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De Soto

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De Soto Flights as Low as $209

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

United
Wed, Oct 1 - Sat, Oct 4
IAH
George Bush Intercontinental
DSM
Des Moines Intl.
$209 Roundtrip, found 1 day ago
$209
Roundtrip
found 1 day ago
Select United flight, departing Wed, Oct 1 from George Bush Intercontinental to Des Moines Intl., returning Sat, Oct 4, priced at $209 found 1 day ago
Frontier Airlines
Mon, Sep 29 - Wed, Oct 8
CVG
Cincinnati - Northern Kentucky Intl.
DSM
Des Moines Intl.
$218 Roundtrip, found 23 hours ago
$218
Roundtrip
found 23 hours ago
Select Frontier Airlines flight, departing Mon, Sep 29 from Cincinnati - Northern Kentucky Intl. to Des Moines Intl., returning Wed, Oct 8, priced at $218 found 23 hours ago
Frontier Airlines
Fri, Sep 5 - Fri, Sep 12
DTW
Detroit Metropolitan Wayne County
DSM
Des Moines Intl.
$232 Roundtrip, found 1 day ago
$232
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Fri, Sep 5 from Detroit Metropolitan Wayne County to Des Moines Intl., returning Fri, Sep 12, priced at $232 found 1 day ago
Frontier Airlines
Wed, Sep 17 - Fri, Sep 19
ONT
Los Angeles - Ontario Intl.
DSM
Des Moines Intl.
$243 Roundtrip, found 2 days ago
$243
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Wed, Sep 17 from Los Angeles - Ontario Intl. to Des Moines Intl., returning Fri, Sep 19, priced at $243 found 2 days ago
Bargain Flight
Sat, Sep 13 - Tue, Sep 16
TPA
Tampa Intl.
DSM
Des Moines Intl.
$247 Roundtrip, found 1 day ago
$247
Roundtrip
found 1 day ago
Select Bargain Flight flight, departing Sat, Sep 13 from Tampa Intl. to Des Moines Intl., returning Tue, Sep 16, priced at $247 found 1 day ago
Frontier Airlines
Thu, Sep 18 - Thu, Sep 25
GEG
Spokane Intl.
DSM
Des Moines Intl.
$248 Roundtrip, found 2 days ago
$248
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Thu, Sep 18 from Spokane Intl. to Des Moines Intl., returning Thu, Sep 25, priced at $248 found 2 days ago
Frontier Airlines
Mon, Sep 8 - Thu, Sep 11
SAN
San Diego Intl.
DSM
Des Moines Intl.
$248 Roundtrip, found 22 hours ago
$248
Roundtrip
found 22 hours ago
Select Frontier Airlines flight, departing Mon, Sep 8 from San Diego Intl. to Des Moines Intl., returning Thu, Sep 11, priced at $248 found 22 hours ago
Frontier Airlines
Thu, Sep 11 - Fri, Sep 12
DCA
Ronald Reagan Washington National
DSM
Des Moines Intl.
$253 Roundtrip, found 1 day ago
$253
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Thu, Sep 11 from Ronald Reagan Washington National to Des Moines Intl., returning Fri, Sep 12, priced at $253 found 1 day ago
Delta
Mon, Sep 29 - Mon, Oct 6
LEX
Blue Grass
DSM
Des Moines Intl.
$253 Roundtrip, found 22 hours ago
$253
Roundtrip
found 22 hours ago
Select Delta flight, departing Mon, Sep 29 from Blue Grass to Des Moines Intl., returning Mon, Oct 6, priced at $253 found 22 hours ago
Delta
Tue, Oct 21 - Wed, Oct 22
BOI
Boise
DSM
Des Moines Intl.
$281 Roundtrip, found 1 day ago
$281
Roundtrip
found 1 day ago
Select Delta flight, departing Tue, Oct 21 from Boise to Des Moines Intl., returning Wed, Oct 22, priced at $281 found 1 day ago
Delta
Thu, Sep 11 - Tue, Sep 16
EWR
Newark Liberty Intl. Airport
DSM
Des Moines Intl.
$296 Roundtrip, found 1 day ago
$296
Roundtrip
found 1 day ago
Select Delta flight, departing Thu, Sep 11 from Newark Liberty Intl. Airport to Des Moines Intl., returning Tue, Sep 16, priced at $296 found 1 day ago
American Airlines
Wed, Oct 22 - Sun, Oct 26
ABQ
Albuquerque Intl. Sunport
DSM
Des Moines Intl.
$301 Roundtrip, found 1 day ago
$301
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Oct 22 from Albuquerque Intl. Sunport to Des Moines Intl., returning Sun, Oct 26, priced at $301 found 1 day ago
Delta
Sat, Sep 13 - Mon, Sep 15
BWI
Baltimore Washington Intl. Thurgood Marshall
DSM
Des Moines Intl.
$302 Roundtrip, found 1 day ago
$302
Roundtrip
found 1 day ago
Select Delta flight, departing Sat, Sep 13 from Baltimore Washington Intl. Thurgood Marshall to Des Moines Intl., returning Mon, Sep 15, priced at $302 found 1 day ago
United
Tue, Oct 7 - Tue, Oct 14
SAF
Santa Fe Municipal
DSM
Des Moines Intl.
$320 Roundtrip, found 1 day ago
$320
Roundtrip
found 1 day ago
Select United flight, departing Tue, Oct 7 from Santa Fe Municipal to Des Moines Intl., returning Tue, Oct 14, priced at $320 found 1 day ago
Delta
Thu, Nov 6 - Sat, Nov 15
CID
Eastern Iowa
DSM
Des Moines Intl.
$387 Roundtrip, found 1 day ago
$387
Roundtrip
found 1 day ago
Select Delta flight, departing Thu, Nov 6 from Eastern Iowa to Des Moines Intl., returning Sat, Nov 15, priced at $387 found 1 day ago
American Airlines
Sat, Sep 6 - Mon, Sep 8
CLD
McClellan-Palomar
DSM
Des Moines Intl.
$409 Roundtrip, found 22 hours ago
$409
Roundtrip
found 22 hours ago
Select American Airlines flight, departing Sat, Sep 6 from McClellan-Palomar to Des Moines Intl., returning Mon, Sep 8, priced at $409 found 22 hours ago

Cheap Flights to De Soto

Fall in love at first flight with your vacation to De Soto by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to De Soto on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in De Soto, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to De Soto

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to De Soto with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the DSM airport.

