Search for Cheap Deals on
4 Star Hotels in Central San Diego

You choose what matters — star rating, location, amenities.

We pick the perfect hotel, packed with all your must-haves.

Your hotel is revealed right after booking!


Featured 4 Star Central San Diego Hotels

San Diego Marriott La Jolla
4 out of 5
Fully refundableReserve now, pay when you stay
  • 23 min drive from San Diego Zoo
The price is $171 per night from Mar 14 to Mar 15
$171
includes taxes & fees
Mar 14 - Mar 15
Stay at this 4-star business-friendly hotel in La Jolla. Enjoy breakfast (surcharge), a 24-hour fitness center, and WiFi (surcharge). Our guests praise the helpful ...
San Diego Marriott La Jolla
Lafayette Hotel & Club
4 out of 5
Fully refundableReserve now, pay when you stay
  • 26 min walk from San Diego Zoo
The price is $232 per night from Mar 13 to Mar 14
$232
includes taxes & fees
Mar 13 - Mar 14
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 3 bars/lounges. Our guests praise the helpful staff in our reviews. ...
Lafayette Hotel & Club
Legacy Resort Hotel & Spa
4 out of 5
Fully refundableReserve now, pay when you stay
  • 4 min drive from San Diego Zoo
The price is $202 per night from Mar 16 to Mar 17
$202
includes taxes & fees
Mar 16 - Mar 17
Stay at this 4-star spa hotel in San Diego. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the pool and the restaurant in ...
Legacy Resort Hotel & Spa
Save an average of 15% on thousands of hotels when you're signed in
Sheraton Mission Valley San Diego Hotel
4 out of 5
Fully refundableReserve now, pay when you stay
  • 5 min drive from San Diego Zoo
The price is $133 per night from Mar 23 to Mar 24
$133
includes taxes & fees
Mar 23 - Mar 24
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and 24-hour room service. Our guests praise the helpful staff ...
Sheraton Mission Valley San Diego Hotel
Hilton San Diego Mission Valley
4 out of 5
Fully refundableReserve now, pay when you stay
  • 5 min drive from San Diego Zoo
The price is $141 per night from Mar 16 to Mar 17
$141
includes taxes & fees
Mar 16 - Mar 17
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and 24-hour room service. Our guests praise the helpful staff ...
Hilton San Diego Mission Valley
Town and Country San Diego
4 out of 5
  • 5 min drive from San Diego Zoo
The price is $213 per night from Mar 14 to Mar 15
$213
includes taxes & fees
Mar 14 - Mar 15
Stay at this 4-star golf hotel in San Diego. Enjoy free WiFi, 2 outdoor pools, and 2 restaurants. Our guests praise the pool and the helpful staff in our reviews. ...
Town and Country San Diego
DoubleTree by Hilton Hotel San Diego - Mission Valley
4 out of 5
Fully refundableReserve now, pay when you stay
  • 6 min drive from San Diego Zoo
The price is $166 per night from Mar 14 to Mar 15
$166
includes taxes & fees
Mar 14 - Mar 15
Book a stay at this business-friendly hotel in San Diego. Enjoy breakfast (surcharge), room service, and a 24-hour fitness center. Our guests praise the helpful ...
DoubleTree by Hilton Hotel San Diego - Mission Valley
Embassy Suites by Hilton San Diego La Jolla
4 out of 5
Fully refundableReserve now, pay when you stay
  • 23 min drive from San Diego Zoo
The price is $184 per night from Mar 28 to Mar 29
$184
includes taxes & fees
Mar 28 - Mar 29
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free breakfast, 2 restaurants, and a free beach shuttle. Our guests praise the breakfast and ...
Embassy Suites by Hilton San Diego La Jolla
Hyatt Regency La Jolla
4 out of 5
Fully refundableReserve now, pay when you stay
  • 23 min drive from San Diego Zoo
The price is $207 per night from Mar 13 to Mar 14
$207
includes taxes & fees
Mar 13 - Mar 14
Book a stay at this eco-certified hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and 24-hour room service. Our guests praise the pool and the helpful ...
Hyatt Regency La Jolla
DoubleTree by Hilton San Diego - Hotel Circle
4 out of 5
Fully refundableReserve now, pay when you stay
  • 4 min drive from San Diego Zoo
The price is $141 per night from Mar 16 to Mar 17
$141
includes taxes & fees
Mar 16 - Mar 17
Stay at this 4-star business-friendly hotel in San Diego. Enjoy breakfast (surcharge), a 24-hour fitness center, and parking (surcharge). Our guests praise the ...
DoubleTree by Hilton San Diego - Hotel Circle
San Diego Marriott Mission Valley
4 out of 5
Fully refundableReserve now, pay when you stay
  • 7 min drive from San Diego Zoo
The price is $162 per night from Mar 23 to Mar 24
$162
includes taxes & fees
Mar 23 - Mar 24
Book a stay at this business-friendly hotel in San Diego. Enjoy breakfast (surcharge), a fitness center, and parking (surcharge). Our guests praise the helpful ...
San Diego Marriott Mission Valley
City24 Hotel Little Italy Mission Hill
4.5 out of 5
Fully refundableReserve now, pay when you stay
  • 8 min walk from San Diego Zoo
The price is $152 per night from Mar 30 to Mar 31
$152
includes taxes & fees
Mar 30 - Mar 31
Stay at this 4.5-star luxury aparthotel in San Diego. Enjoy free WiFi, a rooftop terrace, and parking (surcharge). Popular attractions Port of San Diego and ...
City24 Hotel Little Italy Mission Hill
Don't see what you're looking for?
See all available properties in Central San Diego
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

4-star hotels in Central San Diego

When you want to live it up, but not bust your bank account, then there’s nothing better than a 4-star hotel in Central San Diego for your next trip. You’ll get all the amenities you can think of (and then some) at a rate within your means.

No fault in our stars

So what’s with the star rating anyway? Good question. The star rating has little to do with the price, and more to do with the amenities. 4-Star hotels in Central San Diego as well as everywhere else, usually have all those thoughtful touches that make you go “Ooh,” “Ahh,” and ”YES!” Think amenities like luxury bedding, high-end electronics, concierge service, and restaurants that make eating in a gourmet experience.

Stars that shine

You know there are as many underground spots, inviting lounges, memory-making music venues as there are stars in the sky. But you’ll need the funds to check them all off. That’s why we give you the chance to take us up on the Hotwire Hot Rate. You can snag Central San Diego 4-star hotels and still have plenty of leftover cash to paint the town whatever color you want. Filter hotels by:

  • Hotwire Hot Rate: We’ll snag you a crazy deal on a room by finding your hotel name after you book.
  • Price: You know that paying full price is for suckers? You can get a cheap 4-star hotel in Central San Diego starting at $133 per night.
  • Amenities: What makes you flip for your trip? Full-service spa? Heated pool? 24-hour room service? Get a hotel that’ll send you over the moon.

Do you deserve a swanky hotel with a ton of amenities? Yes, yes you do. And you also deserve a sweet deal on it. Book with Hotwire today and get that star-studded Central San Diego 4-star hotel and have plenty of cash left over to spend at that secret super star joint in the city.