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Hotels in Eastern South Dakota

Choose from 953 Eastern South Dakota Hotel Deals

Days Inn by Wyndham Sioux Falls Empire

Days Inn by Wyndham Sioux Falls Empire

2 out of 5
3401 Gateway Blvd Sioux Falls SD
  • 9 min drive from Denny Sanford Premier Center
Book a stay at this business-friendly hotel in Sioux Falls. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.8/10 Good! (1,133 reviews)
"Room nothing like in the picture. Room smelled so bad like a wet dog. Sticky floors, so small not even a closet or rack to put your bag in, but don't worry there are two hangers hanging on the wall to use. Bathtub so gross, I didn't even use it! Doors were peeling, sheets dirty. Such a depressing, ..."

Reviewed on Jun 11, 2026

Days Inn by Wyndham Sioux Falls Empire
Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

3 out of 5
1301 West Russell Sioux Falls SD
  • 9 min walk from Denny Sanford Premier Center
Book a stay at this family-friendly hotel in Sioux Falls. Enjoy free WiFi, free parking, and 3 indoor pools. Our guests praise the pool and the helpful staff ...
7.8/10 Good! (1,585 reviews)
"Great water park! We had so much fun!"

Reviewed on Jun 11, 2026

Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr
Hotel On Phillips

Hotel On Phillips

2.5 out of 5
100 N Phillips Ave Sioux Falls SD
  • 5 min drive from Denny Sanford Premier Center
Stay at this hotel in Sioux Falls. Enjoy free WiFi, free parking, and a free airport shuttle. Our guests praise the restaurant and the helpful staff in our reviews. ...
9.6/10 Exceptional! (1,441 reviews)
"Very nice hotel. It was actually a lowest cost hotel, than many of the other."

Reviewed on Jun 10, 2026

Hotel On Phillips
Highpoint Hotel

Highpoint Hotel

3 out of 5
1530 W 22nd St Sioux Falls SD
  • 5 min drive from Denny Sanford Premier Center
Stay at this hotel in Sioux Falls. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Denny Sanford Premier Center and Falls Park ...
9.8/10 Exceptional! (119 reviews)
"Incredible experience, would stay here again in a heartbeat!"

Reviewed on Jun 10, 2026

Highpoint Hotel
AeroStay Hotel

AeroStay Hotel

2.5 out of 5
2821 N Jaycee Lane Sioux Falls SD
  • 5 min drive from Denny Sanford Premier Center
Book a stay at this business-friendly hotel in Sioux Falls. Enjoy free breakfast, a 24-hour fitness center, and parking (surcharge). Our guests praise the helpful ...
8.8/10 Excellent! (1,119 reviews)
"Rooms were very clean. I did not hear a lot of plane noise. I absolutely love the convenience because I had an early morning flight. You definitely can’t beat the convenience of it."

Reviewed on Jun 11, 2026

AeroStay Hotel
Clubhouse Hotel Suites Sioux Falls

Clubhouse Hotel Suites Sioux Falls

3 out of 5
2320 South Louise Avenue Sioux Falls SD
  • 7 min drive from Denny Sanford Premier Center
Book a stay at this business-friendly hotel in Sioux Falls. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in ...
9.6/10 Exceptional! (1,064 reviews)
"My husband and I looked for 2 days for a hotel that would have a pool with a slide that accommodated dogs. We have stayed here in the past and could finally afford the room charge to enjoy the pool. We even sacrificed drive time on our trip to take the kids to their grandparents for some summer fun. ..."

Reviewed on Jun 10, 2026

Clubhouse Hotel Suites Sioux Falls
Country Inn & Suites by Radisson, Sioux Falls

Country Inn & Suites by Radisson, Sioux Falls

3 out of 5
200 E 8th St Sioux Falls SD
  • 5 min drive from Denny Sanford Premier Center
Book a stay at this business-friendly hotel in Sioux Falls. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
8.4/10 Very Good! (1,262 reviews)
"It's by far my favorite place to stay in Sioux Falls. Keep up the good work! Thank You!"

Reviewed on Jun 11, 2026

Country Inn & Suites by Radisson, Sioux Falls
Baymont by Wyndham Sioux Falls

Baymont by Wyndham Sioux Falls

2.5 out of 5
3200 South Meadow Avenue Sioux Falls SD
  • 9 min drive from Denny Sanford Premier Center
Book a stay at this business-friendly hotel in Sioux Falls. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in ...
8/10 Very Good! (1,975 reviews)
"need better pelows"

Reviewed on Jun 10, 2026

Baymont by Wyndham Sioux Falls
La Quinta Inn & Suites by Wyndham Sioux Falls

La Quinta Inn & Suites by Wyndham Sioux Falls

3 out of 5
4521 W. 41st Street Sioux Falls SD
  • 9 min drive from Denny Sanford Premier Center
Book a stay at this business-friendly hotel in Sioux Falls. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,578 reviews)
"Very clean very nice up to date would stay there again"

Reviewed on Jun 11, 2026

La Quinta Inn & Suites by Wyndham Sioux Falls
Thunderbird Lodge

Thunderbird Lodge

2 out of 5
1601 S Burr St Mitchell SD
  • 3 hours drive from Denny Sanford Premier Center
Stay at this motel in Mitchell. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
8.4/10 Very Good! (1,383 reviews)
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Reviewed on Jun 10, 2026

Thunderbird Lodge
Baymont by Wyndham Sioux Falls West (67058) Sioux/ Near Airport

Baymont by Wyndham Sioux Falls West (67058) Sioux/ Near Airport

2.5 out of 5
3101 W Russell St Sioux Falls SD
  • 25 min walk from Denny Sanford Premier Center
Book a stay at this business-friendly hotel in Sioux Falls. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7/10 Good! (1,019 reviews)
"You get what you pay for. Our bathroom had spackle on the walls. Glad we only needed a bed for the night. Would not want to stay there longer."

Reviewed on Jun 10, 2026

Baymont by Wyndham Sioux Falls West (67058) Sioux/ Near Airport
The Center Inn

The Center Inn

2.5 out of 5
900 E 20th St Sioux Falls SD
  • 7 min drive from Denny Sanford Premier Center
Stay at this hotel in Sioux Falls. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. ...
8.4/10 Very Good! (799 reviews)
"We had no bath towels, washcloths and only one bar of soap when we checked in. Had to go to desk and request. Bed was poorly made. Parking was unusual. If closest lot was full oh had to go around block to enter 2nd row of parking."

Reviewed on Jun 11, 2026

The Center Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Eastern South Dakota

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Frequently Asked Questions About Eastern South Dakota hotels

Where can I find the best last-minute travel deals?

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How many hotels are there in Eastern South Dakota?

With over 953 hotels in Eastern South Dakota, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $79.

How to find cheap car rentals in Eastern South Dakota?

Finding a cheap car rental deal in Eastern South Dakota is as easy as scoring cheap hotels in Eastern South Dakota. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.