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Hotels in St. Charles

Choose from 484 St. Charles Hotel Deals

Kahler Grand Hotel
Kahler Grand Hotel
3 out of 5
20 2nd Ave Sw, Rochester, MN
  • 2 min walk from Mayo Clinic
The price is $172 per night from Nov 28 to Nov 29
$172
includes taxes & fees
Nov 28 - Nov 29
Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the helpful staff and ...
8/10 Very Good! (1,188 reviews)
"There are obvious signs of neglect, like the signs by the elevators that say fitness center on level M except on level M where the signs say fitness is in level 11. That took me twenty minutes to figure out. They are on level M, lol."

Reviewed on Nov 25, 2024

Kahler Grand Hotel
Med City Inn & Suites - Mayo Clinic Area
Med City Inn & Suites - Mayo Clinic Area
2.5 out of 5
435 16th Ave Nw, Rochester, MN
  • 26 min walk from Mayo Clinic
The price is $91 per night from Nov 28 to Nov 29
$91
includes taxes & fees
Nov 28 - Nov 29
Book a stay at this family-friendly motel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (1,006 reviews)
"The bed sheets and bathroom were pretty clean. Carpet in rooms are gross and property outdated. For the price it was good. The staff was great! Breakfast was same everyday but not terrible"

Reviewed on Nov 24, 2024

Med City Inn & Suites - Mayo Clinic Area
AmericInn by Wyndham Rochester Near Mayo Clinic
AmericInn by Wyndham Rochester Near Mayo Clinic
3 out of 5
1625 Broadway Ave S, Rochester, MN
  • 4 min drive from Mayo Clinic
The price is $85 per night from Nov 30 to Dec 1
$85
includes taxes & fees
Nov 30 - Dec 1
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the restaurant and the helpful ...
7.8/10 Good! (625 reviews)
"Overall pretty decent spot"

Reviewed on Nov 25, 2024

AmericInn by Wyndham Rochester Near Mayo Clinic
Kahler Inn and Suites - Mayo Clinic Area
Kahler Inn and Suites - Mayo Clinic Area
3.5 out of 5
9 3rd Ave Nw, Rochester, MN
  • 3 min walk from Mayo Clinic
The price is $146 per night from Nov 28 to Nov 29
$146
includes taxes & fees
Nov 28 - Nov 29
Stay at this 3.5-star business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the helpful staff and the ...
7.6/10 Good! (1,260 reviews)
Convenient and good price
"It's my go to when I have appointments at the Mayo Clinic. Convenient, great price, and there's a workout room, pool, and complimentary breakfast. Parking in their garage can be limited and really tight spots for any vehicle over midsized, but there IS a parking garage across the street. There's ..."

Reviewed on Nov 27, 2024

Kahler Inn and Suites - Mayo Clinic Area
Hyatt House Rochester/Mayo Clinic Area
Hyatt House Rochester/Mayo Clinic Area
3 out of 5
110 Civic Center Drive NW, Rochester, MN
  • 7 min walk from Mayo Clinic
The price is $129 per night from Nov 29 to Nov 30
$129
includes taxes & fees
Nov 29 - Nov 30
Stay at this 3-star business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and a free area shuttle. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (758 reviews)
"It was very comfortable. I was there for a clinic appointment. The shuttle was late and I had to call a cab but still made it to my apartment on time no complaints otherwise and they did let me stay an extended late check out and I ended up staying the second night as well, very glad to hear that ..."

Reviewed on Nov 26, 2024

Hyatt House Rochester/Mayo Clinic Area
EVEN Hotel Rochester - Mayo Clinic Area, an IHG Hotel
EVEN Hotel Rochester - Mayo Clinic Area, an IHG Hotel
4 out of 5
101 11TH Avenue SW, Suite A, Rochester, MN
  • 17 min walk from Mayo Clinic
The price is $106 per night from Dec 27 to Dec 28
$106
includes taxes & fees
Dec 27 - Dec 28
Stay at this 4-star business-friendly hotel in Rochester. Enjoy free WiFi, breakfast (surcharge), and a free area shuttle. Our guests praise the helpful staff ...
9.4/10 Exceptional! (748 reviews)
"Accommodating,cleanliness, dog friendly and outgoing staff."

