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Hotels in Upstate South Carolina

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Hilton Greenville

Hilton Greenville

3.5 out of 5
45 W Orchard Park Dr Greenville SC
  • 1 hour drive from Clemson University
Book a stay at this business-friendly hotel in Greenville. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and ...
8.2/10 Very Good! (1,001 reviews)
Place is very

Reviewed on Jan 21, 2026

Hilton Greenville
Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection

4 out of 5
44 EAST CAMPERDOWN WAY Greenville SC
  • 1 hour drive from Clemson University
Book a stay at this spa hotel in Greenville. Enjoy a full-service spa, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful staff ...
9.4/10 Exceptional! (439 reviews)
Awesome place and service

Reviewed on Jan 23, 2026

Grand Bohemian Lodge Greenville, Autograph Collection
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

3.5 out of 5
851 Congaree Rd Greenville SC
  • 1 hour drive from Clemson University
Book a stay at this business-friendly hotel in Greenville. Enjoy free WiFi, free parking, and 2 restaurants. Our guests praise the helpful staff and the room ...
8.4/10 Very Good! (1,001 reviews)
The room was so clean and everything was quiet. I will be back

Reviewed on Jan 29, 2026

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
Hyatt Regency Greenville

Hyatt Regency Greenville

3.5 out of 5
220 N Main St Greenville SC
  • 1 hour drive from Clemson University
Book a stay at this business-friendly hotel in Greenville. Enjoy free WiFi, an outdoor pool, and breakfast (surcharge). Our guests praise the helpful staff and ...
8.6/10 Excellent! (1,004 reviews)
:Perfect

Reviewed on Jan 22, 2026

Hyatt Regency Greenville
Sleep Inn Spartanburg Southwest

Sleep Inn Spartanburg Southwest

2.5 out of 5
501 South Blackstock Rd Spartanburg SC
  • 2 hours drive from Clemson University
Book a stay at this business-friendly hotel in Spartanburg. Enjoy free breakfast, free WiFi, and free parking. Popular attractions WestGate Mall and Regal Spartan ...
5.8/10 (535 reviews)
Girl at check-in was more focused on a personal phone call than checking us in. Was rude when informed that light switch did not turn on any lights in the room. Yelled up from lobby that you have to walk into the DARK room and turn light on next to the bed. Light by TV did not work, did not offer ...

Reviewed on Jan 6, 2026

Sleep Inn Spartanburg Southwest
Embassy Suites Greenville Golf Resort & Conference Center

Embassy Suites Greenville Golf Resort & Conference Center

3.5 out of 5
670 Verdae Blvd Greenville SC
  • 1 hour drive from Clemson University
Book a stay at this golf resort in Greenville. Enjoy free breakfast, a golf course, and a free airport shuttle. Our guests praise the breakfast and the helpful ...
8.8/10 Excellent! (1,041 reviews)
Room was spotless, staff was great, love the shower gel and shampoo! Always a good time at this facility - you never need to go out the hotel provides it all!

Reviewed on Jan 25, 2026

Embassy Suites Greenville Golf Resort & Conference Center
Hampton Inn & Suites Greenville-Downtown-RiverPlace

Hampton Inn & Suites Greenville-Downtown-RiverPlace

2.5 out of 5
171 Riverplace Greenville SC
  • 1 hour drive from Clemson University
Book a stay at this business-friendly hotel in Greenville. Enjoy free breakfast, free WiFi, and room service. Our guests praise the helpful staff and the clean ...
9.2/10 Wonderful! (1,009 reviews)
Breakfast fare needs improvement for a higher end Hampton Inn

Reviewed on Jan 25, 2026

Hampton Inn & Suites Greenville-Downtown-RiverPlace
Embassy Suites by Hilton Greenville Downtown Riverplace

Embassy Suites by Hilton Greenville Downtown Riverplace

3.5 out of 5
250 Riverplace Greenville SC
  • 1 hour drive from Clemson University
Book a stay at this business-friendly hotel in Greenville. Enjoy free breakfast, free WiFi, and 2 restaurants. Our guests praise the bar and the helpful staff ...
9/10 Wonderful! (1,007 reviews)
The room was neat and clean. The cleaning and kitchen staff were very kind and courteous. It was a great stay.

Reviewed on Jan 24, 2026

Embassy Suites by Hilton Greenville Downtown Riverplace
Wooded Cottage - 3 Mi to Clemson University

Wooded Cottage - 3 Mi to Clemson University

3 out of 5
Clemson SC
  • 6 min drive from Clemson University
Stay at this cottage in Clemson. Enjoy air conditioning. Popular attractions Clemson Area African American Museum and Larry W. Abernathy Waterfront Park are ...
Wooded Cottage - 3 Mi to Clemson University
Hyatt Place Greenville Downtown

Hyatt Place Greenville Downtown

3 out of 5
128 East Broad Street Greenville SC
  • 1 hour drive from Clemson University
Book a stay at this business-friendly hotel in Greenville. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the breakfast ...
9.2/10 Wonderful! (1,007 reviews)
Great place, great experience. All it is missing an upgrade on the tv systems. Other than that, exactly what I needed. Staff is friendly too.

Reviewed on Jan 26, 2026

Hyatt Place Greenville Downtown
Hyatt Place Greenville/Haywood

Hyatt Place Greenville/Haywood

3 out of 5
40 W Orchard Park Dr Greenville SC
  • 1 hour drive from Clemson University
Book a stay at this business-friendly hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.8/10 Good! (1,007 reviews)
Friendly staff and comfortable room

Reviewed on Jan 21, 2026

Hyatt Place Greenville/Haywood
Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center

2.5 out of 5
1310 Tiger Blvd Clemson SC
  • 22 min walk from Clemson University
Book a stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the helpful staff and the ...
8.2/10 Very Good! (1,001 reviews)
Rooms are clean. Staff was very pleasant.

Reviewed on Jan 20, 2026

Best Western Plus Clemson Hotel & Conference Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Upstate South Carolina

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For you, intrepid voyager, Hotwire has a large selection of the best hotels in Upstate South Carolina.

Choosing the right hotel in South Carolina has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Upstate South Carolina’s 2,946 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $68. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Upstate South Carolina hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Upstate South Carolina. No matter your reason for visiting Upstate South Carolina, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Upstate South Carolina hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Upstate South Carolina for as low as $68.

How many hotels are there in Upstate South Carolina?

With over 2,946 hotels in Upstate South Carolina, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $68.

How to find cheap car rentals in Upstate South Carolina?

Finding a cheap car rental deal in Upstate South Carolina is as easy as scoring cheap hotels in Upstate South Carolina. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.