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4 Star Hotels in Upstate South Carolina

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Featured 4 Star Upstate South Carolina Hotels

The Shepherd Hotel Downtown Clemson
4 out of 5
Fully refundableReserve now, pay when you stay
  • 12 min walk from Clemson University
The price is $188 per night from Dec 22 to Dec 23
$188
includes taxes & fees
Dec 22 - Dec 23
Stay at this 4-star hotel in Clemson. Enjoy free WiFi, breakfast (surcharge), and valet parking (surcharge). Our guests praise the helpful staff and the clean ...
The Shepherd Hotel Downtown Clemson
Grand Bohemian Lodge Greenville, Autograph Collection
4 out of 5
Fully refundableReserve now, pay when you stay
  • 1 hour drive from Clemson University
The price is $364 per night from Dec 22 to Dec 23
$364
includes taxes & fees
Dec 22 - Dec 23
Stay at this 4-star spa hotel in Greenville. Enjoy a full-service spa, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful staff ...
Grand Bohemian Lodge Greenville, Autograph Collection
The Westin Poinsett Greenville
4 out of 5
  • 1 hour drive from Clemson University
The price is $172 per night from Dec 22 to Dec 23
$172
includes taxes & fees
Dec 22 - Dec 23
Stay at this 4-star business-friendly hotel in Greenville. Enjoy breakfast (surcharge), a free airport shuttle, and 24-hour room service. Our guests praise the ...
The Westin Poinsett Greenville
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Hotel Hartness
4 out of 5
  • 2 hours drive from Clemson University
The price is $234 per night from Dec 15 to Dec 16
$234
includes taxes & fees
Dec 15 - Dec 16
Stay at this 4-star spa hotel in Greenville. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the breakfast and the helpful staff in ...
Hotel Hartness
Greenville Marriott
4 out of 5
Fully refundableReserve now, pay when you stay
  • 2 hours drive from Clemson University
The price is $144 per night from Dec 13 to Dec 14
$144
includes taxes & fees
Dec 13 - Dec 14
Book a stay at this business-friendly hotel in Greenville. Enjoy free parking, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful ...
Greenville Marriott
The Abernathy of Clemson
4 out of 5
Fully refundableReserve now, pay when you stay
  • 15 min walk from Clemson University
The price is $165 per night from Dec 8 to Dec 9
$165
includes taxes & fees
Dec 8 - Dec 9
Stay at this 4-star business-friendly hotel in Clemson. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in our ...
The Abernathy of Clemson
Liberty Hall Bed and Breakfast
4 out of 5
  • 10 min drive from Clemson University
The price is $178 per night from Dec 1 to Dec 2
$178
includes taxes & fees
Dec 1 - Dec 2
Stay at this 4-star B&B in Pendleton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
Liberty Hall Bed and Breakfast
Hotel Domestique
4 out of 5
  • 2 hours drive from Clemson University
The price is $494 per night from Dec 1 to Dec 2
$494
includes taxes & fees
Dec 1 - Dec 2
Stay at this 4-star boutique hotel in Travelers Rest. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Mountain Park Golf and Les Mullinax ...
Hotel Domestique
The Station by Compo Hotels
4 out of 5
  • 1 hour drive from Clemson University
The price is $312 per night from Dec 1 to Dec 2
$312
includes taxes & fees
Dec 1 - Dec 2
Stay at this 4-star aparthotel in Travelers Rest. Enjoy free WiFi, free parking, and a pillow menu. Popular attractions Carolina Honey Bee Company and Furman ...
The Station by Compo Hotels
Lake Hartwell Frank Howard Home Clemson
4 out of 5
  • 14 min drive from Clemson University
The price is $445 per night from Dec 2 to Dec 3
$445
includes taxes & fees
Dec 2 - Dec 3
Stay at this 4-star vacation home in Anderson. Enjoy free WiFi, free parking, and cable TV channels. Popular attractions Woodburn and Agricultural Museum are ...
Lake Hartwell Frank Howard Home Clemson
34 Allen St
4 out of 5
  • 1 hour drive from Clemson University
Stay at this 4-star family-friendly vacation home in Greenville. Enjoy free WiFi, free parking, and a garden. Popular attractions Falls Park on the Reedy and ...
34 Allen St
140 Catlin Circle
4 out of 5
  • 1 hour drive from Clemson University
Stay at this 4-star family-friendly vacation home in Greenville. Enjoy free WiFi, free parking, and a garden. Popular attractions Bon Secours Wellness Arena ...
140 Catlin Circle
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

4-star hotels in Upstate South Carolina

When you want to live it up, but not bust your bank account, then there’s nothing better than a 4-star hotel in Upstate South Carolina for your next trip. You’ll get all the amenities you can think of (and then some) at a rate within your means.

No fault in our stars

So what’s with the star rating anyway? Good question. The star rating has little to do with the price, and more to do with the amenities. 4-Star hotels in Upstate South Carolina as well as everywhere else, usually have all those thoughtful touches that make you go “Ooh,” “Ahh,” and ”YES!” Think amenities like luxury bedding, high-end electronics, concierge service, and restaurants that make eating in a gourmet experience.

Stars that shine

You know there are as many underground spots, inviting lounges, memory-making music venues as there are stars in the sky. But you’ll need the funds to check them all off. That’s why we give you the chance to take us up on the Hotwire Hot Rate. You can snag Upstate South Carolina 4-star hotels and still have plenty of leftover cash to paint the town whatever color you want. Filter hotels by:

  • Hotwire Hot Rate: We’ll snag you a crazy deal on a room by finding your hotel name after you book.
  • Price: You know that paying full price is for suckers? You can get a cheap 4-star hotel in Upstate South Carolina starting at $144 per night.
  • Amenities: What makes you flip for your trip? Full-service spa? Heated pool? 24-hour room service? Get a hotel that’ll send you over the moon.

Do you deserve a swanky hotel with a ton of amenities? Yes, yes you do. And you also deserve a sweet deal on it. Book with Hotwire today and get that star-studded Upstate South Carolina 4-star hotel and have plenty of cash left over to spend at that secret super star joint in the city.