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Hotels in Sedgewickville

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Choose from 83 Sedgewickville Hotel Deals

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

3 out of 5
3003 SOUTH OLD ORCHARD ROAD Jackson MO
  • 6 hours drive from Mississippi River
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.8/10 Excellent! (674 reviews)
Very clean premises, easy check-in, quiet, good breakfast and Wendy, the receptionist was the BEST ever in providing professional, quality and attentive customer service with a smile and warm welcome!

Reviewed on Dec 15, 2025

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

3 out of 5
225 Drury Lane Jackson MO
  • 5 hours drive from Mississippi River
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9.6/10 Exceptional! (1,008 reviews)
Great location! Great staff well above and beyond. Will definitely stay again.

Reviewed on Dec 21, 2025

Drury Inn & Suites Jackson MO
Quality Inn

Quality Inn

2.5 out of 5
2011 North Kingshighway Cape Girardeau MO
  • 6 hours drive from Mississippi River
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our ...
7/10 Good! (686 reviews)
Comfortable bed

Reviewed on Dec 16, 2025

Quality Inn
Holiday Inn Express & Suites Perryville by IHG

Holiday Inn Express & Suites Perryville by IHG

2.5 out of 5
2020 Jefferson St Perryville MO
  • 5 hours drive from Mississippi River
Book a stay at this business-friendly hotel in Perryville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9.2/10 Wonderful! (542 reviews)
Clean room

Reviewed on Dec 21, 2025

Holiday Inn Express & Suites Perryville by IHG
Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau

2.5 out of 5
2520 Veterans Memorial Dr Cape Girardeau MO
  • 6 hours drive from Mississippi River
Stay at this hotel in Cape Girardeau. Enjoy free breakfast, free parking, and a fitness center. Popular attractions Cape Girardeau Conservation Nature Center ...
9.4/10 Exceptional! (103 reviews)
Hotel was very clean, quiet and has a great location!

Reviewed on Dec 21, 2025

Tru By Hilton Cape Girardeau
Super 8 by Wyndham Perryville

Super 8 by Wyndham Perryville

2 out of 5
1119 Vincent Dr Perryville MO
  • 5 hours drive from Mississippi River
Book a stay at this business-friendly motel in Perryville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (941 reviews)
Clean and comfortable room

Reviewed on Dec 18, 2025

Super 8 by Wyndham Perryville
Madison Inn Lodge

Madison Inn Lodge

2.5 out of 5
730 Plaza Drive Fredericktown MO
  • 5 hours drive from Mississippi River
Book a stay at this business-friendly motel in Fredericktown. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the property condition in ...
7.4/10 Good! (297 reviews)
Room was not exactly smelling nice, but room was clean and comfortable. The lodge was close to expressway and shopping. Staff was very friendly. I would stay there again.

Reviewed on Oct 13, 2025

Madison Inn Lodge
Comfort Suites Jackson-Cape Girardeau

Comfort Suites Jackson-Cape Girardeau

2.5 out of 5
2904 Old Orchard Rd Jackson MO
  • 6 hours drive from Mississippi River
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Cape Girardeau Conservation Nature ...
8/10 Very Good! (740 reviews)
Room was clean and affordable for one night. The morning person could have been more attentive to me being there for breakfast. No greeting at all and sat on her phone. I was the only one down in the breakfast area. Be more aware of her surroundings while working alone.

Reviewed on Dec 19, 2025

Comfort Suites Jackson-Cape Girardeau
Town House Inn

Town House Inn

2.5 out of 5
517 E Jackson Blvd Jackson MO
  • 6 hours drive from Mississippi River
Stay at this motel in Jackson. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff in our reviews. Popular attractions ...
7.6/10 Good! (426 reviews)
Upon arrival, the room I was given had problems: there were cockroaches scurrying about in the kitchenette area. Plus the room smelled like a smoker's room, even though the room sign stated it was smoke free. Not a good way to start! I went to the on-site manager and explained, and to his credit, ...

Reviewed on Dec 24, 2025

Town House Inn
Days Inn by Wyndham Perryville

Days Inn by Wyndham Perryville

2 out of 5
1500 Liberty Street Perryville MO
  • 5 hours drive from Mississippi River
Book a stay at this business-friendly hotel in Perryville. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Perryville Country Club and ...
6.8/10 (415 reviews)
Clean

Reviewed on Oct 13, 2025

Days Inn by Wyndham Perryville
EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel

3 out of 5
301 1st St Marble Hill MO
  • 6 hours drive from Mississippi River
Stay at this hotel in Marble Hill. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews.
9.6/10 Exceptional! (84 reviews)
Clean rooms, great value.

Reviewed on Nov 28, 2025

EC Reed's Mercantile and Hotel
Quality Inn Perryville I-55

Quality Inn Perryville I-55

2.5 out of 5
1517 S. Perryville Blvd. Perryville MO
  • 5 hours drive from Mississippi River
Stay at this hotel in Perryville. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Perryville Country Club and Saint Marys Lake are located ...
6.6/10 (124 reviews)
This was an overnight trip…Our bathroom was dirty and there weren’t any extra towels or toilet paper in the room. Also the fire alarm went off at 6am without an explanation..They offered yogurt but didn’t have the key to the cabinet.

Reviewed on Aug 11, 2025

Quality Inn Perryville I-55
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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