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St. Charles

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St. Charles Flights as Low as $225

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Delta
Wed, Sep 9 - Sat, Sep 12
STL
Lambert-St. Louis Intl.
RST
Rochester Intl.
$225 Roundtrip, found 5 days ago
$225
Roundtrip
found 5 days ago
Select Delta flight, departing Wed, Sep 9 from Lambert-St. Louis Intl. to Rochester Intl., returning Sat, Sep 12, priced at $225 found 5 days ago
Delta
Fri, Oct 9 - Mon, Oct 12
MSP
Minneapolis - St. Paul Intl.
RST
Rochester Intl.
$249 Roundtrip, found 4 hours ago
$249
Roundtrip
found 4 hours ago
Select Delta flight, departing Fri, Oct 9 from Minneapolis - St. Paul Intl. to Rochester Intl., returning Mon, Oct 12, priced at $249 found 4 hours ago
Delta
Sat, Sep 5 - Tue, Sep 8
STL
Lambert-St. Louis Intl.
RST
Rochester Intl.
$256 Roundtrip, found 5 days ago
$256
Roundtrip
found 5 days ago
Select Delta flight, departing Sat, Sep 5 from Lambert-St. Louis Intl. to Rochester Intl., returning Tue, Sep 8, priced at $256 found 5 days ago
Delta
Thu, Sep 10 - Sat, Sep 12
STL
Lambert-St. Louis Intl.
RST
Rochester Intl.
$264 Roundtrip, found 5 days ago
$264
Roundtrip
found 5 days ago
Select Delta flight, departing Thu, Sep 10 from Lambert-St. Louis Intl. to Rochester Intl., returning Sat, Sep 12, priced at $264 found 5 days ago
Delta
Wed, Sep 9 - Wed, Sep 23
STL
Lambert-St. Louis Intl.
RST
Rochester Intl.
$266 Roundtrip, found 3 days ago
$266
Roundtrip
found 3 days ago
Select Delta flight, departing Wed, Sep 9 from Lambert-St. Louis Intl. to Rochester Intl., returning Wed, Sep 23, priced at $266 found 3 days ago
Delta
Tue, Sep 1 - Sat, Sep 12
EWR
Newark Liberty Intl. Airport
RST
Rochester Intl.
$270 Roundtrip, found 20 hours ago
$270
Roundtrip
found 20 hours ago
Select Delta flight, departing Tue, Sep 1 from Newark Liberty Intl. Airport to Rochester Intl., returning Sat, Sep 12, priced at $270 found 20 hours ago
American Airlines
Tue, Sep 1 - Sat, Sep 12
EWR
Newark Liberty Intl. Airport
RST
Rochester Intl.
$270 Roundtrip, found 20 hours ago
$270
Roundtrip
found 20 hours ago
Select American Airlines flight, departing Tue, Sep 1 from Newark Liberty Intl. Airport to Rochester Intl., returning Sat, Sep 12, priced at $270 found 20 hours ago
Delta
Wed, Sep 9 - Thu, Sep 24
STL
Lambert-St. Louis Intl.
RST
Rochester Intl.
$272 Roundtrip, found 3 days ago
$272
Roundtrip
found 3 days ago
Select Delta flight, departing Wed, Sep 9 from Lambert-St. Louis Intl. to Rochester Intl., returning Thu, Sep 24, priced at $272 found 3 days ago
Delta
Thu, Sep 10 - Thu, Sep 24
STL
Lambert-St. Louis Intl.
RST
Rochester Intl.
$278 Roundtrip, found 3 days ago
$278
Roundtrip
found 3 days ago
Select Delta flight, departing Thu, Sep 10 from Lambert-St. Louis Intl. to Rochester Intl., returning Thu, Sep 24, priced at $278 found 3 days ago
Delta
Fri, Jul 17 - Mon, Aug 3
TVC
Cherry Capital
RST
Rochester Intl.
$285 Roundtrip, found 11 hours ago
$285
Roundtrip
found 11 hours ago
Select Delta flight, departing Fri, Jul 17 from Cherry Capital to Rochester Intl., returning Mon, Aug 3, priced at $285 found 11 hours ago
Delta
Tue, Sep 29 - Sun, Oct 18
STL
Lambert-St. Louis Intl.
RST
Rochester Intl.
$287 Roundtrip, found 3 days ago
$287
Roundtrip
found 3 days ago
Select Delta flight, departing Tue, Sep 29 from Lambert-St. Louis Intl. to Rochester Intl., returning Sun, Oct 18, priced at $287 found 3 days ago
American Airlines
Tue, Jun 30 - Tue, Jul 14
DTW
Detroit Metropolitan Wayne County
RST
Rochester Intl.
$291 Roundtrip, found 7 hours ago
$291
Roundtrip
found 7 hours ago
Select American Airlines flight, departing Tue, Jun 30 from Detroit Metropolitan Wayne County to Rochester Intl., returning Tue, Jul 14, priced at $291 found 7 hours ago
Delta
Tue, Sep 8 - Sat, Sep 12
LGA
LaGuardia
RST
Rochester Intl.
$308 Roundtrip, found 23 hours ago
$308
Roundtrip
found 23 hours ago
Select Delta flight, departing Tue, Sep 8 from LaGuardia to Rochester Intl., returning Sat, Sep 12, priced at $308 found 23 hours ago
Delta
Tue, Jul 14 - Tue, Jul 21
SAN
San Diego Intl.
RST
Rochester Intl.
$435 Roundtrip, found 21 hours ago
$435
Roundtrip
found 21 hours ago
Select Delta flight, departing Tue, Jul 14 from San Diego Intl. to Rochester Intl., returning Tue, Jul 21, priced at $435 found 21 hours ago
American Airlines
Sat, Jul 4 - Sat, Jul 4
PIA
Greater Peoria Regional
RST
Rochester Intl.
$506 Roundtrip, found 4 days ago
$506
Roundtrip
found 4 days ago
Select American Airlines flight, departing Sat, Jul 4 from Greater Peoria Regional to Rochester Intl., returning Sat, Jul 4, priced at $506 found 4 days ago
Delta
Wed, Aug 19 - Thu, Aug 20
JFK
John F. Kennedy Intl.
RST
Rochester Intl.
$605 Roundtrip, found 4 hours ago
$605
Roundtrip
found 4 hours ago
Select Delta flight, departing Wed, Aug 19 from John F. Kennedy Intl. to Rochester Intl., returning Thu, Aug 20, priced at $605 found 4 hours ago

