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Hotels in Southwest Illinois

Choose from 655 Southwest Illinois Hotel Deals

Drury Plaza Hotel Mt. Vernon
Drury Plaza Hotel Mt. Vernon
3 out of 5
145 North 44th Street , Mount Vernon, IL
  • 2 hours drive from Southern Illinois University
The price is $117 per night from Feb 21 to Feb 22
$117
includes taxes & fees
Feb 21 - Feb 22
Stay at this 3-star business-friendly hotel in Mount Vernon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.6/10 Exceptional! (1,231 reviews)
"Drury plaza hotels are always lovely. This one was the same. The only downside was the parking lot lighting - it was so intense that it was practically daylight in our room, even with the curtains closed. Not sure if this was a defect or if it was meant to be this way, but there was basically a spotlight ..."

Reviewed on Feb 7, 2025

Drury Plaza Hotel Mt. Vernon
Super 8 by Wyndham O'Fallon
Super 8 by Wyndham O'Fallon
2 out of 5
1100 Eastgate Dr, O'Fallon, IL
  • 3 hours drive from Southern Illinois University
The price is $58 per night from Feb 23 to Feb 24
$58
includes taxes & fees
Feb 23 - Feb 24
Book a stay at this business-friendly hotel in O'Fallon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.6/10 Good! (1,004 reviews)
"Nice property"

Reviewed on Feb 4, 2025

Super 8 by Wyndham O'Fallon
Drury Inn & Suites St. Louis O'Fallon, IL
Drury Inn & Suites St. Louis O'Fallon, IL
3 out of 5
1118 Central Park Drive, O'Fallon, IL
  • 3 hours drive from Southern Illinois University
The price is $120 per night from Feb 17 to Feb 18
$120
includes taxes & fees
Feb 17 - Feb 18
Stay at this 3-star business-friendly hotel in O'Fallon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,000 reviews)
"Excellent property, have stayed multiple times and will stay again…"

Reviewed on Feb 3, 2025

Drury Inn & Suites St. Louis O'Fallon, IL
Drury Inn & Suites Marion
Drury Inn & Suites Marion
3 out of 5
2706 W DeYoung St, Marion, IL
  • 42 min drive from Southern Illinois University
The price is $140 per night from Feb 23 to Feb 24
$140
includes taxes & fees
Feb 23 - Feb 24
Stay at this 3-star business-friendly hotel in Marion. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,003 reviews)
"The food options were nice. The lobby area is great for groups. Staff was super nice and attentive."

Reviewed on Feb 7, 2025

Drury Inn & Suites Marion
Red Lion Inn & Suites Pontoon Beach
Red Lion Inn & Suites Pontoon Beach
2.5 out of 5
1240 E Chain Of Rocks Rd, Granite City, IL
  • 3 hours drive from Southern Illinois University
The price is $67 per night from Feb 12 to Feb 13
$67
includes taxes & fees
Feb 12 - Feb 13
Stay at this hotel in Granite City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
8/10 Very Good! (258 reviews)
"Bed was awful that’s it. Everything else was GREAT"

Reviewed on Feb 5, 2025

Red Lion Inn & Suites Pontoon Beach
Walker's Bluff Casino Resort
Walker's Bluff Casino Resort
4.5 out of 5
777 Walkers Bluff Way, Carterville, IL
  • 19 min drive from Southern Illinois University
The price is $144 per night from Feb 12 to Feb 13
$144
includes taxes & fees
Feb 12 - Feb 13
Stay at this 4.5-star luxury resort in Carterville. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff and the clean rooms ...
9.2/10 Wonderful! (280 reviews)
"Very clean rooms!"

