Hotels Near
Mira Mesa

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Featured Mira Mesa Hotels

The Dana on Mission Bay
The Dana on Mission Bay
3.5 out of 5
1710 W Mission Bay Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 spa tubs. Our guests praise the pool and the restaurant in ...
8.6/10 Excellent! (3,175 reviews)
"Was a great stay for a getaway"

Reviewed on Feb 17, 2025

The Dana on Mission Bay
Wyndham San Diego Bayside
Wyndham San Diego Bayside
4 out of 5
1355 N Harbor Drive, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.2/10 Very Good! (5,634 reviews)
"The location is fantastic!"

Reviewed on Feb 17, 2025

Wyndham San Diego Bayside
Omni San Diego Hotel
Omni San Diego Hotel
4 out of 5
675 L St, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the bar and the helpful ...
9/10 Wonderful! (1,840 reviews)
"Very nice"

Reviewed on Feb 17, 2025

Omni San Diego Hotel
Hard Rock Hotel San Diego
Hard Rock Hotel San Diego
4 out of 5
207 5th Ave, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our ...
8.8/10 Excellent! (2,576 reviews)
"Second time staying at the Hard Rock and it was a great visit once again. Everything exceeded my expectations."

Reviewed on Feb 18, 2025

Hard Rock Hotel San Diego
Hyatt Regency Mission Bay Spa and Marina
Hyatt Regency Mission Bay Spa and Marina
4 out of 5
1441 Quivira Rd, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star spa hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...
8.4/10 Very Good! (1,459 reviews)
"Really nice modern, recently remodeled rooms and grounds. Staff were super friendly and helpful, would definitely come back again!"

Reviewed on Feb 17, 2025

Hyatt Regency Mission Bay Spa and Marina
Comfort Inn Sea World Area
Comfort Inn Sea World Area
3.5 out of 5
3880 Greenwood St, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.4/10 Very Good! (1,616 reviews)
Clean and comfortable
"Remodeled. Comfy beds. Main door to room would get stuck or jammed but no biggie. Pretty quiet area. Parking available just really narrow spaces. Main eating area closed due to remodel and construction. Breakfast was grab and go, vouchers are given for breakfast. Other than that everything was ..."

Reviewed on Feb 18, 2025

Comfort Inn Sea World Area
Sheraton Mission Valley San Diego Hotel
Sheraton Mission Valley San Diego Hotel
4 out of 5
1433 Camino Del Rio S, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and 24-hour room service. Our guests praise the helpful staff ...
8.4/10 Very Good! (1,323 reviews)
"Amazing"

Reviewed on Feb 17, 2025

Sheraton Mission Valley San Diego Hotel
Handlery Hotel
Handlery Hotel
3.5 out of 5
950 Hotel Cir N, San Diego, CA
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the bar in our reviews. ...
7.8/10 Good! (1,589 reviews)
"Overall, a nice property in a convenient and central part of town. Was a bit disappointed with the check-in experience, I requested a room with a balcony and paid a premium for this option. When I got to my room, my balcony "view" was of the parking lot and busy freeway! Not worth the $50 up charge. ..."

Reviewed on Feb 17, 2025

Handlery Hotel
Humphreys Half Moon Inn
Humphreys Half Moon Inn
3.5 out of 5
2303 Shelter Island Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Diego. Enjoy a marina, a nightclub, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
9/10 Wonderful! (2,127 reviews)
"Very well!"

Reviewed on Feb 18, 2025

Humphreys Half Moon Inn
Sheraton San Diego Resort
Sheraton San Diego Resort
4 out of 5
1380 Harbor Island Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Diego. Enjoy 3 outdoor pools, 6 restaurants, and a marina. Our guests praise the pool and the restaurant in ...
8/10 Very Good! (2,557 reviews)
"So beautiful"

Reviewed on Feb 18, 2025

Sheraton San Diego Resort
Lafayette Hotel & Club
Lafayette Hotel & Club
4 out of 5
2223 El Cajon Blvd, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 3 bars/lounges. Our guests praise the helpful staff in our reviews. ...
9/10 Wonderful! (614 reviews)
"Love this hotel. We have stayed in this property twice and both times have been amazing . I would highly recommend it"

Reviewed on Feb 15, 2025

Lafayette Hotel & Club
San Diego Marriott La Jolla
San Diego Marriott La Jolla
4 out of 5
4240 La Jolla Village Dr, La Jolla, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in La Jolla. Enjoy breakfast (surcharge), a 24-hour fitness center, and WiFi (surcharge). Our guests praise the helpful ...
8.2/10 Very Good! (1,604 reviews)
"Very good staff and very good safe hotel"

Reviewed on Feb 10, 2025

San Diego Marriott La Jolla
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Mira Mesa

San Diego is a city that has a lot going on, but you have your sights set on Mira Mesa. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Mira Mesa has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Mira Mesa hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of San Diego so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Mira Mesa underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Mira Mesa city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Mira Mesa cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Mira Mesa at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $106
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Mira Mesa hotel you want, book it, and never look back. Because your great escape is ahead of you.