Hotels Near
Little Italy

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Featured Little Italy Hotels

Urban Boutique Hotel
Urban Boutique Hotel
3 out of 5
1654 Columbia Street, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in San Diego. Enjoy free WiFi, a 24-hour front desk, and a 24-hour business center. Our guests praise the helpful ...
8.4/10 Very Good! (1,163 reviews)
"Small room but nice for the price."

Reviewed on Feb 17, 2025

Urban Boutique Hotel
Hotel Zindel
Hotel Zindel
2 out of 5
505 W Grape St, San Diego, CA
Stay at this hotel in San Diego. Enjoy free WiFi, Netflix, and hydromassage showerheads. Popular attractions Port of San Diego and USS Midway Museum are located ...
7.4/10 Good! (357 reviews)
"Quiet. Clean. The parking lot is hard to find."

Reviewed on Feb 14, 2025

Hotel Zindel
La Pensione Hotel
La Pensione Hotel
3 out of 5
606 West Date Street, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in San Diego. Enjoy free WiFi, a 24-hour fitness center, and a 24-hour front desk. Our guests praise the helpful ...
8.4/10 Very Good! (1,639 reviews)
"This was an excellent location for LIttle Italy, right in the middle of all the action. The room was clean, bed was comfortable, it had a small refrigerator, and a decent shower. The negative would be the room was VERY small and only have queen size beds. (That's all that will fit) We had a party ..."

Reviewed on Feb 17, 2025

La Pensione Hotel
Hilton Garden Inn San Diego Downtown/Bayside
Hilton Garden Inn San Diego Downtown/Bayside
3.5 out of 5
2137 Pacific Highway, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and a fitness center. Our guests praise the helpful staff ...
8.4/10 Very Good! (1,037 reviews)
"The stay was good the only thing was the air conditioning wasn't working good it got very warm in the room"

Reviewed on Feb 17, 2025

Hilton Garden Inn San Diego Downtown/Bayside
Homewood Suites by Hilton San Diego Downtown/Bayside
Homewood Suites by Hilton San Diego Downtown/Bayside
3.5 out of 5
2137 Pacific Highway, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star hotel in San Diego. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful staff in our ...
8.4/10 Very Good! (1,006 reviews)
"fast check in"

Reviewed on Feb 16, 2025

Homewood Suites by Hilton San Diego Downtown/Bayside
The Dana on Mission Bay
The Dana on Mission Bay
3.5 out of 5
1710 W Mission Bay Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 spa tubs. Our guests praise the pool and the restaurant in ...
8.6/10 Excellent! (3,175 reviews)
"Was a great stay for a getaway"

Reviewed on Feb 17, 2025

The Dana on Mission Bay
Omni San Diego Hotel
Omni San Diego Hotel
4 out of 5
675 L St, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the bar and the helpful ...
9/10 Wonderful! (1,833 reviews)
"Staff was very friendly"

Reviewed on Feb 15, 2025

Omni San Diego Hotel
Hard Rock Hotel San Diego
Hard Rock Hotel San Diego
4 out of 5
207 5th Ave, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our ...
8.8/10 Excellent! (2,577 reviews)
"Great Location! Cool Vibe!"

Reviewed on Feb 15, 2025

Hard Rock Hotel San Diego
Hyatt Regency Mission Bay Spa and Marina
Hyatt Regency Mission Bay Spa and Marina
4 out of 5
1441 Quivira Rd, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star spa hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...
8.4/10 Very Good! (1,459 reviews)
"Really nice modern, recently remodeled rooms and grounds. Staff were super friendly and helpful, would definitely come back again!"

Reviewed on Feb 17, 2025

Hyatt Regency Mission Bay Spa and Marina
Comfort Inn Sea World Area
Comfort Inn Sea World Area
3.5 out of 5
3880 Greenwood St, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.4/10 Very Good! (1,585 reviews)
"Clean room"

Reviewed on Feb 15, 2025

Comfort Inn Sea World Area
Wyndham San Diego Bayside
Wyndham San Diego Bayside
4 out of 5
1355 N Harbor Drive, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.2/10 Very Good! (5,634 reviews)
"The location is fantastic!"

Reviewed on Feb 17, 2025

Wyndham San Diego Bayside
Sheraton Mission Valley San Diego Hotel
Sheraton Mission Valley San Diego Hotel
4 out of 5
1433 Camino Del Rio S, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and 24-hour room service. Our guests praise the helpful staff ...
8.4/10 Very Good! (1,323 reviews)
"Amazing"

Reviewed on Feb 17, 2025

Sheraton Mission Valley San Diego Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Little Italy

San Diego is a city that has a lot going on, but you have your sights set on Little Italy. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Little Italy has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Little Italy hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of San Diego so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Little Italy underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Little Italy city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Little Italy cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Little Italy at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $110
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Little Italy hotel you want, book it, and never look back. Because your great escape is ahead of you.