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Hotels in St. Charles

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Tonight Sep 27 - Sep 28This weekend Sep 27 - Sep 29

Choose from 502 St. Charles Hotel Deals

Kahler Grand Hotel
Kahler Grand Hotel
3 out of 5
20 2nd Ave Sw, Rochester, MN
  • 2 min walk from Mayo Clinic
The price is $172 per night from Oct 3 to Oct 4
$172
includes taxes & fees
Oct 3 - Oct 4
Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the helpful staff and ...
8/10 Very Good! (1,114 reviews)
"Good value"

Reviewed on Sep 25, 2024

Kahler Grand Hotel
AmericInn by Wyndham Rochester Near Mayo Clinic
AmericInn by Wyndham Rochester Near Mayo Clinic
3 out of 5
1625 Broadway Ave S, Rochester, MN
  • 4 min drive from Mayo Clinic
The price is $85 per night from Oct 3 to Oct 4
$85
includes taxes & fees
Oct 3 - Oct 4
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the restaurant and the helpful ...
7.8/10 Good! (554 reviews)
"Pet friendly, location"

Reviewed on Sep 23, 2024

AmericInn by Wyndham Rochester Near Mayo Clinic
EVEN Hotel Rochester - Mayo Clinic Area, an IHG Hotel
EVEN Hotel Rochester - Mayo Clinic Area, an IHG Hotel
4 out of 5
101 11TH Avenue SW, Suite A, Rochester, MN
  • 17 min walk from Mayo Clinic
The price is $125 per night from Oct 5 to Oct 6
$125
includes taxes & fees
Oct 5 - Oct 6
Stay at this 4-star business-friendly hotel in Rochester. Enjoy free WiFi, breakfast (surcharge), and a free area shuttle. Our guests praise the helpful staff ...
9.4/10 Exceptional! (703 reviews)
"I was surprised to arrive to the hotel that advertised “on-site parking” to be told that the parking lot was full and that I had to find street parking which was quite dark. It would be nice if you could light the sidewalk so it didn’t feel scary. I’m not familiar with the area so parking and walking ..."

Reviewed on Sep 24, 2024

EVEN Hotel Rochester - Mayo Clinic Area, an IHG Hotel
Med City Inn & Suites - Mayo Clinic Area
Med City Inn & Suites - Mayo Clinic Area
2.5 out of 5
435 16th Ave Nw, Rochester, MN
  • 26 min walk from Mayo Clinic
The price is $91 per night from Sep 28 to Sep 29
$91
includes taxes & fees
Sep 28 - Sep 29
Book a stay at this family-friendly motel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (1,001 reviews)
"Just a wonderful and friendly place"

Reviewed on Sep 24, 2024

Med City Inn & Suites - Mayo Clinic Area
Kahler Inn and Suites - Mayo Clinic Area
Kahler Inn and Suites - Mayo Clinic Area
3.5 out of 5
9 3rd Ave Nw, Rochester, MN
  • 3 min walk from Mayo Clinic
The price is $166 per night from Sep 29 to Sep 30
$166
includes taxes & fees
Sep 29 - Sep 30
Stay at this 3.5-star business-friendly hotel in Rochester. Enjoy free WiFi, breakfast (surcharge), and a fitness center. Our guests praise the helpful staff ...
7.4/10 Good! (1,261 reviews)
"Th front desk check in person was the best I had ever seen. Friendly, kind and you could tell he enjoyed his job. You don’t see that much these days so was very nice to see."

Reviewed on Sep 26, 2024

Kahler Inn and Suites - Mayo Clinic Area
Hyatt House Rochester/Mayo Clinic Area
Hyatt House Rochester/Mayo Clinic Area
3 out of 5
110 Civic Center Drive NW, Rochester, MN
  • 7 min walk from Mayo Clinic
The price is $136 per night from Oct 13 to Oct 14
$136
includes taxes & fees
Oct 13 - Oct 14
Stay at this 3-star business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and a free area shuttle. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (705 reviews)
Very comfortable stay
"This was an official trip. The hotel was easily walkable distance from the Mayo. It was one of the b3st hotels i have stayed recently in. Great space insite the room and ambience in the lobby. They serve breakfast in the mornings which is a big plus."

Reviewed on Sep 22, 2024

Hyatt House Rochester/Mayo Clinic Area
Hotel Indigo Rochester – Mayo Clinic Area, an IHG Hotel
Hotel Indigo Rochester – Mayo Clinic Area, an IHG Hotel
3.5 out of 5
220 S Broadway, Rochester, MN
  • 6 min walk from Mayo Clinic
The price is $141 per night from Oct 12 to Oct 13
$141
includes taxes & fees
Oct 12 - Oct 13
Stay at this 3.5-star business-friendly hotel in Rochester. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the restaurant and ...
8.8/10 Excellent! (603 reviews)
"Will definitely stay there again."

