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Southern Indiana

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Southern Indiana Flights as Low as $335

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

United
Tue, Oct 13 - Sun, Oct 18
BUF
Buffalo Niagara Intl.
OWB
Owensboro-Daviess County Regional
$335 Roundtrip, found 5 hours ago
$335
Roundtrip
found 5 hours ago
Select United flight, departing Tue, Oct 13 from Buffalo Niagara Intl. to Owensboro-Daviess County Regional, returning Sun, Oct 18, priced at $335 found 5 hours ago
United
Tue, Oct 13 - Sun, Oct 18
BUF
Buffalo Niagara Intl.
OWB
Owensboro-Daviess County Regional
$344 Roundtrip, found 5 hours ago
$344
Roundtrip
found 5 hours ago
Select United flight, departing Tue, Oct 13 from Buffalo Niagara Intl. to Owensboro-Daviess County Regional, returning Sun, Oct 18, priced at $344 found 5 hours ago
United
Tue, Oct 13 - Sun, Oct 18
BUF
Buffalo Niagara Intl.
OWB
Owensboro-Daviess County Regional
$395 Roundtrip, found 5 hours ago
$395
Roundtrip
found 5 hours ago
Select United flight, departing Tue, Oct 13 from Buffalo Niagara Intl. to Owensboro-Daviess County Regional, returning Sun, Oct 18, priced at $395 found 5 hours ago
United
Thu, Oct 8 - Wed, Oct 14
BUF
Buffalo Niagara Intl.
OWB
Owensboro-Daviess County Regional
$448 Roundtrip, found 4 days ago
$448
Roundtrip
found 4 days ago
Select United flight, departing Thu, Oct 8 from Buffalo Niagara Intl. to Owensboro-Daviess County Regional, returning Wed, Oct 14, priced at $448 found 4 days ago
United
Mon, Oct 12 - Sun, Oct 18
BUF
Buffalo Niagara Intl.
OWB
Owensboro-Daviess County Regional
$529 Roundtrip, found 2 days ago
$529
Roundtrip
found 2 days ago
Select United flight, departing Mon, Oct 12 from Buffalo Niagara Intl. to Owensboro-Daviess County Regional, returning Sun, Oct 18, priced at $529 found 2 days ago
United
Thu, Oct 8 - Wed, Oct 14
BUF
Buffalo Niagara Intl.
OWB
Owensboro-Daviess County Regional
$534 Roundtrip, found 4 days ago
$534
Roundtrip
found 4 days ago
Select United flight, departing Thu, Oct 8 from Buffalo Niagara Intl. to Owensboro-Daviess County Regional, returning Wed, Oct 14, priced at $534 found 4 days ago
United
Tue, Oct 13 - Fri, Oct 16
BUF
Buffalo Niagara Intl.
OWB
Owensboro-Daviess County Regional
$554 Roundtrip, found 2 days ago
$554
Roundtrip
found 2 days ago
Select United flight, departing Tue, Oct 13 from Buffalo Niagara Intl. to Owensboro-Daviess County Regional, returning Fri, Oct 16, priced at $554 found 2 days ago
United
Tue, Oct 6 - Wed, Oct 14
BUF
Buffalo Niagara Intl.
OWB
Owensboro-Daviess County Regional
$561 Roundtrip, found 2 days ago
$561
Roundtrip
found 2 days ago
Select United flight, departing Tue, Oct 6 from Buffalo Niagara Intl. to Owensboro-Daviess County Regional, returning Wed, Oct 14, priced at $561 found 2 days ago
United
Tue, Oct 13 - Fri, Oct 16
BUF
Buffalo Niagara Intl.
OWB
Owensboro-Daviess County Regional
$566 Roundtrip, found 2 days ago
$566
Roundtrip
found 2 days ago
Select United flight, departing Tue, Oct 13 from Buffalo Niagara Intl. to Owensboro-Daviess County Regional, returning Fri, Oct 16, priced at $566 found 2 days ago
United
Thu, Oct 8 - Wed, Oct 14
BUF
Buffalo Niagara Intl.
OWB
Owensboro-Daviess County Regional
$567 Roundtrip, found 3 hours ago
$567
Roundtrip
found 3 hours ago
Select United flight, departing Thu, Oct 8 from Buffalo Niagara Intl. to Owensboro-Daviess County Regional, returning Wed, Oct 14, priced at $567 found 3 hours ago
United
Tue, Oct 13 - Fri, Oct 16
BUF
Buffalo Niagara Intl.
OWB
Owensboro-Daviess County Regional
$576 Roundtrip, found 2 days ago
$576
Roundtrip
found 2 days ago
Select United flight, departing Tue, Oct 13 from Buffalo Niagara Intl. to Owensboro-Daviess County Regional, returning Fri, Oct 16, priced at $576 found 2 days ago
United
Sat, Oct 10 - Fri, Oct 16
BUF
Buffalo Niagara Intl.
OWB
Owensboro-Daviess County Regional
$581 Roundtrip, found 2 days ago
$581
Roundtrip
found 2 days ago
Select United flight, departing Sat, Oct 10 from Buffalo Niagara Intl. to Owensboro-Daviess County Regional, returning Fri, Oct 16, priced at $581 found 2 days ago
United
Tue, Sep 22 - Fri, Oct 9
BUF
Buffalo Niagara Intl.
SDF
Louisville Intl.
$591 Roundtrip, found 9 hours ago
$591
Roundtrip
found 9 hours ago
Select United flight, departing Tue, Sep 22 from Buffalo Niagara Intl. to Louisville Intl., returning Fri, Oct 9, priced at $591 found 9 hours ago
Delta
Tue, Sep 22 - Fri, Oct 9
BUF
Buffalo Niagara Intl.
SDF
Louisville Intl.
$610 Roundtrip, found 9 hours ago
$610
Roundtrip
found 9 hours ago
Select Delta flight, departing Tue, Sep 22 from Buffalo Niagara Intl. to Louisville Intl., returning Fri, Oct 9, priced at $610 found 9 hours ago
American Airlines
Tue, Sep 22 - Tue, Oct 6
BUF
Buffalo Niagara Intl.
SDF
Louisville Intl.
$616 Roundtrip, found 1 day ago
$616
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Sep 22 from Buffalo Niagara Intl. to Louisville Intl., returning Tue, Oct 6, priced at $616 found 1 day ago
Southwest Airlines
Tue, Sep 22 - Fri, Oct 9
BUF
Buffalo Niagara Intl.
SDF
Louisville Intl.
$728 Roundtrip, found 9 hours ago
$728
Roundtrip
found 9 hours ago
Select Southwest Airlines flight, departing Tue, Sep 22 from Buffalo Niagara Intl. to Louisville Intl., returning Fri, Oct 9, priced at $728 found 9 hours ago

