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Hotels in Santee

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Tonight Mar 15 - Mar 16Next weekend Mar 21 - Mar 23

Choose from 9471 Santee Hotel Deals

The Dana on Mission Bay
The Dana on Mission Bay
3.5 out of 5
1710 W Mission Bay Dr, San Diego, CA
  • 16 min drive from Santee Lakes
The price is $202 per night from Mar 23 to Mar 24
$202
includes taxes & fees
Mar 23 - Mar 24
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in ...
8.6/10 Excellent! (3,258 reviews)
"Everyone was so nice and accommodating! The grounds were beautiful"

Reviewed on Mar 13, 2025

The Dana on Mission Bay
San Diego Marriott La Jolla
San Diego Marriott La Jolla
4 out of 5
4240 La Jolla Village Dr, La Jolla, CA
  • 5 min drive from Santee Lakes
The price is $171 per night from Apr 5 to Apr 6
$171
includes taxes & fees
Apr 5 - Apr 6
Stay at this 4-star business-friendly hotel in La Jolla. Enjoy breakfast (surcharge), a 24-hour fitness center, and WiFi (surcharge). Our guests praise the helpful ...
8.4/10 Very Good! (1,631 reviews)
"Private"

Reviewed on Mar 12, 2025

San Diego Marriott La Jolla
Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
2.5 out of 5
2485 Hotel Circle Place, San Diego, CA
  • 17 min drive from Santee Lakes
The price is $160 per night from Mar 23 to Mar 24
$160
includes taxes & fees
Mar 23 - Mar 24
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
7.8/10 Good! (1,340 reviews)
"Unpleasant smell when you run the water for the first time"

Reviewed on Mar 14, 2025

Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
San Diego Mission Bay Resort
San Diego Mission Bay Resort
4 out of 5
1775 E Mission Bay Dr, San Diego, CA
  • 14 min drive from Santee Lakes
The price is $259 per night from Apr 13 to Apr 14
$259
includes taxes & fees
Apr 13 - Apr 14
Book a stay at this beach hotel in San Diego. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the pool and the helpful staff in our ...
8.2/10 Very Good! (1,143 reviews)
"Beautiful resort. We were in the tower on the top floor facing the highway so it was constantly loud with those sounds when on the balcony. The room was quiet, and the staff very accommodating when it came to daily service. Their Spa Breeza was to die for. I really loved being pampered and my massage ..."

Reviewed on Mar 8, 2025

San Diego Mission Bay Resort
Wyndham San Diego Bayside
Wyndham San Diego Bayside
4 out of 5
1355 N Harbor Drive, San Diego, CA
  • 23 min drive from Santee Lakes
The price is $171 per night from Apr 13 to Apr 14
$171
includes taxes & fees
Apr 13 - Apr 14
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.2/10 Very Good! (5,595 reviews)
"Close to everything! Shuttle service feom airport to hotel was quick and easy."

Reviewed on Mar 14, 2025

Wyndham San Diego Bayside
Comfort Inn Sea World Area
Comfort Inn Sea World Area
3.5 out of 5
3880 Greenwood St, San Diego, CA
  • 18 min drive from Santee Lakes
The price is $123 per night from Mar 16 to Mar 17
$123
includes taxes & fees
Mar 16 - Mar 17
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.4/10 Very Good! (1,732 reviews)
"Concerning outside of the fence."

Reviewed on Mar 11, 2025

Comfort Inn Sea World Area
Inn By The Sea La Jolla
Inn By The Sea La Jolla
3.5 out of 5
7830 Fay Ave, La Jolla, CA
  • 6 min drive from Santee Lakes
The price is $233 per night from Mar 30 to Mar 31
$233
includes taxes & fees
Mar 30 - Mar 31
Stay at this 3.5-star hotel in La Jolla. Enjoy free WiFi, room service, and a fitness center. Our guests praise the pool and the helpful staff in our reviews. ...
9.2/10 Wonderful! (1,478 reviews)
"It was great and the view we where so close to the beach. Walking distance and safe. Plus the pool was warm even though it was cold outside. Parking was great since I did not Want to go look for public parking the staff was so attentive and very nice."

