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Featured Southwest Illinois Resorts & Hotels with Spas
Drury Inn & Suites St. Louis Fairview Heights
12 Ludwig Dr, Fairview Heights, IL
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Fairview Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Drury Inn & Suites Marion
2706 W DeYoung St, Marion, IL
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in Marion. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Comfort Suites Mount Vernon
404 South 44th Street, Mount Vernon, IL
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Mount Vernon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Quality Inn O'Fallon IL - St. Louis
1409 W US 50, O'Fallon, IL
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in O'Fallon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Days Inn by Wyndham Pontoon Beach
5105 Highway 111, Granite City, IL
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Granite City. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Six Mile Regional Library ...
Days Inn & Suites by Wyndham Caseyville
2423 Old Country Inn Drive, Caseyville, IL
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Caseyville. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Pleasant Ridge Park and Cahokia ...
Americas Best Value Inn Mount Vernon
222 South 44th Street, Mount Vernon, IL
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Mount Vernon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the property condition in our ...
Best Western Marion Hotel
400 Comfort Dr, Marion, IL
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Marion. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Comfort Inn & Suites Marion I-57
2403 Black Diamond Dr, Marion, IL
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Marion. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Drury Plaza Hotel Mt. Vernon
145 North 44th Street , Mount Vernon, IL
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in Mount Vernon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Drury Inn & Suites St. Louis O'Fallon, IL
1118 Central Park Drive, O'Fallon, IL
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in O'Fallon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Econo Lodge
1806 Bittle Place, Marion, IL
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Marion. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels by Star Rating
More Hotel Options in Southwest Illinois
- Hotels with Free Parking in Southwest Illinois
- Family Hotels in Southwest Illinois
- Pet-friendly Hotels in Southwest Illinois
- Hotels with a Pool in Southwest Illinois
- Hotels with an Indoor Pool in Southwest Illinois
- Historic Hotels in Southwest Illinois
- Hotels with Hot Tubs in Southwest Illinois
- Luxury Hotels in Southwest Illinois
- Winery Hotels in Southwest Illinois
- Hotel Wedding Venues in Southwest Illinois
Top Points of Interests in Southwest Illinois
- Hotels near Southern Illinois University
- Hotels near Lake of Egypt
- Hotels near Rend Lake
- Hotels near O'Fallon Family Sports Park
- Hotels near Scott Air Force Base
- Hotels near Marion Cultural and Civic Center
- Hotels near Giant City State Park
- Hotels near Carlyle Lake
- Hotels near DuQuoin State Fairgrounds
- Hotels near Gateway Conference Center
- Hotels near McKendree University
- Hotels near Cahokia Mounds State Historic Site
- Hotels near St. Claire Square Mall
- Hotels near National Shrine of Our Lady of the Snows
- Hotels near World Wide Technology Raceway
- Hotels near St. Clair Bowl
- Hotels near The Gardens at SIUE
- Hotels near The Edge
- Hotels near Southwestern Illinois College
- Hotels near FanDuel Sportsbook and Horse Racing
Cities near Southwest Illinois
- St. Charles Hotels (68.76 mi)
- Paducah Hotels (91.58 mi)
- Maryland Heights Hotels (62.9 mi)
- Ste Genevieve Hotels (37.06 mi)
- Cape Girardeau Hotels (63.87 mi)
- Bridgeton Hotels (64.13 mi)
- Chesterfield Hotels (67.53 mi)
- Hazelwood Hotels (63.47 mi)
- Marion Hotels (44.25 mi)
- Mount Vernon Hotels (29.96 mi)
- O'Fallon Hotels (35.6 mi)
- Carbondale Hotels (36.79 mi)
- St. Ann Hotels (61.71 mi)
- Sikeston Hotels (93.64 mi)
- Ozarks Hotels (182.52 mi)
- Metropolis Hotels (83.99 mi)
- Collinsville Hotels (42.26 mi)
- Fenton Hotels (57.51 mi)
- Farmington Hotels (61.53 mi)
- Alton Hotels (60.69 mi)
Car Rentals Near Southwest Illinois
- Car rentals in St. Charles
- Car rentals in Paducah
- Car rentals in Maryland Heights
- Car rentals in Ste Genevieve
- Car rentals in Cape Girardeau
- Car rentals in Bridgeton
- Car rentals in Chesterfield
- Car rentals in Hazelwood
- Car rentals in Marion
- Car rentals in Mount Vernon
- Car rentals in O'Fallon
- Car rentals in Carbondale
- Car rentals in St. Ann
- Car rentals in Sikeston
- Car rentals in Ozarks
- Car rentals in Metropolis
Top Spa Resort Destinations
- Annapolis Spa Hotels
- Ottawa Valley Spa Hotels
- Tallahassee Spa Hotels
- Appalachian Mountains Spa Hotels
- Corpus Christi Spa Hotels
- Raleigh Spa Hotels
- Syracuse Spa Hotels
- Chattanooga Spa Hotels
- Grand Canyon Spa Hotels
- Toledo Spa Hotels
- Edmonton Spa Hotels
- El Paso Spa Hotels
- Omaha Spa Hotels
- Cincinnati Spa Hotels
- Fargo Spa Hotels
- Des Moines Spa Hotels
- Dayton Spa Hotels
- Flagstaff Spa Hotels
- Little Rock Spa Hotels
- Waco Spa Hotels