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Hotels in Southwest Illinois

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Choose from 766 Southwest Illinois Hotel Deals

Drury Inn & Suites Marion

Drury Inn & Suites Marion

3 out of 5
2706 W DeYoung St Marion IL
  • 42 min drive from Southern Illinois University
Book a stay at this business-friendly hotel in Marion. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,007 reviews)
"Solid stay, no frills but no disappointment either"

Reviewed on Jun 4, 2026

Drury Inn & Suites Marion
Drury Inn & Suites St. Louis Fairview Heights

Drury Inn & Suites St. Louis Fairview Heights

3 out of 5
12 Ludwig Dr Fairview Heights IL
  • 3 hours drive from Southern Illinois University
Book a stay at this business-friendly hotel in Fairview Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,011 reviews)
"Clean room. Quiet area. Big breakfast selection"

Reviewed on Jun 3, 2026

Drury Inn & Suites St. Louis Fairview Heights
Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon

3.5 out of 5
145 North 44th Street  Mount Vernon IL
  • 2 hours drive from Southern Illinois University
Book a stay at this business-friendly hotel in Mount Vernon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.6/10 Exceptional! (1,707 reviews)
"Very nice!"

Reviewed on Jun 5, 2026

Drury Plaza Hotel Mt. Vernon
Super 8 by Wyndham O'Fallon

Super 8 by Wyndham O'Fallon

2 out of 5
1100 Eastgate Dr O'Fallon IL
  • 3 hours drive from Southern Illinois University
Book a stay at this business-friendly hotel in O'Fallon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
6.8/10 (1,002 reviews)
"Place is trash. But for 65$. Well ok."

Reviewed on Jun 4, 2026

Super 8 by Wyndham O'Fallon
Drury Inn & Suites St. Louis O'Fallon, IL

Drury Inn & Suites St. Louis O'Fallon, IL

3 out of 5
1118 Central Park Drive O'Fallon IL
  • 3 hours drive from Southern Illinois University
Book a stay at this business-friendly hotel in O'Fallon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.6/10 Exceptional! (1,005 reviews)
"Clean room. Only 1/2 of hot tub bubblea"

Reviewed on Jun 3, 2026

Drury Inn & Suites St. Louis O'Fallon, IL
The Principal Hotel

The Principal Hotel

3.5 out of 5
310 S Main St Columbia IL
  • 3 hours drive from Southern Illinois University
Stay at this hotel in Columbia. Enjoy free WiFi, free parking, and a fitness center. Popular attractions Triple Lakes Golf Course and Eckert’s Millstadt Farm ...
9.6/10 Exceptional! (281 reviews)
"The property was nice. We were in town for a wedding and it was close to the venue. I booked a room that was supposed to have two queen beds and a twin size bed. It ended up having two queen beds and a very uncomfortable pullout sofa. Also, most hotels have an 11 AM checkout. This one is 10 AM and ..."

Reviewed on Jun 5, 2026

The Principal Hotel
Welcome Suites

Welcome Suites

2 out of 5
148 Regency Park O'Fallon IL
  • 3 hours drive from Southern Illinois University
Book a stay at this business-friendly hotel in O'Fallon. Enjoy free WiFi, free parking, and a fitness center. Popular attractions O'Fallon Family Sports Park ...
5.8/10 (269 reviews)
"There was fighting in the halls and loud neighbors. My fridge didn't work all my food spoiled. They couldn't give me a remote that worked with the TV had to buy my own and program it. They kicked me out because I had my emotional support cats with me. Mind you I was suppose to be there 19 days and ..."

Reviewed on Jun 3, 2026

Welcome Suites
Walker's Bluff Casino Resort

Walker's Bluff Casino Resort

4.5 out of 5
777 Walkers Bluff Way Carterville IL
  • 19 min drive from Southern Illinois University
Book a stay at this luxury resort in Carterville. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff and the clean rooms ...
9.4/10 Exceptional! (463 reviews)
"The pool and jacuzzi are amazing. The rooms are clean and very nice."

Reviewed on Jun 4, 2026

Walker's Bluff Casino Resort
Drury Inn & Suites St. Louis Collinsville

Drury Inn & Suites St. Louis Collinsville

3 out of 5
602 N Bluff Rd Collinsville IL
  • 3 hours drive from Southern Illinois University
Book a stay at this business-friendly hotel in Collinsville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.6/10 Exceptional! (1,011 reviews)
"The staff went above and beyond multiple times in multiple ways during our visit. Location is extremely convenient to St. Louis, with the benefits of free parking, free breakfast (and dinner!), and swimming pool not readily available at downtown hotels."

Reviewed on Jun 5, 2026

Drury Inn & Suites St. Louis Collinsville
Quality Inn & Suites near St. Louis and I-255

Quality Inn & Suites near St. Louis and I-255

2.5 out of 5
1607 Pontiac Dr East St. Louis IL
  • 3 hours drive from Southern Illinois University
Book a stay at this business-friendly hotel in East St. Louis. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
7.4/10 Good! (1,001 reviews)
"The rooms we’re half cleaned the beds we’re dirty i noticed after turning the sheets Down to go to sleep there was dirt and debris the pool water was salty don’t ask and breakfast was cold no tongs to pick up food it wasn’t flavorful the batter for waffles was sour tasting no milk that I seen I did ..."

Reviewed on May 24, 2026

Quality Inn & Suites near St. Louis and I-255
Comfort Suites Mount Vernon

Comfort Suites Mount Vernon

2.5 out of 5
404 South 44th Street Mount Vernon IL
  • 2 hours drive from Southern Illinois University
Book a stay at this business-friendly hotel in Mount Vernon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,046 reviews)
"Our room was clean and comfortable. Towels and other amenities were nice. One of the nicest rooms I have stayed in at a reasonable price. Value for the cost is off the charts. Thank you comfort inns and suites for a nice nights stay. And breakfast was the nicest I have had at a chain hotel."

Reviewed on Jun 2, 2026

Comfort Suites Mount Vernon
Holiday Inn Express & Suites Mount Vernon by IHG

Holiday Inn Express & Suites Mount Vernon by IHG

2.5 out of 5
300 Potomac Blvd Mount Vernon IL
  • 2 hours drive from Southern Illinois University
Book a stay at this business-friendly hotel in Mount Vernon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,001 reviews)
"Stay here twice every year when I go to and from college. Only place I stay."

Reviewed on Jun 3, 2026

Holiday Inn Express & Suites Mount Vernon by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Southwest Illinois

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For you, intrepid voyager, Hotwire has a large selection of the best hotels in Southwest Illinois.

Choosing the right hotel in Illinois has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Southwest Illinois’s 766 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $66. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Southwest Illinois hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Southwest Illinois. No matter your reason for visiting Southwest Illinois, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Southwest Illinois hotels

Where can I find the best last-minute travel deals?

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How many hotels are there in Southwest Illinois?

With over 766 hotels in Southwest Illinois, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $66.

How to find cheap car rentals in Southwest Illinois?

Finding a cheap car rental deal in Southwest Illinois is as easy as scoring cheap hotels in Southwest Illinois. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.