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Hotels in St. Charles

Choose from 497 St. Charles Hotel Deals

Kahler Grand Hotel
Kahler Grand Hotel
3 out of 5
20 2nd Ave Sw, Rochester, MN
  • 2 min walk from Mayo Clinic
The price is $187 per night from Apr 25 to Apr 26
$187
includes taxes & fees
Apr 25 - Apr 26
Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the helpful staff and ...
8.2/10 Very Good! (1,347 reviews)
"Close to Mayo clinic with underground access to clinic. Helpful staff. Pretty easy to find Broken roller on chair in room Bathtub faucet shower lever stuck Parking in parking garage high price, but easily accessed from hotel No street level parking. Bad rib steaks!"

Reviewed on Apr 20, 2025

Kahler Grand Hotel
AmericInn by Wyndham Rochester Near Mayo Clinic
AmericInn by Wyndham Rochester Near Mayo Clinic
3 out of 5
1625 Broadway Ave S, Rochester, MN
  • 4 min drive from Mayo Clinic
The price is $88 per night from Apr 27 to Apr 28
$88
includes taxes & fees
Apr 27 - Apr 28
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the restaurant and the helpful ...
8/10 Very Good! (817 reviews)
"Everyone was so nice!"

Reviewed on Apr 21, 2025

AmericInn by Wyndham Rochester Near Mayo Clinic
Med City Inn & Suites - Mayo Clinic Area
Med City Inn & Suites - Mayo Clinic Area
2.5 out of 5
435 16th Ave Nw, Rochester, MN
  • 26 min walk from Mayo Clinic
The price is $92 per night from Apr 25 to Apr 26
$92
includes taxes & fees
Apr 25 - Apr 26
Book a stay at this family-friendly motel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (1,000 reviews)
"Noisy, windows need replacing."

Reviewed on Apr 15, 2025

Med City Inn & Suites - Mayo Clinic Area
Hyatt House Rochester/Mayo Clinic Area
Hyatt House Rochester/Mayo Clinic Area
3 out of 5
110 Civic Center Drive NW, Rochester, MN
  • 7 min walk from Mayo Clinic
The price is $123 per night from May 24 to May 25
$123
includes taxes & fees
May 24 - May 25
Stay at this 3-star business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and a free area shuttle. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (872 reviews)
"Very nice"

Reviewed on Apr 20, 2025

Hyatt House Rochester/Mayo Clinic Area
Kahler Inn and Suites - Mayo Clinic Area
Kahler Inn and Suites - Mayo Clinic Area
3.5 out of 5
9 3rd Ave Nw, Rochester, MN
  • 3 min walk from Mayo Clinic
The price is $175 per night from Apr 27 to Apr 28
$175
includes taxes & fees
Apr 27 - Apr 28
Stay at this 3.5-star business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the helpful staff and the ...
7.6/10 Good! (1,337 reviews)
"No problems. Easy access to Mayo."

Reviewed on Apr 16, 2025

Kahler Inn and Suites - Mayo Clinic Area
Hotel Indigo Rochester – Mayo Clinic Area by IHG
Hotel Indigo Rochester – Mayo Clinic Area by IHG
3.5 out of 5
220 S Broadway, Rochester, MN
  • 6 min walk from Mayo Clinic
The price is $135 per night from May 16 to May 17
$135
includes taxes & fees
May 16 - May 17
Stay at this 3.5-star business-friendly hotel in Rochester. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the restaurant and ...
8.8/10 Excellent! (738 reviews)
"Needs hot tub. Very convenient if you’re having anything at the mayo. Direct entry from hospital to hotel. Great restaurants within walking distance of all kinds. Ubers are 1-3min waits. Nice clean facilities great rooms."

Reviewed on Apr 16, 2025

Hotel Indigo Rochester – Mayo Clinic Area by IHG
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
3 out of 5
4353 Canal Pl SE, Rochester, MN
  • 11 min drive from Mayo Clinic
The price is $78 per night from Apr 27 to Apr 28
$78
includes taxes & fees
Apr 27 - Apr 28
Stay at this 3-star business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...
7.4/10 Good! (1,000 reviews)
"A good, reasonably priced hotel."

Reviewed on Apr 19, 2025

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
Hampton Inn Rochester-South
Hampton Inn Rochester-South
2.5 out of 5
1755 S Broadway, Rochester, MN
  • 4 min drive from Mayo Clinic
The price is $110 per night from May 24 to May 25
$110
includes taxes & fees
May 24 - May 25
Stay at this hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
8.8/10 Excellent! (1,004 reviews)
"Overall a great property that is well maintained, quiet and accommodating. Breakfast (eggs) were subpar, but everything else was great."

Reviewed on Apr 21, 2025

Hampton Inn Rochester-South
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
2.5 out of 5
1517 16th St Sw, Rochester, MN
  • 5 min drive from Mayo Clinic
The price is $108 per night from Apr 28 to Apr 29
$108
includes taxes & fees
Apr 28 - Apr 29
Book a stay at this family-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our ...
8.2/10 Very Good! (593 reviews)
"Staff was great and first two nights good. Third night there was several parties going on and notified staff of loud music at 11 pm and had to leave property at midnight for several hours because could not sleep and started to feel unsafe. Aware that events are held there and may be loud at times. ..."

Reviewed on Apr 21, 2025

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
EVEN Hotel Rochester - Mayo Clinic Area by IHG
EVEN Hotel Rochester - Mayo Clinic Area by IHG
4 out of 5
101 11TH Avenue SW, Suite A, Rochester, MN
  • 17 min walk from Mayo Clinic
The price is $139 per night from May 25 to May 26
$139
includes taxes & fees
May 25 - May 26
Stay at this 4-star business-friendly hotel in Rochester. Enjoy free WiFi, breakfast (surcharge), and a free area shuttle. Our guests praise the helpful staff ...
9.4/10 Exceptional! (816 reviews)
Clean, comfortable, convenient.
"I am very particular about hotels/accommodations. I’ve stayed here many times and I will continue to do so. It is clean, comfortable, convenient, and everyone is helpful and friendly."

Reviewed on Apr 10, 2025

EVEN Hotel Rochester - Mayo Clinic Area by IHG
TownePlace Suites by Marriott Rochester Mayo Clinic Area
TownePlace Suites by Marriott Rochester Mayo Clinic Area
3 out of 5
601 2ND STREET SW, Rochester, MN
  • 7 min walk from Mayo Clinic
The price is $125 per night from May 16 to May 17
$125
includes taxes & fees
May 16 - May 17
Stay at this 3-star hotel in Rochester. Enjoy free breakfast, free WiFi, and a free area shuttle. Our guests praise the breakfast and the helpful staff in our ...
9.6/10 Exceptional! (404 reviews)
"This was a really nice hotel close to Mayo. Only, I guess my husband and I weren't really happy that they didn't have a complimentary coffee bar as some of the other hotels have. We just rather enjoy this feature at the other hotels. There is a Spyhouse Coffee shop at the location, so that's why ..."

Reviewed on Apr 19, 2025

TownePlace Suites by Marriott Rochester Mayo Clinic Area
The Berkman
The Berkman
3 out of 5
217 14th Ave SW, Rochester, MN
  • 24 min walk from Mayo Clinic
The price is $137 per night from May 16 to May 17
$137
includes taxes & fees
May 16 - May 17
Stay at this 3-star golf aparthotel in Rochester. Enjoy free WiFi, an outdoor pool, and a rooftop terrace. Our guests praise the helpful staff in our reviews. ...
9.6/10 Exceptional! (285 reviews)
"Great Place."

Reviewed on Apr 21, 2025

The Berkman
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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