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Hotels in Sedgewickville

Choose from 83 Sedgewickville Hotel Deals

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

3 out of 5
3003 SOUTH OLD ORCHARD ROAD Jackson MO
  • 6 hours drive from Mississippi River
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9/10 Wonderful! (736 reviews)
Clean and quiet. Cute New Italian place- within a mile called Roma. Very family friendly!

Reviewed on Mar 27, 2026

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

3 out of 5
225 Drury Lane Jackson MO
  • 5 hours drive from Mississippi River
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9.6/10 Exceptional! (1,003 reviews)
Breakfast was fresh a s very tasty. Eggs, sausage, buscuits, gravy, waffles, juice, soda, and coffee. Parking was ample and safe. Pool In room fridge. Everything was clean and fresh smelling. I had a very pleasant stay here and will return again in my future trips here. :)

Reviewed on Mar 29, 2026

Drury Inn & Suites Jackson MO
Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North

2.5 out of 5
2011 North Kingshighway Cape Girardeau MO
  • 6 hours drive from Mississippi River
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our ...
7.2/10 Good! (721 reviews)
It was a clean room at a fair price. No frills but clean and staff were polite.

Reviewed on Mar 31, 2026

Quality Inn Cape Girardeau North
Holiday Inn Express & Suites Perryville by IHG

Holiday Inn Express & Suites Perryville by IHG

2.5 out of 5
2020 Jefferson St Perryville MO
  • 5 hours drive from Mississippi River
Book a stay at this business-friendly hotel in Perryville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9.2/10 Wonderful! (572 reviews)
Breakfast was good nice beds very nice stay

Reviewed on Mar 30, 2026

Holiday Inn Express & Suites Perryville by IHG
Comfort Suites Jackson-Cape Girardeau

Comfort Suites Jackson-Cape Girardeau

2.5 out of 5
2904 Old Orchard Rd Jackson MO
  • 6 hours drive from Mississippi River
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Cape Girardeau Conservation Nature ...
8.2/10 Very Good! (755 reviews)
There was no water pressure, luke warm water both nights. The breakfast was subpar & with an hour left with breakfast the workers refused to refill empty items. Several people complained to no avail. Breakfast area was dirty & two people sitting upfront playing on their phones. We made our first ...

Reviewed on Mar 22, 2026

Comfort Suites Jackson-Cape Girardeau
Super 8 by Wyndham Perryville

Super 8 by Wyndham Perryville

2 out of 5
1119 Vincent Dr Perryville MO
  • 5 hours drive from Mississippi River
Book a stay at this business-friendly motel in Perryville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (972 reviews)
Good breakfast and clean rooms.

Reviewed on Mar 28, 2026

Super 8 by Wyndham Perryville
Days Inn by Wyndham Perryville

Days Inn by Wyndham Perryville

2 out of 5
1500 Liberty Street Perryville MO
  • 5 hours drive from Mississippi River
Book a stay at this business-friendly hotel in Perryville. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Perryville Country Club and ...
6.8/10 (428 reviews)
When we got to our room, it was open and not cleaned...at 9pm! Got another room....while it appeared to have been cleaned, ready for customers...the floor was carpet and chunks of debri on it, headboard had footprints and handprints on it, shower curtain was torn and dirty, the tv remote did not ...

Reviewed on Mar 25, 2026

Days Inn by Wyndham Perryville
Town House Inn

Town House Inn

2.5 out of 5
517 E Jackson Blvd Jackson MO
  • 6 hours drive from Mississippi River
Stay at this motel in Jackson. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff in our reviews. Popular attractions ...
7.6/10 Good! (440 reviews)
Great owners

Reviewed on Mar 3, 2026

Town House Inn
Madison Inn Lodge

Madison Inn Lodge

2.5 out of 5
730 Plaza Drive Fredericktown MO
  • 5 hours drive from Mississippi River
Book a stay at this business-friendly motel in Fredericktown. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the property condition in ...
7.6/10 Good! (298 reviews)
Rooms were clean! Beds were comfortable, and the staff were very accommodating.

Reviewed on Mar 18, 2026

Madison Inn Lodge
Quality Inn Perryville I-55

Quality Inn Perryville I-55

2.5 out of 5
1517 S. Perryville Blvd. Perryville MO
  • 5 hours drive from Mississippi River
Stay at this hotel in Perryville. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Perryville Country Club and Saint Marys Lake are located ...
6.6/10 (128 reviews)
satisfactory

Reviewed on Mar 12, 2026

Quality Inn Perryville I-55
EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel

3 out of 5
301 1st St Marble Hill MO
  • 6 hours drive from Mississippi River
Stay at this hotel in Marble Hill. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews.
9.6/10 Exceptional! (85 reviews)
Parking was easy. The staff were super friendly and helpful. Room was nice and comfortable. I definetely recommend staying here if you are in this area.

Reviewed on Mar 22, 2026

EC Reed's Mercantile and Hotel
Urban Lofts

Urban Lofts

3 out of 5
102 N Jackson St Perryville MO
  • 5 hours drive from Mississippi River
Stay at this aparthotel in Perryville. Enjoy free WiFi, free parking, and dry cleaning or laundry services. Popular attractions Feltz Street Park and Perryville ...
9.2/10 Wonderful! (17 reviews)
Great place to stay!

Reviewed on Oct 21, 2024

Urban Lofts
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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