Hotels Near
Mira Mesa

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Featured Mira Mesa Hotels

Handlery Hotel
Handlery Hotel
3.5 out of 5
950 Hotel Cir N, San Diego, CA
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the bar in our ...
8/10 Very Good! (1,856 reviews)
"Needs serious updating"

Reviewed on Jul 10, 2025

Handlery Hotel
Wyndham San Diego Bayside
Wyndham San Diego Bayside
4 out of 5
1355 N Harbor Drive, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.2/10 Very Good! (5,716 reviews)
"Nice hotel in the heart of San Diego"

Reviewed on Jul 12, 2025

Wyndham San Diego Bayside
Marriott Marquis San Diego Marina
Marriott Marquis San Diego Marina
4 out of 5
333 W Harbor Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
Book a stay at this spa hotel in San Diego. Enjoy 2 outdoor pools, a full-service spa, and 5 restaurants. Our guests praise the pool and the helpful staff in ...
9/10 Wonderful! (1,741 reviews)
"Great location, served its purpose for the 4Th"

Reviewed on Jul 11, 2025

Marriott Marquis San Diego Marina
Manchester Grand Hyatt San Diego
Manchester Grand Hyatt San Diego
4 out of 5
1 Market Pl, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star eco-certified hotel in San Diego. Enjoy free WiFi, 6 restaurants, and 3 bars/lounges. Our guests praise the pool and the bar in our reviews. ...
8.8/10 Excellent! (2,775 reviews)
"Wakable and nice staff."

Reviewed on Jul 11, 2025

Manchester Grand Hyatt San Diego
The Dana on Mission Bay
The Dana on Mission Bay
3.5 out of 5
1710 W Mission Bay Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in ...
8.8/10 Excellent! (3,557 reviews)
Wonderful San Diego Hotel
"Loved The Dana. Will be back!"

Reviewed on Jul 9, 2025

The Dana on Mission Bay
Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
2.5 out of 5
2485 Hotel Circle Place, San Diego, CA
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
8/10 Very Good! (1,793 reviews)
Review
"The stay was great. Check in easy and quick. Staff were accommodating"

Reviewed on Jul 10, 2025

Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
The Dextro Hotel, BW Premier Collection
The Dextro Hotel, BW Premier Collection
3 out of 5
1617 1st Avenue, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
7.4/10 Good! (1,019 reviews)
"We had a great stay"

Reviewed on Jul 12, 2025

The Dextro Hotel, BW Premier Collection
DoubleTree by Hilton San Diego - Del Mar
DoubleTree by Hilton San Diego - Del Mar
4 out of 5
11915 El Camino Real, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in San Diego. Enjoy breakfast (surcharge), room service, and a fitness center. Our guests praise the helpful staff ...
8/10 Very Good! (1,256 reviews)
"Liked the ease of freeway access. Shower was slow to drain."

Reviewed on Jul 12, 2025

DoubleTree by Hilton San Diego - Del Mar
The Little Italy Hotel Downtown San Diego
The Little Italy Hotel Downtown San Diego
4 out of 5
1646 Front St, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and parking (surcharge). Our guests praise the helpful staff in our reviews. ...
7.8/10 Good! (1,007 reviews)
"Fantastic hotel, parking was extremely tight to go up or down ramp to other levels."

Reviewed on Jul 9, 2025

The Little Italy Hotel Downtown San Diego
Bay Club Hotel & Marina
Bay Club Hotel & Marina
3.5 out of 5
2131 Shelter Island Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy free WiFi, a marina, and a health club. Our guests praise the breakfast and the restaurant ...
9/10 Wonderful! (2,687 reviews)
Great area on the bay
"Nice hotel with great views from balcony looking at marina. Room is large. Service by all staff is excellent! Would book again! Aron and Joshua at front desk are great at thier jobs. Bar staff is excellent. House keeping is good."

Reviewed on Jul 10, 2025

Bay Club Hotel & Marina
Hilton San Diego Bayfront
Hilton San Diego Bayfront
4 out of 5
1 Park Blvd, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star spa hotel in San Diego. Enjoy a full-service spa, 2 bars/lounges, and breakfast (surcharge). Our guests praise the pool and the helpful staff ...
8.4/10 Very Good! (1,575 reviews)
"We loved our stay here; everything was perfect. The pool was nice, the shuttle to Coronado Beach was awesome, and of course, it's next to Petco Park. We’ll definitely be back."

Reviewed on Jul 11, 2025

Hilton San Diego Bayfront
San Diego Marriott La Jolla
San Diego Marriott La Jolla
4 out of 5
4240 La Jolla Village Dr, La Jolla, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in La Jolla. Enjoy breakfast (surcharge), a 24-hour fitness center, and valet parking (surcharge). Our guests praise ...
8.4/10 Very Good! (1,913 reviews)
"It was a nice and clean place. But the elevator was too slow."

Reviewed on Jul 10, 2025

San Diego Marriott La Jolla
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Mira Mesa

San Diego is a city that has a lot going on, but you have your sights set on Mira Mesa. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Mira Mesa has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Mira Mesa hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of San Diego so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Mira Mesa underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Mira Mesa city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Mira Mesa cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Mira Mesa at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $128
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Mira Mesa hotel you want, book it, and never look back. Because your great escape is ahead of you.