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Featured Luxury Upstate South Carolina
The Westin Poinsett Greenville
120 South Main St, Greenville, SC
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in Greenville. Enjoy breakfast (surcharge), a free airport shuttle, and 24-hour room service. Our guests praise the ...
Hyatt Regency Greenville
220 N Main St, Greenville, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Greenville. Enjoy free WiFi, an outdoor pool, and breakfast (surcharge). Our guests praise the helpful staff and ...
Sleep Inn at Greenville Convention Cente
231 N Pleasantburg Dr, Greenville, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
The Bleckley Inn
151 E Church St, Anderson, SC
Stay at this 3.5-star business-friendly hotel in Anderson. Enjoy free parking, a rooftop terrace, and a fitness center. Popular attractions Church Street Heritage ...
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
851 Congaree Rd, Greenville, SC
Fully refundable
Stay at this 3.5-star business-friendly hotel in Greenville. Enjoy free WiFi, free parking, and 2 restaurants. Our guests praise the helpful staff and the room ...
Red Roof Inn Spartanburg – I-26
6765 Pottery Rd, Spartanburg, SC
Fully refundableReserve now, pay when you stay
Stay at this hotel in Spartanburg. Enjoy free breakfast, free WiFi, and free parking. Popular attractions County University Soccer Stadium and Susan Jacobs Arboretum ...
Quality Inn Clemson near University
3430 Clemson Blvd, Anderson, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Anderson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
La Quinta Inn & Suites by Wyndham Greenville Haywood
65 W Orchard Park Dr, Greenville, SC
Fully refundableReserve now, pay when you stay
Stay at this hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. ...
Hilton Greenville
45 W Orchard Park Dr, Greenville, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Greenville. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and ...
Best Western Travelers Rest Greenville
110 Hawkins Rd, Travelers Rest, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Travelers Rest. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Embassy Suites Greenville Golf Resort & Conference Center
670 Verdae Blvd, Greenville, SC
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star golf resort in Greenville. Enjoy free breakfast, a golf course, and a free airport shuttle. Our guests praise the breakfast and the helpful ...
Comfort Inn Greenville - Haywood Mall
246 Congaree Road, Greenville, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels by Star Rating
More Hotel Options in Upstate South Carolina
- Hotels with Free Parking in Upstate South Carolina
- Family Hotels in Upstate South Carolina
- Hotels with a Pool in Upstate South Carolina
- Pet-friendly Hotels in Upstate South Carolina
- Historic Hotels in Upstate South Carolina
- Hotel Wedding Venues in Upstate South Carolina
- Romantic Hotels in Upstate South Carolina
- Apartment Hotel in Upstate South Carolina
- Hotels with Hot Tubs in Upstate South Carolina
- Resorts & Hotels with Spas in Upstate South Carolina
Upstate South Carolina Neighborhoods
- Greenville Downtown Hotels (8.63 mi)
- Nicholtown Hotels (7.29 mi)
- West End Hotels (8.94 mi)
- Overbrook Historic District Hotels (8.1 mi)
- Hampton-Pinckney Historic District Hotels (9.35 mi)
- Colonel Elias Earle Historic District Hotels (9.34 mi)
- Pettigru Street Historic District Hotels (8.31 mi)
- Woodside Cotton Mill Village Historic District Hotels (10.12 mi)
- Downtown Hotels (38.83 mi)
Top Points of Interests in Upstate South Carolina
- Hotels near Clemson University
- Hotels near Falls Park on the Reedy
- Hotels near BMW Performance Center
- Hotels near Lake Jocassee
- Hotels near Haywood Mall
- Hotels near Prisma Health Greenville Memorial Hospital
- Hotels near Bon Secours Wellness Arena
- Hotels near Greenville Convention Center
- Hotels near The Peace Center
- Hotels near Wofford College
- Hotels near Fluor Field at the West End
- Hotels near Anderson University
- Hotels near Fred W. Symmes Chapel
- Hotels near Table Rock State Park
- Hotels near Memorial Stadium
- Hotels near Bob Jones University
- Hotels near Devils Fork State Park
- Hotels near University of South Carolina Upstate
- Hotels near Converse College
- Hotels near WestGate Mall
Cities near Upstate South Carolina
- Greenville Hotels (8.73 mi)
- Highlands Hotels (55.49 mi)
- Lake Lure Hotels (45.56 mi)
- Hendersonville Hotels (39.13 mi)
- Brevard Hotels (40.98 mi)
- Rock Hill Hotels (71.73 mi)
- Franklin Hotels (68.54 mi)
- Anderson Hotels (28.12 mi)
- Spartanburg Hotels (23.13 mi)
- Clemson Hotels (32.31 mi)
- North Carolina Mountains Hotels (64.32 mi)
- Seneca Hotels (38.76 mi)
- Black Mountain Hotels (58.45 mi)
- Cashiers Hotels (52.06 mi)
- Gastonia Hotels (70.54 mi)
- Blue Ridge Mountains Hotels (68.54 mi)
- Clayton Hotels (64.05 mi)
- Greer Hotels (11.86 mi)
- Shelby Hotels (55.26 mi)
- Simpsonville Hotels (2.78 mi)
Car Rentals Near Upstate South Carolina
- Car rentals in Greenville
- Car rentals in Highlands
- Car rentals in Lake Lure
- Car rentals in Hendersonville
- Car rentals in Brevard
- Car rentals in Rock Hill
- Car rentals in Franklin
- Car rentals in Anderson
- Car rentals in Spartanburg
- Car rentals in Clemson
- Car rentals in North Carolina Mountains
- Car rentals in Seneca
- Car rentals in Black Mountain
- Car rentals in Cashiers
- Car rentals in Gastonia
- Car rentals in Blue Ridge Mountains
Top Luxury Hotel Destinations
- Amarillo Luxury Hotels
- Sioux Falls Luxury Hotels
- Fort Wayne Luxury Hotels
- South Padre Island Luxury Hotels
- Cheyenne Luxury Hotels
- Corpus Christi Luxury Hotels
- Gettysburg Luxury Hotels
- Fresno Luxury Hotels
- Fayetteville Luxury Hotels
- Springfield Luxury Hotels
- Flagstaff Luxury Hotels
- Tuscaloosa Luxury Hotels
- Toledo Luxury Hotels
- Traverse City Luxury Hotels
- Twin Falls Luxury Hotels
- Scranton Luxury Hotels
- Columbia Luxury Hotels
- Catalina Island Luxury Hotels
- Shreveport Luxury Hotels
- Tallahassee Luxury Hotels
Top Booked Hotels in Upstate South Carolina
- Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
- Hilton Greenville
- Hyatt Regency Greenville
- Best Western Plus Greenville I-385 Inn & Suites
- Hyatt Place Greenville/Downtown
- Comfort Inn Greenville - Haywood Mall
- Embassy Suites Greenville Golf Resort & Conference Center
- Hyatt Place Greenville/Haywood
- La Quinta Inn & Suites by Wyndham Greenville Haywood