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Hotels in Upstate South Carolina

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Choose from 2930 Upstate South Carolina Hotel Deals

Hilton Greenville

Hilton Greenville

3.5 out of 5
45 W Orchard Park Dr Greenville SC
  • 1 hour drive from Clemson University
Book a stay at this business-friendly hotel in Greenville. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and ...
8.2/10 Very Good! (1,001 reviews)
Good

Reviewed on Jan 2, 2026

Hilton Greenville
Homewood Suites by Hilton Greenville Downtown

Homewood Suites by Hilton Greenville Downtown

3 out of 5
950 South Main Street Greenville SC
  • 1 hour drive from Clemson University
Book a stay at this business-friendly hotel in Greenville. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the helpful staff and the ...
9.4/10 Exceptional! (1,002 reviews)
The ladies in charge of breakfast (Michelle and Dana) are amazing and keep it stocked. Essence at the front desk really cares and checked in with us several times during our three-night stay.

Reviewed on Jan 1, 2026

Homewood Suites by Hilton Greenville Downtown
Embassy Suites Greenville Golf Resort & Conference Center

Embassy Suites Greenville Golf Resort & Conference Center

3.5 out of 5
670 Verdae Blvd Greenville SC
  • 1 hour drive from Clemson University
Book a stay at this golf resort in Greenville. Enjoy free breakfast, a golf course, and a free airport shuttle. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,011 reviews)
Yes

Reviewed on Jan 2, 2026

Embassy Suites Greenville Golf Resort & Conference Center
Wooded Cottage - 3 Mi to Clemson University

Wooded Cottage - 3 Mi to Clemson University

3 out of 5
Clemson SC
  • 6 min drive from Clemson University
Stay at this cottage in Clemson. Enjoy air conditioning. Popular attractions Clemson Area African American Museum and Larry W. Abernathy Waterfront Park are ...
Wooded Cottage - 3 Mi to Clemson University
Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection

4 out of 5
44 EAST CAMPERDOWN WAY Greenville SC
  • 1 hour drive from Clemson University
Book a stay at this spa hotel in Greenville. Enjoy a full-service spa, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful staff ...
9.4/10 Exceptional! (430 reviews)
Awesome place.

Reviewed on Dec 31, 2025

Grand Bohemian Lodge Greenville, Autograph Collection
La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.

La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.

3 out of 5
11 Ketron Court Greenville SC
  • 1 hour drive from Clemson University
Book a stay at this business-friendly hotel in Greenville. Enjoy free breakfast, free WiFi, and a 24-hour front desk. Our guests praise the helpful staff and ...
8.6/10 Excellent! (91 reviews)
good breakfast, good staff. Nice and clean

Reviewed on Jan 2, 2026

La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.
Hyatt Regency Greenville

Hyatt Regency Greenville

3.5 out of 5
220 N Main St Greenville SC
  • 1 hour drive from Clemson University
Book a stay at this business-friendly hotel in Greenville. Enjoy free WiFi, an outdoor pool, and breakfast (surcharge). Our guests praise the helpful staff and ...
8.6/10 Excellent! (1,001 reviews)
Yes

Reviewed on Jan 1, 2026

Hyatt Regency Greenville
Best Western Greenville Airport Inn

Best Western Greenville Airport Inn

2.5 out of 5
5009 Pelham Road Greenville SC
  • 2 hours drive from Clemson University
Stay at this hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. ...
7.6/10 Good! (1,006 reviews)
It was clean nice peaceful and quiet no disturbance rest well great

Reviewed on Dec 24, 2025

Best Western Greenville Airport Inn
The Westin Poinsett Greenville

The Westin Poinsett Greenville

4 out of 5
120 South Main St Greenville SC
  • 1 hour drive from Clemson University
Book a stay at this business-friendly hotel in Greenville. Enjoy breakfast (surcharge), a free airport shuttle, and 24-hour room service. Our guests praise the ...
9.2/10 Wonderful! (1,009 reviews)
Yes the bar & the staff that worked at mid shift were excellent. The breakfast & presentation with the staff coordination exceeded my expectations...

Reviewed on Jan 2, 2026

The Westin Poinsett Greenville
ECHO Suites Extended Stay by Wyndham Spartanburg

ECHO Suites Extended Stay by Wyndham Spartanburg

2 out of 5
490 W Blackstock Road Spartanburg SC
  • 2 hours drive from Clemson University
Book a stay at this business-friendly hotel in Spartanburg. Enjoy free WiFi, free parking, and a 24-hour fitness center. Popular attractions Regal Spartan and ...
8/10 Very Good! (310 reviews)
Little to no amenities (be prepared), expensive to rent a coffee maker, front desk staff not very friendly, could hear a lot of noise from upstairs room.

Reviewed on Dec 29, 2025

ECHO Suites Extended Stay by Wyndham Spartanburg
Aloft Greenville Downtown

Aloft Greenville Downtown

3 out of 5
5 North Laurens Street Greenville SC
  • 1 hour drive from Clemson University
Book a stay at this business-friendly hotel in Greenville. Enjoy free WiFi, breakfast (surcharge), and a fitness center. Our guests praise the helpful staff ...
9/10 Wonderful! (1,005 reviews)
Great location - easy walk to everything in DT Greenville (unless you are spending a lot of time in the West End). The Hotel, Lobby & Room were all clean and accommodating!

Reviewed on Jan 4, 2026

Aloft Greenville Downtown
Best Western Plus Greenville I-385 Inn & Suites

Best Western Plus Greenville I-385 Inn & Suites

2.5 out of 5
831 Congaree Rd Greenville SC
  • 1 hour drive from Clemson University
Book a stay at this business-friendly hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,428 reviews)
The room was clean, staffs were welcoming and the breakfast food was good.

Reviewed on Dec 28, 2025

Best Western Plus Greenville I-385 Inn & Suites
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Upstate South Carolina

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For you, intrepid voyager, Hotwire has a large selection of the best hotels in Upstate South Carolina.

Choosing the right hotel in South Carolina has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Upstate South Carolina’s 2,930 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $79. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Upstate South Carolina hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Upstate South Carolina. No matter your reason for visiting Upstate South Carolina, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Upstate South Carolina hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Upstate South Carolina for as low as $79.

How many hotels are there in Upstate South Carolina?

With over 2,930 hotels in Upstate South Carolina, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $79.

How to find cheap car rentals in Upstate South Carolina?

Finding a cheap car rental deal in Upstate South Carolina is as easy as scoring cheap hotels in Upstate South Carolina. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.