Cheap Flights to St. Charles

Fall in love at first flight with your vacation to St. Charles by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to St. Charles on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in St. Charles, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to St. Charles

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to St. Charles with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the RST airport.

What is the cheapest month to fly to St. Charles?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to St. Charles are in September, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to St. Charles?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to St. Charles.

What airport is best to fly into St. Charles?

When you’re planning your trip to St. Charles, convenience is the name of the game. Luckily, St. Charles Rochester Intl. Airport is nearby so you can deplane and get going on checking off everything on your St. Charles must-do list.

How much are flights to St. Charles?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to St. Charles on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $225, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to St. Charles?

The trick to saving a stack of cash on your flight to St. Charles? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $225 right now, why wait?

St. Charles Flight Information
Destination airport
Rochester Intl.
Destination airport IATA code
RST
Roundtrip price
$225

Last Minute Hotel Deals in St. Charles

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

3 out of 5
401 6th St Sw Rochester MN
Book a stay at this golf hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the restaurant in our reviews. ...
8.6/10 Excellent! (1,016 reviews)
"Absolutely amazing hotel to stay at if you have celiac or need to be gluten free. It was a dream! Rooms are a little dated but overall great place and location to Mayo!"

Reviewed on Jun 23, 2026

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Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
Kahler Grand Hotel

Kahler Grand Hotel

3 out of 5
20 2nd Ave Sw Rochester MN
Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the helpful staff and ...
8.4/10 Very Good! (2,161 reviews)
"The Kahler is always an excellent choice…particularly if you are visiting the Mayo Clinic."

Reviewed on Jun 22, 2026

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Kahler Grand Hotel
Kahler Inn and Suites - Mayo Clinic Area

Kahler Inn and Suites - Mayo Clinic Area

3.5 out of 5
9 3rd Ave Nw Rochester MN
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the helpful staff and the ...
8/10 Very Good! (1,592 reviews)
"Excellent breakfast daily. Parking below not user friendly."

Reviewed on Jun 22, 2026

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Kahler Inn and Suites - Mayo Clinic Area
AmericInn by Wyndham Rochester Near Mayo Clinic

AmericInn by Wyndham Rochester Near Mayo Clinic

3 out of 5
1625 Broadway Ave S Rochester MN
Book a stay at this spa hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the restaurant and the helpful staff in our ...
8/10 Very Good! (1,362 reviews)
"Easy check in and out. Quiet room"

Reviewed on Jun 20, 2026

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AmericInn by Wyndham Rochester Near Mayo Clinic
Med City Inn & Suites - Mayo Clinic Area

Med City Inn & Suites - Mayo Clinic Area

2.5 out of 5
435 16th Ave Nw Rochester MN
Book a stay at this family-friendly motel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8/10 Very Good! (1,004 reviews)
"Once hot breakfast was added it was a great improvement. The dining area is keep clean & isn’t crowded. Staff at front desk varied from nice to snarky. My Doctor cancelled my surgery for medical reasons & ordered me back in 2 weeks. No refunds or credits at given or allowed. Think carefully about ..."

Reviewed on Jun 22, 2026

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Med City Inn & Suites - Mayo Clinic Area
Hyatt House Rochester/Mayo Clinic Area

Hyatt House Rochester/Mayo Clinic Area

3 out of 5
110 Civic Center Drive NW Rochester MN
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and a free area shuttle. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,004 reviews)
"Staff were uniformly friendly and helpful. That made all the difference for us since we were commuting to/from Mayo Clinic. The free breakfast was decent, but lacked variety, wearing thin during our 1 week stay. Trash was not emptied nearly often enough from the small bins near the elevators. Also ..."

Reviewed on Jun 19, 2026

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Hyatt House Rochester/Mayo Clinic Area
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

3 out of 5
4353 Canal Pl SE Rochester MN
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...
7.4/10 Good! (1,067 reviews)
"The mattress on the bed was well used. A dip in the middle. 😏 The shower/tub in the bathroom was slippery when using the shower. My husband almost fell. There was no closet. However, it was quiet and the staff was very gracious. We will stay there again."

Reviewed on Jun 21, 2026

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La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
EVEN Hotel Rochester - Mayo Clinic Area by IHG

EVEN Hotel Rochester - Mayo Clinic Area by IHG

4 out of 5
101 11TH Avenue SW Rochester MN
Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
9.4/10 Exceptional! (1,003 reviews)
"Amazing place to stay , highly recommend"

Reviewed on Jun 21, 2026

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EVEN Hotel Rochester - Mayo Clinic Area by IHG
See all 487 properties in St. Charles
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.