Hotels Near
Little Italy

Check Last Minute Little Italy Hotel Deals

Tonight Mar 23 - Mar 24Next weekend Mar 28 - Mar 30

You choose what matters — star rating, location, amenities.

We pick the perfect hotel, packed with all your must-haves.

Your hotel is revealed right after booking!


Featured Little Italy Hotels

The Little Italy Hotel Downtown San Diego
The Little Italy Hotel Downtown San Diego
4 out of 5
1646 Front St, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star hotel in San Diego. Enjoy free WiFi, parking (surcharge), and a 24-hour front desk. Our guests praise the helpful staff in our reviews. Popular ...
7.6/10 Good! (1,011 reviews)
"Nice hotel, some outlets in room didn’t work though."

Reviewed on Mar 22, 2025

The Little Italy Hotel Downtown San Diego
Hampton Inn San Diego-Downtown
Hampton Inn San Diego-Downtown
2.5 out of 5
San Diego
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and a rooftop terrace. Our guests praise the breakfast and the helpful ...
8/10 Very Good! (1,815 reviews)
"Fabulous"

Reviewed on Mar 20, 2025

Hampton Inn San Diego-Downtown
La Pensione Hotel
La Pensione Hotel
3 out of 5
606 West Date Street, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in San Diego. Enjoy free WiFi, a 24-hour fitness center, and a 24-hour front desk. Our guests praise the helpful ...
8.4/10 Very Good! (1,665 reviews)
"Awesome location! Heart of Little Italy! Main Sqare across street from Hotel… Restaurants and Bars right outside Hotel entrance. Walking distance to Seaport Village, Portside Pier, 10 minutes Uber from Airport. Coffee shop and courtyard in the same bldg, has great coffee and morning eats. We loved ..."

Reviewed on Mar 21, 2025

La Pensione Hotel
Homewood Suites by Hilton San Diego Downtown/Bayside
Homewood Suites by Hilton San Diego Downtown/Bayside
3.5 out of 5
2137 Pacific Highway, San Diego, CA
Stay at this 3.5-star hotel in San Diego. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful staff in our ...
8.4/10 Very Good! (1,002 reviews)
Great location, very helpful people!
"Everything was good.. family upstairs was a little noisy but Nicholas handled it. Also one of the elevators was out so little bit of waiting but otherwise we really enjoyed our stay!!"

Reviewed on Mar 16, 2025

Homewood Suites by Hilton San Diego Downtown/Bayside
Hotel Zindel
Hotel Zindel
2 out of 5
505 W Grape St, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this hotel in San Diego. Enjoy Netflix, hydromassage showerheads, and an in-room coffeemaker. Popular attractions Port of San Diego and USS Midway Museum ...
7.6/10 Good! (399 reviews)
"I like the no check in and I don’t like the fact there’s no parking."

Reviewed on Mar 22, 2025

Hotel Zindel
The Dana on Mission Bay
The Dana on Mission Bay
3.5 out of 5
1710 W Mission Bay Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in ...
8.8/10 Excellent! (3,284 reviews)
"Love this hotel!"

Reviewed on Mar 22, 2025

The Dana on Mission Bay
San Diego Marriott La Jolla
San Diego Marriott La Jolla
4 out of 5
4240 La Jolla Village Dr, La Jolla, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in La Jolla. Enjoy breakfast (surcharge), a 24-hour fitness center, and WiFi (surcharge). Our guests praise the helpful ...
8.4/10 Very Good! (1,655 reviews)
"Location"

Reviewed on Mar 22, 2025

San Diego Marriott La Jolla
Wyndham San Diego Bayside
Wyndham San Diego Bayside
4 out of 5
1355 N Harbor Drive, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.2/10 Very Good! (5,633 reviews)
"Nice place to stay"

Reviewed on Mar 23, 2025

Wyndham San Diego Bayside
San Diego Mission Bay Resort
San Diego Mission Bay Resort
4 out of 5
1775 E Mission Bay Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
Book a stay at this beach hotel in San Diego. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the pool and the helpful staff in our ...
8.2/10 Very Good! (1,146 reviews)
"The service and Staff were excellent in providing information and follow-up. This may sound silly, but for someone like me with a bad back, the toilet bowl was far too low to the ground making it difficult to stand up."

Reviewed on Mar 21, 2025

San Diego Mission Bay Resort
Manchester Grand Hyatt San Diego
Manchester Grand Hyatt San Diego
4 out of 5
1 Market Pl, San Diego, CA
Fully refundableReserve now, pay when you stay
Book a stay at this eco-certified hotel in San Diego. Enjoy free WiFi, 6 restaurants, and 3 bars/lounges. Our guests praise the pool and the bar in our reviews. ...
9/10 Wonderful! (2,792 reviews)
"yyu"

Reviewed on Mar 23, 2025

Manchester Grand Hyatt San Diego
Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
2.5 out of 5
2485 Hotel Circle Place, San Diego, CA
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
7.8/10 Good! (1,369 reviews)
Convenient
"Best Western is in a great location easy on and off the freeway. Room was clean. Breakfast was very good. When we visit San Diego we stay at this Best Western in Hotel Circle."

Reviewed on Mar 22, 2025

Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
Comfort Inn Sea World Area
Comfort Inn Sea World Area
3.5 out of 5
3880 Greenwood St, San Diego, CA
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.4/10 Very Good! (1,782 reviews)
"Very nice people and very good breakfast"

Reviewed on Mar 20, 2025

Comfort Inn Sea World Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Little Italy

San Diego is a city that has a lot going on, but you have your sights set on Little Italy. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Little Italy has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Little Italy hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of San Diego so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Little Italy underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Little Italy city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Little Italy cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Little Italy at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $127
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Little Italy hotel you want, book it, and never look back. Because your great escape is ahead of you.