Hotels Near
San Francisco

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Featured San Francisco Hotels

Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
Avenida Balboa Panama City
Fully refundableReserve now, pay when you stay
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
8.4/10 Very Good! (1,281 reviews)
Clean room, comfortable, spacious. The breakfast was really good!

Reviewed on Dec 18, 2025

Megapolis Hotel Panamá
Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

4 out of 5
Av. Balboa con Calle 53 Panama City Panama
Fully refundableReserve now, pay when you stay
Book a stay at this spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the breakfast and the helpful ...
8.8/10 Excellent! (1,015 reviews)
It was a very nice stay. The room is nice, organized and clean with a great view of the city. The blankets are a little too warm and we wished for a lighter blankets. Breakfast buffet was very good with many food choices and best custom eggs cooked tailored to our demands. Uber to Casco Viejo was ...

Reviewed on Dec 15, 2025

Las Americas Golden Tower Panama
Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel

3.5 out of 5
Italy Avenue, Punta Paitilla Panama City Panama
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in ...
9.2/10 Wonderful! (2,140 reviews)
I had a wonderful stay at this hotel and highly recommend it. The location is excellent and very central, very close to the Jewish community, including a synagogue and Chabad. Everything is within walking distance — a pleasant neighborhood with a park, supermarket, pharmacy, and a shopping mall. ...

Reviewed on Dec 21, 2025

Plaza Paitilla Inn Hotel
JW Marriott Panama

JW Marriott Panama

5 out of 5
Calle Punta Colon, Punta Pacifica Panama City Panama
Fully refundableReserve now, pay when you stay
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, 4 outdoor pools, and 3 restaurants. Our guests praise the helpful staff in our reviews. Popular ...
8.8/10 Excellent! (1,000 reviews)
Just wonderful hotel

Reviewed on Dec 16, 2025

JW Marriott Panama
Sheraton Grand Panama

Sheraton Grand Panama

4 out of 5
Via Israel And 77th Street Panama City Panama
Fully refundableReserve now, pay when you stay
Book a stay at this spa resort in Panama City. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff and the property condition ...
8.4/10 Very Good! (993 reviews)
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Reviewed on Dec 11, 2025

Sheraton Grand Panama
Decapolis Hotel Panama City

Decapolis Hotel Panama City

4 out of 5
Avenida Balboa Con Multicentro Panama City Panama
Fully refundableReserve now, pay when you stay
Book a stay at this spa hotel in Panama City. Enjoy free breakfast, free WiFi, and free valet parking. Our guests praise the breakfast and the helpful staff ...
8.4/10 Very Good! (1,458 reviews)
Clean room… amazing staff, breakfast was delicious our favorite hotel always

Reviewed on Dec 19, 2025

Decapolis Hotel Panama City
Ramada Plaza by Wyndham Panama Punta Pacifica

Ramada Plaza by Wyndham Panama Punta Pacifica

4 out of 5
Via Israel y Calle 71, San Francisco Panama City Panama
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and room service. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (1,121 reviews)
Super confortable, clean, Nice personnel!! Love our stay

Reviewed on Dec 16, 2025

Ramada Plaza by Wyndham Panama Punta Pacifica
Aloft Panama

Aloft Panama

3.5 out of 5
Via Israel & Calle 76 Panama City Panama
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Panama City. Enjoy free WiFi, free parking, and a nightclub. Our guests praise the helpful staff in our reviews. ...
8.6/10 Excellent! (893 reviews)
The room allowed for a beautiful view of both city and ocean. The layout was modern, different, but also beautiful. A microwave would have been an easy convenience for reheating of left over food from their onsite restaurants. I particularly loved the conjoined areas to step over into Sheraton hotel ...

Reviewed on Dec 16, 2025

Aloft Panama
Residence Inn by Marriott Panama City

Residence Inn by Marriott Panama City

4 out of 5
CALLE RAMON H JURADO EDIFICO P Panama City
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9/10 Wonderful! (540 reviews)
Excellent !

Reviewed on Dec 19, 2025

Residence Inn by Marriott Panama City
Courtyard by Marriott Panama Multiplaza Mall

Courtyard by Marriott Panama Multiplaza Mall

4 out of 5
Via Israel Multiplaza Pacific Mall Panama City Panama
Book a stay at this business-friendly hotel in Panama City. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in ...
8.8/10 Excellent! (1,003 reviews)
Didn't have breakfast but very nice hotel connected to the mall which around Christmas time was chaotic

Reviewed on Dec 17, 2025

Courtyard by Marriott Panama Multiplaza Mall
San Francisco by Wynwood House

San Francisco by Wynwood House

3 out of 5
C. 73 Este 12250 Panama City Provincia de Panamá
Stay at this aparthotel in Panama City. Enjoy free WiFi, valet parking (surcharge), and a 24-hour front desk. Popular attractions Albrook Shopping Mall and Multiplaza ...
9/10 Wonderful! (56 reviews)
Clean and walkable location

Reviewed on Dec 7, 2025

San Francisco by Wynwood House
ESHEL SUITES PANAMA

ESHEL SUITES PANAMA

2.5 out of 5
9 C. Tomas Gabriel Duque Panama City Panamá Province
Stay at this aparthotel in Panama City. Enjoy free WiFi, parking (surcharge), and an airport shuttle (surcharge). Popular attractions Albrook Shopping Mall and ...
10/10 Exceptional! (5 reviews)
Loved the property and the location, it was clean , nice and I really enjoyed my stay there

Reviewed on Apr 4, 2025

ESHEL SUITES PANAMA
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in San Francisco

Panama City is a city that has a lot going on, but you have your sights set on San Francisco. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that San Francisco has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of San Francisco hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of Panama City so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the San Francisco underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the San Francisco city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of San Francisco cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in San Francisco at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $111
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the San Francisco hotel you want, book it, and never look back. Because your great escape is ahead of you.