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4 Star Hotels in Upstate South Carolina

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Featured 4 Star Upstate South Carolina Hotels

Hotel Hartness
4 out of 5
Fully refundableReserve now, pay when you stay
  • 2 hours drive from Clemson University
The price is $252 per night from Nov 17 to Nov 18
$252
includes taxes & fees
Nov 17 - Nov 18
Stay at this 4-star spa hotel in Greenville. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the breakfast and the helpful staff in ...
Hotel Hartness
The Shepherd Hotel Downtown Clemson
4 out of 5
  • 12 min walk from Clemson University
The price is $199 per night from Nov 17 to Nov 18
$199
includes taxes & fees
Nov 17 - Nov 18
Stay at this 4-star hotel in Clemson. Enjoy free WiFi, breakfast (surcharge), and valet parking (surcharge). Our guests praise the helpful staff and the clean ...
The Shepherd Hotel Downtown Clemson
Grand Bohemian Lodge Greenville, Autograph Collection
4 out of 5
Fully refundableReserve now, pay when you stay
  • 1 hour drive from Clemson University
The price is $385 per night from Dec 11 to Dec 12
$385
includes taxes & fees
Dec 11 - Dec 12
Stay at this 4-star spa hotel in Greenville. Enjoy a full-service spa, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful staff ...
Grand Bohemian Lodge Greenville, Autograph Collection
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The Westin Poinsett Greenville
4 out of 5
Fully refundableReserve now, pay when you stay
  • 1 hour drive from Clemson University
The price is $191 per night from Nov 25 to Nov 26
$191
includes taxes & fees
Nov 25 - Nov 26
Stay at this 4-star business-friendly hotel in Greenville. Enjoy breakfast (surcharge), a free airport shuttle, and 24-hour room service. Our guests praise the ...
The Westin Poinsett Greenville
The Abernathy of Clemson
4 out of 5
  • 15 min walk from Clemson University
The price is $165 per night from Nov 24 to Nov 25
$165
includes taxes & fees
Nov 24 - Nov 25
Stay at this 4-star business-friendly hotel in Clemson. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in our ...
The Abernathy of Clemson
Greenville Marriott
4 out of 5
Fully refundableReserve now, pay when you stay
  • 2 hours drive from Clemson University
The price is $144 per night from Nov 21 to Nov 22
$144
includes taxes & fees
Nov 21 - Nov 22
Book a stay at this business-friendly hotel in Greenville. Enjoy free parking, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful ...
Greenville Marriott
Liberty Hall Bed and Breakfast
4 out of 5
  • 10 min drive from Clemson University
Stay at this 4-star B&B in Pendleton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
Liberty Hall Bed and Breakfast
The Station by Compo Hotels
4 out of 5
  • 1 hour drive from Clemson University
The price is $312 per night from Nov 21 to Nov 22
$312
includes taxes & fees
Nov 21 - Nov 22
Stay at this aparthotel in Travelers Rest. Enjoy free WiFi, free parking, and a pillow menu. Popular attractions Carolina Honey Bee Company and Furman University ...
The Station by Compo Hotels
Hotel Domestique
4 out of 5
  • 2 hours drive from Clemson University
The price is $494 per night from Nov 17 to Nov 18
$494
includes taxes & fees
Nov 17 - Nov 18
Stay at this 4-star boutique hotel in Travelers Rest. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Poinsett Bridge and Cherokee Valley ...
Hotel Domestique
Lake Hartwell Frank Howard Home Clemson
4 out of 5
  • 14 min drive from Clemson University
The price is $492 per night from Dec 2 to Dec 3
$492
includes taxes & fees
Dec 2 - Dec 3
Stay at this 4-star vacation home in Anderson. Enjoy free WiFi, free parking, and cable TV channels. Popular attractions Woodburn and Agricultural Museum are ...
Lake Hartwell Frank Howard Home Clemson
34 Allen St
4 out of 5
  • 1 hour drive from Clemson University
Stay at this 4-star family-friendly vacation home in Greenville. Enjoy free WiFi, free parking, and a garden. Popular attractions Falls Park on the Reedy and ...
34 Allen St
140 Catlin Circle
4 out of 5
  • 1 hour drive from Clemson University
Stay at this 4-star family-friendly vacation home in Greenville. Enjoy free WiFi, free parking, and a garden. Popular attractions Bon Secours Wellness Arena ...
140 Catlin Circle
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

4-star hotels in Upstate South Carolina

When you want to live it up, but not bust your bank account, then there’s nothing better than a 4-star hotel in Upstate South Carolina for your next trip. You’ll get all the amenities you can think of (and then some) at a rate within your means.

No fault in our stars

So what’s with the star rating anyway? Good question. The star rating has little to do with the price, and more to do with the amenities. 4-Star hotels in Upstate South Carolina as well as everywhere else, usually have all those thoughtful touches that make you go “Ooh,” “Ahh,” and ”YES!” Think amenities like luxury bedding, high-end electronics, concierge service, and restaurants that make eating in a gourmet experience.

Stars that shine

You know there are as many underground spots, inviting lounges, memory-making music venues as there are stars in the sky. But you’ll need the funds to check them all off. That’s why we give you the chance to take us up on the Hotwire Hot Rate. You can snag Upstate South Carolina 4-star hotels and still have plenty of leftover cash to paint the town whatever color you want. Filter hotels by:

  • Hotwire Hot Rate: We’ll snag you a crazy deal on a room by finding your hotel name after you book.
  • Price: You know that paying full price is for suckers? You can get a cheap 4-star hotel in Upstate South Carolina starting at $144 per night.
  • Amenities: What makes you flip for your trip? Full-service spa? Heated pool? 24-hour room service? Get a hotel that’ll send you over the moon.

Do you deserve a swanky hotel with a ton of amenities? Yes, yes you do. And you also deserve a sweet deal on it. Book with Hotwire today and get that star-studded Upstate South Carolina 4-star hotel and have plenty of cash left over to spend at that secret super star joint in the city.