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De Soto

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De Soto Flights as Low as $105

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Frontier Airlines
Wed, Oct 8 - Mon, Oct 13
DEN
Denver Intl.
DSM
Des Moines Intl.
$105 Roundtrip, found 20 hours ago
$105
Roundtrip
found 20 hours ago
Select Frontier Airlines flight, departing Wed, Oct 8 from Denver Intl. to Des Moines Intl., returning Mon, Oct 13, priced at $105 found 20 hours ago
United
Wed, Oct 8 - Mon, Oct 13
DEN
Denver Intl.
DSM
Des Moines Intl.
$150 Roundtrip, found 20 hours ago
$150
Roundtrip
found 20 hours ago
Select United flight, departing Wed, Oct 8 from Denver Intl. to Des Moines Intl., returning Mon, Oct 13, priced at $150 found 20 hours ago
American Airlines
Tue, Oct 7 - Sat, Oct 11
DEN
Denver Intl.
DSM
Des Moines Intl.
$170 Roundtrip, found 1 day ago
$170
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Oct 7 from Denver Intl. to Des Moines Intl., returning Sat, Oct 11, priced at $170 found 1 day ago
Frontier Airlines
Thu, Nov 6 - Sun, Nov 9
PHX
Sky Harbor Intl.
DSM
Des Moines Intl.
$192 Roundtrip, found 1 day ago
$192
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Thu, Nov 6 from Sky Harbor Intl. to Des Moines Intl., returning Sun, Nov 9, priced at $192 found 1 day ago
American Airlines
Tue, Oct 28 - Sat, Nov 1
ORD
O'Hare Intl.
DSM
Des Moines Intl.
$192 Roundtrip, found 19 hours ago
$192
Roundtrip
found 19 hours ago
Select American Airlines flight, departing Tue, Oct 28 from O'Hare Intl. to Des Moines Intl., returning Sat, Nov 1, priced at $192 found 19 hours ago
Bargain Flight
Sat, Nov 15 - Tue, Nov 18
PHL
Philadelphia Intl.
DSM
Des Moines Intl.
$229 Roundtrip, found 1 day ago
$229
Roundtrip
found 1 day ago
Select Bargain Flight flight, departing Sat, Nov 15 from Philadelphia Intl. to Des Moines Intl., returning Tue, Nov 18, priced at $229 found 1 day ago
Frontier Airlines
Thu, Oct 23 - Mon, Oct 27
DTW
Detroit Metropolitan Wayne County
DSM
Des Moines Intl.
$236 Roundtrip, found 1 day ago
$236
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Thu, Oct 23 from Detroit Metropolitan Wayne County to Des Moines Intl., returning Mon, Oct 27, priced at $236 found 1 day ago
Frontier Airlines
Thu, Sep 18 - Sun, Sep 21
LAS
Harry Reid Intl.
DSM
Des Moines Intl.
$236 Roundtrip, found 5 days ago
$236
Roundtrip
found 5 days ago
Select Frontier Airlines flight, departing Thu, Sep 18 from Harry Reid Intl. to Des Moines Intl., returning Sun, Sep 21, priced at $236 found 5 days ago
Delta
Tue, Oct 21 - Mon, Oct 27
MBS
MBS Intl.
DSM
Des Moines Intl.
$249 Roundtrip, found 1 day ago
$249
Roundtrip
found 1 day ago
Select Delta flight, departing Tue, Oct 21 from MBS Intl. to Des Moines Intl., returning Mon, Oct 27, priced at $249 found 1 day ago
American Airlines
Thu, Oct 23 - Mon, Oct 27
FNT
Bishop Intl.
DSM
Des Moines Intl.
$252 Roundtrip, found 1 day ago
$252
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Oct 23 from Bishop Intl. to Des Moines Intl., returning Mon, Oct 27, priced at $252 found 1 day ago
Bargain Flight
Wed, Oct 15 - Sat, Oct 25
CLT
Charlotte-Douglas Intl.
DSM
Des Moines Intl.
$253 Roundtrip, found 1 day ago
$253
Roundtrip
found 1 day ago
Select Bargain Flight flight, departing Wed, Oct 15 from Charlotte-Douglas Intl. to Des Moines Intl., returning Sat, Oct 25, priced at $253 found 1 day ago
Bargain Flight
Tue, Nov 11 - Sat, Nov 15
SEA
Seattle - Tacoma Intl.
DSM
Des Moines Intl.
$286 Roundtrip, found 20 hours ago
$286
Roundtrip
found 20 hours ago
Select Bargain Flight flight, departing Tue, Nov 11 from Seattle - Tacoma Intl. to Des Moines Intl., returning Sat, Nov 15, priced at $286 found 20 hours ago
United
Fri, Oct 10 - Sun, Oct 12
RAP
Rapid City Regional
DSM
Des Moines Intl.
$295 Roundtrip, found 21 hours ago
$295
Roundtrip
found 21 hours ago
Select United flight, departing Fri, Oct 10 from Rapid City Regional to Des Moines Intl., returning Sun, Oct 12, priced at $295 found 21 hours ago
Bargain Flight
Sun, Sep 21 - Sat, Sep 27
RDU
Raleigh - Durham Intl.
DSM
Des Moines Intl.
$295 Roundtrip, found 6 days ago
$295
Roundtrip
found 6 days ago
Select Bargain Flight flight, departing Sun, Sep 21 from Raleigh - Durham Intl. to Des Moines Intl., returning Sat, Sep 27, priced at $295 found 6 days ago
American Airlines
Fri, Oct 10 - Tue, Oct 14
TTN
Mercer
DSM
Des Moines Intl.
$297 Roundtrip, found 4 days ago
$297
Roundtrip
found 4 days ago
Select American Airlines flight, departing Fri, Oct 10 from Mercer to Des Moines Intl., returning Tue, Oct 14, priced at $297 found 4 days ago
United
Thu, Sep 18 - Mon, Sep 22
SGU
St. George
DSM
Des Moines Intl.
$373 Roundtrip, found 1 day ago
$373
Roundtrip
found 1 day ago
Select United flight, departing Thu, Sep 18 from St. George to Des Moines Intl., returning Mon, Sep 22, priced at $373 found 1 day ago

Cheap Flights to De Soto

Fall in love at first flight with your vacation to De Soto by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to De Soto on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in De Soto, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to De Soto

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to De Soto with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the DSM airport.