Cheap Flights to Southern Indiana

Fall in love at first flight with your vacation to Southern Indiana by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Southern Indiana on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Southern Indiana, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Southern Indiana

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Southern Indiana with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the SDF airport.

What is the cheapest month to fly to Southern Indiana?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Southern Indiana are in October, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Southern Indiana?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Southern Indiana.

What airport is best to fly into Southern Indiana?

When you’re planning your trip to Southern Indiana, convenience is the name of the game. Luckily, Southern Indiana Evansville Regional Airport is nearby so you can deplane and get going on checking off everything on your Southern Indiana must-do list.

How much are flights to Southern Indiana?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Southern Indiana on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $335, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Southern Indiana?

The trick to saving a stack of cash on your flight to Southern Indiana? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $335 right now, why wait?

Southern Indiana Flight Information
Destination airport
Owensboro-Daviess County Regional
Destination airport IATA code
OWB
Roundtrip price
$334

Last Minute Hotel Deals in Southern Indiana

Radisson Hotel Louisville North

Radisson Hotel Louisville North

3 out of 5
505 Marriott Drive Clarksville IN
Book a stay at this business-friendly hotel in Clarksville. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the clean rooms in our reviews. ...
7/10 Good! (3,402 reviews)
"Great people at the hotel bar. Easy access to freeway and general area to find things to do, whether it's Indiana side or Kentucky side. Tons of parking at this hotel - very big facility. Nice pool are, and a small fitness room next to the pool area."

