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5 Star Hotels in Mediterranean Region

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Tonight Mar 30 - Mar 31Next weekend Apr 4 - Apr 6

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Featured 5 Star Mediterranean Region Hotels

Grand Hyatt Athens
5 out of 5
Fully refundableReserve now, pay when you stay
  • 3 hours drive from Lake Ohrid
The price is $162 per night from Apr 13 to Apr 14
$162
includes taxes & fees
Apr 13 - Apr 14
Stay at this 5-star luxury hotel in Athens. Enjoy free WiFi, an outdoor pool, and a full-service spa. Our guests praise the breakfast and the pool in our reviews. ...
Grand Hyatt Athens
Sofitel Athens Airport
5 out of 5
Fully refundableReserve now, pay when you stay
The price is $289 per night from Apr 15 to Apr 16
$289
includes taxes & fees
Apr 15 - Apr 16
Stay at this 5-star luxury hotel in Spata-Artemida. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the breakfast and the pool in our ...
Sofitel Athens Airport
Grand Hyatt Barcelona
5 out of 5
Fully refundableReserve now, pay when you stay
  • 47 hours drive from Lake Ohrid
The price is $246 per night from Apr 13 to Apr 14
$246
includes taxes & fees
Apr 13 - Apr 14
Stay at this 5-star luxury hotel in Barcelona. Enjoy free WiFi, an outdoor pool, and a full-service spa. Our guests praise the helpful staff and the clean rooms ...
Grand Hyatt Barcelona
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Nobu Hotel Barcelona
5 out of 5
Fully refundableReserve now, pay when you stay
  • 47 hours drive from Lake Ohrid
The price is $256 per night from Apr 21 to Apr 22
$256
includes taxes & fees
Apr 21 - Apr 22
Stay at this 5-star luxury hotel in Barcelona. Enjoy free WiFi, an outdoor pool, and a full-service spa. Our guests praise the breakfast and the restaurant in ...
Nobu Hotel Barcelona
Barceló Torre de Madrid
5 out of 5
Fully refundable
  • 64 hours drive from Lake Ohrid
The price is $253 per night from Apr 14 to Apr 15
$253
includes taxes & fees
Apr 14 - Apr 15
Stay at this 5-star luxury hotel in Madrid. Enjoy free WiFi, breakfast (surcharge), and 24-hour room service. Our guests praise the breakfast and the helpful ...
Barceló Torre de Madrid
Corinthia Lisbon
5 out of 5
Fully refundableReserve now, pay when you stay
The price is $193 per night from Mar 31 to Apr 1
$193
includes taxes & fees
Mar 31 - Apr 1
Stay at this 5-star luxury hotel in Lisbon. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the breakfast and the helpful staff in ...
Corinthia Lisbon
Lamaro Hotel
5 out of 5
Fully refundableReserve now, pay when you stay
  • 47 hours drive from Lake Ohrid
The price is $271 per night from Mar 31 to Apr 1
$271
includes taxes & fees
Mar 31 - Apr 1
Stay at this 5-star luxury hotel in Barcelona. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the breakfast and the bar in ...
Lamaro Hotel
Electra Metropolis Athens
5 out of 5
Fully refundable
  • 2 hours drive from Lake Ohrid
The price is $273 per night from Mar 31 to Apr 1
$273
includes taxes & fees
Mar 31 - Apr 1
Stay at this 5-star luxury hotel in Athens. Enjoy free WiFi, an outdoor pool, and a full-service spa. Our guests praise the breakfast and the pool in our reviews. ...
Electra Metropolis Athens
Electra Palace Athens
5 out of 5
Fully refundable
  • 2 hours drive from Lake Ohrid
The price is $292 per night from Mar 31 to Apr 1
$292
includes taxes & fees
Mar 31 - Apr 1
Stay at this 5-star luxury hotel in Athens. Enjoy free WiFi, an outdoor pool, and a full-service spa. Our guests praise the breakfast and the restaurant in our ...
Electra Palace Athens
La Mamounia
5 out of 5
The price is $716 per night from Mar 31 to Apr 1
$716
includes taxes & fees
Mar 31 - Apr 1
Stay at this 5-star luxury hotel in Marrakech. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular ...
La Mamounia
Hyatt Regency Barcelona Tower
5 out of 5
Fully refundableReserve now, pay when you stay
  • 48 hours drive from Lake Ohrid
The price is $159 per night from Apr 13 to Apr 14
$159
includes taxes & fees
Apr 13 - Apr 14
Stay at this 5-star luxury hotel in L'Hospitalet de Llobregat. Enjoy free WiFi, an outdoor pool, and 2 restaurants. Our guests praise the helpful staff in our ...
Hyatt Regency Barcelona Tower
EPIC SANA Marques Hotel
5 out of 5
Fully refundableReserve now, pay when you stay
The price is $247 per night from Mar 31 to Apr 1
$247
includes taxes & fees
Mar 31 - Apr 1
Stay at this 5-star luxury hotel in Lisbon. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the breakfast and the pool in our reviews. ...
EPIC SANA Marques Hotel
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

5-Star Hotel in Mediterranean Region

It’s time. No more meh motels and so-so stays. This vacation it’s all about living it up, and that starts with a great hotel. You want first-class service and award-winning restaurants. Well, let us introduce you to a 5-star hotel in Mediterranean Region.

So nice you’ll blink twice

What makes a hotel worthy of supreme star-age? For starters, the service has to be top-notch and personalized. These hotels often have 24-hour room service, a welcome gift upon your arrival, and help you with your bags—even if you travel light.

Are they nicer? Heck yeah, they are! Most 5-star hotels have jaw-dropping aesthetics that give an authentic feel of class. And we’re not talking about that faux-gold soap dish your Aunt Tilda puts out for the guests—it’s the real deal.

Stars in your eyes

Are 5-stars hotels worth it? If you like the finer things in life, then yes, they sure are. But we also know you’re the type that likes to get your caviar on a fish stick budget. We’re right there with you, and that is why we make it easy to find the best 5-star hotel in Mediterranean Region for you. Sort by:

  • Price: Want to live large, but keep that budget balanced? We got you. We have 5-star hotels starting at $159.

  • Amenities: Mediterranean Region skyline view? Maybe a heated indoor pool? Looking for a Michelin-star restaurant? Search for the hotels that have the amenities you desire.

  • Hotwire Hot Rate: We’ll tell you the name of the hotel after you book, and you might just save a ton.

When you’re looking for the top 5-star hotels in Mediterranean Region—but don’t want to pay top dollar—let us help you out. You can get that posh palace of your dreams, and have money left to take on Mediterranean Region your way.