Hotels Near
San Francisco

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Featured San Francisco Hotels

JW Marriott Panama
JW Marriott Panama
5 out of 5
Calle Punta Colon, Punta Pacifica, Panama City, Panama
Fully refundableReserve now, pay when you stay
Stay at this 5-star luxury hotel in Panama City. Enjoy free WiFi, 4 outdoor pools, and 3 restaurants. Our guests praise the helpful staff and the property condition ...
8.8/10 Excellent! (1,003 reviews)
"Everything about it was spectacular. Food was wonderful. Casino next door. Pool is fun. And the staff are pleasant."

Reviewed on Apr 13, 2025

JW Marriott Panama
Sheraton Grand Panama
Sheraton Grand Panama
4 out of 5
Via Israel And 77th Street, Panama City, Panama
Fully refundableReserve now, pay when you stay
Stay at this 4-star spa resort in Panama City. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff and the property condition ...
8.4/10 Very Good! (860 reviews)
5 Stars all the way
"This was simply put, an outstanding stay from start to finish. The staff were amazing, the room was clean, the housekeeping was always on time and helpful, just a wonderful experience for me and my 3 kids. We were on the club floor which was an extra special experience. These folks know what they ..."

Reviewed on Apr 6, 2025

Sheraton Grand Panama
Plaza Paitilla Inn Hotel
Plaza Paitilla Inn Hotel
3.5 out of 5
Italy Avenue, Punta Paitilla, Winston Churchill Street, Panama City, Panama
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool ...
9.2/10 Wonderful! (2,001 reviews)
"I stayed here for a week in 2023, so-so experience. I felt the property had improved a great deal. Breakfast buffet is quite excellent with a wide variety of offerings. The small workout work had improved in the quality of its equipment. I liked that an early check (5 hours) cost me only $35. Definitely ..."

Reviewed on Apr 13, 2025

Plaza Paitilla Inn Hotel
Decapolis Hotel Panama City
Decapolis Hotel Panama City
4 out of 5
Avenida Balboa Con Multicentro, Panama City, Panama
Fully refundableReserve now, pay when you stay
Stay at this 4-star spa hotel in Panama City. Enjoy free breakfast, free WiFi, and free valet parking. Our guests praise the breakfast and the helpful staff ...
8.4/10 Very Good! (1,136 reviews)
"It is great!!!"

Reviewed on Apr 13, 2025

Decapolis Hotel Panama City
Ramada Plaza By Wyndham Panama Punta Pacífica
Ramada Plaza By Wyndham Panama Punta Pacífica
4 out of 5
Via Israel y Calle 71, San Francisco, Panama City, Panama
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and room service. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (1,002 reviews)
"This was my first time in Panama and we loved it. The hotel was very comfortable and the food was amazing. We loved the blackout shades, the pool was great and we loved everything. Definitely will be back."

Reviewed on Apr 17, 2025

Ramada Plaza By Wyndham Panama Punta Pacífica
Megapolis Hotel Panamá
Megapolis Hotel Panamá
4.5 out of 5
Avenida Balboa, Panama City
Fully refundableReserve now, pay when you stay
Stay at this 4.5-star luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
8.2/10 Very Good! (847 reviews)
"The ability to interact with the staff"

Reviewed on Apr 14, 2025

Megapolis Hotel Panamá
Las Americas Golden Tower Panama
Las Americas Golden Tower Panama
4 out of 5
Av. Balboa con Calle 53, Paitilla, Panama City, Panama
Fully refundableReserve now, pay when you stay
Stay at this 4-star spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the breakfast and the helpful ...
8.8/10 Excellent! (1,002 reviews)
"Would definitely rebook again!"

Reviewed on Apr 15, 2025

Las Americas Golden Tower Panama
Residence Inn by Marriott Panama City
Residence Inn by Marriott Panama City
4 out of 5
CALLE RAMON H JURADO EDIFICO P, Panama City
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9/10 Wonderful! (452 reviews)
"I enjoyed my stay at this Marriott. My suite was roomy and comfortable. The service was excellent. My room was cleaned nicely every day. The breakfast Buffett was delicious. My only complaint is that I was given a handicapped room when I didn’t ask for one. The room was still nice , but I prefer ..."

Reviewed on Apr 15, 2025

Residence Inn by Marriott Panama City
Courtyard by Marriott Panama Multiplaza Mall
Courtyard by Marriott Panama Multiplaza Mall
4 out of 5
Via Israel Multiplaza Pacific Mall, Panama City, Panama
Stay at this 4-star business-friendly hotel in Panama City. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in ...
8.8/10 Excellent! (999 reviews)
"The staff service was excellent."

Reviewed on Mar 31, 2025

Courtyard by Marriott Panama Multiplaza Mall
Aloft Panama
Aloft Panama
3.5 out of 5
Via Israel & Calle 76, Panama City, Panama
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star business-friendly hotel in Panama City. Enjoy free WiFi, free parking, and a nightclub. Our guests praise the helpful staff in our reviews. ...
8.6/10 Excellent! (797 reviews)
"Great place to stay if your traveling with family."

Reviewed on Mar 27, 2025

Aloft Panama
San Francisco by Wynwood House
San Francisco by Wynwood House
4 out of 5
C. 73 Este, Panama City, Provincia de Panamá
Stay at this 4-star aparthotel in Panama City. Enjoy free WiFi, valet parking (surcharge), and a 24-hour front desk. Popular attractions Albrook Shopping Mall ...
9.4/10 Exceptional! (34 reviews)
A Week in Panama City
"Great place to stay while visiting Panama. Very walkable to restaurants, bars, shopping, etc. Great views of the city from balcony and rooftop pool. Ubers available all the time and very affordable. We would definitely stay again."

Reviewed on Apr 16, 2025

San Francisco by Wynwood House
Boutique Apartments Panamá Coco del Mar
Boutique Apartments Panamá Coco del Mar
3.5 out of 5
Av. Cincuentenario, Panama City, Provincia de Panamá
Stay at this 3.5-star apartment in Panama City. Enjoy free WiFi, free parking, and an outdoor pool. Popular attractions Albrook Shopping Mall and Multiplaza ...
7.2/10 Good! (86 reviews)
"We always stay here. Apt 21B is nice! Will be back for sure."

Reviewed on Apr 5, 2025

Boutique Apartments Panamá Coco del Mar
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in San Francisco

Panama City is a city that has a lot going on, but you have your sights set on San Francisco. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that San Francisco has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of San Francisco hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of Panama City so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the San Francisco underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the San Francisco city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of San Francisco cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in San Francisco at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $103
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the San Francisco hotel you want, book it, and never look back. Because your great escape is ahead of you.