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Hotels in Sedgewickville

Choose from 89 Sedgewickville Hotel Deals

Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

3 out of 5
225 Drury Lane Jackson MO
  • 5 hours drive from Mississippi River
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9.6/10 Exceptional! (1,004 reviews)
"Could not have asked for a better experience! Staff was welcoming, very helpful, and super efficient. Pool and hot tub was very clean, temperature was great, and had ample towels and seating. Kickbacks was amazing!!!! We went to Iron Mountain Railroad, Trail of Tears State Park and Bollinger Grist ..."

Reviewed on Jun 28, 2026

Drury Inn & Suites Jackson MO
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

3 out of 5
3003 SOUTH OLD ORCHARD ROAD Jackson MO
  • 6 hours drive from Mississippi River
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9/10 Wonderful! (789 reviews)
"Hotel was conveniently located to sportsplex. Standard fair breakfast. Beds slept well."

Reviewed on Jun 27, 2026

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North

2.5 out of 5
2011 North Kingshighway Cape Girardeau MO
  • 6 hours drive from Mississippi River
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our ...
7/10 Good! (769 reviews)
"Our room was nice, loved the refrigerator with a separate freezer! The bed needs to be replaced - had a definite dip toward the middle. Toilet seat also needed to be tightened which we notified staff about."

Reviewed on Jun 28, 2026

Quality Inn Cape Girardeau North
Holiday Inn Express & Suites Perryville by IHG

Holiday Inn Express & Suites Perryville by IHG

2.5 out of 5
2020 Jefferson St Perryville MO
  • 5 hours drive from Mississippi River
Book a stay at this business-friendly hotel in Perryville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9.2/10 Wonderful! (600 reviews)
"The room was clean and spacious. The staff was very helpful."

Reviewed on Jun 29, 2026

Holiday Inn Express & Suites Perryville by IHG
Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau

2.5 out of 5
2520 Veterans Memorial Dr Cape Girardeau MO
  • 6 hours drive from Mississippi River
Stay at this hotel in Cape Girardeau. Enjoy free breakfast, free parking, and a fitness center. Popular attractions Cape Girardeau Conservation Nature Center ...
9.6/10 Exceptional! (141 reviews)
"The entire experience was great. The only thing I missed was maybe some potoes added to the breakfast menu for non meat eaters and stubborn toddlers."

Reviewed on Jun 26, 2026

Tru By Hilton Cape Girardeau
Super 8 by Wyndham Perryville

Super 8 by Wyndham Perryville

2 out of 5
1119 Vincent Dr Perryville MO
  • 5 hours drive from Mississippi River
Book a stay at this business-friendly motel in Perryville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (1,002 reviews)
"Ok on cleanliness but needed more staff cleaning breakfast room"

Reviewed on Jun 10, 2026

Super 8 by Wyndham Perryville
Madison Inn Lodge

Madison Inn Lodge

2.5 out of 5
730 Plaza Drive Fredericktown MO
  • 5 hours drive from Mississippi River
Book a stay at this business-friendly motel in Fredericktown. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the property condition in ...
7.6/10 Good! (304 reviews)
"Comfy beds. Good air conditioning."

Reviewed on Jun 22, 2026

Madison Inn Lodge
Comfort Suites Jackson-Cape Girardeau

Comfort Suites Jackson-Cape Girardeau

2.5 out of 5
2904 Old Orchard Rd Jackson MO
  • 6 hours drive from Mississippi River
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Cape Girardeau Conservation Nature ...
8.2/10 Very Good! (771 reviews)
"We stayed at Comfort Suites in Jackson, Missouri, for two nights and had a very pleasant experience overall. The rooms could use a few cosmetic updates and minor touch-ups, but they were clean, comfortable, and well-maintained where it mattered most. The staff was friendly, welcoming, and helpful ..."

Reviewed on Jun 21, 2026

Comfort Suites Jackson-Cape Girardeau
EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel

3 out of 5
301 1st St Marble Hill MO
  • 6 hours drive from Mississippi River
Stay at this hotel in Marble Hill. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews.
9.6/10 Exceptional! (101 reviews)
"It was clean and the check-in was pleasant. Not much to offer otherwise."

Reviewed on Jun 21, 2026

EC Reed's Mercantile and Hotel
The Atrium - A Boutique Hotel

The Atrium - A Boutique Hotel

2 out of 5
112 W Ste Maries St Perryville MO
  • 5 hours drive from Mississippi River
Stay at this aparthotel in Perryville. Enjoy free WiFi, free parking, and bathrobes. Popular attractions Feltz Street Park and Perryville Country Club are located ...
9.6/10 Exceptional! (4 reviews)
"What an amazing little suite wrapped in a very thought-filled overall venue. Very unique room with a so many details. The overall building with fire pit, game rooms, and local vendor items…all was quite amazing. Every element is thought out very well. It is very convenient and overall comfortable. ..."

Reviewed on Jun 13, 2026

The Atrium - A Boutique Hotel
Town House Inn

Town House Inn

2.5 out of 5
517 E Jackson Blvd Jackson MO
  • 6 hours drive from Mississippi River
Stay at this motel in Jackson. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff in our reviews. Popular attractions ...
Town House Inn
Days Inn by Wyndham Perryville

Days Inn by Wyndham Perryville

2 out of 5
1500 Liberty Street Perryville MO
  • 5 hours drive from Mississippi River
Book a stay at this business-friendly hotel in Perryville. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Perryville Country Club and ...
6.8/10 (444 reviews)
"I don’t have any idea where the bad reviews are coming from. The hotel was clean. Staff was inviting. Location is right off I-55 by plenty of other businesses. We came in at night after deciding to take a break from driving & had looked for a cheaper hotel. The room was spacious & clean. A/C worked ..."

Reviewed on Jun 26, 2026

Days Inn by Wyndham Perryville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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