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De Soto

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De Soto Flights as Low as $179

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Frontier Airlines
Sun, Aug 24 - Sun, Aug 31
DEN
Denver Intl.
DSM
Des Moines Intl.
$179 Roundtrip, found 4 hours ago
$179
Roundtrip
found 4 hours ago
Select Frontier Airlines flight, departing Sun, Aug 24 from Denver Intl. to Des Moines Intl., returning Sun, Aug 31, priced at $179 found 4 hours ago
Frontier Airlines
Mon, Aug 18 - Thu, Aug 21
DEN
Denver Intl.
DSM
Des Moines Intl.
$182 Roundtrip, found 3 hours ago
$182
Roundtrip
found 3 hours ago
Select Frontier Airlines flight, departing Mon, Aug 18 from Denver Intl. to Des Moines Intl., returning Thu, Aug 21, priced at $182 found 3 hours ago
American Airlines
Tue, Jul 29 - Sun, Aug 3
ORD
O'Hare Intl.
DSM
Des Moines Intl.
$193 Roundtrip, found 1 day ago
$193
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Jul 29 from O'Hare Intl. to Des Moines Intl., returning Sun, Aug 3, priced at $193 found 1 day ago
Delta
Thu, Aug 21 - Thu, Aug 21
DEN
Denver Intl.
DSM
Des Moines Intl.
$194 Roundtrip, found 4 hours ago
$194
Roundtrip
found 4 hours ago
Select Delta flight, departing Thu, Aug 21 from Denver Intl. to Des Moines Intl., returning Thu, Aug 21, priced at $194 found 4 hours ago
United
Sun, Aug 24 - Sun, Aug 31
DEN
Denver Intl.
DSM
Des Moines Intl.
$197 Roundtrip, found 4 hours ago
$197
Roundtrip
found 4 hours ago
Select United flight, departing Sun, Aug 24 from Denver Intl. to Des Moines Intl., returning Sun, Aug 31, priced at $197 found 4 hours ago
Delta
Tue, Jul 15 - Tue, Jul 15
LAS
Harry Reid Intl.
DSM
Des Moines Intl.
$215 Roundtrip, found 1 day ago
$215
Roundtrip
found 1 day ago
Select Delta flight, departing Tue, Jul 15 from Harry Reid Intl. to Des Moines Intl., returning Tue, Jul 15, priced at $215 found 1 day ago
Delta
Tue, Nov 4 - Tue, Nov 11
VPS
Northwest Florida Regional
DSM
Des Moines Intl.
$215 Roundtrip, found 4 hours ago
$215
Roundtrip
found 4 hours ago
Select Delta flight, departing Tue, Nov 4 from Northwest Florida Regional to Des Moines Intl., returning Tue, Nov 11, priced at $215 found 4 hours ago
Delta
Tue, Nov 4 - Mon, Nov 10
PNS
Pensacola Intl.
DSM
Des Moines Intl.
$217 Roundtrip, found 12 hours ago
$217
Roundtrip
found 12 hours ago
Select Delta flight, departing Tue, Nov 4 from Pensacola Intl. to Des Moines Intl., returning Mon, Nov 10, priced at $217 found 12 hours ago
United
Thu, Sep 4 - Thu, Sep 11
LAX
Los Angeles Intl.
DSM
Des Moines Intl.
$237 Roundtrip, found 4 hours ago
$237
Roundtrip
found 4 hours ago
Select United flight, departing Thu, Sep 4 from Los Angeles Intl. to Des Moines Intl., returning Thu, Sep 11, priced at $237 found 4 hours ago
Bargain Flight
Tue, Jun 24 - Tue, Jul 22
PHX
Sky Harbor Intl.
DSM
Des Moines Intl.
$242 Roundtrip, found 13 hours ago
$242
Roundtrip
found 13 hours ago
Select Bargain Flight flight, departing Tue, Jun 24 from Sky Harbor Intl. to Des Moines Intl., returning Tue, Jul 22, priced at $242 found 13 hours ago
Bargain Flight
Wed, Jul 9 - Tue, Jul 15
DCA
Ronald Reagan Washington National
DSM
Des Moines Intl.
$267 Roundtrip, found 9 hours ago
$267
Roundtrip
found 9 hours ago
Select Bargain Flight flight, departing Wed, Jul 9 from Ronald Reagan Washington National to Des Moines Intl., returning Tue, Jul 15, priced at $267 found 9 hours ago
Delta
Mon, Aug 4 - Wed, Aug 6
JAX
Jacksonville Intl.
DSM
Des Moines Intl.
$281 Roundtrip, found 4 days ago
$281
Roundtrip
found 4 days ago
Select Delta flight, departing Mon, Aug 4 from Jacksonville Intl. to Des Moines Intl., returning Wed, Aug 6, priced at $281 found 4 days ago
United
Tue, Aug 5 - Tue, Aug 12
BWI
Baltimore Washington Intl. Thurgood Marshall
DSM
Des Moines Intl.
$301 Roundtrip, found 12 hours ago
$301
Roundtrip
found 12 hours ago
Select United flight, departing Tue, Aug 5 from Baltimore Washington Intl. Thurgood Marshall to Des Moines Intl., returning Tue, Aug 12, priced at $301 found 12 hours ago
Delta
Mon, Jun 23 - Fri, Jul 4
CAE
Columbia Metropolitan
DSM
Des Moines Intl.
$310 Roundtrip, found 12 hours ago
$310
Roundtrip
found 12 hours ago
Select Delta flight, departing Mon, Jun 23 from Columbia Metropolitan to Des Moines Intl., returning Fri, Jul 4, priced at $310 found 12 hours ago
United
Thu, Jun 26 - Tue, Jul 1
PDX
Portland Intl.
DSM
Des Moines Intl.
$625 Roundtrip, found 1 day ago
$625
Roundtrip
found 1 day ago
Select United flight, departing Thu, Jun 26 from Portland Intl. to Des Moines Intl., returning Tue, Jul 1, priced at $625 found 1 day ago
Alaska Airlines
Thu, Jun 26 - Tue, Jul 1
PDX
Portland Intl.
DSM
Des Moines Intl.
$938 Roundtrip, found 1 day ago
$938
Roundtrip
found 1 day ago
Select Alaska Airlines flight, departing Thu, Jun 26 from Portland Intl. to Des Moines Intl., returning Tue, Jul 1, priced at $938 found 1 day ago

