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Hotels in Eastern South Dakota

Choose from 952 Eastern South Dakota Hotel Deals

Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

3 out of 5
1301 West Russell Sioux Falls SD
  • 10 min walk from Denny Sanford Premier Center
Book a stay at this family-friendly hotel in Sioux Falls. Enjoy free WiFi, free parking, and 3 indoor pools. Our guests praise the pool and the helpful staff ...
7.6/10 Good! (1,499 reviews)
The pool was great! Always a kid favorite. Only complaint would be the fridge in our room didn’t work.

Reviewed on Jan 26, 2026

Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr
La Quinta Inn & Suites by Wyndham Sioux Falls

La Quinta Inn & Suites by Wyndham Sioux Falls

3 out of 5
4521 W. 41st Street Sioux Falls SD
  • 9 min drive from Denny Sanford Premier Center
Book a stay at this business-friendly hotel in Sioux Falls. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,563 reviews)
Room was spotless

Reviewed on Jan 28, 2026

La Quinta Inn & Suites by Wyndham Sioux Falls
AeroStay Hotel

AeroStay Hotel

2.5 out of 5
2821 N Jaycee Lane Sioux Falls SD
  • 5 min drive from Denny Sanford Premier Center
Book a stay at this business-friendly hotel in Sioux Falls. Enjoy free breakfast, a 24-hour fitness center, and parking (surcharge). Our guests praise the helpful ...
8.8/10 Excellent! (1,060 reviews)
We always stay here when we have early morning flights. The rooms are always clean and staff is very professional and helpful.

Reviewed on Jan 24, 2026

AeroStay Hotel
Hotel On Phillips

Hotel On Phillips

2.5 out of 5
100 N Phillips Ave Sioux Falls SD
  • 5 min drive from Denny Sanford Premier Center
Stay at this hotel in Sioux Falls. Enjoy free WiFi, free parking, and a free airport shuttle. Our guests praise the restaurant and the helpful staff in our reviews. ...
9.4/10 Exceptional! (1,348 reviews)
Staff was great, room was clean and elegant. I requested the add on champagne packet since we were staying for my husband’s birthday celebration. They carried this out with ease -my husband was surprised

Reviewed on Jan 26, 2026

Hotel On Phillips
Clubhouse Hotel Suites Sioux Falls

Clubhouse Hotel Suites Sioux Falls

3 out of 5
2320 South Louise Avenue Sioux Falls SD
  • 7 min drive from Denny Sanford Premier Center
Book a stay at this business-friendly hotel in Sioux Falls. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in ...
9.4/10 Exceptional! (1,010 reviews)
Nice

Reviewed on Jan 25, 2026

Clubhouse Hotel Suites Sioux Falls
Country Inn & Suites by Radisson, Sioux Falls, SD

Country Inn & Suites by Radisson, Sioux Falls, SD

3 out of 5
200 E 8th St Sioux Falls SD
  • 5 min drive from Denny Sanford Premier Center
Book a stay at this business-friendly hotel in Sioux Falls. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
8.4/10 Very Good! (1,188 reviews)
Great stay. Very quite

Reviewed on Jan 24, 2026

Country Inn & Suites by Radisson, Sioux Falls, SD
Baymont by Wyndham Sioux Falls

Baymont by Wyndham Sioux Falls

2.5 out of 5
3200 South Meadow Avenue Sioux Falls SD
  • 9 min drive from Denny Sanford Premier Center
Book a stay at this business-friendly hotel in Sioux Falls. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in ...
8/10 Very Good! (1,835 reviews)
Clean room and good breakfast

Reviewed on Jan 26, 2026

Baymont by Wyndham Sioux Falls
Comfort Inn & Suites at Sanford Sports Complex

Comfort Inn & Suites at Sanford Sports Complex

2.5 out of 5
3900 N HERCULES AVE Sioux Falls SD
  • 5 min drive from Denny Sanford Premier Center
Book a stay at this business-friendly hotel in Sioux Falls. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9.4/10 Exceptional! (939 reviews)
Room was clean.

Reviewed on Jan 27, 2026

Comfort Inn & Suites at Sanford Sports Complex
Canopy By Hilton Sioux Falls Downtown

Canopy By Hilton Sioux Falls Downtown

4 out of 5
120 E. 4th Place Sioux Falls SD
  • 4 min drive from Denny Sanford Premier Center
Stay at this hotel in Sioux Falls. Enjoy free WiFi, breakfast (surcharge), and room service. Popular attractions Denny Sanford Premier Center and Falls Park ...
9.4/10 Exceptional! (172 reviews)
Clean room, very classy

Reviewed on Jan 27, 2026

Canopy By Hilton Sioux Falls Downtown
AmericInn by Wyndham Sioux Falls

AmericInn by Wyndham Sioux Falls

2.5 out of 5
3508 S Gateway Blvd Sioux Falls SD
  • 9 min drive from Denny Sanford Premier Center
Stay at this hotel in Sioux Falls. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
7.8/10 Good! (1,043 reviews)
Clean room and pleasant staff

Reviewed on Jan 26, 2026

AmericInn by Wyndham Sioux Falls
AmericInn by Wyndham Sioux Falls North

AmericInn by Wyndham Sioux Falls North

2.5 out of 5
3300 W Russell St Sioux Falls SD
  • 26 min walk from Denny Sanford Premier Center
Book a stay at this business-friendly hotel in Sioux Falls. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in ...
8.8/10 Excellent! (1,419 reviews)
Everything was excellent.

Reviewed on Jan 20, 2026

AmericInn by Wyndham Sioux Falls North
Days Inn by Wyndham Sioux Falls Empire

Days Inn by Wyndham Sioux Falls Empire

2 out of 5
3401 Gateway Blvd Sioux Falls SD
  • 9 min drive from Denny Sanford Premier Center
Book a stay at this business-friendly hotel in Sioux Falls. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.8/10 Good! (1,082 reviews)
Clean room

Reviewed on Jan 20, 2026

Days Inn by Wyndham Sioux Falls Empire
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Eastern South Dakota

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Frequently Asked Questions About Eastern South Dakota hotels

Where can I find the best last-minute travel deals?

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How many hotels are there in Eastern South Dakota?

With over 952 hotels in Eastern South Dakota, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $60.

How to find cheap car rentals in Eastern South Dakota?

Finding a cheap car rental deal in Eastern South Dakota is as easy as scoring cheap hotels in Eastern South Dakota. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.