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Hotels in Main Street Hyannis

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Tonight Sep 22 - Sep 23Next weekend Sep 27 - Sep 29

Choose from 5715 Main Street Hyannis Hotel Deals

Hyannis Inn
Hyannis Inn
2 out of 5
473 MAIN ST, Hyannis, MA
  • 4 min walk from John F. Kennedy Hyannis Museum
The price is $130 per night from Oct 14 to Oct 15
$130
includes taxes & fees
Oct 14 - Oct 15
Stay at this motel in Hyannis. Enjoy free WiFi, free parking, and a garden. Our guests praise the pool and the helpful staff in our reviews. Popular attractions ...
8.4/10 Very Good! (937 reviews)
"Great"

Reviewed on Sep 19, 2024

Hyannis Inn
Cape Cod Inn
Cape Cod Inn
2 out of 5
447 Main St, Hyannis, MA
  • 3 min walk from John F. Kennedy Hyannis Museum
The price is $109 per night from Sep 23 to Sep 24
$109
includes taxes & fees
Sep 23 - Sep 24
Stay at this motel in Hyannis. Enjoy free WiFi, free parking, and daily housekeeping. Our guests praise the helpful staff and the clean rooms in our reviews. ...
8.6/10 Excellent! (406 reviews)
"The stay was good but the restaurant was closed. Was not happy about that."

Reviewed on Sep 18, 2024

Cape Cod Inn
Hyannis Plaza Hotel
Hyannis Plaza Hotel
2.5 out of 5
662 Main Street, Hyannis, MA
  • 10 min walk from John F. Kennedy Hyannis Museum
The price is $106 per night from Oct 22 to Oct 23
$106
includes taxes & fees
Oct 22 - Oct 23
Book a stay at this luxury hotel in Hyannis. Enjoy free parking, an outdoor pool, and a 24-hour front desk. Popular attractions Hyannis Harbor and Cape Codder ...
6.8/10 (630 reviews)
"Was a nice little hotel, staff were very friendly, room was very clean. Enjoyed our stay very much."

Reviewed on Sep 13, 2024

Hyannis Plaza Hotel
Americas Best Value Inn & Suites Hyannis Cape Cod
Americas Best Value Inn & Suites Hyannis Cape Cod
2 out of 5
206 Main St, Hyannis, MA
  • 6 min walk from John F. Kennedy Hyannis Museum
The price is $102 per night from Sep 23 to Sep 24
$102
includes taxes & fees
Sep 23 - Sep 24
Stay at this hotel in Hyannis. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the clean rooms and the overall value in our reviews. Popular ...
7.4/10 Good! (1,001 reviews)
"Everything was close by"

Reviewed on Sep 19, 2024

Americas Best Value Inn & Suites Hyannis Cape Cod
Bayside Resort Hotel
Bayside Resort Hotel
3 out of 5
225 Route 28, West Yarmouth, MA
  • 26 min walk from John F. Kennedy Hyannis Museum
The price is $176 per night from Oct 21 to Oct 22
$176
includes taxes & fees
Oct 21 - Oct 22
Stay at this 3-star beach hotel in West Yarmouth. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our reviews. ...
8.6/10 Excellent! (1,178 reviews)
"Room was clean and comfortable. Lovely outdoor lounge area with fire pits and picnic tables. We had a balcony room that we really enjoyed."

Reviewed on Sep 21, 2024

Bayside Resort Hotel
Riviera Beach Resort
Riviera Beach Resort
3 out of 5
327 South Shore Drive, South Yarmouth, MA
  • 10 min drive from John F. Kennedy Hyannis Museum
The price is $182 per night from Sep 29 to Sep 30
$182
includes taxes & fees
Sep 29 - Sep 30
Book a stay at this beach hotel in South Yarmouth. Enjoy free WiFi, an outdoor pool, and a private beach. Our guests praise the helpful staff and the clean rooms ...
8/10 Very Good! (1,002 reviews)
"It was right in the beach so very convenient"

Reviewed on Sep 17, 2024

Riviera Beach Resort
Cape Sands Inn
Cape Sands Inn
2.5 out of 5
149 Main St - RT 28, West Yarmouth, MA
  • 23 min walk from John F. Kennedy Hyannis Museum
The price is $74 per night from Sep 23 to Sep 24
$74
includes taxes & fees
Sep 23 - Sep 24
Book a stay at this family-friendly motel in West Yarmouth. Enjoy free parking, an outdoor pool, and a sauna. Our guests praise the pool and the helpful staff ...
8.2/10 Very Good! (1,006 reviews)
"Clean and functional for a night’s stay. Felt like your foot might go through the floor in places in ground floor room and if you have people above you will hear every footstep loudly."

