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Hotels in St. Charles

Choose from 499 St. Charles Hotel Deals

Kahler Grand Hotel

Kahler Grand Hotel

3 out of 5
20 2nd Ave Sw Rochester MN
  • 2 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the helpful staff and ...
8.4/10 Very Good! (2,127 reviews)
"Rooms are kind of small, but fair price and most important connected to Mayo. I use them any time I have an appointment there."

Reviewed on Jun 1, 2026

Kahler Grand Hotel
Kahler Inn and Suites - Mayo Clinic Area

Kahler Inn and Suites - Mayo Clinic Area

3.5 out of 5
9 3rd Ave Nw Rochester MN
  • 3 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the helpful staff and the ...
8/10 Very Good! (1,582 reviews)
"A bit of an old, confusing building, but the staff did their best to make it comfortable."

Reviewed on Jun 1, 2026

Kahler Inn and Suites - Mayo Clinic Area
Hyatt House Rochester/Mayo Clinic Area

Hyatt House Rochester/Mayo Clinic Area

3 out of 5
110 Civic Center Drive NW Rochester MN
  • 7 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and a free area shuttle. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,006 reviews)
"Great location, a few minutes walk to the civic center. Plenty of good food options around the area. The staff is friendly and helpful, rooms and commons are clean, loved the breakfast menu."

Reviewed on Jun 1, 2026

Hyatt House Rochester/Mayo Clinic Area
Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

3 out of 5
401 6th St Sw Rochester MN
  • 8 min walk from Mayo Clinic
Book a stay at this golf hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the restaurant in our reviews. ...
8.6/10 Excellent! (1,009 reviews)
"nice quiet clean hotel, enjoyed the pool with basketball and jacuzzi. quiet but close to downtown. can walk or drive to downtown. restaurant is nice & convenient. they privide shuttle to & from destination during available times."

Reviewed on May 31, 2026

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG

3.5 out of 5
220 S Broadway Rochester MN
  • 6 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the restaurant and ...
8.8/10 Excellent! (1,004 reviews)
"Great option in Rochester"

Reviewed on May 31, 2026

Hotel Indigo Rochester – Mayo Clinic Area by IHG
Med City Inn & Suites - Mayo Clinic Area

Med City Inn & Suites - Mayo Clinic Area

2.5 out of 5
435 16th Ave Nw Rochester MN
  • 26 min walk from Mayo Clinic
Book a stay at this family-friendly motel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8/10 Very Good! (1,003 reviews)
"Pretty good place for the price. I felt safe and the people were really nice."

Reviewed on May 30, 2026

Med City Inn & Suites - Mayo Clinic Area
EVEN Hotel Rochester - Mayo Clinic Area by IHG

EVEN Hotel Rochester - Mayo Clinic Area by IHG

4 out of 5
101 11TH Avenue SW Rochester MN
  • 17 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
9.4/10 Exceptional! (1,003 reviews)
"Weird experience at the front desk, where the manager guy seemed super annoyed. He reprimanded a customer checking in for parking in the garage before check-in (how are we supposed to know not to do this), and another person because he couldn’t find their booking, complaining loudly that “everyone ..."

Reviewed on May 31, 2026

EVEN Hotel Rochester - Mayo Clinic Area by IHG
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

2.5 out of 5
1517 16th St Sw Rochester MN
  • 5 min drive from Mayo Clinic
Book a stay at this family-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our ...
8.2/10 Very Good! (928 reviews)
"Great place"

Reviewed on May 29, 2026

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
AmericInn by Wyndham Rochester Near Mayo Clinic

AmericInn by Wyndham Rochester Near Mayo Clinic

3 out of 5
1625 Broadway Ave S Rochester MN
  • 4 min drive from Mayo Clinic
Book a stay at this spa hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the restaurant and the helpful staff in our ...
8/10 Very Good! (1,340 reviews)
"Only stayed for one night, but was fine. Room was clean, staff was friendly enough. would stay again. Weekends are always to expensive though."

Reviewed on Jun 1, 2026

AmericInn by Wyndham Rochester Near Mayo Clinic
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

3 out of 5
4353 Canal Pl SE Rochester MN
  • 11 min drive from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...
7.4/10 Good! (1,057 reviews)
"Everything was great 👍 wonderful breakfast"

Reviewed on May 31, 2026

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
Hampton Inn Rochester-South

Hampton Inn Rochester-South

2.5 out of 5
1755 S Broadway Rochester MN
  • 4 min drive from Mayo Clinic
Stay at this hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
9/10 Wonderful! (1,006 reviews)
"Staff"

Reviewed on May 31, 2026

Hampton Inn Rochester-South
Express Suites Riverport Inn & Suites

Express Suites Riverport Inn & Suites

3 out of 5
900 Bruski Dr Winona MN
  • 2 hours drive from Mayo Clinic
Book a stay at this business-friendly hotel in Winona. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Express Suites Riverport Inn & Suites
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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