Hotels Near
Medical Center

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Featured Medical Center Hotels

Hollywood Casino at Greektown
Hollywood Casino at Greektown
4 out of 5
1200 Saint Antoine St, Detroit, MI
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in Detroit. Enjoy 5 restaurants, a casino, and 5 bars/lounges. Our guests praise the helpful staff and the convenient ...
8.6/10 Excellent! (3,483 reviews)
"First off the staff were outstanding. Room service was quick. All the food we ordered was delicious. Room was very clean and the view was incredible. Staff made this a very comfortable and easy stay. Exactly what I needed in a short weekend getaway. The women running the front desk were welcoming ..."

Reviewed on Mar 29, 2025

Hollywood Casino at Greektown
La Quinta Inn & Suites by Wyndham Detroit Metro Airport
La Quinta Inn & Suites by Wyndham Detroit Metro Airport
3 out of 5
30847 Flynn Drive, Romulus, MI
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in Romulus. Enjoy free breakfast, free WiFi, and a free airport shuttle. Our guests praise the breakfast and the ...
8.2/10 Very Good! (2,062 reviews)
"Great place to stay and park! Clean and friendly! We will definitely stay there again"

Reviewed on Mar 31, 2025

La Quinta Inn & Suites by Wyndham Detroit Metro Airport
Atheneum Suite Hotel
Atheneum Suite Hotel
4 out of 5
1000 Brush Avenue, Detroit, MI
Fully refundableReserve now, pay when you stay
Book a stay at this boutique hotel in Detroit. Enjoy free WiFi, breakfast (surcharge), and a free area shuttle. Our guests praise the bar and the helpful staff ...
9/10 Wonderful! (1,737 reviews)
"We had a great time."

Reviewed on Mar 31, 2025

Atheneum Suite Hotel
MotorCity Casino Hotel
MotorCity Casino Hotel
4.5 out of 5
2901 Grand River Ave, Detroit, MI
Fully refundableReserve now, pay when you stay
Stay at this 4.5-star luxury hotel in Detroit. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the breakfast and the helpful staff in ...
8.6/10 Excellent! (3,695 reviews)
"Good location"

Reviewed on Apr 1, 2025

MotorCity Casino Hotel
The Westin Southfield Detroit
The Westin Southfield Detroit
4 out of 5
1500 Town Center, Southfield, MI
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in Southfield. Enjoy breakfast (surcharge), room service, and a health club. Our guests praise the helpful staff ...
8.2/10 Very Good! (1,008 reviews)
"Loved it will stay again"

Reviewed on Mar 29, 2025

The Westin Southfield Detroit
The Siren Hotel, an Ash Hotel
The Siren Hotel, an Ash Hotel
4 out of 5
1509 Broadway St., Detroit, MI
Fully refundableReserve now, pay when you stay
Stay at this 4-star hotel in Detroit. Enjoy free WiFi, 3 bars/lounges, and breakfast (surcharge). Our guests praise the restaurant and the helpful staff in our ...
8.8/10 Excellent! (1,475 reviews)
"Ivory at the front desk was a pleasure to work with."

Reviewed on Mar 30, 2025

The Siren Hotel, an Ash Hotel
Sonder Gabriel Richard
Sonder Gabriel Richard
3.5 out of 5
305 Michigan Avenue, Detroit, MI
Stay at this 3.5-star aparthotel in Detroit. Enjoy a fitness center, concierge services, and in-room washers/dryers. Our guests praise the helpful staff and ...
8.8/10 Excellent! (1,169 reviews)
"Good property and excellent area!"

Reviewed on Mar 30, 2025

Sonder Gabriel Richard
MGM Grand Detroit
MGM Grand Detroit
4.5 out of 5
1777 3rd Street, Detroit, MI
Stay at this 4.5-star luxury hotel in Detroit. Enjoy free parking, a full-service spa, and 8 restaurants. Our guests praise the helpful staff and the clean rooms ...
8.2/10 Very Good! (1,083 reviews)
"Nice casino, general eateries are overpriced. TAP restaurant is great."

Reviewed on Mar 31, 2025

MGM Grand Detroit
The Godfrey Detroit, Curio Collection By Hilton
The Godfrey Detroit, Curio Collection By Hilton
4 out of 5
1401 Michigan Avenue, Detroit, MI
Fully refundableReserve now, pay when you stay
Stay at this 4-star hotel in Detroit. Enjoy free WiFi, 2 restaurants, and 3 bars/lounges. Our guests praise the restaurant and the helpful staff in our reviews. ...
9/10 Wonderful! (1,410 reviews)
Fun stay
"Hotel staff very friendly. Only negatives were we had to make a request from the front desk twice before it was fulfilled. And when waiting for valet the second day we had to wait 30mins for our car."

Reviewed on Mar 31, 2025

The Godfrey Detroit, Curio Collection By Hilton
Fort Pontchartrain Detroit, a Wyndham Hotel
Fort Pontchartrain Detroit, a Wyndham Hotel
3.5 out of 5
2 Washington Blvd, Detroit, MI
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Detroit. Enjoy free WiFi, breakfast (surcharge), and a fitness center. Our guests praise the helpful staff and ...
8/10 Very Good! (2,052 reviews)
"The staff was not very friendly of professional"

Reviewed on Mar 30, 2025

Fort Pontchartrain Detroit, a Wyndham Hotel
Shinola Hotel
Shinola Hotel
4 out of 5
1400 Woodward Ave, Detroit, MI
Stay at this 4-star luxury hotel in Detroit. Enjoy free breakfast, free WiFi, and 4 restaurants. Our guests praise the helpful staff and the clean rooms in our ...
9.4/10 Exceptional! (1,104 reviews)
"Beautiful property. Our room was one of a kind and clean. Will be back again!"

Reviewed on Mar 31, 2025

Shinola Hotel
Cambria Hotel Detroit Downtown
Cambria Hotel Detroit Downtown
4 out of 5
600 WEST LAFAYETTE, Detroit, MI
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in Detroit. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean ...
9.2/10 Wonderful! (567 reviews)
"Great place to stay!"

Reviewed on Apr 1, 2025

Cambria Hotel Detroit Downtown
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Medical Center

Detroit is a city that has a lot going on, but you have your sights set on Medical Center. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Medical Center has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Medical Center hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of Detroit so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Medical Center underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Medical Center city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Medical Center cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Medical Center at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $100
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Medical Center hotel you want, book it, and never look back. Because your great escape is ahead of you.