Search for Cheap Deals on
Hotels in Mesilla

Photo by Lane

Check Last Minute Mesilla Hotel Deals

Tonight Apr 13 - Apr 14Next weekend Apr 18 - Apr 20

Choose from 337 Mesilla Hotel Deals

Hotel Encanto de Las Cruces
Hotel Encanto de Las Cruces
3.5 out of 5
705 S Telshor Blvd, Las Cruces, NM
  • 9 min drive from Mesillia Plaza
The price is $161 per night from Apr 20 to Apr 21
$161
includes taxes & fees
Apr 20 - Apr 21
Stay at this 3.5-star business-friendly hotel in Las Cruces. Enjoy 3 bars/lounges, a nightclub, and breakfast (surcharge). Our guests praise the pool and the ...
8.8/10 Excellent! (1,284 reviews)
"The bed was AWESOME. Same for the pillows"

Reviewed on Apr 10, 2025

Hotel Encanto de Las Cruces
La Quinta Inn & Suites by Wyndham Las Cruces Organ Mountain
La Quinta Inn & Suites by Wyndham Las Cruces Organ Mountain
2.5 out of 5
1500 Hickory Dr, Las Cruces, NM
  • 23 min walk from Mesillia Plaza
The price is $72 per night from Apr 20 to Apr 21
$72
includes taxes & fees
Apr 20 - Apr 21
Book a stay at this business-friendly hotel in Las Cruces. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.2/10 Very Good! (2,048 reviews)
"It was decent as always. Great for the price. Didnt have any soap/body wash/conditioner in the dispensers. And waster was blasting out of the shower head. Other than that it was a good stay."

Reviewed on Apr 10, 2025

La Quinta Inn & Suites by Wyndham Las Cruces Organ Mountain
Days Inn by Wyndham Las Cruces
Days Inn by Wyndham Las Cruces
2.5 out of 5
755 Avenida De Mesilla, Las Cruces, NM
  • 25 min walk from Mesillia Plaza
The price is $57 per night from May 11 to May 12
$57
includes taxes & fees
May 11 - May 12
Book a stay at this business-friendly hotel in Las Cruces. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8/10 Very Good! (1,129 reviews)
"Great option! The room has also a work station, which came handy for my meeting Zoom calls! The staff is very friendly, I will stay again"

Reviewed on Apr 11, 2025

Days Inn by Wyndham Las Cruces
Best Western Mission Inn
Best Western Mission Inn
2.5 out of 5
1765 S Main St, Las Cruces, NM
  • 28 min walk from Mesillia Plaza
The price is $84 per night from Apr 15 to Apr 16
$84
includes taxes & fees
Apr 15 - Apr 16
Book a stay at this business-friendly hotel in Las Cruces. Enjoy free breakfast, free parking, and a 24-hour front desk. Our guests praise the breakfast and ...
8.8/10 Excellent! (1,135 reviews)
"Beautiful"

Reviewed on Apr 11, 2025

Best Western Mission Inn
Comfort Suites Las Cruces I-25 North
Comfort Suites Las Cruces I-25 North
2.5 out of 5
236 N Telshor Blvd., Las Cruces, NM
  • 9 min drive from Mesillia Plaza
The price is $140 per night from May 4 to May 5
$140
includes taxes & fees
May 4 - May 5
Book a stay at this business-friendly hotel in Las Cruces. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,001 reviews)
great service, great breakfast, comfortable beds
"Room was still being cleaned after 4pm and was not able to go in the room,but that was not a problem because the hospitality of the front desk was amazing as he kept me in the loop of when the room was done, which wasn't long after."

