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Hotels in Southwest Illinois

Choose from 680 Southwest Illinois Hotel Deals

Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon

3 out of 5
145 North 44th Street , Mount Vernon, IL
  • 2 hours drive from Southern Illinois University
Stay at this 3-star business-friendly hotel in Mount Vernon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.6/10 Exceptional! (1,396 reviews)
"excellent"

Reviewed on Jul 14, 2025

Drury Plaza Hotel Mt. Vernon
Best Western Plus Pontoon Beach

Best Western Plus Pontoon Beach

3 out of 5
4 Regency Pkwy, Granite City, IL
  • 3 hours drive from Southern Illinois University
Stay at this 3-star business-friendly hotel in Granite City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8.4/10 Very Good! (702 reviews)
"Excellent stay."

Reviewed on Jul 13, 2025

Best Western Plus Pontoon Beach
Super 8 by Wyndham O'Fallon

Super 8 by Wyndham O'Fallon

2 out of 5
1100 Eastgate Dr, O'Fallon, IL
  • 3 hours drive from Southern Illinois University
Book a stay at this business-friendly hotel in O'Fallon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.4/10 Good! (1,001 reviews)
"Its great overall"

Reviewed on Jul 14, 2025

Super 8 by Wyndham O'Fallon
Drury Inn & Suites Marion

Drury Inn & Suites Marion

3 out of 5
2706 W DeYoung St, Marion, IL
  • 42 min drive from Southern Illinois University
Stay at this 3-star business-friendly hotel in Marion. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.2/10 Wonderful! (1,004 reviews)
"Get pomace for a stop. Evening drink and snack was an added bonus"

Reviewed on Jul 8, 2025

Drury Inn & Suites Marion
Quality Inn & Suites near St. Louis and I-255

Quality Inn & Suites near St. Louis and I-255

2.5 out of 5
1607 Pontiac Dr, East St. Louis, IL
  • 3 hours drive from Southern Illinois University
Book a stay at this business-friendly hotel in East St. Louis. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
7.4/10 Good! (1,004 reviews)
"Stay was pretty good. It’s close to my family."

Reviewed on Jul 6, 2025

Quality Inn & Suites near St. Louis and I-255
Drury Inn & Suites St. Louis Fairview Heights

Drury Inn & Suites St. Louis Fairview Heights

3 out of 5
12 Ludwig Dr, Fairview Heights, IL
  • 3 hours drive from Southern Illinois University
Book a stay at this business-friendly hotel in Fairview Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,020 reviews)
"We very much enjoyed our stay. The only downside was that multiple staff made comments regarding our mature 9yo to the effect that they werent happy he was perceived to be without supervision. He was supervised or with another responsible sibling at all times and we've never had that issue at any ..."

Reviewed on Jul 14, 2025

Drury Inn & Suites St. Louis Fairview Heights
Days Inn & Suites by Wyndham Caseyville

Days Inn & Suites by Wyndham Caseyville

2.5 out of 5
2423 Old Country Inn Drive, Caseyville, IL
  • 3 hours drive from Southern Illinois University
Book a stay at this business-friendly hotel in Caseyville. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Pleasant Ridge Park and Cahokia ...
3.8/10 (254 reviews)
"Maybe they need to repair the ice machine and bring back the snacks machines with card options. Maybe a convenient store inside. Repair the coin washer plus other things. But I still think it’s the best option to do the main things you do on a room: rest and be relaxed."

Reviewed on Jun 30, 2025

Days Inn & Suites by Wyndham Caseyville
Red Lion Inn & Suites Pontoon Beach

Red Lion Inn & Suites Pontoon Beach

2.5 out of 5
1240 E Chain Of Rocks Rd, Granite City, IL
  • 3 hours drive from Southern Illinois University
Stay at this hotel in Granite City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
7.8/10 Good! (433 reviews)
"Me gustaría que tuviera tabla de planchar y plancha en las habitaciones."

Reviewed on Jul 15, 2025

Red Lion Inn & Suites Pontoon Beach
La Quinta Inn & Suites by Wyndham O'Fallon, IL - St. Louis

La Quinta Inn & Suites by Wyndham O'Fallon, IL - St. Louis

3 out of 5
136 Regency Park, O'Fallon, IL
  • 3 hours drive from Southern Illinois University
Stay at this 3-star business-friendly hotel in O'Fallon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...
6.2/10 (1,007 reviews)
Honest review
"Room was clean and everything else. However the smell when you go through those doors are not the best, stink really bad."

Reviewed on Jun 30, 2025

La Quinta Inn & Suites by Wyndham O'Fallon, IL - St. Louis
Motel 6 Caseyville, IL - Caseyville Il

Motel 6 Caseyville, IL - Caseyville Il

2 out of 5
2431 Old Country Inn Dr, Caseyville, IL
  • 3 hours drive from Southern Illinois University
Stay at this motel in Caseyville. Enjoy free parking, an outdoor pool, and a 24-hour front desk. Our guests praise the property condition in our reviews. Popular ...
6.2/10 (1,004 reviews)
Responsible pet owners only
"Stayed for 7 days. Everything was great till the last day when someone in the room next to us left their dog in the room unattended and they barked for 3 hours straight. We even checked out an hour early just to get away from the dogs yapping"

Reviewed on Jul 11, 2025

Motel 6 Caseyville, IL - Caseyville Il
Comfort Inn Collinsville near St. Louis

Comfort Inn Collinsville near St. Louis

2.5 out of 5
8 Commerce Dr, Collinsville, IL
  • 3 hours drive from Southern Illinois University
Book a stay at this business-friendly hotel in Collinsville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.4/10 Very Good! (791 reviews)
"Nice clean facility with a great breakfast."

Reviewed on Jul 12, 2025

Comfort Inn Collinsville near St. Louis
Baymont by Wyndham Marion

Baymont by Wyndham Marion

2.5 out of 5
2608 W Main St, Marion, IL
  • 43 min drive from Southern Illinois University
Book a stay at this business-friendly hotel in Marion. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.2/10 Very Good! (1,031 reviews)
"The air conditioner was on and room stayed cool throughout our stay. Some USB charging stations did not work."

Reviewed on Jul 14, 2025

Baymont by Wyndham Marion
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Southwest Illinois

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For you, intrepid voyager, Hotwire has a large selection of the best hotels in Southwest Illinois.

Choosing the right hotel in Illinois has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Southwest Illinois’s 680 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $60. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Southwest Illinois hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Southwest Illinois. No matter your reason for visiting Southwest Illinois, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Southwest Illinois hotels

Where can I find the best last-minute travel deals?

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How many hotels are there in Southwest Illinois?

With over 680 hotels in Southwest Illinois, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $60.

How to find cheap car rentals in Southwest Illinois?

Finding a cheap car rental deal in Southwest Illinois is as easy as scoring cheap hotels in Southwest Illinois. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.