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Hotels in Upstate South Carolina

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Choose from 2747 Upstate South Carolina Hotel Deals

Days Inn by Wyndham Anderson
Days Inn by Wyndham Anderson
2 out of 5
1007 George Smith Mill Rd, Anderson, SC
  • 28 min drive from Clemson University
Book a stay at this business-friendly motel in Anderson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,007 reviews)
"Everything was great. I'd definitely book again."

Reviewed on Jun 30, 2025

Days Inn by Wyndham Anderson
Hyatt Regency Greenville
Hyatt Regency Greenville
3.5 out of 5
220 N Main St, Greenville, SC
  • 1 hour drive from Clemson University
Book a stay at this business-friendly hotel in Greenville. Enjoy free WiFi, an outdoor pool, and breakfast (surcharge). Our guests praise the helpful staff and ...
8.6/10 Excellent! (1,008 reviews)
"Great location."

Reviewed on Jun 29, 2025

Hyatt Regency Greenville
La Quinta Inn & Suites by Wyndham Greenville Haywood
La Quinta Inn & Suites by Wyndham Greenville Haywood
3 out of 5
65 W Orchard Park Dr, Greenville, SC
  • 1 hour drive from Clemson University
Stay at this 3-star hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. ...
7.2/10 Good! (1,010 reviews)
"I had a three-night stay at this hotel. There were a few things with the property that caught my eye. 1) The continental breakfast is OK. Sparse, but there is some substance to it. Would have liked to have had larger coffee cups instead of the small ones provided. I stopped on two of the three mornings ..."

Reviewed on Jun 29, 2025

La Quinta Inn & Suites by Wyndham Greenville Haywood
Comfort Inn Greenville - Haywood Mall
Comfort Inn Greenville - Haywood Mall
2.5 out of 5
246 Congaree Road, Greenville, SC
  • 1 hour drive from Clemson University
Book a stay at this business-friendly hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8/10 Very Good! (1,008 reviews)
"Breakfast was good"

Reviewed on Jun 28, 2025

Comfort Inn Greenville - Haywood Mall
Hilton Greenville
Hilton Greenville
3.5 out of 5
45 W Orchard Park Dr, Greenville, SC
  • 1 hour drive from Clemson University
Stay at this 3.5-star business-friendly hotel in Greenville. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and ...
8/10 Very Good! (1,006 reviews)
"It’s location was convenient and the area had enough eating places nearby."

Reviewed on Jun 30, 2025

Hilton Greenville
Woodspring Suites Greenville Airport
Woodspring Suites Greenville Airport
2.5 out of 5
205 Entertainment Blvd, Greenville, SC
  • 2 hours drive from Clemson University
Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Haywood Mall and BMW Performance Center are located nearby.
8.4/10 Very Good! (81 reviews)
"Great stay!"

Reviewed on Jun 28, 2025

Woodspring Suites Greenville Airport
Best Western Plus Greenville I-385 Inn & Suites
Best Western Plus Greenville I-385 Inn & Suites
2.5 out of 5
831 Congaree Rd, Greenville, SC
  • 1 hour drive from Clemson University
Book a stay at this business-friendly hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,338 reviews)
"It did the job for a two night stay. The bed was comfortable and room.was clean. Breakfast was above average."

Reviewed on Jun 26, 2025

Best Western Plus Greenville I-385 Inn & Suites
Hyatt Place Greenville/Haywood
Hyatt Place Greenville/Haywood
3 out of 5
40 W Orchard Park Dr, Greenville, SC
  • 1 hour drive from Clemson University
Book a stay at this business-friendly hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.6/10 Good! (1,008 reviews)
"This is a literal gem!! The rooms are so spacious and clean. The complimentary breakfast makes the stay ever better! 10/10 recommend"

Reviewed on Jun 29, 2025

Hyatt Place Greenville/Haywood
Grand Bohemian Lodge Greenville, Autograph Collection
Grand Bohemian Lodge Greenville, Autograph Collection
4 out of 5
44 EAST CAMPERDOWN WAY, Greenville, SC
  • 1 hour drive from Clemson University
Stay at this 4-star spa hotel in Greenville. Enjoy a full-service spa, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful staff ...
9.4/10 Exceptional! (350 reviews)
"Beautiful property"

Reviewed on Jun 24, 2025

Grand Bohemian Lodge Greenville, Autograph Collection
Wingate by Wyndham - Greenville-Airport
Wingate by Wyndham - Greenville-Airport
2.5 out of 5
33 Beacon Dr, Greenville, SC
  • 2 hours drive from Clemson University
Book a stay at this business-friendly hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.2/10 Very Good! (1,008 reviews)
"It was very comfortable,and CLEAN."

Reviewed on Jun 30, 2025

Wingate by Wyndham - Greenville-Airport
Days Inn by Wyndham Greenville
Days Inn by Wyndham Greenville
2 out of 5
60 Roper Mountain Rd, Greenville, SC
  • 1 hour drive from Clemson University
Book a stay at this business-friendly motel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
5.8/10 (1,005 reviews)
"Really liked this property and will come here again. My only reasons for giving 4 ⭐s is because I wasn't there long enough. Staff was cool, helpful, and quick with the reservation. The very same person that checked me in let me know how to handle the late checkout and keeping the room for the following ..."

Reviewed on Jun 29, 2025

Days Inn by Wyndham Greenville
Aloft Greenville Downtown
Aloft Greenville Downtown
3 out of 5
5 North Laurens Street, Greenville, SC
  • 1 hour drive from Clemson University
Stay at this 3-star business-friendly hotel in Greenville. Enjoy free WiFi, breakfast (surcharge), and a fitness center. Our guests praise the helpful staff ...
9/10 Wonderful! (1,005 reviews)
"Didn’t like all the homeless people sleeping around the property directly out front in courtyard area and side areas."

Reviewed on Jun 30, 2025

Aloft Greenville Downtown
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Upstate South Carolina

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For you, intrepid voyager, Hotwire has a large selection of the best hotels in Upstate South Carolina.

Choosing the right hotel in South Carolina has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Upstate South Carolina’s 2,747 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as . In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Upstate South Carolina hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Upstate South Carolina. No matter your reason for visiting Upstate South Carolina, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Upstate South Carolina hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Upstate South Carolina for as low as .

How many hotels are there in Upstate South Carolina?

With over 2,747 hotels in Upstate South Carolina, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as .

How to find cheap car rentals in Upstate South Carolina?

Finding a cheap car rental deal in Upstate South Carolina is as easy as scoring cheap hotels in Upstate South Carolina. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.