Reviewed on Nov 25, 2024

EVEN Hotel Rochester - Mayo Clinic Area, an IHG Hotel
Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
3 out of 5
401 6th St Sw, Rochester, MN
  • 8 min walk from Mayo Clinic
The price is $142 per night from Nov 28 to Nov 29
$142
includes taxes & fees
Nov 28 - Nov 29
Book a stay at this golf hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the restaurant in our reviews. ...
8.2/10 Very Good! (1,000 reviews)
"They understand hospitality. Excellent free continuous shuttle service to Mayo Clinic, grocery store, etc. Ample free breakfast with variety. Very clean. Friendly & helpful staff. Close to Mayo/ downtown. We’ll be back."

Reviewed on Nov 16, 2024

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
Hotel Indigo Rochester – Mayo Clinic Area, an IHG Hotel
Hotel Indigo Rochester – Mayo Clinic Area, an IHG Hotel
3.5 out of 5
220 S Broadway, Rochester, MN
  • 6 min walk from Mayo Clinic
The price is $115 per night from Dec 27 to Dec 28
$115
includes taxes & fees
Dec 27 - Dec 28
Stay at this 3.5-star business-friendly hotel in Rochester. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the restaurant and ...
8.8/10 Excellent! (641 reviews)
"The hotel was close to great restaurants. The staff was excellent, the food was decent and the rooms were very clean. I will definitely visit again when I come back to town."

Reviewed on Nov 22, 2024

Hotel Indigo Rochester – Mayo Clinic Area, an IHG Hotel
Hampton Inn Rochester-South
Hampton Inn Rochester-South
2.5 out of 5
1755 S Broadway, Rochester, MN
  • 4 min drive from Mayo Clinic
The price is $111 per night from Dec 17 to Dec 18
$111
includes taxes & fees
Dec 17 - Dec 18
Stay at this hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
8.8/10 Excellent! (1,006 reviews)
"Service was excellent"

Reviewed on Nov 23, 2024

Hampton Inn Rochester-South
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
3 out of 5
4353 Canal Pl SE, Rochester, MN
  • 11 min drive from Mayo Clinic
The price is $77 per night from Dec 15 to Dec 16
$77
includes taxes & fees
Dec 15 - Dec 16
Stay at this 3-star business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...
7.6/10 Good! (1,005 reviews)
"I loved how close we were to the theatre and shopping and main highway."

Reviewed on Nov 22, 2024

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
Holiday Inn Express Rochester South - Mayo Area, an IHG Hotel
Holiday Inn Express Rochester South - Mayo Area, an IHG Hotel
2.5 out of 5
4141 Maine Avenue SE, Rochester, MN
  • 10 min drive from Mayo Clinic
The price is $97 per night from Dec 22 to Dec 23
$97
includes taxes & fees
Dec 22 - Dec 23
Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, free parking, and a fitness center. Our guests praise the breakfast and the helpful ...
8.6/10 Excellent! (1,002 reviews)
"Nice property, clean, quiet neighborhood. Would stay here again"

Reviewed on Nov 16, 2024

Holiday Inn Express Rochester South - Mayo Area, an IHG Hotel
TownePlace Suites by Marriott Rochester Mayo Clinic Area
TownePlace Suites by Marriott Rochester Mayo Clinic Area
3 out of 5
601 2ND STREET SW, Rochester, MN
  • 7 min walk from Mayo Clinic
The price is $121 per night from Dec 13 to Dec 14
$121
includes taxes & fees
Dec 13 - Dec 14
Stay at this 3-star hotel in Rochester. Enjoy free breakfast, free WiFi, and a free area shuttle. Our guests praise the breakfast and the helpful staff in our ...
9.6/10 Exceptional! (343 reviews)
"Staff was very helpful"

Reviewed on Nov 21, 2024

TownePlace Suites by Marriott Rochester Mayo Clinic Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in St. Charles

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Frequently Asked Questions About St. Charles hotels

Where can I find the best last-minute travel deals?

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How many hotels are there in St. Charles?

With over 484 hotels in St. Charles, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $77.

How to find cheap car rentals in St. Charles?

Finding a cheap car rental deal in St. Charles is as easy as scoring cheap hotels in St. Charles. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can even save up to 60% off a car rental deal if you book a Hotwire Hot Rate at the last minute.

Is it safe to travel to St. Charles now?

With recent COVID-19 closures and reopenings, many people are wondering, “Is it safe to travel to St. Charles right now?” When it’s time to book your getaway, be sure to check out the most up-to-date information on all safety measures, any restrictions, and guidance on traveling during the coronavirus pandemic.