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5 Star Hotels in Mediterranean Region

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Featured 5 Star Mediterranean Region Hotels

Sofitel Athens Airport
5 out of 5
Fully refundableReserve now, pay when you stay
The price is $266 per night from Feb 8 to Feb 9
$266
includes taxes & fees
Feb 8 - Feb 9
Stay at this 5-star luxury hotel in Spata-Artemida. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the breakfast and the pool in our ...
Sofitel Athens Airport
Hotel Puerta América
5 out of 5
Fully refundable
  • 5 hours drive from Duoro River
The price is $164 per night from Feb 16 to Feb 17
$164
includes taxes & fees
Feb 16 - Feb 17
Stay at this 5-star luxury hotel in Madrid. Enjoy free WiFi, an outdoor pool, and 2 restaurants. Our guests praise the helpful staff in our reviews. Popular ...
Hotel Puerta América
Grand Hyatt Athens
5 out of 5
Fully refundableReserve now, pay when you stay
The price is $122 per night from Feb 24 to Feb 25
$122
includes taxes & fees
Feb 24 - Feb 25
Stay at this 5-star luxury hotel in Athens. Enjoy free WiFi, an outdoor pool, and a full-service spa. Our guests praise the breakfast and the pool in our reviews. ...
Grand Hyatt Athens
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La Mamounia
5 out of 5
  • 26 hours drive from Duoro River
The price is $1,582 per night from Mar 4 to Mar 5
$1,582
includes taxes & fees
Mar 4 - Mar 5
Stay at this 5-star luxury hotel in Marrakech. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular ...
La Mamounia
W Barcelona
5 out of 5
Fully refundableReserve now, pay when you stay
  • 17 hours drive from Duoro River
The price is $341 per night from Feb 21 to Feb 22
$341
includes taxes & fees
Feb 21 - Feb 22
Stay at this 5-star luxury hotel in Barcelona. Enjoy free WiFi, an outdoor pool, and a full-service spa. Our guests praise the helpful staff and the property ...
W Barcelona
Lopesan Costa Meloneras Resort & Spa
5 out of 5
  • 45 hours drive from Duoro River
The price is $328 per night from Feb 6 to Feb 7
$328
includes taxes & fees
Feb 6 - Feb 7
Stay at this 5-star luxury hotel in San Bartolomé de Tirajana. Enjoy free WiFi, 6 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful ...
Lopesan Costa Meloneras Resort & Spa
Grand Hyatt Barcelona
5 out of 5
Fully refundableReserve now, pay when you stay
  • 17 hours drive from Duoro River
The price is $190 per night from Feb 21 to Feb 22
$190
includes taxes & fees
Feb 21 - Feb 22
Stay at this 5-star luxury hotel in Barcelona. Enjoy free WiFi, an outdoor pool, and a full-service spa. Our guests praise the helpful staff and the clean rooms ...
Grand Hyatt Barcelona
Baglioni Hotel Regina - The Leading Hotels of the World
5 out of 5
Fully refundableReserve now, pay when you stay
  • 31 hours drive from Duoro River
The price is $462 per night from Feb 9 to Feb 10
$462
includes taxes & fees
Feb 9 - Feb 10
Stay at this 5-star luxury hotel in Rome. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the helpful staff in our reviews. ...
Baglioni Hotel Regina - The Leading Hotels of the World
Lamaro Hotel
5 out of 5
Fully refundableReserve now, pay when you stay
  • 17 hours drive from Duoro River
The price is $249 per night from Feb 9 to Feb 10
$249
includes taxes & fees
Feb 9 - Feb 10
Stay at this 5-star luxury hotel in Barcelona. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the breakfast and the bar in ...
Lamaro Hotel
Sonder Paseo de Gracia
5 out of 5
  • 17 hours drive from Duoro River
The price is $163 per night from Feb 13 to Feb 14
$163
includes taxes & fees
Feb 13 - Feb 14
Stay at this 5-star luxury hotel in Barcelona. Enjoy breakfast (surcharge), a 24-hour fitness center, and a 24-hour front desk. Our guests praise the helpful ...
Sonder Paseo de Gracia
Athenaeum InterContinental, an IHG Hotel
5 out of 5
Fully refundable
The price is $133 per night from Feb 14 to Feb 15
$133
includes taxes & fees
Feb 14 - Feb 15
Stay at this 5-star luxury hotel in Athens. Enjoy free WiFi, an outdoor pool, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular ...
Athenaeum InterContinental, an IHG Hotel
Hotel Alfonso XIII, a Luxury Collection Hotel, Seville
5 out of 5
  • 11 hours drive from Duoro River
The price is $396 per night from Feb 28 to Mar 1
$396
includes taxes & fees
Feb 28 - Mar 1
Stay at this 5-star luxury hotel in Seville. Enjoy 2 restaurants, breakfast (surcharge), and 24-hour room service. Our guests praise the helpful staff and the ...
Hotel Alfonso XIII, a Luxury Collection Hotel, Seville
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5-Star Hotel in Mediterranean Region

It’s time. No more meh motels and so-so stays. This vacation it’s all about living it up, and that starts with a great hotel. You want first-class service and award-winning restaurants. Well, let us introduce you to a 5-star hotel in Mediterranean Region.

So nice you’ll blink twice

What makes a hotel worthy of supreme star-age? For starters, the service has to be top-notch and personalized. These hotels often have 24-hour room service, a welcome gift upon your arrival, and help you with your bags—even if you travel light.

Are they nicer? Heck yeah, they are! Most 5-star hotels have jaw-dropping aesthetics that give an authentic feel of class. And we’re not talking about that faux-gold soap dish your Aunt Tilda puts out for the guests—it’s the real deal.

Stars in your eyes

Are 5-stars hotels worth it? If you like the finer things in life, then yes, they sure are. But we also know you’re the type that likes to get your caviar on a fish stick budget. We’re right there with you, and that is why we make it easy to find the best 5-star hotel in Mediterranean Region for you. Sort by:

  • Price: Want to live large, but keep that budget balanced? We got you. We have 5-star hotels starting at $122.

  • Amenities: Mediterranean Region skyline view? Maybe a heated indoor pool? Looking for a Michelin-star restaurant? Search for the hotels that have the amenities you desire.

  • Hotwire Hot Rate: We’ll tell you the name of the hotel after you book, and you might just save a ton.

When you’re looking for the top 5-star hotels in Mediterranean Region—but don’t want to pay top dollar—let us help you out. You can get that posh palace of your dreams, and have money left to take on Mediterranean Region your way.