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Hotels in Sedgewickville

Choose from 65 Sedgewickville Hotel Deals

Tru By Hilton Cape Girardeau
Tru By Hilton Cape Girardeau
2.5 out of 5
2520 Veterans Memorial Dr, Cape Girardeau, MO
  • 6 hours drive from Mississippi River
Stay at this hotel in Cape Girardeau. Enjoy free breakfast, free parking, and a fitness center. Popular attractions Cape Girardeau Conservation Nature Center ...
9.6/10 Exceptional! (41 reviews)
"Very nice to stay in a brand new hotel. So clean. Everyone seemed very nice and helpful. Love the extra games and pool table to keep the kids busy. Loved that you had cookies and milk although we didn't make it down for that. I thought it was a wonderful idea."

Reviewed on Jul 11, 2025

Tru By Hilton Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3 out of 5
3003 SOUTH OLD ORCHARD ROAD, Jackson, MO
  • 6 hours drive from Mississippi River
Stay at this 3-star business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.8/10 Excellent! (582 reviews)
"Our first room was stained, dirty, and not acceptable. I asked for another room and was given a room that looked like it was in another hotel altogether. It was clean, big, comfortable. Perfect. The staff was super friendly and helpful."

Reviewed on Jul 4, 2025

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Quality Inn
Quality Inn
2.5 out of 5
2011 North Kingshighway, Cape Girardeau, MO
  • 6 hours drive from Mississippi River
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our ...
7/10 Good! (605 reviews)
"The hospitality team members were warm and helpful. The amenities were a bit basic. When I asked for half-and-half to be added to the options on the coffee set-up, they explained that that chain did not allow them to offer that. The water in the pool looked an odd shade of green. We'd picked the ..."

Reviewed on Jul 5, 2025

Quality Inn
Drury Inn & Suites Jackson MO
Drury Inn & Suites Jackson MO
3 out of 5
225 Drury Lane, Jackson, MO
  • 5 hours drive from Mississippi River
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9.6/10 Exceptional! (1,005 reviews)
Weekend was just right
"Only issue was a little hair in the bath tub. Overall 5 star service will definitely be returning."

Reviewed on Jun 30, 2025

Drury Inn & Suites Jackson MO
Super 8 by Wyndham Perryville
Super 8 by Wyndham Perryville
2 out of 5
1119 Vincent Dr, Perryville, MO
  • 5 hours drive from Mississippi River
Book a stay at this business-friendly motel in Perryville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (877 reviews)
Quick Stop
"Perfect hotel for a quick nights stay on our travels back home"

Reviewed on Jul 6, 2025

Super 8 by Wyndham Perryville
Holiday Inn Express & Suites Perryville by IHG
Holiday Inn Express & Suites Perryville by IHG
2.5 out of 5
2020 Jefferson St, Perryville, MO
  • 5 hours drive from Mississippi River
Book a stay at this business-friendly hotel in Perryville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9.2/10 Wonderful! (479 reviews)
"Good place"

Reviewed on Jul 10, 2025

Holiday Inn Express & Suites Perryville by IHG
Comfort Suites Jackson-Cape Girardeau
Comfort Suites Jackson-Cape Girardeau
2.5 out of 5
2904 Old Orchard Rd, Jackson, MO
  • 6 hours drive from Mississippi River
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Cape Girardeau Conservation Nature ...
8/10 Very Good! (719 reviews)
"Great area, fast check in, quiet, very spacious"

Reviewed on Jun 29, 2025

Comfort Suites Jackson-Cape Girardeau
Madison Inn Lodge
Madison Inn Lodge
2.5 out of 5
730 Plaza Drive, Fredericktown, MO
  • 5 hours drive from Mississippi River
Book a stay at this business-friendly motel in Fredericktown. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the property condition in ...
7.4/10 Good! (280 reviews)
"Clean, very handicap accessible. In need of some updates- rust around TP holder, etc Due to using 3rd party booking they were not able to refund one night when we had to leave early for family issue. Staff friendly. Convenient to that small town amenities."

Reviewed on Jul 5, 2025

Madison Inn Lodge
Days Inn by Wyndham Perryville
Days Inn by Wyndham Perryville
2 out of 5
1500 Liberty Street, Perryville, MO
  • 5 hours drive from Mississippi River
Book a stay at this business-friendly hotel in Perryville. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Perryville Country Club and ...
6.8/10 (406 reviews)
"Great walking area for my dog"

Reviewed on May 29, 2025

Days Inn by Wyndham Perryville
Quality Inn Perryville I-55
Quality Inn Perryville I-55
2.5 out of 5
1517 S. Perryville Blvd., Perryville, MO
  • 5 hours drive from Mississippi River
Stay at this hotel in Perryville. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Perryville Country Club and Saint Marys Lake are located ...
6.6/10 (111 reviews)
"The room was clean and comfortable"

Reviewed on Jun 17, 2025

Quality Inn Perryville I-55
EC Reed's Mercantile and Hotel
EC Reed's Mercantile and Hotel
3 out of 5
301 1st St, Marble Hill, MO
  • 6 hours drive from Mississippi River
Stay at this 3-star hotel in Marble Hill. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews.
9.6/10 Exceptional! (75 reviews)
"Great, clean room and the restaurant attached was delicious- best breakfast!"

Reviewed on Jun 29, 2025

EC Reed's Mercantile and Hotel
Town House Inn
Town House Inn
2.5 out of 5
517 E Jackson Blvd, Jackson, MO
  • 6 hours drive from Mississippi River
Stay at this motel in Jackson. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff in our reviews. Popular attractions ...
7.6/10 Good! (396 reviews)
"Only negative was no ice in ice machine."

Reviewed on Mar 29, 2025

Town House Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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