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Hotels in Central San Diego

Choose from 1459 Central San Diego Hotel Deals

Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N, San Diego, CA
  • 4 min drive from San Diego Zoo
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the bar in our ...
8/10 Very Good! (1,885 reviews)
"It was a nice, quiet area. Perfect for a lowkey getaway"

Reviewed on Jul 20, 2025

Handlery Hotel
Best Western Inn & Suites San Diego – Zoo/SeaWorld Area

Best Western Inn & Suites San Diego – Zoo/SeaWorld Area

2.5 out of 5
2485 Hotel Circle Place, San Diego, CA
  • 5 min drive from San Diego Zoo
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
8/10 Very Good! (1,834 reviews)
"Hotel was conveniently located clean area and great size room, hated I had to pay for parking but overall great"

Reviewed on Jul 19, 2025

Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
Hampton Inn San Diego/Mission Valley

Hampton Inn San Diego/Mission Valley

2.5 out of 5
2151 Hotel Circle South, San Diego, CA
  • 4 min drive from San Diego Zoo
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and ...
8.6/10 Excellent! (1,128 reviews)
"like location, cleaness"

Reviewed on Jul 19, 2025

Hampton Inn San Diego/Mission Valley
San Diego Marriott La Jolla

San Diego Marriott La Jolla

4 out of 5
4240 La Jolla Village Dr, La Jolla, CA
  • 23 min drive from San Diego Zoo
Stay at this 4-star business-friendly hotel in La Jolla. Enjoy breakfast (surcharge), a 24-hour fitness center, and valet parking (surcharge). Our guests praise ...
8.4/10 Very Good! (1,937 reviews)
"Clean and comfortable"

Reviewed on Jul 20, 2025

San Diego Marriott La Jolla
Kings Inn San Diego

Kings Inn San Diego

2.5 out of 5
1333 Hotel Cir S, San Diego, CA
  • 4 min drive from San Diego Zoo
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the breakfast and the pool in our reviews. Popular ...
8.6/10 Excellent! (3,329 reviews)
"It was good for the price."

Reviewed on Jul 20, 2025

Kings Inn San Diego
Hilton San Diego Mission Valley

Hilton San Diego Mission Valley

4 out of 5
901 Camino Del Rio S, San Diego, CA
  • 5 min drive from San Diego Zoo
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the ...
8/10 Very Good! (1,819 reviews)
Awesome!
"Friendly staff, clean rooms, easy access to places! Had a great time in San Diego and a great rest at Hilton! Thanks team!"

Reviewed on Jul 17, 2025

Hilton San Diego Mission Valley
Lafayette Hotel & Club

Lafayette Hotel & Club

4 out of 5
2223 El Cajon Blvd, San Diego, CA
  • 26 min walk from San Diego Zoo
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 3 bars/lounges. Our guests praise the helpful staff in our reviews. ...
9.2/10 Wonderful! (979 reviews)
"Extremely beautiful and unique boutique hotel"

Reviewed on Jul 18, 2025

Lafayette Hotel & Club
Embassy Suites by Hilton San Diego La Jolla

Embassy Suites by Hilton San Diego La Jolla

4 out of 5
4550 La Jolla Village Dr, San Diego, CA
  • 23 min drive from San Diego Zoo
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free breakfast, 2 restaurants, and a free beach shuttle. Our guests praise the breakfast and ...
8.8/10 Excellent! (1,575 reviews)
"No bell boy to help with luggage and valet parking staff. Not kids friendly pool or play area"

Reviewed on Jul 18, 2025

Embassy Suites by Hilton San Diego La Jolla
Days Inn by Wyndham San Diego Hotel Circle

Days Inn by Wyndham San Diego Hotel Circle

3 out of 5
543 Hotel Circle S, San Diego, CA
  • 4 min drive from San Diego Zoo
Stay at this 3-star business-friendly hotel in San Diego. Enjoy free WiFi, a fitness center, and parking (surcharge). Our guests praise the helpful staff and ...
7.8/10 Good! (2,236 reviews)
"I did not like the fact that I had to pay $20 a day for parking. Hotel parking was not always available and you had to drive around or sit and wait until parking was available. No one should have to go through that."

Reviewed on Jul 19, 2025

Days Inn by Wyndham San Diego Hotel Circle
DoubleTree by Hilton Hotel San Diego - Mission Valley

DoubleTree by Hilton Hotel San Diego - Mission Valley

4 out of 5
7450 Hazard Center Dr, San Diego, CA
  • 6 min drive from San Diego Zoo
Book a stay at this business-friendly hotel in San Diego. Enjoy breakfast (surcharge), room service, and a 24-hour fitness center. Our guests praise the helpful ...
8.2/10 Very Good! (1,187 reviews)
"It's a great location to reach many parts of the city."

Reviewed on Jul 19, 2025

DoubleTree by Hilton Hotel San Diego - Mission Valley
Crowne Plaza San Diego - Mission Valley by IHG

Crowne Plaza San Diego - Mission Valley by IHG

3.5 out of 5
2270 Hotel Cir N, San Diego, CA
  • 4 min drive from San Diego Zoo
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and room service. Popular attractions San Diego Zoo and Mission ...
7.4/10 Good! (1,009 reviews)
"Nice hotel , but what I didn’t like was that we had to pay for an extra room for 6 people 2 of them being kids."

Reviewed on Jul 18, 2025

Crowne Plaza San Diego - Mission Valley by IHG
Homewood Suites by Hilton San Diego Hotel Circle/SeaWorld Area

Homewood Suites by Hilton San Diego Hotel Circle/SeaWorld Area

3 out of 5
2201 Hotel Circle S, San Diego, CA
  • 4 min drive from San Diego Zoo
Book a stay at this family-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
8.6/10 Excellent! (1,022 reviews)
"Nice I just wasn’t to happy with breakfast options"

Reviewed on Jul 19, 2025

Homewood Suites by Hilton San Diego Hotel Circle/SeaWorld Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Central San Diego

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If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $133. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Central San Diego hotel deals at the last minute.

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Frequently Asked Questions About Central San Diego hotels

Where can I find the best last-minute travel deals?

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How many hotels are there in Central San Diego?

With over 1,459 hotels in Central San Diego, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $133.

How to find cheap car rentals in Central San Diego?

Finding a cheap car rental deal in Central San Diego is as easy as scoring cheap hotels in Central San Diego. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.