Hotels Near
Santa Ana

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Featured Santa Ana Hotels

Casco View Apartments
Casco View Apartments
3 out of 5
C. 16 Oeste, Panama City, Provincia de Panamá
Stay at this 3-star condo in Panama City. Enjoy free WiFi, premium bedding, and in-room washers/dryers. Popular attractions Albrook Shopping Mall and Cinta Costera ...
9.2/10 Wonderful! (39 reviews)
"I liked the buildings quietness and modern style."

Reviewed on Jun 23, 2025

Casco View Apartments
Hotel Riu Plaza Panama
Hotel Riu Plaza Panama
5 out of 5
Calle 50, Urb. Marbella, Panama City, Panama
Fully refundableReserve now, pay when you stay
Stay at this 5-star luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. ...
9/10 Wonderful! (4,093 reviews)
"I really love it there it reminds me of home"

Reviewed on Jul 12, 2025

Hotel Riu Plaza Panama
Dreams Playa Bonita Panama - All Inclusive
Dreams Playa Bonita Panama - All Inclusive
4 out of 5
KM 7, Road to Veracruz, Veracruz, Panama
Fully refundableReserve now, pay when you stay
Stay at this 4-star beach property in Veracruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the pool and the helpful staff in our reviews. ...
7.2/10 Good! (1,001 reviews)
"We had a wonderful stay at Dreams Playa Bonita. The staff is very welcoming and hospitable. The room was clean and with a beautiful beach view. We loved that they had breakfast, lunch, and dinner all included. They also have coffee and snack shops open throughout the day! To us, this has been the ..."

Reviewed on Jul 5, 2025

Dreams Playa Bonita Panama - All Inclusive
Sheraton Grand Panama
Sheraton Grand Panama
4 out of 5
Via Israel And 77th Street, Panama City, Panama
Fully refundableReserve now, pay when you stay
Stay at this 4-star spa resort in Panama City. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff and the property condition ...
8.4/10 Very Good! (891 reviews)
"a clean and nice hotel , Lobby area was very nice with some nice shopping places, the rooms need a little update especially the bathroom, the service was excellent friendly and courteous"

Reviewed on Jul 8, 2025

Sheraton Grand Panama
Crowne Plaza Panama Airport by IHG
Crowne Plaza Panama Airport by IHG
4 out of 5
Ave. Domingo Diaz, Corregimineto De Tocumen Hacia El, Tocumen, Panama
Fully refundable
Stay at this 4-star family-friendly hotel in Tocumen. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the breakfast and ...
8.4/10 Very Good! (2,144 reviews)
"Not bad for a stop through"

Reviewed on Jul 7, 2025

Crowne Plaza Panama Airport by IHG
Waymore Hotel Spa & Casino
Waymore Hotel Spa & Casino
4 out of 5
Calle Augusto Samuel Boyd y Calle Eusebi, Panama City
Fully refundableReserve now, pay when you stay
Stay at this 4-star spa B&B in Panama City. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Albrook Shopping Mall and Via Espana are located ...
9/10 Wonderful! (332 reviews)
"This is a very clean and fancy hotel. The location is not ideal, but the amenities make it worth it."

Reviewed on Jul 10, 2025

Waymore Hotel Spa & Casino
The Westin Playa Bonita Panama
The Westin Playa Bonita Panama
5 out of 5
Km 6 Road to Veracruz, Veracruz, Panama
Fully refundableReserve now, pay when you stay
Stay at this 5-star luxury hotel in Veracruz. Enjoy free parking, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
8/10 Very Good! (1,006 reviews)
"Excellent"

Reviewed on Jul 8, 2025

The Westin Playa Bonita Panama
Hotel El Panama by Faranda Grand, a member of Radisson Individuals
Hotel El Panama by Faranda Grand, a member of Radisson Individuals
4 out of 5
Via Espana 111, Panama City, Panama
Stay at this 4-star spa hotel in Panama City. Enjoy free breakfast, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. ...
7.6/10 Good! (1,002 reviews)
"close to transport, needs to be better mentain"

Reviewed on Jul 6, 2025

Hotel El Panama by Faranda Grand, a member of Radisson Individuals
JW Marriott Panama
JW Marriott Panama
5 out of 5
Calle Punta Colon, Punta Pacifica, Panama City, Panama
Fully refundableReserve now, pay when you stay
Stay at this 5-star luxury hotel in Panama City. Enjoy free WiFi, 4 outdoor pools, and 3 restaurants. Our guests praise the helpful staff and the property condition ...
8.8/10 Excellent! (1,009 reviews)
Excellent overall
"Wonderful hotel for a long stay. Breakfast at the executive club has excellent service. Suites are excellent and beds are comfortable. Corridors of the floors where the rooms are, are always dirty and need vacuuming. Food trays from room service stay outside the rooms forever."

Reviewed on Jul 8, 2025

JW Marriott Panama
Ramada Plaza By Wyndham Panama Punta Pacífica
Ramada Plaza By Wyndham Panama Punta Pacífica
4 out of 5
Via Israel y Calle 71, San Francisco, Panama City, Panama
Stay at this 4-star business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and room service. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (1,007 reviews)
Nice place
"Nice hotel at a decent price, check in was awkward but no problems. Easy check out."

Reviewed on Jul 9, 2025

Ramada Plaza By Wyndham Panama Punta Pacífica
Megapolis Hotel Panamá
Megapolis Hotel Panamá
4.5 out of 5
Avenida Balboa, Panama City
Fully refundableReserve now, pay when you stay
Stay at this 4.5-star luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
8.2/10 Very Good! (945 reviews)
"Big hotel. Uber are very easy and cheap to get"

Reviewed on Jul 9, 2025

Megapolis Hotel Panamá
Principe Hotel and Suites
Principe Hotel and Suites
3 out of 5
Via Argentina, Panama City, Panama
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in Panama City. Enjoy free WiFi, free parking, and room service. Our guests praise the helpful staff and the clean ...
8.8/10 Excellent! (1,391 reviews)
"Good place to stay."

Reviewed on Jul 10, 2025

Principe Hotel and Suites
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Santa Ana

Panama City is a city that has a lot going on, but you have your sights set on Santa Ana. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Santa Ana has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Santa Ana hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of Panama City so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Santa Ana underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Santa Ana city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Santa Ana cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Santa Ana at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $64
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Santa Ana hotel you want, book it, and never look back. Because your great escape is ahead of you.