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Choose from 510 St. Charles Hotel Deals

Kahler Grand Hotel

Kahler Grand Hotel

3 out of 5
20 2nd Ave Sw Rochester MN
  • 2 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the helpful staff and ...
8.2/10 Very Good! (1,898 reviews)
Everything stood out

Reviewed on Feb 14, 2026

Kahler Grand Hotel
AmericInn by Wyndham Rochester Near Mayo Clinic

AmericInn by Wyndham Rochester Near Mayo Clinic

3 out of 5
1625 Broadway Ave S Rochester MN
  • 4 min drive from Mayo Clinic
Book a stay at this spa hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the restaurant and the helpful staff in our ...
8/10 Very Good! (1,204 reviews)
Pleasant hotel.

Reviewed on Feb 5, 2026

AmericInn by Wyndham Rochester Near Mayo Clinic
Kahler Inn and Suites - Mayo Clinic Area

Kahler Inn and Suites - Mayo Clinic Area

3.5 out of 5
9 3rd Ave Nw Rochester MN
  • 3 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the helpful staff and the ...
7.8/10 Good! (1,526 reviews)
The room was comfortable, the bedding, nice. The hotel was quiet at night, but there's massive construction going on in every direction, from which the noise starts at 7:30am. Every hotel in the area would be the same for noise. Breakfast was good except the pancakes were tough like shoe leather, ...

Reviewed on Feb 6, 2026

Kahler Inn and Suites - Mayo Clinic Area
Aspen Suites

Aspen Suites

3 out of 5
1211 2nd Street Rochester MN
  • 21 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9/10 Wonderful! (723 reviews)
It was a very nice stay, everyone was very nice helpful, and on their game. Definitely will be staying again. Great thanks to all. Keep up the great work. Love the location in regards to the hospital. Made our visit to a loved one extremely convenient. I can’t think of anything that needed improvement ...

Reviewed on Feb 12, 2026

Aspen Suites
EVEN Hotel Rochester - Mayo Clinic Area by IHG

EVEN Hotel Rochester - Mayo Clinic Area by IHG

4 out of 5
101 11TH Avenue SW Rochester MN
  • 17 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
9.2/10 Wonderful! (992 reviews)
Could use more staff in hotel. Rooms were ok. Shuttle to Mayo was a little crowded at times.

Reviewed on Feb 3, 2026

EVEN Hotel Rochester - Mayo Clinic Area by IHG
Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG

3.5 out of 5
220 S Broadway Rochester MN
  • 6 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the restaurant and ...
8.8/10 Excellent! (929 reviews)
Nice spacious hotel, everyone was generous!

Reviewed on Feb 8, 2026

Hotel Indigo Rochester – Mayo Clinic Area by IHG
Hyatt House Rochester/Mayo Clinic Area

Hyatt House Rochester/Mayo Clinic Area

3 out of 5
110 Civic Center Drive NW Rochester MN
  • 7 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and a free area shuttle. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,005 reviews)
Clean, comfortable. Most of the staff were very kind and accommodating. One particular evening front desk person was very unprofessional and rude. Overall, good stay.

Reviewed on Feb 6, 2026

Hyatt House Rochester/Mayo Clinic Area
Brentwood Inn & Suites

Brentwood Inn & Suites

2.5 out of 5
123 Fourth Ave. NW Rochester MN
  • 5 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and parking (surcharge). Our guests praise the breakfast and the helpful ...
8.8/10 Excellent! (1,001 reviews)
Very convenient for Mayo appointments

Reviewed on Feb 8, 2026

Brentwood Inn & Suites
The Berkman

The Berkman

3 out of 5
217 14th Ave SW Rochester MN
  • 24 min walk from Mayo Clinic
Book a stay at this golf aparthotel in Rochester. Enjoy free WiFi, an outdoor pool, and a rooftop terrace. Our guests praise the helpful staff in our reviews. ...
9.6/10 Exceptional! (383 reviews)
Everything was excellent, second time staying there.

Reviewed on Jan 25, 2026

The Berkman
Spark by Hilton Rochester South

Spark by Hilton Rochester South

3 out of 5
4165 Maine Ave SE Rochester MN
  • 10 min drive from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9.2/10 Wonderful! (370 reviews)
Room was very clean, staff was excellent in every way

Reviewed on Feb 7, 2026

Spark by Hilton Rochester South
SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

3 out of 5
1125 2nd St Sw Rochester MN
  • 19 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8.4/10 Very Good! (961 reviews)
Everything was fine

Reviewed on Feb 2, 2026

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys
Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

3 out of 5
401 6th St Sw Rochester MN
  • 8 min walk from Mayo Clinic
Book a stay at this golf hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the restaurant in our reviews. ...
8.6/10 Excellent! (1,003 reviews)
Easy access to Mayo Clinic and downtown

Reviewed on Feb 10, 2026

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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