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Hotels in Central San Diego

Choose from 1576 Central San Diego Hotel Deals

Best Western Seven Seas

Best Western Seven Seas

3 out of 5
411 Hotel Circle South San Diego CA
  • 4 min drive from San Diego Zoo
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, free parking, and 2 hot tubs. Our guests praise the pool and the restaurant in our ...
8/10 Very Good! (3,571 reviews)
"I’ve never had a more horrible experience. The water was hot when I needed it to be cold and it was cold when I needed to be hot. It was loud at night and it was a dingy dirty and looked like something out of a horror movie they were ants randomly crawling up my arm when I was trying to sleep so ..."

Reviewed on Jun 3, 2026

Best Western Seven Seas
Days Inn by Wyndham San Diego Hotel Circle

Days Inn by Wyndham San Diego Hotel Circle

3 out of 5
543 Hotel Circle S San Diego CA
  • 4 min drive from San Diego Zoo
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, a fitness center, and parking (surcharge). Our guests praise the helpful staff and ...
8/10 Very Good! (2,751 reviews)
"Great little place to stay. We went to sea world from Orange County and I didn’t want to drive back at night so we stayed just for the night. Room is just what you would expect. The highlight was the heated pool. San Diego is always cold at night so it was perfect for the kids."

Reviewed on Jun 2, 2026

Days Inn by Wyndham San Diego Hotel Circle
California Suites Hotel

California Suites Hotel

2 out of 5
5415 Clairemont Mesa Blvd San Diego CA
  • 16 min drive from San Diego Zoo
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the ...
7.8/10 Good! (2,601 reviews)
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Reviewed on Jun 1, 2026

California Suites Hotel
The Alcala Hotel Mission Valley/Seaworld

The Alcala Hotel Mission Valley/Seaworld

2.5 out of 5
San Diego CA
  • 5 min drive from San Diego Zoo
Book a stay at this golf hotel in San Diego. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our ...
8.2/10 Very Good! (153 reviews)
"Overall we had a great stay. Staff were welcoming and attentive. Request for towels and hairdryer was prompt."

Reviewed on Jun 3, 2026

The Alcala Hotel Mission Valley/Seaworld
San Diego Marriott Mission Valley

San Diego Marriott Mission Valley

4 out of 5
8757 Rio San Diego Dr San Diego CA
  • 7 min drive from San Diego Zoo
Book a stay at this business-friendly hotel in San Diego. Enjoy breakfast (surcharge), a fitness center, and parking (surcharge). Our guests praise the helpful ...
8.8/10 Excellent! (1,012 reviews)
"Nice"

Reviewed on Jun 3, 2026

San Diego Marriott Mission Valley
Lafayette Hotel & Club

Lafayette Hotel & Club

4 out of 5
2223 El Cajon Blvd San Diego CA
  • 26 min walk from San Diego Zoo
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 3 bars/lounges. Our guests praise the helpful staff in our reviews. ...
9.4/10 Exceptional! (1,682 reviews)
"Loved it. Especially the enchanting book of history in the room."

Reviewed on Jun 3, 2026

Lafayette Hotel & Club
Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N San Diego CA
  • 4 min drive from San Diego Zoo
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the helpful staff ...
8.4/10 Very Good! (2,567 reviews)
"Great location for us for quick vacation. Clean. Food was superior grade and better than the Hilton. Pool was a great bonus."

Reviewed on Jun 3, 2026

Handlery Hotel
Best Western Inn & Suites San Diego – Zoo/SeaWorld Area

Best Western Inn & Suites San Diego – Zoo/SeaWorld Area

2.5 out of 5
2485 Hotel Circle Place San Diego CA
  • 5 min drive from San Diego Zoo
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
8/10 Very Good! (2,696 reviews)
"Very good for its price"

Reviewed on Jun 3, 2026

Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
Kings Inn San Diego

Kings Inn San Diego

2.5 out of 5
1333 Hotel Cir S San Diego CA
  • 4 min drive from San Diego Zoo
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the breakfast and the pool in our reviews. Popular ...
8.8/10 Excellent! (3,709 reviews)
"The property was very clean, the staff was awesome, but the place needs to be updated."

Reviewed on Jun 3, 2026

Kings Inn San Diego
Legacy Resort Hotel & Spa

Legacy Resort Hotel & Spa

4 out of 5
875 Hotel Circle South San Diego CA
  • 4 min drive from San Diego Zoo
Book a stay at this spa hotel in San Diego. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the pool and the restaurant in ...
9.2/10 Wonderful! (3,010 reviews)
"I liked the location and the services was outstanding."

Reviewed on Jun 3, 2026

Legacy Resort Hotel & Spa
DoubleTree by Hilton Hotel San Diego - Mission Valley

DoubleTree by Hilton Hotel San Diego - Mission Valley

4 out of 5
7450 Hazard Center Dr San Diego CA
  • 6 min drive from San Diego Zoo
Book a stay at this business-friendly hotel in San Diego. Enjoy breakfast (surcharge), room service, and a 24-hour fitness center. Our guests praise the helpful ...
8.4/10 Very Good! (1,684 reviews)
"The property was nicer than I excepted. It was a great stay. Not to mention the cookies they give - delicious! The cafe inside the hotel is also nice and convenient. The only thing I will say is both my brother’s family and mine stayed at the hotel. We both received a $4 fee charged to our cards ..."

Reviewed on Jun 1, 2026

DoubleTree by Hilton Hotel San Diego - Mission Valley
Crowne Plaza San Diego - Mission Valley by IHG

Crowne Plaza San Diego - Mission Valley by IHG

3.5 out of 5
2270 Hotel Cir N San Diego CA
  • 4 min drive from San Diego Zoo
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and room service. Popular attractions San Diego Zoo and Mission ...
Crowne Plaza San Diego - Mission Valley by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Central San Diego

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For you, intrepid voyager, Hotwire has a large selection of the best hotels in Central San Diego.

Choosing the right hotel in California has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Central San Diego’s 1,576 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $102. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Central San Diego hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Central San Diego. No matter your reason for visiting Central San Diego, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Central San Diego hotels

Where can I find the best last-minute travel deals?

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How many hotels are there in Central San Diego?

With over 1,576 hotels in Central San Diego, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $102.

How to find cheap car rentals in Central San Diego?

Finding a cheap car rental deal in Central San Diego is as easy as scoring cheap hotels in Central San Diego. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.