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Hotels in St. Charles

Choose from 500 St. Charles Hotel Deals

Kahler Grand Hotel
Kahler Grand Hotel
3 out of 5
20 2nd Ave Sw, Rochester, MN
  • 2 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the helpful staff and ...
8.2/10 Very Good! (1,368 reviews)
"I enjoyed my room and the pool area. I was disappointed to learn as I was checking out that $25 was taken from my security deposit for one night parking in the hotel public ramp. (Public parking is fee on weekends in Rochester.)"

Reviewed on May 12, 2025

Kahler Grand Hotel
Med City Inn & Suites - Mayo Clinic Area
Med City Inn & Suites - Mayo Clinic Area
2.5 out of 5
435 16th Ave Nw, Rochester, MN
  • 26 min walk from Mayo Clinic
Book a stay at this family-friendly motel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (1,012 reviews)
"Hotel was convenient being just off of highway 52 and very close to mayo. Room was very large and quiet. I would stay there again."

Reviewed on May 10, 2025

Med City Inn & Suites - Mayo Clinic Area
AmericInn by Wyndham Rochester Near Mayo Clinic
AmericInn by Wyndham Rochester Near Mayo Clinic
3 out of 5
1625 Broadway Ave S, Rochester, MN
  • 4 min drive from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the restaurant and the helpful ...
8/10 Very Good! (852 reviews)
"Nice friendly sraff"

Reviewed on May 12, 2025

AmericInn by Wyndham Rochester Near Mayo Clinic
Hyatt House Rochester/Mayo Clinic Area
Hyatt House Rochester/Mayo Clinic Area
3 out of 5
110 Civic Center Drive NW, Rochester, MN
  • 7 min walk from Mayo Clinic
Stay at this 3-star business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and a free area shuttle. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (888 reviews)
"The hotel was clean and convenient to downtown restaurants and businesses."

Reviewed on May 11, 2025

Hyatt House Rochester/Mayo Clinic Area
Kahler Inn and Suites - Mayo Clinic Area
Kahler Inn and Suites - Mayo Clinic Area
3.5 out of 5
9 3rd Ave Nw, Rochester, MN
  • 3 min walk from Mayo Clinic
Stay at this 3.5-star business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the helpful staff and the ...
7.6/10 Good! (1,362 reviews)
"Housekeeping staff was excellent. The front desk staff was efficient but not very friendly. Parking is limited and if you park in their garage, the charge is 1 $15 a day even if you can't find space to park everyday you are there. We didn't want to leave by car because we didn't want to pay double ..."

Reviewed on May 13, 2025

Kahler Inn and Suites - Mayo Clinic Area
Hotel Indigo Rochester – Mayo Clinic Area by IHG
Hotel Indigo Rochester – Mayo Clinic Area by IHG
3.5 out of 5
220 S Broadway, Rochester, MN
  • 6 min walk from Mayo Clinic
Stay at this 3.5-star business-friendly hotel in Rochester. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the restaurant and ...
8.8/10 Excellent! (758 reviews)
Great Value
"Staff was friendly, nice clean room and confident to Mayo Clinic"

Reviewed on May 9, 2025

Hotel Indigo Rochester – Mayo Clinic Area by IHG
SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys
SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys
3 out of 5
1125 2nd St Sw, Rochester, MN
  • 19 min walk from Mayo Clinic
Stay at this 3-star business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8.4/10 Very Good! (780 reviews)
"Stay was excellent. Very friendly. Helped us book another night when we ended up having to stay"

Reviewed on May 11, 2025

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys
The Berkman
The Berkman
3 out of 5
217 14th Ave SW, Rochester, MN
  • 24 min walk from Mayo Clinic
Stay at this 3-star golf aparthotel in Rochester. Enjoy free WiFi, an outdoor pool, and a rooftop terrace. Our guests praise the helpful staff in our reviews. ...
9.6/10 Exceptional! (292 reviews)
"It was a perfect spot for our family. Clean and spacious!"

Reviewed on May 3, 2025

The Berkman
Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys
Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys
3 out of 5
161 13th Ave Sw, Rochester, MN
  • 24 min walk from Mayo Clinic
Stay at this 3-star business-friendly hotel in Rochester. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the helpful staff and ...
9/10 Wonderful! (703 reviews)
"The hotel was very clean, plenty of towels, and staff were wonderful. There were a few restaurants in walking distance and we tried two of them. Great weekend."

Reviewed on May 12, 2025

Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
3 out of 5
4353 Canal Pl SE, Rochester, MN
  • 11 min drive from Mayo Clinic
Stay at this 3-star business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...
7.2/10 Good! (1,013 reviews)
"Nice stay"

Reviewed on May 13, 2025

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
EVEN Hotel Rochester - Mayo Clinic Area by IHG
EVEN Hotel Rochester - Mayo Clinic Area by IHG
4 out of 5
101 11TH Avenue SW, Suite A, Rochester, MN
  • 17 min walk from Mayo Clinic
Stay at this 4-star business-friendly hotel in Rochester. Enjoy free WiFi, breakfast (surcharge), and a free area shuttle. Our guests praise the helpful staff ...
9.4/10 Exceptional! (819 reviews)
"Would stay again"

Reviewed on Apr 27, 2025

EVEN Hotel Rochester - Mayo Clinic Area by IHG
Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
3 out of 5
401 6th St Sw, Rochester, MN
  • 8 min walk from Mayo Clinic
Book a stay at this golf hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the restaurant in our reviews. ...
8.4/10 Very Good! (1,005 reviews)
Clean, comfortable, great shuttle service for Mayo
"Room was dated but functional and clean. Clean bedding, plenty of plug ins. Pool area clearly needs updating. The hot tub was closed. 'Workout' room had 3 machines. Breakfast had more variety than alot of hotels I've stayed at. Hot scrambled eggs, sausage, biscuits/gravy along with fresh fruits and ..."

Reviewed on May 10, 2025

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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