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Independent in Southeast Missouri

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Tonight Jan 11 - Jan 12Next weekend Jan 17 - Jan 19

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Featured Southeast Missouri Independent

The Riverview
The Riverview
3.5 out of 5
777 Main St, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star hotel in Cape Girardeau. Enjoy free WiFi, free parking, and 2 restaurants. Popular attractions Isle Casino Cape Girardeau and Riverfront ...
The Riverview
New Orleans Inn Portageville
New Orleans Inn Portageville
2.5 out of 5
600 US-61, Portageville, MO
Fully refundableReserve now, pay when you stay
Stay at this motel in Portageville. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our ...
New Orleans Inn Portageville
The Farmstead Hotel
The Farmstead Hotel
2.5 out of 5
778 E 3rd St, Caruthersville, MO
Fully refundableReserve now, pay when you stay
Stay at this hotel in Caruthersville. Enjoy free WiFi, free parking, and a casino. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
The Farmstead Hotel
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 out of 5
100 Matthews Lane, Sikeston, MO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Town House Inn
Town House Inn
2.5 out of 5
517 E Jackson Blvd, Jackson, MO
Fully refundableReserve now, pay when you stay
Stay at this motel in Jackson. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff in our reviews. Popular attractions ...
Town House Inn
Dexter Inn
Dexter Inn
2.5 out of 5
1807 W Business US Highway 60, Dexter, MO
Fully refundableReserve now, pay when you stay
Stay at this hotel in Dexter. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff in our reviews. Popular attractions The ...
Dexter Inn
Country Yard Inn and Suite
Country Yard Inn and Suite
2 out of 5
110 South Interstate Drive, Sikeston, MO
Fully refundableReserve now, pay when you stay
Stay at this motel in Sikeston. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions The Book Bug and Boot Heel Golf Club are located ...
Country Yard Inn and Suite
Echo Bluff State Park
Echo Bluff State Park
2.5 out of 5
34489 Echo Bluff Dr, Salem, MO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Salem. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Echo Bluff State Park and ...
Echo Bluff State Park
Bullwinkles Rustic Lodge
Bullwinkles Rustic Lodge
2.5 out of 5
399 Hwy T, Poplar Bluff, MO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Poplar Bluff. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
Bullwinkles Rustic Lodge
Madison Inn Lodge
Madison Inn Lodge
2.5 out of 5
730 Plaza Drive, Fredericktown, MO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly motel in Fredericktown. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the property condition in ...
Madison Inn Lodge
Honeysuckle Inn - Mountain View
Honeysuckle Inn - Mountain View
3 out of 5
1207 E Hwy 60, Mountain View, MO
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in Mountain View. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
Honeysuckle Inn - Mountain View
Town House Inn Cape Giradreau
Town House Inn Cape Giradreau
2.5 out of 5
505 North Kingshighway Street, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
Stay at this motel in Cape Girardeau. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Cape Splash Family Aquatic Center and Show ...
Town House Inn Cape Giradreau
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Independent hotels in Southeast Missouri

You’ve already taken the guesswork out of your next vacation. You know you want a Independent hotel in Southeast Missouri. What can you say? You like their style, they’re in a good part of Southeast Missouri, and they never let you down. New bar in town? You’re the first one to check it out. Spiciest item on the menu? You can take the heat. But even the best gamblers hedge their bets. No matter how crazy good your trip is, you want something familiar waiting for you at the end of the day.

All in a name

We all have favorites. There’s nothing wrong with knowing what you like. You like to stay at Independent near , Southeast Missouri to do the tourist thing (because sometimes it is fun) and then hit up the places that aren’t on the map. And no matter what fun you get into, you have Independent hotels with their comfy beds and thoughtful amenities waiting to tuck you in.

As you like it

Have a price you want to stick to, so you can paint the town red? Maybe, it’s all about the hotel features. Who couldn’t use a hot tub? Pick your pleasure by:

  • Hotwire Hot Rate: Grab the Independent hotel in Southeast Missouri at an absolute steal. After you book it, we’ll tell you the hotel name. You might nab that 4-star hotel for a 2-star price.
  • Price: How low can we go? Quite low in fact. Check out our prices per night, starting at $64.
  • Amenities: Grab a cocktail at the lounge and maybe wander upstairs to the rooftop terrace—all the stuff that makes a great vacay.

You’ve already done the hard part—figuring out where you want to stay. Now it’s time to use the money you saved to let the real fun begin. Underground shows? Off-beat attractions? Rooftop escapes? The choice is yours. The only thing wonderfully predictable about this trip is the Independent room you’ll be staying in.