Reviewed on Sep 23, 2024

Hotel Indigo Rochester – Mayo Clinic Area, an IHG Hotel
Hampton Inn Rochester-South
Hampton Inn Rochester-South
2.5 out of 5
1755 S Broadway, Rochester, MN
  • 4 min drive from Mayo Clinic
The price is $98 per night from Oct 19 to Oct 20
$98
includes taxes & fees
Oct 19 - Oct 20
Stay at this hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
8.8/10 Excellent! (1,001 reviews)
"."

Reviewed on Sep 24, 2024

Hampton Inn Rochester-South
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
3 out of 5
4353 Canal Pl SE, Rochester, MN
  • 11 min drive from Mayo Clinic
The price is $87 per night from Sep 29 to Sep 30
$87
includes taxes & fees
Sep 29 - Sep 30
Stay at this 3-star business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...
7.6/10 Good! (1,001 reviews)
overall, pretty good.
"Ice machines on first and second floor did not work. Waffles stuck in waffle maker, The man working the breakfast was not helpful. There should have been some spray or something."

Reviewed on Sep 23, 2024

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
Country Inn & Suites Rochester South Mayo Clinic
Country Inn & Suites Rochester South Mayo Clinic
3 out of 5
77 Woodlake Drive SE, Rochester, MN
  • 8 min drive from Mayo Clinic
The price is $91 per night from Oct 13 to Oct 14
$91
includes taxes & fees
Oct 13 - Oct 14
Stay at this 3-star family-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8.2/10 Very Good! (1,006 reviews)
"Quiet and nice"

Reviewed on Sep 26, 2024

Country Inn & Suites Rochester South Mayo Clinic
TownePlace Suites by Marriott Rochester Mayo Clinic Area
TownePlace Suites by Marriott Rochester Mayo Clinic Area
3 out of 5
601 2ND STREET SW, Rochester, MN
  • 7 min walk from Mayo Clinic
The price is $136 per night from Oct 4 to Oct 5
$136
includes taxes & fees
Oct 4 - Oct 5
Stay at this 3-star hotel in Rochester. Enjoy free breakfast, free WiFi, and a free area shuttle. Our guests praise the breakfast and the helpful staff in our ...
9.6/10 Exceptional! (323 reviews)
hotel stay
"Marriott stays are always awesome. Just poor shower pressure. Pillows are always too soft,not just Marriott's but all hotels. 🙂"

Reviewed on Sep 22, 2024

TownePlace Suites by Marriott Rochester Mayo Clinic Area
Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
3 out of 5
401 6th St Sw, Rochester, MN
  • 8 min walk from Mayo Clinic
The price is $142 per night from Sep 28 to Sep 29
$142
includes taxes & fees
Sep 28 - Sep 29
Book a stay at this golf hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the restaurant in our reviews. ...
8.2/10 Very Good! (1,002 reviews)
Comfort and convenience
"Great for a visit to Mayo Clinic and pet friendly"

Reviewed on Sep 25, 2024

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

HOTW-Hotel-Deals-726-959@2x.jpg (1918×258)*Savings based on Hot Rate® hotel bookings as compared with the lowest published rates found on leading retail travel sites. Hot Rates are different from retail rates. With Hot Rates you enter the date, location and star rating. Hotel revealed only after booking. All bookings final.

Find cheap hotels in St. Charles

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For you, intrepid voyager, Hotwire has a large selection of the best hotels in St. Charles.

Choosing the right hotel in Minnesota has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of St. Charles’s 502 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $85. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get up to 60% St. Charles hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in St. Charles. No matter your reason for visiting St. Charles, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About St. Charles hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can save up to 60% off your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in St. Charles for as low as $85.

How many hotels are there in St. Charles?

With over 502 hotels in St. Charles, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $85.

How to find cheap car rentals in St. Charles?

Finding a cheap car rental deal in St. Charles is as easy as scoring cheap hotels in St. Charles. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can even save up to 60% off a car rental deal if you book a Hotwire Hot Rate at the last minute.

Is it safe to travel to St. Charles now?

With recent COVID-19 closures and reopenings, many people are wondering, “Is it safe to travel to St. Charles right now?” When it’s time to book your getaway, be sure to check out the most up-to-date information on all safety measures, any restrictions, and guidance on traveling during the coronavirus pandemic.