Hotels Near
San Francisco

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Featured San Francisco Hotels

JW Marriott Panama
JW Marriott Panama
5 out of 5
Calle Punta Colon, Punta Pacifica, Panama City, Panama
Fully refundableReserve now, pay when you stay
Stay at this 5-star luxury hotel in Panama City. Enjoy free WiFi, 4 outdoor pools, and 3 restaurants. Our guests praise the helpful staff and the property condition ...
8.8/10 Excellent! (1,003 reviews)
"Best place to enjoy a vacation"

Reviewed on May 3, 2025

JW Marriott Panama
Plaza Paitilla Inn Hotel
Plaza Paitilla Inn Hotel
3.5 out of 5
Italy Avenue, Punta Paitilla, Winston Churchill Street, Panama City, Panama
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool ...
9.2/10 Wonderful! (2,040 reviews)
"Clean and nice view"

Reviewed on May 5, 2025

Plaza Paitilla Inn Hotel
Megapolis Hotel Panamá
Megapolis Hotel Panamá
4.5 out of 5
Avenida Balboa, Panama City
Fully refundableReserve now, pay when you stay
Stay at this 4.5-star luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
8.2/10 Very Good! (880 reviews)
"Property I’d very nice clean and in a very nice and safe area"

Reviewed on May 6, 2025

Megapolis Hotel Panamá
Las Americas Golden Tower Panama
Las Americas Golden Tower Panama
4 out of 5
Av. Balboa con Calle 53, Paitilla, Panama City, Panama
Fully refundableReserve now, pay when you stay
Stay at this 4-star spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the breakfast and the helpful ...
8.8/10 Excellent! (1,001 reviews)
"Great stay ! Stayed here for one night and the staff was very accommodating, gave me a wonderful room with a nice view. Would definitely stay here again!"

Reviewed on May 7, 2025

Las Americas Golden Tower Panama
Ramada Plaza By Wyndham Panama Punta Pacífica
Ramada Plaza By Wyndham Panama Punta Pacífica
4 out of 5
Via Israel y Calle 71, San Francisco, Panama City, Panama
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and room service. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (1,009 reviews)
"If you are looking for a very clean, great location and excellent staff this would bne the place. This is the only place we stay we when we fly into the city."

Reviewed on May 1, 2025

Ramada Plaza By Wyndham Panama Punta Pacífica
Decapolis Hotel Panama City
Decapolis Hotel Panama City
4 out of 5
Avenida Balboa Con Multicentro, Panama City, Panama
Fully refundableReserve now, pay when you stay
Stay at this 4-star spa hotel in Panama City. Enjoy free breakfast, free WiFi, and free valet parking. Our guests praise the breakfast and the helpful staff ...
8.4/10 Very Good! (1,180 reviews)
"Awesome staff"

Reviewed on May 4, 2025

Decapolis Hotel Panama City
Sheraton Grand Panama
Sheraton Grand Panama
4 out of 5
Via Israel And 77th Street, Panama City, Panama
Fully refundableReserve now, pay when you stay
Stay at this 4-star spa resort in Panama City. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff and the property condition ...
8.4/10 Very Good! (865 reviews)
5 Stars all the way
"This was simply put, an outstanding stay from start to finish. The staff were amazing, the room was clean, the housekeeping was always on time and helpful, just a wonderful experience for me and my 3 kids. We were on the club floor which was an extra special experience. These folks know what they ..."

Reviewed on Apr 6, 2025

Sheraton Grand Panama
Courtyard by Marriott Panama Multiplaza Mall
Courtyard by Marriott Panama Multiplaza Mall
4 out of 5
Via Israel Multiplaza Pacific Mall, Panama City, Panama
Stay at this 4-star business-friendly hotel in Panama City. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in ...
8.8/10 Excellent! (1,001 reviews)
"It was quiet staff very helpful worth the stay"

Reviewed on Apr 27, 2025

Courtyard by Marriott Panama Multiplaza Mall
Residence Inn by Marriott Panama City
Residence Inn by Marriott Panama City
4 out of 5
CALLE RAMON H JURADO EDIFICO P, Panama City
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9/10 Wonderful! (461 reviews)
"This is a well maintained property, it is very clean and I found the amenities very convenient. The breakfast options were really good as well. The hotel staff were friendly and very helpful."

Reviewed on May 7, 2025

Residence Inn by Marriott Panama City
Aloft Panama
Aloft Panama
3.5 out of 5
Via Israel & Calle 76, Panama City, Panama
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star business-friendly hotel in Panama City. Enjoy free WiFi, free parking, and a nightclub. Our guests praise the helpful staff in our reviews. ...
"Staff that work at restaurants are extremely helpful and friendly"

Reviewed on Apr 29, 2025

Aloft Panama
San Francisco by Wynwood House
San Francisco by Wynwood House
4 out of 5
C. 73 Este, Panama City, Provincia de Panamá
Stay at this 4-star aparthotel in Panama City. Enjoy free WiFi, valet parking (surcharge), and a 24-hour front desk. Popular attractions Albrook Shopping Mall ...
9.4/10 Exceptional! (37 reviews)
"Very neat and lots of restaurants in the area. Mall is close by."

Reviewed on Apr 21, 2025

San Francisco by Wynwood House
Boutique Apartments Panamá Coco del Mar
Boutique Apartments Panamá Coco del Mar
3.5 out of 5
Av. Cincuentenario, Panama City, Provincia de Panamá
Stay at this 3.5-star apartment in Panama City. Enjoy free WiFi, free parking, and an outdoor pool. Popular attractions Albrook Shopping Mall and Multiplaza ...
7.2/10 Good! (87 reviews)
"Spectacular view from the 31st floor of the city and partial ocean greeted us every morning, with a nice little patio to enjoy it from too. Three bedrooms, all with nice beds, plus a nice and large main and dining area. Everything worked well, including the air conditioning. Very safe residential ..."

Reviewed on May 5, 2025

Boutique Apartments Panamá Coco del Mar
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in San Francisco

Panama City is a city that has a lot going on, but you have your sights set on San Francisco. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that San Francisco has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of San Francisco hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of Panama City so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the San Francisco underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the San Francisco city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of San Francisco cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in San Francisco at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $102
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the San Francisco hotel you want, book it, and never look back. Because your great escape is ahead of you.