Search for Cheap Deals onHotels in Southwest Illinois
Check Last Minute Southwest Illinois Hotel Deals
Choose from 680 Southwest Illinois Hotel Deals

Drury Plaza Hotel Mt. Vernon
Reviewed on Jul 14, 2025

Best Western Plus Pontoon Beach
Reviewed on Jul 13, 2025

Super 8 by Wyndham O'Fallon
Reviewed on Jul 14, 2025

Drury Inn & Suites Marion
Reviewed on Jul 8, 2025

Quality Inn & Suites near St. Louis and I-255
Reviewed on Jul 6, 2025

Drury Inn & Suites St. Louis Fairview Heights
Reviewed on Jul 14, 2025

Days Inn & Suites by Wyndham Caseyville
Reviewed on Jun 30, 2025

Red Lion Inn & Suites Pontoon Beach
Reviewed on Jul 15, 2025

La Quinta Inn & Suites by Wyndham O'Fallon, IL - St. Louis
Reviewed on Jun 30, 2025

Motel 6 Caseyville, IL - Caseyville Il
Reviewed on Jul 11, 2025

Comfort Inn Collinsville near St. Louis
Reviewed on Jul 12, 2025

Baymont by Wyndham Marion
Reviewed on Jul 14, 2025
Find cheap hotels in Southwest Illinois
You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Southwest Illinois hotel with Hotwire to complete your one-of-a-kind travel checklist.
For you, intrepid voyager, Hotwire has a large selection of the best hotels in Southwest Illinois.
Choosing the right hotel in Illinois has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Southwest Illinois’s 680 hotels. Choose the one that best catches your trip’s tourist drift.
If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $60. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Southwest Illinois hotel deals at the last minute.
While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Southwest Illinois. No matter your reason for visiting Southwest Illinois, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.
Frequently Asked Questions About Southwest Illinois hotels
Where can I find the best last-minute travel deals?
If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Southwest Illinois for as low as $60.
How many hotels are there in Southwest Illinois?
With over 680 hotels in Southwest Illinois, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $60.
How to find cheap car rentals in Southwest Illinois?
Finding a cheap car rental deal in Southwest Illinois is as easy as scoring cheap hotels in Southwest Illinois. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.
Top Booked Hotels in Southwest Illinois
- Best Western Plus Pontoon Beach
- Super 8 by Wyndham O'Fallon
- Quality Inn & Suites near St. Louis and I-255
- Days Inn & Suites by Wyndham Caseyville
- Red Lion Inn & Suites Pontoon Beach
- La Quinta Inn & Suites by Wyndham O'Fallon, IL - St. Louis
- Motel 6 Caseyville, IL - Caseyville Il
- Comfort Inn Collinsville near St. Louis
- Baymont by Wyndham Marion
- Best Western Troy Hotel
- Days Inn by Wyndham Collinsville/St. Louis
- Comfort Suites Fairview Heights
- Hotel Brand
- Hotel Class
- Near An Airport
- Areas Of Southwest Illinois
- Near An Attraction
- Hotel Theme
- Other Cities Near Southwest Illinois
- Hotels near Southern Illinois University
- Hotels near Lake of Egypt
- Hotels near World Wide Technology Raceway
- Hotels near Rend Lake
- Hotels near Giant City State Park
- Hotels near Scott Air Force Base
- Hotels near Carlyle Lake
- Hotels near The Edge
- Hotels near St. Claire Square Mall
- Hotels near Cahokia Mounds State Historic Site
- Hotels near DuQuoin State Fairgrounds
- Hotels near O'Fallon Family Sports Park
- Hotels near Marion Cultural and Civic Center
- Hotels near I-57 Drag Strip
- Hotels near McKendree University
- Hotels near Tunnel Hill State Trail
- Hotels near Ferne Clyffe State Park
- Hotels near National Shrine of Our Lady of the Snows
- Hotels near FanDuel Sportsbook and Horse Racing
- Hotels near St. Clair Bowl
- Hotels with Free Parking in Southwest Illinois
- Family Hotels in Southwest Illinois
- Pet-friendly Hotels in Southwest Illinois
- Hotels with a Pool in Southwest Illinois
- Hotels with an Indoor Pool in Southwest Illinois
- Historic Hotels in Southwest Illinois
- Hotels with Hot Tubs in Southwest Illinois
- Luxury Hotels in Southwest Illinois
- Resorts & Hotels with Spas in Southwest Illinois
- Winery Hotels in Southwest Illinois
- Hotel Wedding Venues in Southwest Illinois
- Apartment Hotel in Southwest Illinois
- Hotels with smoking rooms in Southwest Illinois
- Romantic Hotels in Southwest Illinois
- Beach Hotels in Southwest Illinois
- Casinos in Southwest Illinois
- Waterpark Hotels in Southwest Illinois
- Adults Only Resorts & Hotels in Southwest Illinois
- Hotels with Early Check-in in Southwest Illinois
- St. Charles Hotels
- Paducah Hotels
- Maryland Heights Hotels
- Chesterfield Hotels
- Cape Girardeau Hotels
- O'Fallon Hotels
- Marion Hotels
- Mount Vernon Hotels
- Carbondale Hotels
- Hazelwood Hotels
- Fairview Heights Hotels
- Collinsville Hotels
- Grafton Hotels
- Fenton Hotels
- Alton Hotels
- Ozarks Hotels
- Sikeston Hotels
- Eureka Hotels
- Farmington Hotels
- Edwardsville Hotels