Hotels Near
San Francisco

Photo by Hideki Yamagata

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Featured San Francisco Hotels

Sheraton Grand Panama
Sheraton Grand Panama
4 out of 5
Via Israel And 77th Street, Panama City, Panama
Fully refundableReserve now, pay when you stay
Stay at this 4-star spa resort in Panama City. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff and the property condition ...
8.4/10 Very Good! (890 reviews)
"I attended an event and thia was well staffed. Beautiful place!"

Reviewed on Jun 30, 2025

Sheraton Grand Panama
JW Marriott Panama
JW Marriott Panama
5 out of 5
Calle Punta Colon, Punta Pacifica, Panama City, Panama
Fully refundableReserve now, pay when you stay
Stay at this 5-star luxury hotel in Panama City. Enjoy free WiFi, 4 outdoor pools, and 3 restaurants. Our guests praise the helpful staff and the property condition ...
8.8/10 Excellent! (1,006 reviews)
"We truly enjoyed our stay at this hotel and will be back in future!"

Reviewed on Jul 7, 2025

JW Marriott Panama
Ramada Plaza By Wyndham Panama Punta Pacífica
Ramada Plaza By Wyndham Panama Punta Pacífica
4 out of 5
Via Israel y Calle 71, San Francisco, Panama City, Panama
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and room service. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (1,003 reviews)
"Beauty"

Reviewed on Jul 6, 2025

Ramada Plaza By Wyndham Panama Punta Pacífica
Megapolis Hotel Panamá
Megapolis Hotel Panamá
4.5 out of 5
Avenida Balboa, Panama City
Fully refundableReserve now, pay when you stay
Stay at this 4.5-star luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
8.2/10 Very Good! (938 reviews)
"Staff was friendly,"

Reviewed on Jul 8, 2025

Megapolis Hotel Panamá
Decapolis Hotel Panama City
Decapolis Hotel Panama City
4 out of 5
Avenida Balboa Con Multicentro, Panama City, Panama
Fully refundableReserve now, pay when you stay
Stay at this 4-star spa hotel in Panama City. Enjoy free breakfast, free WiFi, and free valet parking. Our guests praise the breakfast and the helpful staff ...
8.4/10 Very Good! (1,231 reviews)
"Nice hotel. Good area"

Reviewed on Jul 9, 2025

Decapolis Hotel Panama City
Las Americas Golden Tower Panama
Las Americas Golden Tower Panama
4 out of 5
Av. Balboa con Calle 53, Paitilla, Panama City, Panama
Fully refundableReserve now, pay when you stay
Stay at this 4-star spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the breakfast and the helpful ...
8.8/10 Excellent! (1,000 reviews)
"Good hotel for the price that I paid"

Reviewed on Jun 30, 2025

Las Americas Golden Tower Panama
Plaza Paitilla Inn Hotel
Plaza Paitilla Inn Hotel
3.5 out of 5
Italy Avenue, Punta Paitilla, Winston Churchill Street, Panama City, Panama
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool ...
9.2/10 Wonderful! (2,064 reviews)
"Awesome place to stay. The breakfast was really good, and the staff was very nice."

Reviewed on Jul 7, 2025

Plaza Paitilla Inn Hotel
Residence Inn by Marriott Panama City
Residence Inn by Marriott Panama City
4 out of 5
CALLE RAMON H JURADO EDIFICO P, Panama City
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9/10 Wonderful! (481 reviews)
"No nonsense business hotel. Good location. HUGE rooms. Complicated access to the elevator from the street or mall; it’s somewhat hidden and then in the elevator itself, the Lobby floor was a bit of a mystery or guessing game."

Reviewed on Jun 30, 2025

Residence Inn by Marriott Panama City
Courtyard by Marriott Panama Multiplaza Mall
Courtyard by Marriott Panama Multiplaza Mall
4 out of 5
Via Israel Multiplaza Pacific Mall, Panama City, Panama
Stay at this 4-star business-friendly hotel in Panama City. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in ...
8.8/10 Excellent! (1,001 reviews)
"Overall clean. A bathrooms a bit dated. Breakfast was good. And locations was good for shopping as its right across multiplaza mall."

Reviewed on Jul 3, 2025

Courtyard by Marriott Panama Multiplaza Mall
Aloft Panama
Aloft Panama
3.5 out of 5
Via Israel & Calle 76, Panama City, Panama
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star business-friendly hotel in Panama City. Enjoy free WiFi, free parking, and a nightclub. Our guests praise the helpful staff in our reviews. ...
8.6/10 Excellent! (819 reviews)
"Excelente ubicación , equipo de trabajadores ,limpieza , nos gustó mucho la atención ,el desayuno delicioso ,gracias y volveremos."

Reviewed on Jul 7, 2025

Aloft Panama
Boutique Apartments Panamá Coco del Mar
Boutique Apartments Panamá Coco del Mar
3.5 out of 5
Av. Cincuentenario, Panama City, Provincia de Panamá
Stay at this 3.5-star apartment in Panama City. Enjoy free WiFi, free parking, and an outdoor pool. Popular attractions Albrook Shopping Mall and Multiplaza ...
7.2/10 Good! (103 reviews)
"The property is located in a perfect easy accessible location. It was very clean and dmall essentials were missing like salt sugar, the 2nd bedroom was missing the ac control so my son and mother had to sleep in the living room. Theyofferedtocome during hours that i had planned tours in the city. ..."

Reviewed on Jul 8, 2025

Boutique Apartments Panamá Coco del Mar
San Francisco by Wynwood House
San Francisco by Wynwood House
4 out of 5
C. 73 Este, Panama City, Provincia de Panamá
Stay at this 4-star aparthotel in Panama City. Enjoy free WiFi, valet parking (surcharge), and a 24-hour front desk. Popular attractions Albrook Shopping Mall ...
9.4/10 Exceptional! (38 reviews)
"✅ What I Loved 1. Very Safe & Walkable The San Francisco neighborhood feels secure at all hours. Busy, well-lit streets and friendly locals made evening strolls stress‑free—perfect for exploring on foot. 2. Convenient Food & Grocery Access You’re spoiled for choice! Within just a few blocks, you’ll ..."

Reviewed on Jun 14, 2025

San Francisco by Wynwood House
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in San Francisco

Panama City is a city that has a lot going on, but you have your sights set on San Francisco. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that San Francisco has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of San Francisco hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of Panama City so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the San Francisco underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the San Francisco city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of San Francisco cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in San Francisco at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $102
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the San Francisco hotel you want, book it, and never look back. Because your great escape is ahead of you.