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Independent in Southeast Missouri

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Featured Southeast Missouri Independent

The Riverview

The Riverview

4 out of 5
777 Main St Cape Girardeau MO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free WiFi, free parking, and 2 restaurants. Popular attractions Isle Casino Cape Girardeau ...
The Riverview
The Farmstead Hotel

The Farmstead Hotel

2.5 out of 5
778 E 3rd St Caruthersville MO
Fully refundableReserve now, pay when you stay
Stay at this hotel in Caruthersville. Enjoy free WiFi, free parking, and a casino. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
The Farmstead Hotel
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

2.5 out of 5
100 Matthews Lane Sikeston MO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Century Casino & Hotel Caruthersville

Century Casino & Hotel Caruthersville

2 out of 5
777 E 3rd St Caruthersville MO
Fully refundableReserve now, pay when you stay
Stay at this hotel in Caruthersville. Enjoy free WiFi, free parking, and a casino. Popular attractions Century Casino Caruthersville and Caruthersville Public ...
Century Casino & Hotel Caruthersville
Honeysuckle Inn - Mountain View

Honeysuckle Inn - Mountain View

3 out of 5
1207 E Hwy 60 Mountain View MO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Mountain View. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
Honeysuckle Inn - Mountain View
Dexter Inn

Dexter Inn

2.5 out of 5
1807 W Business US Highway 60 Dexter MO
Fully refundableReserve now, pay when you stay
Stay at this hotel in Dexter. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff in our reviews. Popular attractions The ...
Dexter Inn
New Orleans Inn Portageville

New Orleans Inn Portageville

2.5 out of 5
600 US-61 Portageville MO
Fully refundableReserve now, pay when you stay
Stay at this motel in Portageville. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our ...
New Orleans Inn Portageville
Echo Bluff State Park

Echo Bluff State Park

2.5 out of 5
34489 Echo Bluff Dr Eminence MO
Book a stay at this business-friendly hotel in Eminence. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Echo Bluff State Park and ...
Echo Bluff State Park
Town House Inn Cape Giradreau

Town House Inn Cape Giradreau

2.5 out of 5
505 North Kingshighway Street Cape Girardeau MO
Fully refundableReserve now, pay when you stay
Stay at this motel in Cape Girardeau. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Cape Splash Family Aquatic Center and Show ...
Town House Inn Cape Giradreau
Town House Inn

Town House Inn

2.5 out of 5
517 E Jackson Blvd Jackson MO
Fully refundableReserve now, pay when you stay
Stay at this motel in Jackson. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff in our reviews. Popular attractions ...
Town House Inn
Madison Inn Lodge

Madison Inn Lodge

2.5 out of 5
730 Plaza Drive Fredericktown MO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly motel in Fredericktown. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the property condition in ...
Madison Inn Lodge
Current River Inn

Current River Inn

3 out of 5
602 Main St Van Buren MO
Fully refundableReserve now, pay when you stay
Stay at this motel in Van Buren. Enjoy free WiFi, free parking, and an outdoor pool. Popular attractions Watercress Spring Camp and Watercress Spring Picnic ...
Current River Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Independent hotels in Southeast Missouri

You’ve already taken the guesswork out of your next vacation. You know you want a Independent hotel in Southeast Missouri. What can you say? You like their style, they’re in a good part of Southeast Missouri, and they never let you down. New bar in town? You’re the first one to check it out. Spiciest item on the menu? You can take the heat. But even the best gamblers hedge their bets. No matter how crazy good your trip is, you want something familiar waiting for you at the end of the day.

All in a name

We all have favorites. There’s nothing wrong with knowing what you like. You like to stay at Independent near , Southeast Missouri to do the tourist thing (because sometimes it is fun) and then hit up the places that aren’t on the map. And no matter what fun you get into, you have Independent hotels with their comfy beds and thoughtful amenities waiting to tuck you in.

As you like it

Have a price you want to stick to, so you can paint the town red? Maybe, it’s all about the hotel features. Who couldn’t use a hot tub? Pick your pleasure by:

  • Hotwire Hot Rate: Grab the Independent hotel in Southeast Missouri at an absolute steal. After you book it, we’ll tell you the hotel name. You might nab that 4-star hotel for a 2-star price.
  • Price: How low can we go? Quite low in fact. Check out our prices per night, starting at $64.
  • Amenities: Grab a cocktail at the lounge and maybe wander upstairs to the rooftop terrace—all the stuff that makes a great vacay.

You’ve already done the hard part—figuring out where you want to stay. Now it’s time to use the money you saved to let the real fun begin. Underground shows? Off-beat attractions? Rooftop escapes? The choice is yours. The only thing wonderfully predictable about this trip is the Independent room you’ll be staying in.