Search for Cheap Deals onHotels in St. Charles
Choose from 507 St. Charles Hotel Deals
Kahler Grand Hotel
Excellent rooms
Reviewed on Jan 21, 2026
AmericInn by Wyndham Rochester Near Mayo Clinic
Very helpful staff. Wasn't able to try breakfast due to my schedule
Reviewed on Jan 17, 2026
EVEN Hotel Rochester - Mayo Clinic Area by IHG
Great hotel!
Reviewed on Jan 21, 2026
Hotel Indigo Rochester – Mayo Clinic Area by IHG
Great room. Nice that checkout is noon. Having Crave Restaurant downstairs is great too.
Reviewed on Jan 20, 2026
Aspen Suites
Outdoor temps were very cold during my stay - below zero Fahrenheit. I was really pleased that underground heated parking was available when I arrived!!! My room was great. Staff very pleasant and helpful.
Reviewed on Jan 20, 2026
Kahler Inn and Suites - Mayo Clinic Area
Didn't experience breakfast.
Reviewed on Jan 20, 2026
Hyatt House Rochester/Mayo Clinic Area
All the above!! Surprisingly pleasant and exceeded expectations. Expedia value was an extra bonus.
Reviewed on Jan 18, 2026
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
Staff welcoming… room was clean
Reviewed on Jan 17, 2026
Hampton Inn Rochester-South
Very good I should say excellent
Reviewed on Jan 18, 2026
Holiday Inn Express Rochester South - Mayo Area by IHG
Room very clean. Lady at front desk not very friendly and breakfast was cold
Reviewed on Jan 8, 2026
Spark by Hilton Rochester South
Clean, quiet and a really nice place to stay.
Reviewed on Jan 21, 2026
Brentwood Inn & Suites
Room was clean and staff was excellent. Access to Mayo Clinic, especially in January was what made this choice for us.
Reviewed on Jan 22, 2026
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