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Hotels in Upstate South Carolina

Check Last Minute Upstate South Carolina Hotel Deals

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Choose from 2611 Upstate South Carolina Hotel Deals

Hilton Greenville
Hilton Greenville
3.5 out of 5
45 W Orchard Park Dr, Greenville, SC
  • 1 hour drive from Clemson University
The price is $134 per night from May 11 to May 12
$134
includes taxes & fees
May 11 - May 12
Book a stay at this business-friendly hotel in Greenville. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and ...
8/10 Very Good! (1,005 reviews)
"Hilton Greenville was very nice and superb staff"

Reviewed on Apr 20, 2025

Hilton Greenville
Hyatt Regency Greenville
Hyatt Regency Greenville
3.5 out of 5
220 N Main St, Greenville, SC
  • 1 hour drive from Clemson University
The price is $153 per night from May 11 to May 12
$153
includes taxes & fees
May 11 - May 12
Book a stay at this business-friendly hotel in Greenville. Enjoy free WiFi, an outdoor pool, and breakfast (surcharge). Our guests praise the helpful staff and ...
8.6/10 Excellent! (1,001 reviews)
"I love the friendly staff and comfortable beds. Its my favorite place to stay in Greenville."

Reviewed on Apr 29, 2025

Hyatt Regency Greenville
Grand Bohemian Lodge Greenville, Autograph Collection
Grand Bohemian Lodge Greenville, Autograph Collection
4 out of 5
44 EAST CAMPERDOWN WAY, Greenville, SC
  • 1 hour drive from Clemson University
The price is $266 per night from May 26 to May 27
$266
includes taxes & fees
May 26 - May 27
Stay at this 4-star spa hotel in Greenville. Enjoy a full-service spa, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful staff ...
9.4/10 Exceptional! (336 reviews)
"Great place, expensive but worth it"

Reviewed on Apr 21, 2025

Grand Bohemian Lodge Greenville, Autograph Collection
Cambria Hotel Greenville
Cambria Hotel Greenville
3 out of 5
135 Carolina Point Parkway, Greenville, SC
  • 2 hours drive from Clemson University
The price is $135 per night from May 11 to May 12
$135
includes taxes & fees
May 11 - May 12
Stay at this 3-star business-friendly hotel in Greenville. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff and the clean ...
9.2/10 Wonderful! (1,015 reviews)
"So very nice!! Great for our 1 night in Greenville!"

Reviewed on Apr 27, 2025

Cambria Hotel Greenville
Hyatt Place Greenville/Downtown
Hyatt Place Greenville/Downtown
3 out of 5
128 East Broad Street, Greenville, SC
  • 1 hour drive from Clemson University
The price is $153 per night from May 26 to May 27
$153
includes taxes & fees
May 26 - May 27
Stay at this 3-star business-friendly hotel in Greenville. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the breakfast ...
9/10 Wonderful! (1,002 reviews)
Will stay here again!
"Friendly & knowledge staff. Clean and well stocked room & lobby."

Reviewed on Apr 26, 2025

Hyatt Place Greenville/Downtown
Embassy Suites Greenville Golf Resort & Conference Center
Embassy Suites Greenville Golf Resort & Conference Center
3.5 out of 5
670 Verdae Blvd, Greenville, SC
  • 1 hour drive from Clemson University
The price is $145 per night from May 11 to May 12
$145
includes taxes & fees
May 11 - May 12
Stay at this 3.5-star golf resort in Greenville. Enjoy free breakfast, a golf course, and a free airport shuttle. Our guests praise the breakfast and the helpful ...
8.8/10 Excellent! (1,000 reviews)
Convenient, comfortable, and caring!
"Very convenient to the interstate and main parts of town. Everyone, EVERYONE was smiling and happy and made us feel very comfortable! Will definitely be staying here again when we come back!"

