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Hotels in Eastern South Dakota

Choose from 953 Eastern South Dakota Hotel Deals

Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

3 out of 5
1301 West Russell Sioux Falls SD
  • 4 min drive from Sanford USD Medical Center
Book a stay at this family-friendly hotel in Sioux Falls. Enjoy free WiFi, free parking, and 3 indoor pools. Our guests praise the pool and the helpful staff ...
7.8/10 Good! (1,581 reviews)
"IM TRYING TO GET MY MONEY BACK THROUGH EXPEDIA, ITS A WATERPARK, I GET IT, BUT NO WINDOWS TO THE OUTSIDE? ITS LIKE BEING ENCLOSED IN A JUNGLE, THE CHLORINE WAS SO STRONG I WAS GETTING SICK AND THERE WAS A GAP BETWEEN THE DOOR, SO GROSS..CHECKED OUT IN AN HOUR..."

Reviewed on Jun 7, 2026

Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr
Days Inn by Wyndham Sioux Falls Empire

Days Inn by Wyndham Sioux Falls Empire

2 out of 5
3401 Gateway Blvd Sioux Falls SD
  • 7 min drive from Sanford USD Medical Center
Book a stay at this business-friendly hotel in Sioux Falls. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.8/10 Good! (1,128 reviews)
"It's an older hotel but still very functional and does the job."

Reviewed on Jun 7, 2026

Days Inn by Wyndham Sioux Falls Empire
Hotel On Phillips

Hotel On Phillips

2.5 out of 5
100 N Phillips Ave Sioux Falls SD
  • 25 min walk from Sanford USD Medical Center
Stay at this hotel in Sioux Falls. Enjoy free WiFi, free parking, and a free airport shuttle. Our guests praise the restaurant and the helpful staff in our reviews. ...
9.6/10 Exceptional! (1,435 reviews)
"Loved the unique room. Bed was super comfortable and we appreciated the high quality of everything. Beautiful lobby and amazing food and drinks at the bar."

Reviewed on Jun 8, 2026

Hotel On Phillips
Highpoint Hotel

Highpoint Hotel

3 out of 5
1530 W 22nd St Sioux Falls SD
  • 5 min walk from Sanford USD Medical Center
Stay at this hotel in Sioux Falls. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Denny Sanford Premier Center and Falls Park ...
9.8/10 Exceptional! (115 reviews)
"Rooms were exceptionally clean. Staff very helpful and friendly. Breakfast and coffee were average at best, need a better selection for breakfast and they need get better coffee."

Reviewed on Jun 8, 2026

Highpoint Hotel
AeroStay Hotel

AeroStay Hotel

2.5 out of 5
2821 N Jaycee Lane Sioux Falls SD
  • 8 min drive from Sanford USD Medical Center
Book a stay at this business-friendly hotel in Sioux Falls. Enjoy free breakfast, a 24-hour fitness center, and parking (surcharge). Our guests praise the helpful ...
8.8/10 Excellent! (1,125 reviews)
"The front desk person was not helpful and didn’t say a word to us. It was 1am but some acknowledgement would’ve been nice. The beds were fine, the pillows were really thick. Bathroom was nice. Continental breakfast options were an apple, Orange or bagel. If you wanted something else you had to pay ..."

Reviewed on Jun 8, 2026

AeroStay Hotel
Clubhouse Hotel Suites Sioux Falls

Clubhouse Hotel Suites Sioux Falls

3 out of 5
2320 South Louise Avenue Sioux Falls SD
  • 5 min drive from Sanford USD Medical Center
Book a stay at this business-friendly hotel in Sioux Falls. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in ...
9.6/10 Exceptional! (1,079 reviews)
"The breakfast was great and we enjoyed the outdoor space ."

Reviewed on Jun 7, 2026

Clubhouse Hotel Suites Sioux Falls
Country Inn & Suites by Radisson, Sioux Falls

Country Inn & Suites by Radisson, Sioux Falls

3 out of 5
200 E 8th St Sioux Falls SD
  • 27 min walk from Sanford USD Medical Center
Book a stay at this business-friendly hotel in Sioux Falls. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
8.6/10 Excellent! (1,255 reviews)
"Everything was to be expected… just hoped for more given the cost."

Reviewed on Jun 8, 2026

Country Inn & Suites by Radisson, Sioux Falls
Baymont by Wyndham Sioux Falls

Baymont by Wyndham Sioux Falls

2.5 out of 5
3200 South Meadow Avenue Sioux Falls SD
  • 7 min drive from Sanford USD Medical Center
Book a stay at this business-friendly hotel in Sioux Falls. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in ...
8/10 Very Good! (1,972 reviews)
"Room was clean enough, except the carpet had a peculiar smell. Staff simple were not friendly. I can understand lack of trust with management but do not take those frustrations out on the customer. I did not create the situation. Breakfast some good some bad featured food. I do not use hot tubs."

Reviewed on Jun 8, 2026

Baymont by Wyndham Sioux Falls
La Quinta Inn & Suites by Wyndham Sioux Falls

La Quinta Inn & Suites by Wyndham Sioux Falls

3 out of 5
4521 W. 41st Street Sioux Falls SD
  • 7 min drive from Sanford USD Medical Center
Book a stay at this business-friendly hotel in Sioux Falls. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,571 reviews)
"Clean and quiet."

Reviewed on Jun 8, 2026

La Quinta Inn & Suites by Wyndham Sioux Falls
Thunderbird Lodge

Thunderbird Lodge

2 out of 5
1601 S Burr St Mitchell SD
  • 3 hours drive from Sanford USD Medical Center
Stay at this motel in Mitchell. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
8.4/10 Very Good! (1,387 reviews)
"Upgrades since our last visit."

Reviewed on Jun 8, 2026

Thunderbird Lodge
The Center Inn

The Center Inn

2.5 out of 5
900 E 20th St Sioux Falls SD
  • 4 min drive from Sanford USD Medical Center
Stay at this hotel in Sioux Falls. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. ...
8.4/10 Very Good! (793 reviews)
"Breakfast was good for continental!"

Reviewed on Jun 8, 2026

The Center Inn
Hyatt Place Sioux Falls South

Hyatt Place Sioux Falls South

3 out of 5
4935 Lakeshore Blvd Sioux Falls SD
  • 7 min drive from Sanford USD Medical Center
Book a stay at this business-friendly hotel in Sioux Falls. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (1,010 reviews)
"We have stayed at this hotel three times and we’re happy with our stay again. Clean modern design, well cared for, clean rooms and helpful staff. Great breakfast in the morning and nice bar for relaxing by the lake in the evening"

Reviewed on Jun 8, 2026

Hyatt Place Sioux Falls South
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Eastern South Dakota

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If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $82. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Eastern South Dakota hotel deals at the last minute.

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Frequently Asked Questions About Eastern South Dakota hotels

Where can I find the best last-minute travel deals?

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How many hotels are there in Eastern South Dakota?

With over 953 hotels in Eastern South Dakota, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $82.

How to find cheap car rentals in Eastern South Dakota?

Finding a cheap car rental deal in Eastern South Dakota is as easy as scoring cheap hotels in Eastern South Dakota. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.