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4 Star Hotels in Central San Diego

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Featured 4 Star Central San Diego Hotels

Legacy Resort Hotel & Spa
4 out of 5
Fully refundableReserve now, pay when you stay
  • 4 min drive from San Diego Zoo
The price is $224 per night from Sep 29 to Sep 30
$224
includes taxes & fees
Sep 29 - Sep 30
Stay at this 4-star spa hotel in San Diego. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the pool and the restaurant in ...
Legacy Resort Hotel & Spa
Hilton San Diego Mission Valley
4 out of 5
Fully refundableReserve now, pay when you stay
  • 5 min drive from San Diego Zoo
The price is $142 per night from Sep 22 to Sep 23
$142
includes taxes & fees
Sep 22 - Sep 23
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and 24-hour room service. Our guests praise the helpful staff ...
Hilton San Diego Mission Valley
San Diego Marriott La Jolla
4 out of 5
Fully refundableReserve now, pay when you stay
  • 23 min drive from San Diego Zoo
The price is $202 per night from Oct 5 to Oct 6
$202
includes taxes & fees
Oct 5 - Oct 6
Book a stay at this business-friendly hotel in La Jolla. Enjoy breakfast (surcharge), a 24-hour fitness center, and WiFi (surcharge). Our guests praise the helpful ...
San Diego Marriott La Jolla
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Town and Country San Diego
4 out of 5
Fully refundableReserve now, pay when you stay
  • 5 min drive from San Diego Zoo
The price is $243 per night from Sep 22 to Sep 23
$243
includes taxes & fees
Sep 22 - Sep 23
Book a stay at this golf hotel in San Diego. Enjoy free WiFi, 2 outdoor pools, and 2 restaurants. Our guests praise the pool and the helpful staff in our reviews. ...
Town and Country San Diego
Sheraton Mission Valley San Diego Hotel
4 out of 5
  • 5 min drive from San Diego Zoo
The price is $141 per night from Sep 22 to Sep 23
$141
includes taxes & fees
Sep 22 - Sep 23
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and 24-hour room service. Our guests praise the helpful staff ...
Sheraton Mission Valley San Diego Hotel
DoubleTree by Hilton Hotel San Diego - Mission Valley
4 out of 5
Fully refundableReserve now, pay when you stay
  • 6 min drive from San Diego Zoo
The price is $162 per night from Sep 22 to Sep 23
$162
includes taxes & fees
Sep 22 - Sep 23
Book a stay at this business-friendly hotel in San Diego. Enjoy breakfast (surcharge), room service, and a 24-hour fitness center. Our guests praise the helpful ...
DoubleTree by Hilton Hotel San Diego - Mission Valley
Lafayette Hotel & Club
4 out of 5
Fully refundableReserve now, pay when you stay
  • 26 min walk from San Diego Zoo
The price is $250 per night from Sep 17 to Sep 18
$250
includes taxes & fees
Sep 17 - Sep 18
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 3 bars/lounges. Our guests praise the helpful staff in our reviews. ...
Lafayette Hotel & Club
DoubleTree by Hilton San Diego - Hotel Circle
4 out of 5
Fully refundableReserve now, pay when you stay
  • 4 min drive from San Diego Zoo
The price is $152 per night from Sep 22 to Sep 23
$152
includes taxes & fees
Sep 22 - Sep 23
Book a stay at this business-friendly hotel in San Diego. Enjoy breakfast (surcharge), a 24-hour fitness center, and parking (surcharge). Our guests praise the ...
DoubleTree by Hilton San Diego - Hotel Circle
Hyatt Regency La Jolla
4 out of 5
  • 23 min drive from San Diego Zoo
The price is $259 per night from Oct 4 to Oct 5
$259
includes taxes & fees
Oct 4 - Oct 5
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and 24-hour room service. Our guests praise the pool and the ...
Hyatt Regency La Jolla
San Diego Marriott Mission Valley
4 out of 5
  • 7 min drive from San Diego Zoo
The price is $190 per night from Sep 22 to Sep 23
$190
includes taxes & fees
Sep 22 - Sep 23
Book a stay at this business-friendly hotel in San Diego. Enjoy breakfast (surcharge), a fitness center, and parking (surcharge). Our guests praise the helpful ...
San Diego Marriott Mission Valley
Residence Inn by Marriott San Diego Mission Valley
4.5 out of 5
  • 4 min drive from San Diego Zoo
Stay at this 4.5-star luxury aparthotel in San Diego. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Popular attractions San Diego Zoo and Balboa ...
Residence Inn by Marriott San Diego Mission Valley
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

4-star hotels in Central San Diego

When you want to live it up, but not bust your bank account, then there’s nothing better than a 4-star hotel in Central San Diego for your next trip. You’ll get all the amenities you can think of (and then some) at a rate within your means.

No fault in our stars

So what’s with the star rating anyway? Good question. The star rating has little to do with the price, and more to do with the amenities. 4-Star hotels in Central San Diego as well as everywhere else, usually have all those thoughtful touches that make you go “Ooh,” “Ahh,” and ”YES!” Think amenities like luxury bedding, high-end electronics, concierge service, and restaurants that make eating in a gourmet experience.

Stars that shine

You know there are as many underground spots, inviting lounges, memory-making music venues as there are stars in the sky. But you’ll need the funds to check them all off. That’s why we give you the chance to take us up on the Hotwire Hot Rate. You can snag Central San Diego 4-star hotels and still have plenty of leftover cash to paint the town whatever color you want. Filter hotels by:

  • Hotwire Hot Rate: We’ll snag you a crazy deal on a room by finding your hotel name after you book.
  • Price: You know that paying full price is for suckers? You can get a cheap 4-star hotel in Central San Diego starting at $141 per night.
  • Amenities: What makes you flip for your trip? Full-service spa? Heated pool? 24-hour room service? Get a hotel that’ll send you over the moon.

Do you deserve a swanky hotel with a ton of amenities? Yes, yes you do. And you also deserve a sweet deal on it. Book with Hotwire today and get that star-studded Central San Diego 4-star hotel and have plenty of cash left over to spend at that secret super star joint in the city.