What is the cheapest month to fly to De Soto?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to De Soto are in October, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to De Soto?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 15 to choose from for your flight to De Soto.

What airport is best to fly into De Soto?

When you’re planning your trip to De Soto, convenience is the name of the game. Luckily, De Soto Des Moines Intl. Airport is nearby so you can deplane and get going on checking off everything on your De Soto must-do list.

How much are flights to De Soto?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to De Soto on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $209, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to De Soto?

The trick to saving a stack of cash on your flight to De Soto? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $209 right now, why wait?

De Soto Flight Information
Destination airport
Des Moines Intl.
Destination airport IATA code
DSM
Roundtrip price
$209

Last Minute Hotel Deals in De Soto

Edgetowner Motel

Edgetowner Motel

2.5 out of 5
804 Guthrie St, De Soto, IA
Book a stay at this business-friendly motel in De Soto. Enjoy free parking, a business center, and a garden. Popular attractions Van Meter Recreation Complex ...
6/10 (143 reviews)
"Its what i was looking for"

Reviewed on Apr 21, 2025

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Edgetowner Motel
Ramada Tropics Resort & Conf Center by Wyndham Des Moines

Ramada Tropics Resort & Conf Center by Wyndham Des Moines

3 out of 5
5000 Merle Hay Rd, Urbandale, IA
Book a stay at this family-friendly hotel in Urbandale. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
5.6/10 (569 reviews)
Just manage expectations and it’ll be fine!
"We booked to stay during the state fair with our 3 year old. The hotel is older, for sure. Certainly not a luxury establishment. That said, though, our rooms were clean. The AC worked very well in our room, almost freezing us out the first night until we adjusted it. Our room opened to the waterpark ..."

Reviewed on Aug 17, 2025

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Ramada Tropics Resort & Conf Center by Wyndham Des Moines
Motel 6 West Des Moines, IA

Motel 6 West Des Moines, IA

2 out of 5
7655 Office Plaza Dr N, West Des Moines, IA
Stay at this motel in West Des Moines. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our ...
7.6/10 Good! (541 reviews)
"It was a good place to stay."

Reviewed on Aug 21, 2025

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Motel 6 West Des Moines, IA
Days Inn & Suites by Wyndham Des Moines Airport

Days Inn & Suites by Wyndham Des Moines Airport

2 out of 5
1901 Hackley Ave, Des Moines, IA
Book a stay at this business-friendly hotel in Des Moines. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.4/10 Very Good! (1,578 reviews)
"This was our second time here. Its a great option for parking and airport shuttle."

Reviewed on Aug 22, 2025

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Days Inn & Suites by Wyndham Des Moines Airport
Stoney Creek Hotel Des Moines - Johnston

Stoney Creek Hotel Des Moines - Johnston

2.5 out of 5
5291 Stoney Creek Court, Johnston, IA
Book a stay at this business-friendly hotel in Johnston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our ...
8.8/10 Excellent! (1,763 reviews)
Love the hotel
"We love the room. Although the carpet in the hallways and it make it a little difficult to walk it still was a great stat."

Reviewed on Aug 20, 2025

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Stoney Creek Hotel Des Moines - Johnston
Sonesta Essential Des Moines

Sonesta Essential Des Moines

2 out of 5
4755 Merle Hay Road, Des Moines, IA
Book a stay at this business-friendly hotel in Des Moines. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...
7.2/10 Good! (1,002 reviews)
"The check in was so easy and quick. I'm a female solo traveler and the place felt very safe. The parking is a little bit far from the door, but still plenty of space. The rooms were very neat, the shower was great and the breakfast looked good. I love that they left me a water bottle in the room ..."

Reviewed on Aug 21, 2025

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Sonesta Essential Des Moines
GrandStay Hotel & Suites

GrandStay Hotel & Suites

2 out of 5
6215 Merle Hay Road, Johnston, IA
Enjoy free breakfast, free WiFi, and free parking. Popular attractions Iowa Gold Star Military Museum and Merle Hay Mall are located nearby.
9.2/10 Wonderful! (369 reviews)
"I thought the property was excellent clean nice the breakfast was totally doable. Would definitely recommend."

Reviewed on Aug 20, 2025

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GrandStay Hotel & Suites
Sheraton West Des Moines Hotel

Sheraton West Des Moines Hotel

3.5 out of 5
1800 50th St, West Des Moines, IA
Book a stay at this business-friendly hotel in West Des Moines. Enjoy breakfast (surcharge), room service, and a fitness center. Our guests praise the helpful ...
8/10 Very Good! (1,000 reviews)
Fair & grandkids
"Room was clean and in good condition. Bed was very comfortable. Breakfast was excellent. Food was fresh and good quality. Only negative I can give is that the TV is very small. Otherwise excellent!"

Reviewed on Aug 18, 2025

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Sheraton West Des Moines Hotel
See all 392 properties in De Soto
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.