Reviewed on Sep 18, 2024

Cape Sands Inn
Cape Codder Resort and Spa
Cape Codder Resort and Spa
3 out of 5
1225 Iyannough Rd, Hyannis, MA
  • 5 min drive from John F. Kennedy Hyannis Museum
The price is $216 per night from Oct 20 to Oct 21
$216
includes taxes & fees
Oct 20 - Oct 21
Book a stay at this spa resort in Hyannis. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the clean rooms in our reviews. Popular attractions ...
7.2/10 Good! (1,002 reviews)
"This property is undergoing renovation and rebranding. When we stayed, there were some problems, not gonna lie. I expect that the next time we stay there, it will be fabulous!"

Reviewed on Sep 18, 2024

Cape Codder Resort and Spa
Aiden by Best Western Cape Cod - West Yarmouth
Aiden by Best Western Cape Cod - West Yarmouth
3 out of 5
476 Route 28, West Yarmouth, MA
  • 5 min drive from John F. Kennedy Hyannis Museum
The price is $140 per night from Oct 6 to Oct 7
$140
includes taxes & fees
Oct 6 - Oct 7
Stay at this 3-star business-friendly hotel in West Yarmouth. Enjoy free parking, an outdoor pool, and breakfast (surcharge). Our guests praise the helpful staff ...
8/10 Very Good! (1,005 reviews)
"Most aspects were excellent. Staff very friendly, but the front desk was not always staffed."

Reviewed on Sep 21, 2024

Aiden by Best Western Cape Cod - West Yarmouth
Fairfield Inn & Suites by Marriott Cape Cod Hyannis
Fairfield Inn & Suites by Marriott Cape Cod Hyannis
2.5 out of 5
867 Iyannough Road, Hyannis, MA
  • 27 min walk from John F. Kennedy Hyannis Museum
The price is $159 per night from Oct 15 to Oct 16
$159
includes taxes & fees
Oct 15 - Oct 16
Book a stay at this business-friendly hotel in Hyannis. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8.8/10 Excellent! (485 reviews)
"Staff was first class. Little inconvenient getting in parking lot from one direction"

Reviewed on Sep 12, 2024

Fairfield Inn & Suites by Marriott Cape Cod Hyannis
Sea Crest Beach Resort
Sea Crest Beach Resort
3.5 out of 5
350 Quaker Rd, North Falmouth, MA
  • 42 min drive from John F. Kennedy Hyannis Museum
The price is $234 per night from Oct 20 to Oct 21
$234
includes taxes & fees
Oct 20 - Oct 21
Book a stay at this beach hotel in North Falmouth. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff and the clean rooms ...
7.6/10 Good! (1,000 reviews)
"Nice beachside resort."

Reviewed on Sep 10, 2024

Sea Crest Beach Resort
The Villages at Ocean Edge
The Villages at Ocean Edge
3.5 out of 5
One Villages Drive, Brewster, MA
  • 31 min drive from John F. Kennedy Hyannis Museum
The price is $228 per night from Oct 14 to Oct 15
$228
includes taxes & fees
Oct 14 - Oct 15
Stay at this 3.5-star spa resort in Brewster. Enjoy 3 outdoor pools, a full-service spa, and 3 restaurants. Our guests praise the helpful staff in our reviews. ...
8.2/10 Very Good! (1,002 reviews)
"Off season so no lines or issues needing reservations. Our cleaning crew was a bit untidy"

Reviewed on Sep 17, 2024

The Villages at Ocean Edge
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

HOTW-Hotel-Deals-726-959@2x.jpg (1918×258)*Savings based on Hot Rate® hotel bookings as compared with the lowest published rates found on leading retail travel sites. Hot Rates are different from retail rates. With Hot Rates you enter the date, location and star rating. Hotel revealed only after booking. All bookings final.

Find cheap hotels in Main Street Hyannis

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If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $74. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get up to 60% Main Street Hyannis hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Main Street Hyannis. No matter your reason for visiting Main Street Hyannis, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Main Street Hyannis hotels

Where can I find the best last-minute travel deals?

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How many hotels are there in Main Street Hyannis?

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Finding a cheap car rental deal in Main Street Hyannis is as easy as scoring cheap hotels in Main Street Hyannis. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can even save up to 60% off a car rental deal if you book a Hotwire Hot Rate at the last minute.

Is it safe to travel to Main Street Hyannis now?

With recent COVID-19 closures and reopenings, many people are wondering, “Is it safe to travel to Main Street Hyannis right now?” When it’s time to book your getaway, be sure to check out the most up-to-date information on all safety measures, any restrictions, and guidance on traveling during the coronavirus pandemic.