Reviewed on Feb 7, 2025

Walker's Bluff Casino Resort
Baymont by Wyndham Marion
Baymont by Wyndham Marion
2.5 out of 5
2608 W Main St, Marion, IL
  • 43 min drive from Southern Illinois University
The price is $90 per night from Feb 23 to Feb 24
$90
includes taxes & fees
Feb 23 - Feb 24
Book a stay at this business-friendly hotel in Marion. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.2/10 Very Good! (1,004 reviews)
"Nice place"

Reviewed on Feb 9, 2025

Baymont by Wyndham Marion
Drury Inn & Suites St. Louis Fairview Heights
Drury Inn & Suites St. Louis Fairview Heights
3 out of 5
12 Ludwig Dr, Fairview Heights, IL
  • 3 hours drive from Southern Illinois University
The price is $111 per night from Feb 17 to Feb 18
$111
includes taxes & fees
Feb 17 - Feb 18
Book a stay at this business-friendly hotel in Fairview Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,003 reviews)
"very clean front staff very helpful"

Reviewed on Feb 6, 2025

Drury Inn & Suites St. Louis Fairview Heights
Hilton Garden Inn St. Louis Shiloh/O'Fallon IL
Hilton Garden Inn St. Louis Shiloh/O'Fallon IL
3 out of 5
360 Regency Park Drive, O'Fallon, IL
  • 3 hours drive from Southern Illinois University
The price is $110 per night from Feb 16 to Feb 17
$110
includes taxes & fees
Feb 16 - Feb 17
Stay at this 3-star business-friendly hotel in O'Fallon. Enjoy free WiFi, free parking, and room service. Our guests praise the helpful staff in our reviews. ...
8/10 Very Good! (822 reviews)
Comfortable home
"Perfect room. The bed was a box spring and we are spoiled by having a memory foam at home so that was a bit different but manageable. Our daughter stayed on the pull out couch and she just loved it. A very comfortable room to say the least. The buffet was overpriced but looked good. We didn’t have ..."

Reviewed on Feb 3, 2025

Hilton Garden Inn St. Louis Shiloh/O'Fallon IL
Super 8 by Wyndham Marion
Super 8 by Wyndham Marion
2 out of 5
2601 Vernell Rd, Marion, IL
  • 43 min drive from Southern Illinois University
The price is $75 per night from Feb 17 to Feb 18
$75
includes taxes & fees
Feb 17 - Feb 18
Book a stay at this business-friendly motel in Marion. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
7.6/10 Good! (1,000 reviews)
"Great stay- staff was wonderful and we had a nice breakfast"

Reviewed on Feb 1, 2025

Super 8 by Wyndham Marion
Comfort Suites Mount Vernon
Comfort Suites Mount Vernon
2.5 out of 5
404 South 44th Street, Mount Vernon, IL
  • 2 hours drive from Southern Illinois University
The price is $124 per night from Feb 23 to Feb 24
$124
includes taxes & fees
Feb 23 - Feb 24
Book a stay at this business-friendly hotel in Mount Vernon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.6/10 Excellent! (1,001 reviews)
"Very accessible, clean, quite and friendly. The rooms were fine and good size with a refrigerator/freezer, microwave and coffee. The free breakfast started early, which was helpful for traveling."

Reviewed on Feb 6, 2025

Comfort Suites Mount Vernon
Drury Inn & Suites St. Louis Collinsville
Drury Inn & Suites St. Louis Collinsville
3 out of 5
602 N Bluff Rd, Collinsville, IL
  • 3 hours drive from Southern Illinois University
The price is $124 per night from Feb 23 to Feb 24
$124
includes taxes & fees
Feb 23 - Feb 24
Stay at this 3-star business-friendly hotel in Collinsville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (1,005 reviews)
"Room was very clean. Bed super comfy. Food excellent. Pool was enjoyable. Overall would recommend and definitely stay again."

Reviewed on Feb 9, 2025

Drury Inn & Suites St. Louis Collinsville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Southwest Illinois

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If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $58. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Southwest Illinois hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Southwest Illinois. No matter your reason for visiting Southwest Illinois, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Southwest Illinois hotels

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How many hotels are there in Southwest Illinois?

With over 655 hotels in Southwest Illinois, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $58.

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Finding a cheap car rental deal in Southwest Illinois is as easy as scoring cheap hotels in Southwest Illinois. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.