Reviewed on Apr 10, 2025

Comfort Suites Las Cruces I-25 North
Drury Inn & Suites Las Cruces
Drury Inn & Suites Las Cruces
3 out of 5
1631 Hickory Loop, Las Cruces, NM
  • 24 min walk from Mesillia Plaza
The price is $125 per night from Apr 20 to Apr 21
$125
includes taxes & fees
Apr 20 - Apr 21
Stay at this 3-star business-friendly hotel in Las Cruces. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,000 reviews)
"Staff was super friendly especially barmaid"

Reviewed on Apr 6, 2025

Drury Inn & Suites Las Cruces
Hilton Garden Inn Las Cruces
Hilton Garden Inn Las Cruces
3 out of 5
2550 Don Roser Dr, Las Cruces, NM
  • 7 min drive from Mesillia Plaza
The price is $126 per night from Apr 19 to Apr 20
$126
includes taxes & fees
Apr 19 - Apr 20
Stay at this 3-star business-friendly hotel in Las Cruces. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and ...
9/10 Wonderful! (1,001 reviews)
"The restaurant and bar were great. The pool and hottub with the fireplace were great."

Reviewed on Apr 4, 2025

Hilton Garden Inn Las Cruces
Quality Inn & Suites Las Cruces - University Area
Quality Inn & Suites Las Cruces - University Area
2.5 out of 5
2200 S Valley Dr, Las Cruces, NM
  • 22 min walk from Mesillia Plaza
The price is $57 per night from May 11 to May 12
$57
includes taxes & fees
May 11 - May 12
Stay at this hotel in Las Cruces. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. ...
7/10 Good! (1,000 reviews)
"The property was not kept well."

Reviewed on Mar 28, 2025

Quality Inn & Suites Las Cruces - University Area
Sleep Inn University
Sleep Inn University
2.5 out of 5
2121 S Triviz Dr, Las Cruces, NM
  • 7 min drive from Mesillia Plaza
The price is $73 per night from Apr 20 to Apr 21
$73
includes taxes & fees
Apr 20 - Apr 21
Book a stay at this business-friendly hotel in Las Cruces. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.6/10 Good! (957 reviews)
"Nice place in a convenient location"

Reviewed on Mar 23, 2025

Sleep Inn University
Springhill Suites By Marriott Las Cruces
Springhill Suites By Marriott Las Cruces
3 out of 5
1611 Hickory Loop, Las Cruces, NM
  • 26 min walk from Mesillia Plaza
The price is $108 per night from Apr 21 to Apr 22
$108
includes taxes & fees
Apr 21 - Apr 22
Stay at this 3-star business-friendly hotel in Las Cruces. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (837 reviews)
"Nice place to stay"

Reviewed on Apr 10, 2025

Springhill Suites By Marriott Las Cruces
Staybridge Suites Las Cruces by IHG
Staybridge Suites Las Cruces by IHG
3 out of 5
2651 Northrise Dr, Las Cruces, NM
  • 13 min drive from Mesillia Plaza
The price is $119 per night from May 4 to May 5
$119
includes taxes & fees
May 4 - May 5
Stay at this 3-star business-friendly hotel in Las Cruces. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.6/10 Excellent! (1,001 reviews)
"Awesome"

Reviewed on Apr 4, 2025

Staybridge Suites Las Cruces by IHG
La Quinta Inn by Wyndham Las Cruces Mesilla Valley
La Quinta Inn by Wyndham Las Cruces Mesilla Valley
2.5 out of 5
790 Avenida De Mesilla, Las Cruces, NM
  • 26 min walk from Mesillia Plaza
The price is $58 per night from May 12 to May 13
$58
includes taxes & fees
May 12 - May 13
Book a stay at this business-friendly hotel in Las Cruces. Enjoy free WiFi, free parking, and a fitness center. Our guests praise the clean rooms in our reviews. ...
5.8/10 (1,002 reviews)
"The staff are wonderful. It is under renovation however"

Reviewed on Apr 5, 2025

La Quinta Inn by Wyndham Las Cruces Mesilla Valley
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Mesilla

You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Mesilla hotel with Hotwire to complete your one-of-a-kind travel checklist.

For you, intrepid voyager, Hotwire has a large selection of the best hotels in Mesilla.

Choosing the right hotel in New Mexico has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Mesilla’s 337 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $57. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Mesilla hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Mesilla. No matter your reason for visiting Mesilla, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Mesilla hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Mesilla for as low as $57.

How many hotels are there in Mesilla?

With over 337 hotels in Mesilla, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $57.

How to find cheap car rentals in Mesilla?

Finding a cheap car rental deal in Mesilla is as easy as scoring cheap hotels in Mesilla. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.