Reviewed on Sep 21, 2026

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Radisson Hotel Louisville North
Santas Lodge and Resort

Santas Lodge and Resort

2.5 out of 5
91 W CHRISTMAS BLVD Santa Claus IN
Stay at this hotel in Santa Claus. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
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Santas Lodge and Resort
Derby Hotel & Suites

Derby Hotel & Suites

2 out of 5
505 K Marriot Dr Clarksville IN
Stay at this hotel in Clarksville. Enjoy free WiFi, free parking, and an outdoor pool. Popular attractions Louisville Slugger Museum and Whiskey Row are located ...
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Derby Hotel & Suites
Bally’s Evansville Casino & Hotel

Bally’s Evansville Casino & Hotel

3 out of 5
421 NW Riverside Drive Evansville IN
Book a stay at this business-friendly hotel in Evansville. Enjoy free WiFi, free parking, and 3 restaurants. Our guests praise the helpful staff and the clean ...
7.8/10 Good! (1,296 reviews)
"I didn’t stay there and you still took my money"

Reviewed on Sep 21, 2026

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Bally’s Evansville Casino & Hotel
Hyatt Place Evansville

Hyatt Place Evansville

3 out of 5
202 Se 2nd St Evansville IN
Book a stay at this business-friendly hotel in Evansville. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (1,007 reviews)
"The staff was very friendly, the room was very clean and well stocked for your needs. We came to town for a concert at the Ford Center so it was a perfect place to stay and were able to just walk to the Ford Center. Would definitely stay here again!"

Reviewed on Sep 21, 2026

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Hyatt Place Evansville
Fairfield Inn By Marriott Evansville East

Fairfield Inn By Marriott Evansville East

3 out of 5
7879 Eagle Crest Blvd Evansville IN
Book a stay at this business-friendly hotel in Evansville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
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Fairfield Inn By Marriott Evansville East
Hampton Inn New Albany Louisville West

Hampton Inn New Albany Louisville West

2.5 out of 5
411 W Spring Street New Albany IN
Book a stay at this business-friendly hotel in New Albany. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.8/10 Excellent! (906 reviews)
"Just in a great location easy access to the highway"

Reviewed on Sep 20, 2026

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Hampton Inn New Albany Louisville West
Drury Inn & Suites Evansville East

Drury Inn & Suites Evansville East

3 out of 5
100 Cross Pointe Blvd Evansville IN
Book a stay at this business-friendly hotel in Evansville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (1,008 reviews)
"Clean, nice , nice location"

Reviewed on Sep 21, 2026

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Drury Inn & Suites Evansville East
See all 1,650 properties in Southern Indiana
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Hotels With Free Airport Shuttle

Courtyard by Marriott Louisville Downtown

Courtyard by Marriott Louisville Downtown

3 out of 5
100 South Second Street Louisville KY
Book a stay at this business-friendly hotel in Louisville. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
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Courtyard by Marriott Louisville Downtown
Comfort Inn & Suites Evansville Airport

Comfort Inn & Suites Evansville Airport

2.5 out of 5
3901 Highway 41 N. Evansville IN
Book a stay at this business-friendly hotel in Evansville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
7.8/10 Good! (1,002 reviews)
"The hot tub was fine but had 4-5 kids in it the whole time. No parents, just their kids."

Reviewed on Sep 21, 2026

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Comfort Inn & Suites Evansville Airport
Embassy Suites Louisville Downtown

Embassy Suites Louisville Downtown

4 out of 5
501 South Fourth Street Louisville KY
Stay at this hotel in Louisville. Enjoy free breakfast, a free airport shuttle, and room service. Our guests praise the breakfast and the helpful staff in our ...
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Embassy Suites Louisville Downtown
Hampton Inn Louisville Downtown

Hampton Inn Louisville Downtown

2.5 out of 5
101 E Jefferson St Louisville KY
Book a stay at this business-friendly hotel in Louisville. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and ...
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Hampton Inn Louisville Downtown
Hilton Garden Inn Louisville Downtown

Hilton Garden Inn Louisville Downtown

3.5 out of 5
350 West Chestnut Street Louisville KY
Book a stay at this business-friendly hotel in Louisville. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and ...
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Hilton Garden Inn Louisville Downtown
Holiday Inn Evansville Airport

Holiday Inn Evansville Airport

4 out of 5
7101 Highway 41 N Evansville IN
Book a stay at this business-friendly hotel in Evansville. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Evansville Wartime Museum and ...
8/10 Very Good! (604 reviews)
"Nice hotel but it doesn’t have a fridge in the room or microwave."

Reviewed on Jan 31, 2020

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Holiday Inn Evansville Airport
See all 1,650 properties in Southern Indiana
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.