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4 Star Hotels in St. Louis

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Featured 4 Star St. Louis Hotels

Hyatt Regency St. Louis at The Arch
4 out of 5
Fully refundableReserve now, pay when you stay
  • 17 min walk from St. Louis Union Station
The price is $117 per night from Dec 30 to Dec 31
$117
includes taxes & fees
Dec 30 - Dec 31
Stay at this 4-star business-friendly hotel in St. Louis. Enjoy free WiFi, 3 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean ...
Hyatt Regency St. Louis at The Arch
Renaissance St. Louis Airport Hotel
4 out of 5
Fully refundableReserve now, pay when you stay
  • 21 min drive from St. Louis Union Station
The price is $133 per night from Jan 24 to Jan 25
$133
includes taxes & fees
Jan 24 - Jan 25, 2025
Stay at this 4-star business-friendly hotel in St. Louis. Enjoy an outdoor pool, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful ...
Renaissance St. Louis Airport Hotel
21C Museum Hotel St Louis
4.5 out of 5
Fully refundableReserve now, pay when you stay
  • 5 min walk from St. Louis Union Station
The price is $170 per night from Dec 30 to Dec 31
$170
includes taxes & fees
Dec 30 - Dec 31
Stay at this 4.5-star luxury hotel in St. Louis. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the pool and the restaurant in our ...
21C Museum Hotel St Louis
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Moonrise Hotel
4 out of 5
Fully refundableReserve now, pay when you stay
  • 10 min drive from St. Louis Union Station
The price is $189 per night from Dec 30 to Dec 31
$189
includes taxes & fees
Dec 30 - Dec 31
Stay at this 4-star boutique hotel in St. Louis. Enjoy free WiFi, free parking, and 2 bars/lounges. Our guests praise the restaurant and the bar in our reviews. ...
Moonrise Hotel
Ameristar Casino Resort and Spa
4.5 out of 5
Fully refundableReserve now, pay when you stay
  • 34 min drive from St. Louis Union Station
The price is $214 per night from Jan 2 to Jan 3
$214
includes taxes & fees
Jan 2 - Jan 3, 2025
Stay at this 4.5-star luxury hotel in St. Charles. Enjoy an outdoor pool, a full-service spa, and 6 restaurants. Our guests praise the clean rooms and the property ...
Ameristar Casino Resort and Spa
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
4 out of 5
Fully refundableReserve now, pay when you stay
  • 13 min walk from St. Louis Union Station
The price is $117 per night from Jan 20 to Jan 21
$117
includes taxes & fees
Jan 20 - Jan 21, 2025
Stay at this 4-star business-friendly hotel in St. Louis. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the bar and the helpful ...
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
The Last Hotel
4.5 out of 5
Fully refundableReserve now, pay when you stay
  • 8 min walk from St. Louis Union Station
The price is $135 per night from Jan 3 to Jan 4
$135
includes taxes & fees
Jan 3 - Jan 4, 2025
Stay at this 4.5-star luxury hotel in St. Louis. Enjoy free WiFi, a 24-hour fitness center, and valet parking (surcharge). Our guests praise the pool and the ...
The Last Hotel
River City Casino & Hotel
4 out of 5
Fully refundableReserve now, pay when you stay
  • 18 min drive from St. Louis Union Station
The price is $139 per night from Jan 2 to Jan 3
$139
includes taxes & fees
Jan 2 - Jan 3, 2025
Stay at this 4-star business-friendly hotel in St. Louis. Enjoy free parking, 5 restaurants, and a casino. Our guests praise the helpful staff and the clean ...
River City Casino & Hotel
Live by Loews - St.Louis
4 out of 5
Fully refundableReserve now, pay when you stay
  • 13 min walk from St. Louis Union Station
The price is $189 per night from Jan 1 to Jan 2
$189
includes taxes & fees
Jan 1 - Jan 2, 2025
Stay at this 4-star business-friendly hotel in St. Louis. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the bar and the helpful ...
Live by Loews - St.Louis
Le Méridien St. Louis Clayton
4 out of 5
Fully refundableReserve now, pay when you stay
  • 13 min drive from St. Louis Union Station
The price is $187 per night from Jan 1 to Jan 2
$187
includes taxes & fees
Jan 1 - Jan 2, 2025
Book a stay at this eco-certified hotel in St. Louis. Enjoy an outdoor pool, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
Le Méridien St. Louis Clayton
St. Louis Union Station Hotel, Curio Collection by Hilton
4 out of 5
Fully refundableReserve now, pay when you stay
  • 1 min walk from St. Louis Union Station
The price is $171 per night from Jan 5 to Jan 6
$171
includes taxes & fees
Jan 5 - Jan 6, 2025
Book a stay at this historic hotel in St. Louis. Enjoy free WiFi, an outdoor pool, and 7 restaurants. Our guests praise the helpful staff and the clean rooms ...
St. Louis Union Station Hotel, Curio Collection by Hilton
Hilton Pennywell St. Louis at the Arch
4 out of 5
Fully refundableReserve now, pay when you stay
  • 16 min walk from St. Louis Union Station
The price is $122 per night from Jan 5 to Jan 6
$122
includes taxes & fees
Jan 5 - Jan 6, 2025
Stay at this 4-star business-friendly hotel in St. Louis. Enjoy breakfast (surcharge), a fitness center, and valet parking (surcharge). Our guests praise the ...
Hilton Pennywell St. Louis at the Arch
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

4-Star Hotels in St. Louis

When you want to live it up, but not bust your bank account, it's time to look into a 4-star hotel in St. Louis for your next vacation. You'll get all the perks you can think of (and more) at a rate within your budget. Catch some Zs on high thread-count sheets, work on your tan by the picturesque pool, expand your palate at a world-class restaurant, take a break from it all at the in-house spa ... All this and more is at your fingertips at St. Louis 4-star hotels.

No fault in our stars

So what's the star rating about anyway? Here's the deal: Star rating doesn't have a lot to do with the price, and way more to do with the glowing amenities. 4-star hotels in St. Louis, Missouri, and everywhere else, usually have all those fancy touches that make you say "Oh," "Wow," and "YES!" Expect perks like personalized concierge services, the latest electronics, luxe bed linens, and restaurants that make eating in a foodie's dream.

Stars in your eyes

You want to live it up on your vacation, but you also know that every dollar you don't spend on your 4-star hotel in St. Louis is an extra one that you can spend out on the town. And, with all there is to do in St. Louis you'll need every last cent. Thankfully, Hotwire has the Hotwire Hot Rate to get you the best bargains, helping you save on our top hotels at the click of a mouse. Finding the right hotel for your trip is important, but it shouldn't be something to stress over. We've made it a snap to find the hotel of your dreams. Filter the best 4-star hotels in St. Louis by:

  • Hotwire Hot Rate: In search of the best deals on the net? Let us pick your hotel. We'll tell you which hotel after you make your reservations, and the savings and accommodations will be spectacular.
  • Price: You're aware that paying full price is for chumps? You can get a cheap 4-star hotel in St. Louis starting at $117 per night.
  • Amenities: What makes your vacation wishes come true? 24-hour room service? Heated pool? Full-service spa? Get a hotel that'll send you over the moon.

You deserve it all. Perks galore and the freshest spot to press reset in St. Louis without blowing all of your fun money. When you book a Hotwire Hot Rate, you get that stellar St. Louis 4-star hotel and have cash left to check off everything on your to-do list on your superstar vacay. Hotwire has 1,899 St. Louis hotels to choose from, but the most popular rooms aren't available long so book your stay today.