Cheap Flights to De Soto

Fall in love at first flight with your vacation to De Soto by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to De Soto on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in De Soto, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to De Soto

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to De Soto with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the DSM airport.

What is the cheapest month to fly to De Soto?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to De Soto are in August, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to De Soto?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 14 to choose from for your flight to De Soto.

What airport is best to fly into De Soto?

When you’re planning your trip to De Soto, convenience is the name of the game. Luckily, De Soto Des Moines Intl. Airport is nearby so you can deplane and get going on checking off everything on your De Soto must-do list.

How much are flights to De Soto?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to De Soto on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $179, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to De Soto?

The trick to saving a stack of cash on your flight to De Soto? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $179 right now, why wait?

De Soto Flight Information
Destination airport
Des Moines Intl.
Destination airport IATA code
DSM
Roundtrip price
$178

Last Minute Hotel Deals in De Soto

Edgetowner Motel
Edgetowner Motel
2.5 out of 5
804 Guthrie St, De Soto, IA
Book a stay at this business-friendly motel in De Soto. Enjoy free parking, a business center, and a garden. Popular attractions Van Meter Recreation Complex ...
6/10 (138 reviews)
"Its what i was looking for"

Reviewed on Apr 21, 2025

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Edgetowner Motel
Days Inn & Suites by Wyndham Des Moines Airport
Days Inn & Suites by Wyndham Des Moines Airport
2 out of 5
1901 Hackley Ave, Des Moines, IA
Book a stay at this business-friendly hotel in Des Moines. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.4/10 Very Good! (1,506 reviews)
"Convenient airport shuttle. Quick and efficient check-in / check-out. Quiet location despite proximity to airport. Our room was decent size. Convenient electrical outlets for charging laptop / phones. Working desk is small but adequate. Comfortable beds. Plenty of hot water. Nice variety for breakfast. ..."

Reviewed on Jun 19, 2025

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Days Inn & Suites by Wyndham Des Moines Airport
Stoney Creek Hotel Des Moines - Johnston
Stoney Creek Hotel Des Moines - Johnston
2.5 out of 5
5291 Stoney Creek Court, Johnston, IA
Book a stay at this business-friendly hotel in Johnston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our ...
8.8/10 Excellent! (1,715 reviews)
"Beautiful property and room for a fair price."

Reviewed on Jun 16, 2025

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Stoney Creek Hotel Des Moines - Johnston
Quality Inn & Suites Des Moines - Merle Hay Road
Quality Inn & Suites Des Moines - Merle Hay Road
2.5 out of 5
4995 Merle Hay Rd, Des Moines, IA
Book a stay at this business-friendly hotel in Des Moines. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.4/10 Good! (925 reviews)
"Very dated but beds were comfortable. Within close proximity of lots of food options with DoorDash as well."

Reviewed on Jun 20, 2025

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Quality Inn & Suites Des Moines - Merle Hay Road
Motel 6 West Des Moines, IA
Motel 6 West Des Moines, IA
2 out of 5
7655 Office Plaza Dr N, West Des Moines, IA
Stay at this motel in West Des Moines. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our ...
7.8/10 Good! (387 reviews)
"Wonderful stay with my dog. Safe parking lot, clean, and very friendly staff. My dog loved all the treats at check-in!"

Reviewed on Jun 18, 2025

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Motel 6 West Des Moines, IA
Ramada Tropics Resort & Conf Center by Wyndham Des Moines
Ramada Tropics Resort & Conf Center by Wyndham Des Moines
3 out of 5
5000 Merle Hay Rd, Urbandale, IA
Book a stay at this family-friendly hotel in Urbandale. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
5.6/10 (462 reviews)
"It was good .. good price ..nice people that worked there.. breakfast was. Ok .. thought be more variety.. like egs .. sausage bacon.. my room toilet was loose ..kinda tilted.. told service people about it too"

Reviewed on Jun 22, 2025

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Ramada Tropics Resort & Conf Center by Wyndham Des Moines
Sonesta Essential Des Moines
Sonesta Essential Des Moines
2 out of 5
4755 Merle Hay Road, Des Moines, IA
Book a stay at this business-friendly hotel in Des Moines. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...
7.2/10 Good! (1,002 reviews)
"Good place to stay"

Reviewed on Jun 21, 2025

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Sonesta Essential Des Moines
La Quinta Inn & Suites by Wyndham Des Moines West Clive
La Quinta Inn & Suites by Wyndham Des Moines West Clive
3 out of 5
1390 Nw 118th St, Clive, IA
Stay at this 3-star family-friendly hotel in Clive. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.6/10 Excellent! (1,001 reviews)
"This hotel was fantastic, great location, comfy beds, decent breakfast. Will stay again."

Reviewed on Jun 20, 2025

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La Quinta Inn & Suites by Wyndham Des Moines West Clive
See all 378 properties in De Soto
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.