What is the cheapest month to fly to De Soto?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to De Soto are in October, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to De Soto?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 12 to choose from for your flight to De Soto.

What airport is best to fly into De Soto?

When you’re planning your trip to De Soto, convenience is the name of the game. Luckily, De Soto Des Moines Intl. Airport is nearby so you can deplane and get going on checking off everything on your De Soto must-do list.

How much are flights to De Soto?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to De Soto on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $105, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to De Soto?

The trick to saving a stack of cash on your flight to De Soto? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $105 right now, why wait?

De Soto Flight Information
Destination airport
De Soto
Destination airport IATA code
DSM

Last Minute Hotel Deals in De Soto

Edgetowner Motel

Edgetowner Motel

2.5 out of 5
804 Guthrie St, De Soto, IA
Book a stay at this business-friendly motel in De Soto. Enjoy free parking, a business center, and a garden. Popular attractions Van Meter Recreation Complex ...
6/10 (143 reviews)
"Its what i was looking for"

Reviewed on Apr 21, 2025

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Edgetowner Motel
Fairfield Inn and Suites by Marriott Des Moines West

Fairfield Inn and Suites by Marriott Des Moines West

2.5 out of 5
7225 Vista Dr, West Des Moines, IA
Book a stay at this business-friendly hotel in West Des Moines. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,003 reviews)
Great I-80 travel stop for a good night rest
"This is a really easy access hotel if you're traveling I-80. The hotel was very clean and smelled nice and the desk staff helped me with a quick check-in. They even came around the desk to say hello to my Doberman traveling with me. The room was clean and the A/C was already set to a nice cool which ..."

Reviewed on Sep 7, 2025

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Fairfield Inn and Suites by Marriott Des Moines West
Days Inn & Suites by Wyndham Des Moines Airport

Days Inn & Suites by Wyndham Des Moines Airport

2 out of 5
1901 Hackley Ave, Des Moines, IA
Book a stay at this business-friendly hotel in Des Moines. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.4/10 Very Good! (1,574 reviews)
"Good place"

Reviewed on Sep 8, 2025

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Days Inn & Suites by Wyndham Des Moines Airport
Stoney Creek Hotel Des Moines - Johnston

Stoney Creek Hotel Des Moines - Johnston

2.5 out of 5
5291 Stoney Creek Court, Johnston, IA
Book a stay at this business-friendly hotel in Johnston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our ...
8.8/10 Excellent! (1,754 reviews)
"Enjoyed the large room. Huge bed. Lovely hot tub. Fireplace was great. Room was super clean. However they missed the wasp nest in the window (we noticed and shut the window do they couldn't get in the room). And that our soap and shampoo were all empty. Otherwise in the Cottages it was great. Loved ..."

Reviewed on Sep 9, 2025

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Stoney Creek Hotel Des Moines - Johnston
Motel 6 West Des Moines, IA

Motel 6 West Des Moines, IA

2 out of 5
7655 Office Plaza Dr N, West Des Moines, IA
Stay at this motel in West Des Moines. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our ...
7.6/10 Good! (573 reviews)
"Stayed here a few times and no major complaints. This most recent visit I had gotten to the motel somewhat early and had to wait about 5-10 minutes before I could access my room. The toilet also seemed to be constantly running water but couldn't hear it with the door closed. Also could not connect ..."

Reviewed on Sep 8, 2025

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Motel 6 West Des Moines, IA
Quality Inn & Suites Des Moines - Merle Hay Road

Quality Inn & Suites Des Moines - Merle Hay Road

2.5 out of 5
4995 Merle Hay Rd, Des Moines, IA
Book a stay at this business-friendly hotel in Des Moines. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.4/10 Good! (1,009 reviews)
"I enjoyed my stay, nothing special, but got the job done."

Reviewed on Sep 10, 2025

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Quality Inn & Suites Des Moines - Merle Hay Road
Sonesta Essential Des Moines

Sonesta Essential Des Moines

2 out of 5
4755 Merle Hay Road, Des Moines, IA
Book a stay at this business-friendly hotel in Des Moines. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...
7.2/10 Good! (1,007 reviews)
"So far this property is clean, updated and the front staff lady is beyond welcoming and friendly!!"

Reviewed on Sep 7, 2025

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Sonesta Essential Des Moines
Ramada Tropics Resort & Conf Center by Wyndham Des Moines

Ramada Tropics Resort & Conf Center by Wyndham Des Moines

3 out of 5
5000 Merle Hay Rd, Urbandale, IA
Book a stay at this family-friendly hotel in Urbandale. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
5.6/10 (594 reviews)
"Great place for families"

Reviewed on Sep 5, 2025

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Ramada Tropics Resort & Conf Center by Wyndham Des Moines
See all 399 properties in De Soto
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.