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5 Star Hotels in Mediterranean Region

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Tonight Sep 28 - Sep 29Next weekend Oct 4 - Oct 6

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Featured 5 Star Mediterranean Region Hotels

Sofitel Athens Airport
5 out of 5
Fully refundableReserve now, pay when you stay
The price is $324 per night from Oct 28 to Oct 29
$324
includes taxes & fees
Oct 28 - Oct 29
Stay at this 5-star luxury hotel in Spata-Artemida. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the breakfast and the pool in our ...
Sofitel Athens Airport
Grand Hyatt Athens
5 out of 5
The price is $163 per night from Oct 26 to Oct 27
$163
includes taxes & fees
Oct 26 - Oct 27
Stay at this 5-star luxury hotel in Athens. Enjoy free WiFi, an outdoor pool, and a full-service spa. Our guests praise the breakfast and the pool in our reviews. ...
Grand Hyatt Athens
Barceló Torre de Madrid
5 out of 5
  • 4 hours drive from Duoro River
The price is $215 per night from Sep 29 to Sep 30
$215
includes taxes & fees
Sep 29 - Sep 30
Stay at this 5-star luxury hotel in Madrid. Enjoy free WiFi, breakfast (surcharge), and 24-hour room service. Our guests praise the breakfast and the helpful ...
Barceló Torre de Madrid
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Grand Hyatt Barcelona
5 out of 5
Fully refundableReserve now, pay when you stay
  • 17 hours drive from Duoro River
The price is $272 per night from Oct 18 to Oct 19
$272
includes taxes & fees
Oct 18 - Oct 19
Stay at this 5-star luxury hotel in Barcelona. Enjoy free WiFi, an outdoor pool, and a full-service spa. Our guests praise the helpful staff and the clean rooms ...
Grand Hyatt Barcelona
Athenaeum InterContinental, an IHG Hotel
5 out of 5
Fully refundable
The price is $161 per night from Oct 27 to Oct 28
$161
includes taxes & fees
Oct 27 - Oct 28
Stay at this 5-star luxury hotel in Athens. Enjoy free WiFi, an outdoor pool, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular ...
Athenaeum InterContinental, an IHG Hotel
Nobu Hotel Barcelona
5 out of 5
Fully refundableReserve now, pay when you stay
  • 17 hours drive from Duoro River
The price is $337 per night from Oct 19 to Oct 20
$337
includes taxes & fees
Oct 19 - Oct 20
Stay at this 5-star luxury hotel in Barcelona. Enjoy free WiFi, an outdoor pool, and a full-service spa. Our guests praise the breakfast and the restaurant in ...
Nobu Hotel Barcelona
Wellington Hotel & Spa Madrid
5 out of 5
Fully refundableReserve now, pay when you stay
  • 5 hours drive from Duoro River
The price is $564 per night from Oct 28 to Oct 29
$564
includes taxes & fees
Oct 28 - Oct 29
Stay at this 5-star luxury hotel in Madrid. Enjoy free WiFi, an outdoor pool, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular ...
Wellington Hotel & Spa Madrid
Electra Metropolis Athens
5 out of 5
Fully refundable
The price is $353 per night from Oct 27 to Oct 28
$353
includes taxes & fees
Oct 27 - Oct 28
Stay at this 5-star luxury hotel in Athens. Enjoy free WiFi, an outdoor pool, and a full-service spa. Our guests praise the breakfast and the pool in our reviews. ...
Electra Metropolis Athens
EPIC SANA Marques Hotel
5 out of 5
Fully refundableReserve now, pay when you stay
  • 2 hours drive from Duoro River
The price is $333 per night from Oct 21 to Oct 22
$333
includes taxes & fees
Oct 21 - Oct 22
Stay at this 5-star luxury hotel in Lisbon. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the breakfast and the pool in our reviews. ...
EPIC SANA Marques Hotel
Hotel Alfonso XIII, a Luxury Collection Hotel, Seville
5 out of 5
Fully refundableReserve now, pay when you stay
  • 11 hours drive from Duoro River
The price is $484 per night from Oct 13 to Oct 14
$484
includes taxes & fees
Oct 13 - Oct 14
Stay at this 5-star luxury hotel in Seville. Enjoy 2 restaurants, breakfast (surcharge), and 24-hour room service. Our guests praise the helpful staff and the ...
Hotel Alfonso XIII, a Luxury Collection Hotel, Seville
W Barcelona
5 out of 5
Fully refundableReserve now, pay when you stay
  • 17 hours drive from Duoro River
The price is $405 per night from Oct 27 to Oct 28
$405
includes taxes & fees
Oct 27 - Oct 28
Stay at this 5-star luxury hotel in Barcelona. Enjoy free WiFi, an outdoor pool, and a full-service spa. Our guests praise the helpful staff and the property ...
W Barcelona
Dolce by Wyndham Athens Attica Riviera
5 out of 5
Fully refundableReserve now, pay when you stay
The price is $217 per night from Oct 6 to Oct 7
$217
includes taxes & fees
Oct 6 - Oct 7
Stay at this 5-star luxury hotel in Markopoulo Mesogaias. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the breakfast and the pool in ...
Dolce by Wyndham Athens Attica Riviera
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

5-Star Hotel in Mediterranean Region

It’s time. No more meh motels and so-so stays. This vacation it’s all about living it up, and that starts with a great hotel. You want first-class service and award-winning restaurants. Well, let us introduce you to a 5-star hotel in Mediterranean Region.

So nice you’ll blink twice

What makes a hotel worthy of supreme star-age? For starters, the service has to be top-notch and personalized. These hotels often have 24-hour room service, a welcome gift upon your arrival, and help you with your bags—even if you travel light.

Are they nicer? Heck yeah, they are! Most 5-star hotels have jaw-dropping aesthetics that give an authentic feel of class. And we’re not talking about that faux-gold soap dish your Aunt Tilda puts out for the guests—it’s the real deal.

Stars in your eyes

Are 5-stars hotels worth it? If you like the finer things in life, then yes, they sure are. But we also know you’re the type that likes to get your caviar on a fish stick budget. We’re right there with you, and that is why we make it easy to find the best 5-star hotel in Mediterranean Region for you. Sort by:

  • Price: Want to live large, but keep that budget balanced? We got you. We have 5-star hotels starting at $161.

  • Amenities: Mediterranean Region skyline view? Maybe a heated indoor pool? Looking for a Michelin-star restaurant? Search for the hotels that have the amenities you desire.

  • Hotwire Hot Rate: We’ll tell you the name of the hotel after you book, and you might just save a ton.

When you’re looking for the top 5-star hotels in Mediterranean Region—but don’t want to pay top dollar—let us help you out. You can get that posh palace of your dreams, and have money left to take on Mediterranean Region your way.