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Hotels in Santee

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Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
  • 16 min drive from Mission Trails Regional Park
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the pool and the restaurant ...
8.2/10 Very Good! (3,223 reviews)
The room was beautiful

Reviewed on Jan 8, 2026

Sheraton San Diego Resort
Bay Club Hotel & Marina

Bay Club Hotel & Marina

3.5 out of 5
2131 Shelter Island Dr San Diego CA
  • 18 min drive from Mission Trails Regional Park
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, a marina, and a health club. Our guests praise the breakfast and the restaurant in ...
9/10 Wonderful! (3,276 reviews)
Clean room, great little restaurant and bar, friendly staff

Reviewed on Jan 13, 2026

Bay Club Hotel & Marina
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

3 out of 5
1617 1st Avenue San Diego CA
  • 17 min drive from Mission Trails Regional Park
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
8.8/10 Excellent! (905 reviews)
Paid parking, if you have truck / big SUV there are not enough space. Hotel, view, location are great.

Reviewed on Jan 13, 2026

The DEXTRO Little Italy, BW Premier Collection
Courtyard by Marriott San Diego Downtown Little Italy

Courtyard by Marriott San Diego Downtown Little Italy

4 out of 5
1646 Front St San Diego CA
  • 17 min drive from Mission Trails Regional Park
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
8.6/10 Excellent! (235 reviews)
i had an early check-in and received an upgraded room!! amazing staff!

Reviewed on Jan 12, 2026

Courtyard by Marriott San Diego Downtown Little Italy
DoubleTree by Hilton Hotel San Diego - Mission Valley

DoubleTree by Hilton Hotel San Diego - Mission Valley

4 out of 5
7450 Hazard Center Dr San Diego CA
  • 9 min drive from Mission Trails Regional Park
Book a stay at this business-friendly hotel in San Diego. Enjoy breakfast (surcharge), room service, and a 24-hour fitness center. Our guests praise the helpful ...
8.2/10 Very Good! (1,475 reviews)
Room was excellent. Very comfortable. I love the friendliness of the staff and the location does not get any better than this. the Trolley is right across the street, (a 5 minute walk). You can get to literally "any place" you need to go in San Diego from the trolley. I will definitely stay here ...

Reviewed on Jan 13, 2026

DoubleTree by Hilton Hotel San Diego - Mission Valley
Hilton San Diego Mission Valley

Hilton San Diego Mission Valley

4 out of 5
901 Camino Del Rio S San Diego CA
  • 10 min drive from Mission Trails Regional Park
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the ...
8/10 Very Good! (2,280 reviews)
It was nice but plain. The room needed puctures or posters for color.

Reviewed on Jan 11, 2026

Hilton San Diego Mission Valley
The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr San Diego CA
  • 11 min drive from Mission Trails Regional Park
Stay at this hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in our reviews. Popular attractions ...
8.8/10 Excellent! (3,990 reviews)
Good service! Staff were very friendly and accommodating.

Reviewed on Jan 14, 2026

The Dana on Mission Bay
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave San Diego CA
  • 19 min drive from Mission Trails Regional Park
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our reviews. ...
8.8/10 Excellent! (3,218 reviews)
Great

Reviewed on Jan 13, 2026

Hard Rock Hotel San Diego
Pendry San Diego

Pendry San Diego

5 out of 5
550 J Street San Diego CA
  • 19 min drive from Mission Trails Regional Park
Book a stay at this luxury hotel in San Diego. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff and the clean rooms ...
9.2/10 Wonderful! (1,000 reviews)
The room was clean, tasteful, and quiet. The staff was very friendly and helpful. We had a wonderful time in Pendry.

Reviewed on Jan 1, 2026

Pendry San Diego
Best Western Seven Seas

Best Western Seven Seas

3 out of 5
411 Hotel Circle South San Diego CA
  • 11 min drive from Mission Trails Regional Park
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, free parking, and 2 hot tubs. Our guests praise the pool and the restaurant in our ...
7.8/10 Good! (3,123 reviews)
Decent hotel. The front desk ladies were very nice. The towels and the pillow cases both had make up on them.

Reviewed on Jan 13, 2026

Best Western Seven Seas
Lafayette Hotel & Club

Lafayette Hotel & Club

4 out of 5
2223 El Cajon Blvd San Diego CA
  • 11 min drive from Mission Trails Regional Park
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 3 bars/lounges. Our guests praise the helpful staff in our reviews. ...
9.2/10 Wonderful! (1,401 reviews)
Amazing hotel

Reviewed on Jan 11, 2026

Lafayette Hotel & Club
San Diego Mission Bay Resort

San Diego Mission Bay Resort

4 out of 5
1775 E Mission Bay Dr San Diego CA
  • 8 min drive from Mission Trails Regional Park
Book a stay at this beach hotel in San Diego. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the pool and the helpful staff in our ...
8.4/10 Very Good! (1,333 reviews)
Great place for our family getaway! Loved the S’mores on the beach!

Reviewed on Jan 13, 2026

San Diego Mission Bay Resort
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Santee

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For you, intrepid voyager, Hotwire has a large selection of the best hotels in Santee.

Choosing the right hotel in California has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Santee’s 9,786 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $81. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Santee hotel deals at the last minute.

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Frequently Asked Questions About Santee hotels

Where can I find the best last-minute travel deals?

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How many hotels are there in Santee?

With over 9,786 hotels in Santee, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $81.

How to find cheap car rentals in Santee?

Finding a cheap car rental deal in Santee is as easy as scoring cheap hotels in Santee. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.