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Hotels in Southwest Illinois

Choose from 740 Southwest Illinois Hotel Deals

Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon

3 out of 5
145 North 44th Street  Mount Vernon IL
  • 2 hours drive from Southern Illinois University
Book a stay at this business-friendly hotel in Mount Vernon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.6/10 Exceptional! (1,648 reviews)
Wonderful place! Friendly staff, great pool! hot tub, and as far as breakfasts go …. This place was the best!!! Anytime we need to stop and are in the area this is where we will stay!

Reviewed on Jan 29, 2026

Drury Plaza Hotel Mt. Vernon
Drury Inn & Suites St. Louis Fairview Heights

Drury Inn & Suites St. Louis Fairview Heights

3 out of 5
12 Ludwig Dr Fairview Heights IL
  • 3 hours drive from Southern Illinois University
Book a stay at this business-friendly hotel in Fairview Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,015 reviews)
All was good. Breakfast especially at 100%.

Reviewed on Jan 22, 2026

Drury Inn & Suites St. Louis Fairview Heights
Super 8 by Wyndham O'Fallon

Super 8 by Wyndham O'Fallon

2 out of 5
1100 Eastgate Dr O'Fallon IL
  • 3 hours drive from Southern Illinois University
Book a stay at this business-friendly hotel in O'Fallon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7/10 Good! (1,000 reviews)
Yes

Reviewed on Jan 24, 2026

Super 8 by Wyndham O'Fallon
Comfort Suites Mount Vernon

Comfort Suites Mount Vernon

2.5 out of 5
404 South 44th Street Mount Vernon IL
  • 2 hours drive from Southern Illinois University
Book a stay at this business-friendly hotel in Mount Vernon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.8/10 Excellent! (1,000 reviews)
Spotless and clean

Reviewed on Jan 27, 2026

Comfort Suites Mount Vernon
La Quinta Inn & Suites by Wyndham Collinsville - St. Louis

La Quinta Inn & Suites by Wyndham Collinsville - St. Louis

3 out of 5
6 Gateway Dr Collinsville IL
  • 3 hours drive from Southern Illinois University
Book a stay at this business-friendly hotel in Collinsville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,004 reviews)
The room seemed claen. The bed was great, everything was great. Except for the shower, when they did a remodel they made the shower door slide the wrong way. There is zero chance of turning the water on without getting blast of cold sprayed on you! So that made me think, i see the cleaners in the ...

Reviewed on Jan 12, 2026

La Quinta Inn & Suites by Wyndham Collinsville - St. Louis
Drury Inn & Suites Marion

Drury Inn & Suites Marion

3 out of 5
2706 W DeYoung St Marion IL
  • 42 min drive from Southern Illinois University
Book a stay at this business-friendly hotel in Marion. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.2/10 Wonderful! (1,014 reviews)
The hotel was one of the cleanest I have been in! We enjoyed the breakfast and the evening meal.

Reviewed on Jan 25, 2026

Drury Inn & Suites Marion
Drury Inn & Suites St. Louis O'Fallon, IL

Drury Inn & Suites St. Louis O'Fallon, IL

3 out of 5
1118 Central Park Drive O'Fallon IL
  • 3 hours drive from Southern Illinois University
Book a stay at this business-friendly hotel in O'Fallon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,007 reviews)
The staff and was friendly and so helpful

Reviewed on Jan 22, 2026

Drury Inn & Suites St. Louis O'Fallon, IL
Quality Inn O'Fallon IL - St. Louis

Quality Inn O'Fallon IL - St. Louis

3 out of 5
1409 W US 50 O'Fallon IL
  • 3 hours drive from Southern Illinois University
Book a stay at this business-friendly hotel in O'Fallon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.4/10 Good! (1,010 reviews)
Great place to stay, very helpful ataff!

Reviewed on Jan 17, 2026

Quality Inn O'Fallon IL - St. Louis
Holiday Inn Express & Suites - O'Fallon /Shiloh by IHG

Holiday Inn Express & Suites - O'Fallon /Shiloh by IHG

2.5 out of 5
3396 Green Mount Crossing Drive Shiloh O'Fallon IL
  • 3 hours drive from Southern Illinois University
Book a stay at this business-friendly hotel in O'Fallon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8.4/10 Very Good! (570 reviews)
Staff was great, will stay again

Reviewed on Jan 21, 2026

Holiday Inn Express & Suites - O'Fallon /Shiloh by IHG
La Quinta Inn & Suites by Wyndham O'Fallon, IL - St. Louis

La Quinta Inn & Suites by Wyndham O'Fallon, IL - St. Louis

3 out of 5
136 Regency Park O'Fallon IL
  • 3 hours drive from Southern Illinois University
Book a stay at this business-friendly hotel in O'Fallon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...
5.8/10 (1,002 reviews)
Everything was really good.

Reviewed on Jan 18, 2026

La Quinta Inn & Suites by Wyndham O'Fallon, IL - St. Louis
Walker's Bluff Casino Resort

Walker's Bluff Casino Resort

4.5 out of 5
777 Walkers Bluff Way Carterville IL
  • 19 min drive from Southern Illinois University
Book a stay at this luxury resort in Carterville. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff and the clean rooms ...
9.2/10 Wonderful! (403 reviews)
Fine

Reviewed on Jan 24, 2026

Walker's Bluff Casino Resort
Baymont by Wyndham O'Fallon St. Louis Area

Baymont by Wyndham O'Fallon St. Louis Area

2.5 out of 5
1320 Park Plaza Drive O'Fallon IL
  • 3 hours drive from Southern Illinois University
Book a stay at this business-friendly hotel in O'Fallon. Enjoy free breakfast, free WiFi, and free parking. Popular attractions O'Fallon Family Sports Park and ...
5.4/10 (444 reviews)
For the money it was a great

Reviewed on Jan 2, 2026

Baymont by Wyndham O'Fallon St. Louis Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Southwest Illinois

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For you, intrepid voyager, Hotwire has a large selection of the best hotels in Southwest Illinois.

Choosing the right hotel in Illinois has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Southwest Illinois’s 740 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $54. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Southwest Illinois hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Southwest Illinois. No matter your reason for visiting Southwest Illinois, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Southwest Illinois hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Southwest Illinois for as low as $54.

How many hotels are there in Southwest Illinois?

With over 740 hotels in Southwest Illinois, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $54.

How to find cheap car rentals in Southwest Illinois?

Finding a cheap car rental deal in Southwest Illinois is as easy as scoring cheap hotels in Southwest Illinois. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.