Reviewed on Apr 23, 2025

Embassy Suites Greenville Golf Resort & Conference Center
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
3.5 out of 5
851 Congaree Rd, Greenville, SC
  • 1 hour drive from Clemson University
The price is $109 per night from May 25 to May 26
$109
includes taxes & fees
May 25 - May 26
Stay at this 3.5-star business-friendly hotel in Greenville. Enjoy free WiFi, free parking, and 2 restaurants. Our guests praise the helpful staff and the room ...
8.4/10 Very Good! (1,003 reviews)
"Thanks"

Reviewed on Apr 27, 2025

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
Best Western Plus Greenville I-385 Inn & Suites
Best Western Plus Greenville I-385 Inn & Suites
2.5 out of 5
831 Congaree Rd, Greenville, SC
  • 1 hour drive from Clemson University
The price is $94 per night from May 18 to May 19
$94
includes taxes & fees
May 18 - May 19
Book a stay at this business-friendly hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,332 reviews)
"Solid hotel location wasn’t bad either and the breakfast was good and the staff was very helpful only bad thing was the elevator not working but that wasn’t that bad to be honest"

Reviewed on Apr 28, 2025

Best Western Plus Greenville I-385 Inn & Suites
La Quinta Inn & Suites by Wyndham Greenville Haywood
La Quinta Inn & Suites by Wyndham Greenville Haywood
2.5 out of 5
65 W Orchard Park Dr, Greenville, SC
  • 1 hour drive from Clemson University
The price is $72 per night from May 4 to May 5
$72
includes taxes & fees
May 4 - May 5
Stay at this hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. ...
7.4/10 Good! (1,006 reviews)
"Lovely stay."

Reviewed on Apr 25, 2025

La Quinta Inn & Suites by Wyndham Greenville Haywood
Best Western Plus Clemson Hotel & Conference Center
Best Western Plus Clemson Hotel & Conference Center
2.5 out of 5
1310 Tiger Blvd, Clemson, SC
  • 22 min walk from Clemson University
The price is $103 per night from May 4 to May 5
$103
includes taxes & fees
May 4 - May 5
Book a stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.2/10 Very Good! (1,000 reviews)
"A great place to stay. Breakfast is very good, plus an on site bar/restaurant with plenty of tvs and good food."

Reviewed on Apr 27, 2025

Best Western Plus Clemson Hotel & Conference Center
Lakeside Lodge Clemson
Lakeside Lodge Clemson
2.5 out of 5
13500 Clemson Blvd, Seneca, SC
  • 5 min drive from Clemson University
The price is $134 per night from May 3 to May 4
$134
includes taxes & fees
May 3 - May 4
Stay at this hotel in Seneca. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
8.8/10 Excellent! (856 reviews)
"The hotel was great. It was very clean and the location was perfect for our trip."

Reviewed on Apr 28, 2025

Lakeside Lodge Clemson
Holiday Inn Greenville - Woodruff Road by IHG
Holiday Inn Greenville - Woodruff Road by IHG
3 out of 5
25 OLD COUNTRY ROAD, Greenville, SC
  • 2 hours drive from Clemson University
The price is $133 per night from Jun 1 to Jun 2
$133
includes taxes & fees
Jun 1 - Jun 2
Stay at this 3-star business-friendly hotel in Greenville. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in our ...
8.4/10 Very Good! (522 reviews)
"Friendly staff"

Reviewed on Apr 25, 2025

Holiday Inn Greenville - Woodruff Road by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Upstate South Carolina

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For you, intrepid voyager, Hotwire has a large selection of the best hotels in Upstate South Carolina.

Choosing the right hotel in South Carolina has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Upstate South Carolina’s 2,611 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $72. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Upstate South Carolina hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Upstate South Carolina. No matter your reason for visiting Upstate South Carolina, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Upstate South Carolina hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Upstate South Carolina for as low as $72.

How many hotels are there in Upstate South Carolina?

With over 2,611 hotels in Upstate South Carolina, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $72.

How to find cheap car rentals in Upstate South Carolina?

Finding a cheap car rental deal in Upstate South Carolina is as easy as scoring cheap hotels in Upstate South Carolina. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.