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Choose from 776 Southwest Illinois Hotel Deals

Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon

3.5 out of 5
145 North 44th Street  Mount Vernon IL
  • 2 hours drive from Southern Illinois University
Book a stay at this business-friendly hotel in Mount Vernon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.6/10 Exceptional! (1,729 reviews)
"Staff was very pleasant, our room was very nice and entire hotel was clean, shiny and classy!"

Reviewed on Jun 11, 2026

Drury Plaza Hotel Mt. Vernon
Drury Inn & Suites St. Louis Fairview Heights

Drury Inn & Suites St. Louis Fairview Heights

3 out of 5
12 Ludwig Dr Fairview Heights IL
  • 3 hours drive from Southern Illinois University
Book a stay at this business-friendly hotel in Fairview Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,019 reviews)
"Great place to stay! And, their breakfast is great too!"

Reviewed on Jun 13, 2026

Drury Inn & Suites St. Louis Fairview Heights
Super 8 by Wyndham O'Fallon

Super 8 by Wyndham O'Fallon

2 out of 5
1100 Eastgate Dr O'Fallon IL
  • 3 hours drive from Southern Illinois University
Book a stay at this business-friendly hotel in O'Fallon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
6.8/10 (1,010 reviews)
"Fine"

Reviewed on Jun 12, 2026

Super 8 by Wyndham O'Fallon
Drury Inn & Suites St. Louis O'Fallon, IL

Drury Inn & Suites St. Louis O'Fallon, IL

3 out of 5
1118 Central Park Drive O'Fallon IL
  • 3 hours drive from Southern Illinois University
Book a stay at this business-friendly hotel in O'Fallon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.6/10 Exceptional! (1,005 reviews)
"A clean room but most impressive was the kind and courteous staff. Breakfast was plentiful and area kept clean. Dinner was impressive considering one usually doesn’t get an evening snack/ dinner with drinks served and included with room. Great for families and events. The hotel was busy and full ..."

Reviewed on Jun 13, 2026

Drury Inn & Suites St. Louis O'Fallon, IL
Drury Inn & Suites Marion

Drury Inn & Suites Marion

3 out of 5
2706 W DeYoung St Marion IL
  • 42 min drive from Southern Illinois University
Book a stay at this business-friendly hotel in Marion. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,016 reviews)
"Great stay. Staff and property was excellent"

Reviewed on Jun 11, 2026

Drury Inn & Suites Marion
The Principal Hotel

The Principal Hotel

3.5 out of 5
310 S Main St Columbia IL
  • 3 hours drive from Southern Illinois University
Stay at this hotel in Columbia. Enjoy free WiFi, free parking, and a fitness center. Popular attractions Triple Lakes Golf Course and Eckert’s Millstadt Farm ...
9.6/10 Exceptional! (296 reviews)
"Everything was so nice, highly recommended. 10/10 The only downside was, bathroom door, barn door, no looks. Perfect for a couple not for family. But my experience was 100% fantastic."

Reviewed on Jun 13, 2026

The Principal Hotel
Quality Inn & Suites near St. Louis and I-255

Quality Inn & Suites near St. Louis and I-255

2.5 out of 5
1607 Pontiac Dr East St. Louis IL
  • 3 hours drive from Southern Illinois University
Book a stay at this business-friendly hotel in East St. Louis. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
7.4/10 Good! (1,007 reviews)
"Decent place to stay. I appreciate the breakfast option. Staff very friendly."

Reviewed on Jun 12, 2026

Quality Inn & Suites near St. Louis and I-255
Welcome Suites

Welcome Suites

2 out of 5
148 Regency Park O'Fallon IL
  • 3 hours drive from Southern Illinois University
Book a stay at this business-friendly hotel in O'Fallon. Enjoy free WiFi, free parking, and a fitness center. Popular attractions O'Fallon Family Sports Park ...
5.8/10 (275 reviews)
"1. I always do the book now and pay later so I know what I’m paying for when I get to the hotel 2. I called the hotel to make sure me arriving early the next morning was ok and they said yes and for some reason they checked me in and charged my card. 3. I wasn’t made aware of that til I went to cancel ..."

Reviewed on Jun 8, 2026

Welcome Suites
Comfort Suites Mount Vernon

Comfort Suites Mount Vernon

2.5 out of 5
404 South 44th Street Mount Vernon IL
  • 2 hours drive from Southern Illinois University
Book a stay at this business-friendly hotel in Mount Vernon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,050 reviews)
"Very nice hotel, breakfast was good, staff was friendly and very easy to get to off the freeway"

Reviewed on Jun 9, 2026

Comfort Suites Mount Vernon
Walker's Bluff Casino Resort

Walker's Bluff Casino Resort

4.5 out of 5
777 Walkers Bluff Way Carterville IL
  • 19 min drive from Southern Illinois University
Book a stay at this luxury resort in Carterville. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff and the clean rooms ...
9.4/10 Exceptional! (468 reviews)
"Fantastic time! Great weekend getaway"

Reviewed on Jun 13, 2026

Walker's Bluff Casino Resort
Quality Inn O'Fallon IL - St. Louis

Quality Inn O'Fallon IL - St. Louis

3 out of 5
1409 W US 50 O'Fallon IL
  • 3 hours drive from Southern Illinois University
Book a stay at this business-friendly hotel in O'Fallon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.4/10 Good! (1,008 reviews)
"This was terrible no working elevator and a multitude of ants in our room"

Reviewed on Jun 13, 2026

Quality Inn O'Fallon IL - St. Louis
Drury Inn & Suites St. Louis Collinsville

Drury Inn & Suites St. Louis Collinsville

3 out of 5
602 N Bluff Rd Collinsville IL
  • 3 hours drive from Southern Illinois University
Book a stay at this business-friendly hotel in Collinsville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.6/10 Exceptional! (1,021 reviews)
"!"

Reviewed on Jun 11, 2026

Drury Inn & Suites St. Louis Collinsville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Southwest Illinois

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For you, intrepid voyager, Hotwire has a large selection of the best hotels in Southwest Illinois.

Choosing the right hotel in Illinois has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Southwest Illinois’s 776 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $65. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Southwest Illinois hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Southwest Illinois. No matter your reason for visiting Southwest Illinois, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Southwest Illinois hotels

Where can I find the best last-minute travel deals?

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How many hotels are there in Southwest Illinois?

With over 776 hotels in Southwest Illinois, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $65.

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Finding a cheap car rental deal in Southwest Illinois is as easy as scoring cheap hotels in Southwest Illinois. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.