Search for Cheap Deals on
Hotels in St. Charles

Choose from 487 St. Charles Hotel Deals

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

3 out of 5
401 6th St Sw Rochester MN
  • 8 min walk from Mayo Clinic
Book a stay at this golf hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the restaurant in our reviews. ...
8.6/10 Excellent! (1,016 reviews)
"Absolutely amazing hotel to stay at if you have celiac or need to be gluten free. It was a dream! Rooms are a little dated but overall great place and location to Mayo!"

Reviewed on Jun 23, 2026

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
Kahler Grand Hotel

Kahler Grand Hotel

3 out of 5
20 2nd Ave Sw Rochester MN
  • 2 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the helpful staff and ...
8.4/10 Very Good! (2,161 reviews)
"The Kahler is always an excellent choice…particularly if you are visiting the Mayo Clinic."

Reviewed on Jun 22, 2026

Kahler Grand Hotel
Kahler Inn and Suites - Mayo Clinic Area

Kahler Inn and Suites - Mayo Clinic Area

3.5 out of 5
9 3rd Ave Nw Rochester MN
  • 3 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the helpful staff and the ...
8/10 Very Good! (1,592 reviews)
"Excellent breakfast daily. Parking below not user friendly."

Reviewed on Jun 22, 2026

Kahler Inn and Suites - Mayo Clinic Area
AmericInn by Wyndham Rochester Near Mayo Clinic

AmericInn by Wyndham Rochester Near Mayo Clinic

3 out of 5
1625 Broadway Ave S Rochester MN
  • 4 min drive from Mayo Clinic
Book a stay at this spa hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the restaurant and the helpful staff in our ...
8/10 Very Good! (1,362 reviews)
"Easy check in and out. Quiet room"

Reviewed on Jun 20, 2026

AmericInn by Wyndham Rochester Near Mayo Clinic
Med City Inn & Suites - Mayo Clinic Area

Med City Inn & Suites - Mayo Clinic Area

2.5 out of 5
435 16th Ave Nw Rochester MN
  • 26 min walk from Mayo Clinic
Book a stay at this family-friendly motel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8/10 Very Good! (1,004 reviews)
"Once hot breakfast was added it was a great improvement. The dining area is keep clean & isn’t crowded. Staff at front desk varied from nice to snarky. My Doctor cancelled my surgery for medical reasons & ordered me back in 2 weeks. No refunds or credits at given or allowed. Think carefully about ..."

Reviewed on Jun 22, 2026

Med City Inn & Suites - Mayo Clinic Area
Hyatt House Rochester/Mayo Clinic Area

Hyatt House Rochester/Mayo Clinic Area

3 out of 5
110 Civic Center Drive NW Rochester MN
  • 7 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and a free area shuttle. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,004 reviews)
"Staff were uniformly friendly and helpful. That made all the difference for us since we were commuting to/from Mayo Clinic. The free breakfast was decent, but lacked variety, wearing thin during our 1 week stay. Trash was not emptied nearly often enough from the small bins near the elevators. Also ..."

Reviewed on Jun 19, 2026

Hyatt House Rochester/Mayo Clinic Area
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

3 out of 5
4353 Canal Pl SE Rochester MN
  • 11 min drive from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...
7.4/10 Good! (1,067 reviews)
"The mattress on the bed was well used. A dip in the middle. 😏 The shower/tub in the bathroom was slippery when using the shower. My husband almost fell. There was no closet. However, it was quiet and the staff was very gracious. We will stay there again."

Reviewed on Jun 21, 2026

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
EVEN Hotel Rochester - Mayo Clinic Area by IHG

EVEN Hotel Rochester - Mayo Clinic Area by IHG

4 out of 5
101 11TH Avenue SW Rochester MN
  • 17 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
9.4/10 Exceptional! (1,003 reviews)
"Amazing place to stay , highly recommend"

Reviewed on Jun 21, 2026

EVEN Hotel Rochester - Mayo Clinic Area by IHG
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

2.5 out of 5
1517 16th St Sw Rochester MN
  • 5 min drive from Mayo Clinic
Book a stay at this family-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our ...
8.2/10 Very Good! (952 reviews)
"Clean room and facilities. Although we didn't have kids, the pool area looked fun for the family. Great location to Mayo Clinic. We will be staying there again on our next trip."

Reviewed on Jun 21, 2026

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
Express Suites Riverport Inn & Suites

Express Suites Riverport Inn & Suites

3 out of 5
900 Bruski Dr Winona MN
  • 2 hours drive from Mayo Clinic
Book a stay at this business-friendly hotel in Winona. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.6/10 Excellent! (1,009 reviews)
"The room was clean when we checked in, but housekeeping didn't come during our two-night visit. The beds were very comfortable. The kitchen in the bar was advertised open until 11:00pm, but it was closed when we went there before 10:00pm. The breakfast was good."

Reviewed on Jun 22, 2026

Express Suites Riverport Inn & Suites
Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG

3.5 out of 5
220 S Broadway Rochester MN
  • 6 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the restaurant and ...
8.8/10 Excellent! (1,005 reviews)
"The staff were nice and helpful. The room and hotel were clean. Housecleaning is advertised as being included, however it is by request only. Requests for what you want done in your room (i.e. trash can emptied, bed made, bathroom cleaned) must be checked and turned in before 8 am for the room to ..."

Reviewed on Jun 22, 2026

Hotel Indigo Rochester – Mayo Clinic Area by IHG
The Berkman

The Berkman

3 out of 5
217 14th Ave SW Rochester MN
  • 24 min walk from Mayo Clinic
Book a stay at this golf aparthotel in Rochester. Enjoy free WiFi, an outdoor pool, and a rooftop terrace. Our guests praise the helpful staff in our reviews. ...
9.6/10 Exceptional! (419 reviews)
"Absolutely beautiful property with great amenities...perfect for a 10 day stay, with everything you need to be self-sustained. Excellent dining choices very close like the Red Cow and the Canadian Honker restaurants...St Mary's Mayo is directly across the street with an active Shuttle to the other ..."

Reviewed on Jun 19, 2026

The Berkman
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in St. Charles

You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your St. Charles hotel with Hotwire to complete your one-of-a-kind travel checklist.

For you, intrepid voyager, Hotwire has a large selection of the best hotels in St. Charles.

Choosing the right hotel in Minnesota has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of St. Charles’s 487 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $87. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great St. Charles hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in St. Charles. No matter your reason for visiting St. Charles, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About St. Charles hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in St. Charles for as low as $87.

How many hotels are there in St. Charles?

With over 487 hotels in St. Charles, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $87.

How to find cheap car rentals in St. Charles?

Finding a cheap car rental deal in St. Charles is as easy as scoring cheap hotels in St. Charles. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.