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Hotels in St. Charles

Choose from 502 St. Charles Hotel Deals

AmericInn by Wyndham Rochester Near Mayo Clinic
AmericInn by Wyndham Rochester Near Mayo Clinic
3 out of 5
1625 Broadway Ave S, Rochester, MN
  • 4 min drive from Mayo Clinic
The price is $88 per night from Apr 7 to Apr 8
$88
includes taxes & fees
Apr 7 - Apr 8
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the restaurant and the helpful ...
7.8/10 Good! (782 reviews)
"Pet friendly, appointments at Mayo."

Reviewed on Apr 1, 2025

AmericInn by Wyndham Rochester Near Mayo Clinic
Kahler Grand Hotel
Kahler Grand Hotel
3 out of 5
20 2nd Ave Sw, Rochester, MN
  • 2 min walk from Mayo Clinic
The price is $187 per night from Apr 4 to Apr 5
$187
includes taxes & fees
Apr 4 - Apr 5
Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the helpful staff and ...
8.2/10 Very Good! (1,332 reviews)
"The two nights we stayed were some of the best sleep we have had in a long time!"

Reviewed on Mar 31, 2025

Kahler Grand Hotel
Kahler Inn and Suites - Mayo Clinic Area
Kahler Inn and Suites - Mayo Clinic Area
3.5 out of 5
9 3rd Ave Nw, Rochester, MN
  • 3 min walk from Mayo Clinic
The price is $169 per night from Apr 4 to Apr 5
$169
includes taxes & fees
Apr 4 - Apr 5
Stay at this 3.5-star business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the helpful staff and the ...
7.6/10 Good! (1,340 reviews)
"Close to Mayo Clinic"

Reviewed on Mar 31, 2025

Kahler Inn and Suites - Mayo Clinic Area
Hyatt House Rochester/Mayo Clinic Area
Hyatt House Rochester/Mayo Clinic Area
3 out of 5
110 Civic Center Drive NW, Rochester, MN
  • 7 min walk from Mayo Clinic
The price is $119 per night from Apr 18 to Apr 19
$119
includes taxes & fees
Apr 18 - Apr 19
Stay at this 3-star business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and a free area shuttle. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (852 reviews)
"The beds were not comfortable, but the property was nice"

Reviewed on Mar 29, 2025

Hyatt House Rochester/Mayo Clinic Area
Hotel Indigo Rochester – Mayo Clinic Area by IHG
Hotel Indigo Rochester – Mayo Clinic Area by IHG
3.5 out of 5
220 S Broadway, Rochester, MN
  • 6 min walk from Mayo Clinic
The price is $135 per night from Apr 11 to Apr 12
$135
includes taxes & fees
Apr 11 - Apr 12
Stay at this 3.5-star business-friendly hotel in Rochester. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the restaurant and ...
8.8/10 Excellent! (723 reviews)
"Wonderful food at Crave and pleasant room"

Reviewed on Mar 30, 2025

Hotel Indigo Rochester – Mayo Clinic Area by IHG
Med City Inn & Suites - Mayo Clinic Area
Med City Inn & Suites - Mayo Clinic Area
2.5 out of 5
435 16th Ave Nw, Rochester, MN
  • 26 min walk from Mayo Clinic
The price is $92 per night from Apr 4 to Apr 5
$92
includes taxes & fees
Apr 4 - Apr 5
Book a stay at this family-friendly motel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (1,000 reviews)
"I really loved this site!!! It was a lovely stay- The staff always went way and beyond!!!!"

Reviewed on Mar 30, 2025

Med City Inn & Suites - Mayo Clinic Area
Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
3 out of 5
401 6th St Sw, Rochester, MN
  • 8 min walk from Mayo Clinic
The price is $142 per night from Apr 4 to Apr 5
$142
includes taxes & fees
Apr 4 - Apr 5
Book a stay at this golf hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the restaurant in our reviews. ...
8.2/10 Very Good! (1,000 reviews)
"It was a very nice room and very nice staff."

Reviewed on Mar 30, 2025

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
3 out of 5
4353 Canal Pl SE, Rochester, MN
  • 11 min drive from Mayo Clinic
The price is $92 per night from Apr 6 to Apr 7
$92
includes taxes & fees
Apr 6 - Apr 7
Stay at this 3-star business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...
7.4/10 Good! (1,001 reviews)
"Was just ok. Staff was ho hum at the front desk and seemed preoccupied at check in and check out. Was just an ok stay."

Reviewed on Mar 31, 2025

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
EVEN Hotel Rochester - Mayo Clinic Area by IHG
EVEN Hotel Rochester - Mayo Clinic Area by IHG
4 out of 5
101 11TH Avenue SW, Suite A, Rochester, MN
  • 17 min walk from Mayo Clinic
The price is $142 per night from Apr 20 to Apr 21
$142
includes taxes & fees
Apr 20 - Apr 21
Stay at this 4-star business-friendly hotel in Rochester. Enjoy free WiFi, breakfast (surcharge), and a free area shuttle. Our guests praise the helpful staff ...
9.4/10 Exceptional! (810 reviews)
"Property is very clean and relaxing."

Reviewed on Mar 30, 2025

EVEN Hotel Rochester - Mayo Clinic Area by IHG
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
2.5 out of 5
1517 16th St Sw, Rochester, MN
  • 5 min drive from Mayo Clinic
The price is $108 per night from Apr 7 to Apr 8
$108
includes taxes & fees
Apr 7 - Apr 8
Book a stay at this family-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our ...
8.2/10 Very Good! (579 reviews)
"Great pool and breakfast."

Reviewed on Mar 28, 2025

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
Holiday Inn Express Rochester South - Mayo Area by IHG
Holiday Inn Express Rochester South - Mayo Area by IHG
2.5 out of 5
4141 Maine Avenue SE, Rochester, MN
  • 10 min drive from Mayo Clinic
The price is $101 per night from Apr 20 to Apr 21
$101
includes taxes & fees
Apr 20 - Apr 21
Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, free parking, and a fitness center. Our guests praise the breakfast and the helpful ...
8.6/10 Excellent! (1,001 reviews)
"Was a great stay"

Reviewed on Apr 1, 2025

Holiday Inn Express Rochester South - Mayo Area by IHG
The Berkman
The Berkman
3 out of 5
217 14th Ave SW, Rochester, MN
  • 24 min walk from Mayo Clinic
The price is $191 per night from Apr 4 to Apr 5
$191
includes taxes & fees
Apr 4 - Apr 5
Stay at this 3-star golf aparthotel in Rochester. Enjoy free WiFi, an outdoor pool, and a rooftop terrace. Our guests praise the helpful staff in our reviews. ...
9.6/10 Exceptional! (280 reviews)
"Very big room lots of room to spread out and get settled. Very nice property!"

Reviewed on Mar 29, 2025

The Berkman
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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