Search for Cheap Deals on
4 Star Hotels in St. Louis

You choose what matters — star rating, location, amenities.

We pick the perfect hotel, packed with all your must-haves.

Your hotel is revealed right after booking!


Featured 4 Star St. Louis Hotels

Hyatt Regency St. Louis at The Arch
4 out of 5
Fully refundableReserve now, pay when you stay
  • 12 min walk from Enterprise Center
The price is $134 per night from May 22 to May 23
$134
includes taxes & fees
May 22 - May 23
Stay at this 4-star business-friendly hotel in St. Louis. Enjoy free WiFi, 3 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean ...
Hyatt Regency St. Louis at The Arch
Moonrise Hotel
4 out of 5
Fully refundableReserve now, pay when you stay
  • 11 min drive from Enterprise Center
The price is $201 per night from May 4 to May 5
$201
includes taxes & fees
May 4 - May 5
Stay at this 4-star boutique hotel in St. Louis. Enjoy free WiFi, free parking, and 2 bars/lounges. Our guests praise the restaurant and the bar in our reviews. ...
Moonrise Hotel
River City Casino & Hotel
4 out of 5
Fully refundableReserve now, pay when you stay
  • 18 min drive from Enterprise Center
The price is $126 per night from May 7 to May 8
$126
includes taxes & fees
May 7 - May 8
Stay at this 4-star business-friendly hotel in St. Louis. Enjoy free parking, 5 restaurants, and a casino. Our guests praise the helpful staff and the clean ...
River City Casino & Hotel
Save an average of 15% on thousands of hotels when you're signed in
DoubleTree by Hilton St. Louis Airport
4 out of 5
Fully refundableReserve now, pay when you stay
  • 23 min drive from Enterprise Center
The price is $129 per night from May 9 to May 10
$129
includes taxes & fees
May 9 - May 10
Stay at this 4-star family-friendly hotel in St. Louis. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the ...
DoubleTree by Hilton St. Louis Airport
21C Museum Hotel St Louis
4.5 out of 5
Fully refundableReserve now, pay when you stay
  • 7 min walk from Enterprise Center
The price is $193 per night from May 6 to May 7
$193
includes taxes & fees
May 6 - May 7
Stay at this 4.5-star luxury hotel in St. Louis. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the pool and the restaurant in our ...
21C Museum Hotel St Louis
Renaissance St. Louis Airport Hotel
4 out of 5
Fully refundableReserve now, pay when you stay
  • 22 min drive from Enterprise Center
The price is $138 per night from May 23 to May 24
$138
includes taxes & fees
May 23 - May 24
Stay at this 4-star business-friendly hotel in St. Louis. Enjoy an outdoor pool, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful ...
Renaissance St. Louis Airport Hotel
Ameristar Casino Resort and Spa
4.5 out of 5
Fully refundableReserve now, pay when you stay
  • 35 min drive from Enterprise Center
The price is $214 per night from Apr 30 to May 1
$214
includes taxes & fees
Apr 30 - May 1
Stay at this 4.5-star luxury hotel in St. Charles. Enjoy an outdoor pool, a full-service spa, and 6 restaurants. Our guests praise the clean rooms and the property ...
Ameristar Casino Resort and Spa
Live by Loews - St.Louis
4 out of 5
  • 8 min walk from Enterprise Center
The price is $213 per night from Apr 27 to Apr 28
$213
includes taxes & fees
Apr 27 - Apr 28
Stay at this 4-star business-friendly hotel in St. Louis. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the bar and the helpful ...
Live by Loews - St.Louis
Le Méridien St. Louis Clayton
4 out of 5
Fully refundableReserve now, pay when you stay
  • 14 min drive from Enterprise Center
The price is $168 per night from Apr 27 to Apr 28
$168
includes taxes & fees
Apr 27 - Apr 28
Book a stay at this eco-certified hotel in St. Louis. Enjoy an outdoor pool, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
Le Méridien St. Louis Clayton
The Last Hotel
4.5 out of 5
  • 9 min walk from Enterprise Center
Stay at this 4.5-star luxury hotel in St. Louis. Enjoy free WiFi, a 24-hour fitness center, and valet parking (surcharge). Our guests praise the pool and the ...
The Last Hotel
Embassy Suites by Hilton St. Louis Downtown
4 out of 5
Fully refundableReserve now, pay when you stay
  • 12 min walk from Enterprise Center
The price is $130 per night from Apr 28 to Apr 29
$130
includes taxes & fees
Apr 28 - Apr 29
Stay at this 4-star business-friendly hotel in St. Louis. Enjoy free breakfast, a fitness center, and WiFi (surcharge). Our guests praise the breakfast and the ...
Embassy Suites by Hilton St. Louis Downtown
Hilton St. Louis Frontenac
4 out of 5
Fully refundableReserve now, pay when you stay
  • 20 min drive from Enterprise Center
The price is $167 per night from May 4 to May 5
$167
includes taxes & fees
May 4 - May 5
Book a stay at this business-friendly hotel in Frontenac. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff and the property ...
Hilton St. Louis Frontenac
Don't see what you're looking for?
See all available properties in St. Louis
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

4-Star Hotels in St. Louis

When you want to live it up, but not bust your bank account, it's time to look into a 4-star hotel in St. Louis for your next vacation. You'll get all the perks you can think of (and more) at a rate within your budget. Catch some Zs on high thread-count sheets, work on your tan by the picturesque pool, expand your palate at a world-class restaurant, take a break from it all at the in-house spa ... All this and more is at your fingertips at St. Louis 4-star hotels.

No fault in our stars

So what's the star rating about anyway? Here's the deal: Star rating doesn't have a lot to do with the price, and way more to do with the glowing amenities. 4-star hotels in St. Louis, Missouri, and everywhere else, usually have all those fancy touches that make you say "Oh," "Wow," and "YES!" Expect perks like personalized concierge services, the latest electronics, luxe bed linens, and restaurants that make eating in a foodie's dream.

Stars in your eyes

You want to live it up on your vacation, but you also know that every dollar you don't spend on your 4-star hotel in St. Louis is an extra one that you can spend out on the town. And, with all there is to do in St. Louis you'll need every last cent. Thankfully, Hotwire has the Hotwire Hot Rate to get you the best bargains, helping you save on our top hotels at the click of a mouse. Finding the right hotel for your trip is important, but it shouldn't be something to stress over. We've made it a snap to find the hotel of your dreams. Filter the best 4-star hotels in St. Louis by:

  • Hotwire Hot Rate: In search of the best deals on the net? Let us pick your hotel. We'll tell you which hotel after you make your reservations, and the savings and accommodations will be spectacular.
  • Price: You're aware that paying full price is for chumps? You can get a cheap 4-star hotel in St. Louis starting at $126 per night.
  • Amenities: What makes your vacation wishes come true? 24-hour room service? Heated pool? Full-service spa? Get a hotel that'll send you over the moon.

You deserve it all. Perks galore and the freshest spot to press reset in St. Louis without blowing all of your fun money. When you book a Hotwire Hot Rate, you get that stellar St. Louis 4-star hotel and have cash left to check off everything on your to-do list on your superstar vacay. Hotwire has 1,797 St. Louis hotels to choose from, but the most popular rooms aren't available long so book your stay today.