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Featured Luxury West Main Historic District
![21c Museum Hotel Louisville](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/be890846_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
21c Museum Hotel Louisville
700 W Main Street, Louisville, KY
Fully refundableReserve now, pay when you stay
Stay at this 4.5-star luxury hotel in Louisville. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the restaurant and the helpful ...
![Galt House Hotel Trademark Collection by Wyndham](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/d3ce3686_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Galt House Hotel Trademark Collection by Wyndham
140 North Fourth Street, Louisville, KY
Fully refundableReserve now, pay when you stay
Book a stay at this spa hotel in Louisville. Enjoy free WiFi, a full-service spa, and 4 restaurants. Our guests praise the restaurant and the helpful staff in ...
![Embassy Suites Louisville Downtown](https://images.trvl-media.com/lodging/10000000/9030000/9027600/9027531/40bb986b_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Embassy Suites Louisville Downtown
501 South Fourth Street, Louisville, KY
Fully refundableReserve now, pay when you stay
Stay at this 4-star hotel in Louisville. Enjoy free breakfast, room service, and a 24-hour fitness center. Our guests praise the breakfast and the helpful staff ...
![Econo Lodge Downtown Louisville](https://images.trvl-media.com/lodging/1000000/30000/27100/27037/d55247ee_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Econo Lodge Downtown Louisville
401 S 2nd St, Louisville, KY
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly motel in Louisville. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the helpful staff and the ...
![The Seelbach Hilton Louisville](https://images.trvl-media.com/lodging/1000000/30000/26000/25958/d22f4bf1_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
The Seelbach Hilton Louisville
500 S 4th St, Louisville, KY
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Louisville. Enjoy breakfast (surcharge), 24-hour room service, and a 24-hour fitness center. Our guests praise ...
![Louisville Marriott Downtown](https://images.trvl-media.com/lodging/2000000/1120000/1111400/1111358/9fbac853_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Louisville Marriott Downtown
280 West Jefferson Street, Louisville, KY
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in Louisville. Enjoy breakfast (surcharge), a 24-hour health club, and valet parking (surcharge). Our guests praise ...
![Hyatt Regency Louisville](https://images.trvl-media.com/lodging/1000000/330000/327000/326983/dad417e1_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Hyatt Regency Louisville
320 West Jefferson Street, Louisville, KY
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Louisville. Enjoy free WiFi, breakfast (surcharge), and a fitness center. Our guests praise the helpful staff ...
![Hampton Inn Louisville Downtown](https://images.trvl-media.com/lodging/1000000/10000/4900/4836/28d098af_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Hampton Inn Louisville Downtown
101 E Jefferson St, Louisville, KY
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Louisville. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and ...
![Residence Inn by Marriott Louisville Downtown](https://images.trvl-media.com/lodging/2000000/1260000/1253100/1253023/c9a652a3_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Residence Inn by Marriott Louisville Downtown
333 East Market Street, Louisville, KY
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in Louisville. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
More Hotel Options in West Main Historic District
- Family Hotels in West Main Historic District
- Historic Hotels in West Main Historic District
- Romantic Hotels in West Main Historic District
- Hotels with a Pool in West Main Historic District
- Hotel Wedding Venues in West Main Historic District
- Hotels with an Indoor Pool in West Main Historic District
- Hotels with Free Airport Shuttle in West Main Historic District
- Resorts & Hotels with Spas in West Main Historic District
- Hotels with Free Parking in West Main Historic District
- Pet-friendly Hotels in West Main Historic District
West Main Historic District Neighborhoods
Top Points of Interests in West Main Historic District
- Hotels near KFC Yum Center
- Hotels near Kentucky International Convention Center
- Hotels near Louisville Slugger Museum
- Hotels near Fourth Street Live!
- Hotels near Whiskey Row
- Hotels near Muhammad Ali Center
- Hotels near Louisville Palace
- Hotels near Kentucky Bourbon Trail Visitor Center
- Hotels near Louisville Slugger Field
- Hotels near 21c Museum Hotel
- Hotels near Belle of Louisville
- Hotels near Evan Williams Bourbon Experience
- Hotels near Frazier International History Museum
- Hotels near Louisville Science Center
- Hotels near Kentucky Center for the Performing Arts
- Hotels near Riverfront Plaza Belvedere
- Hotels near Louisville Glassworks
- Hotels near Actors Theatre of Louisville
- Hotels near Angel's Envy Distillery
- Hotels near Kentucky Center for African American Heritage
Cities near West Main Historic District
- Jeffersonville Hotels (2.36 mi)
- New Albany Hotels (3.69 mi)
- Clarksville Hotels (2.13 mi)
- Shepherdsville Hotels (18.64 mi)
- Elizabeth Hotels (14.59 mi)
- La Grange Hotels (23.49 mi)
- Southern Indiana Hotels (54.12 mi)
- Corydon Hotels (19.7 mi)
- Northern Kentucky Hotels (71.96 mi)
- Brooks Hotels (13.74 mi)
- Sellersburg Hotels (9.82 mi)
- Central United States Hotels (433.61 mi)
- Prospect Hotels (10.25 mi)
- Simpsonville Hotels (22.95 mi)
- East Louisville Hotels (11.61 mi)
- Taylorsville Hotels (27.79 mi)
- Ohio River Valley Hotels (115.16 mi)
- Fairdale Hotels (11.04 mi)
- Crestwood Hotels (16.65 mi)
- Hurstbourne Hotels (9.78 mi)
Car Rentals Near West Main Historic District
- Car rentals in Jeffersonville
- Car rentals in New Albany
- Car rentals in Clarksville
- Car rentals in Shepherdsville
- Car rentals in Elizabeth
- Car rentals in La Grange
- Car rentals in Southern Indiana
- Car rentals in Corydon
- Car rentals in Northern Kentucky
- Car rentals in Brooks
- Car rentals in Sellersburg
- Car rentals in Central United States
- Car rentals in Prospect
- Car rentals in Simpsonville
- Car rentals in East Louisville
- Car rentals in Taylorsville
Top Luxury Hotel Destinations
- Amarillo Luxury Hotels
- Sioux Falls Luxury Hotels
- Fort Wayne Luxury Hotels
- South Padre Island Luxury Hotels
- Cheyenne Luxury Hotels
- Corpus Christi Luxury Hotels
- Gettysburg Luxury Hotels
- Fresno Luxury Hotels
- Fayetteville Luxury Hotels
- Springfield Luxury Hotels
- Flagstaff Luxury Hotels
- Tuscaloosa Luxury Hotels
- Toledo Luxury Hotels
- Traverse City Luxury Hotels
- Twin Falls Luxury Hotels
- Scranton Luxury Hotels
- Columbia Luxury Hotels
- Catalina Island Luxury Hotels
- Shreveport Luxury Hotels
- Tallahassee Luxury Hotels
Top Booked Hotels in West Main Historic District
- Omni Louisville Hotel
- Galt House Hotel Trademark Collection by Wyndham
- Holiday Inn Express & Suites Louisville Downtown, an IHG Hotel
- SpringHill Suites by Marriott Louisville Downtown
- Aloft Louisville Downtown
- Hyatt Regency Louisville
- Fairfield Inn & Suites by Marriott Louisville Downtown
- Courtyard by Marriott Louisville Downtown