed on Oct 25, 2025

DoubleTree by Hilton Hotel & Suites Houston by the Galleria
Club Quarters Hotel Downtown, Houston

Club Quarters Hotel Downtown, Houston

4 out of 5
1085 Rusk Street, Houston, TX
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in Houston. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the restaurant and the helpful ...
8.4/10 Very Good! (3,812 reviews)
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Reviewed on Oct 22, 2025

Club Quarters Hotel Downtown, Houston
Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District

4.5 out of 5
5701 Main Street, Houston, TX
Fully refundableReserve now, pay when you stay
Stay at this 4.5-star luxury aparthotel in Houston. Enjoy free WiFi, a full-service spa, and a rooftop terrace. Our guests praise the helpful staff and the property ...
8.8/10 Excellent! (1,800 reviews)
Very friendly and accommodating staff. They let us check in early which we really appreciated. Enjoyed the pool as well. Food and drink prices were high. Great area to be located in, near museums and Rice University. Also appreciated the free shuttle within three-mile radius of hotel.

Reviewed on Oct 24, 2025

Hotel Zaza Houston Museum District
Magnolia Hotel Houston, A Tribute Portfolio Hotel

Magnolia Hotel Houston, A Tribute Portfolio Hotel

4 out of 5
1100 Texas St, Houston, TX
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in Houston. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the pool and the helpful ...
9/10 Wonderful! (1,224 reviews)
Clean rooms, friendly staff, breakfast was very basic and absolutely not worth the price!

Reviewed on Oct 23, 2025

Magnolia Hotel Houston, A Tribute Portfolio Hotel
DoubleTree by Hilton Hotel Houston - Greenway Plaza

DoubleTree by Hilton Hotel Houston - Greenway Plaza

4 out of 5
Houston
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in Houston. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the helpful staff in our ...
8.2/10 Very Good! (1,260 reviews)
Staff was very friendly. Easy to get in and out. Allowed DoorDash to drop off at our room.

Reviewed on Oct 20, 2025

DoubleTree by Hilton Hotel Houston - Greenway Plaza
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Texas Medical Center

Houston is a city that has a lot going on, but you have your sights set on Texas Medical Center. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Texas Medical Center has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Texas Medical Center hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of Houston so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Texas Medical Center underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Texas Medical Center city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Texas Medical Center cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Texas Medical Center at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $117
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Texas Medical Center hotel you want, book it, and never look back. Because your great escape is ahead of you.