Reviewed on Mar 11, 2025

Inn By The Sea La Jolla
Humphreys Half Moon Inn
Humphreys Half Moon Inn
3.5 out of 5
2303 Shelter Island Dr, San Diego, CA
  • 24 min drive from Santee Lakes
The price is $191 per night from Apr 7 to Apr 8
$191
includes taxes & fees
Apr 7 - Apr 8
Book a stay at this business-friendly hotel in San Diego. Enjoy a marina, a nightclub, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
9/10 Wonderful! (2,181 reviews)
"Location"

Reviewed on Mar 12, 2025

Humphreys Half Moon Inn
The Little Italy Hotel Downtown San Diego
The Little Italy Hotel Downtown San Diego
4 out of 5
1646 Front St, San Diego, CA
  • 23 min drive from Santee Lakes
The price is $147 per night from Mar 16 to Mar 17
$147
includes taxes & fees
Mar 16 - Mar 17
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, a sauna, and parking (surcharge). Our guests praise the helpful staff in our reviews. ...
7.6/10 Good! (1,006 reviews)
"Even though it was comfortable and looked really good in pictures. I had issues with room like the AC wasn’t working but we managed with the windows open that helped cool the room. That being said if the issue persists in summer it won’t be my choice of place to stay."

Reviewed on Mar 13, 2025

The Little Italy Hotel Downtown San Diego
Omni San Diego Hotel
Omni San Diego Hotel
4 out of 5
675 L St, San Diego, CA
  • 25 min drive from Santee Lakes
The price is $295 per night from Apr 3 to Apr 4
$295
includes taxes & fees
Apr 3 - Apr 4
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the bar and the helpful ...
9/10 Wonderful! (1,874 reviews)
"A friend and I had a very pleasant and comfortable stay. The front desk staff we spoke to were helpful and accommodating. We enjoyed being able to easily walk to some downtown restaurants and the nearby Starbucks. On our first morning we had an issue with the shower not working properly. We asked ..."

Reviewed on Mar 11, 2025

Omni San Diego Hotel
Sheraton San Diego Resort
Sheraton San Diego Resort
4 out of 5
1380 Harbor Island Dr, San Diego, CA
  • 22 min drive from Santee Lakes
The price is $222 per night from Mar 23 to Mar 24
$222
includes taxes & fees
Mar 23 - Mar 24
Book a stay at this business-friendly hotel in San Diego. Enjoy 3 outdoor pools, 5 restaurants, and a marina. Our guests praise the pool and the restaurant in ...
8/10 Very Good! (2,563 reviews)
"It was nice amazing views just put sheets with stains in them when housekeeping changed sheets during stay gave us strained sheets"

Reviewed on Mar 11, 2025

Sheraton San Diego Resort
Hard Rock Hotel San Diego
Hard Rock Hotel San Diego
4 out of 5
207 5th Ave, San Diego, CA
  • 25 min drive from Santee Lakes
The price is $272 per night from Apr 13 to Apr 14
$272
includes taxes & fees
Apr 13 - Apr 14
Stay at this 4-star hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our ...
8.8/10 Excellent! (2,593 reviews)
"Very nice place to stay! Very friendly staff! Very clean and easy check in and check out process. Parking is 65$ vallet only at the hotel. But a parking garage about a half a block (3 min walk) is only 15$ overnight parking! I will definitely stay there again when I come back to San Diego!"

Reviewed on Mar 10, 2025

Hard Rock Hotel San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Santee

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If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $123. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Santee hotel deals at the last minute.

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Frequently Asked Questions About Santee hotels

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How many hotels are there in Santee?

With over 9,471 hotels in Santee, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $123.

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Finding a cheap car rental deal in Santee is as easy as scoring cheap hotels in Santee. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.